Leptin activates RhoA/ROCK pathway to induce cytoskeleton remodeling in nucleus pulposus cells

International Journal of Molecular Sciences

Volumn 15, Issue 1, 2014, Pages 1176-1188

  Li, Zheng ^a   Liang, Jinqian ^a   Wu, William Ka Kei ^b   Yu, Xin ^a   Yu, Jun ^b   Weng, Xisheng ^a   Shen, Jianxiong ^a  

^a PEKING UNION MEDICAL COLLEGE HOSPITAL   (China)

^b CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Cytoskeleton; Disc degeneration; F actin; Fluorescent resonance energy transfer (FRET); Leptin

Indexed keywords

4 (1 AMINOETHYL) N (4 PYRIDYL) CYCLOHEXANECARBOXAMIDE; COFILIN 2; EXOENZYME C3; F ACTIN; LEPTIN; LIM KINASE 1; RHO KINASE; RHO KINASE INHIBITOR; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CLINICAL ARTICLE; CONFOCAL LASER MICROSCOPY; CYTOSKELETON; FEMALE; FLUORESCENCE RESONANCE ENERGY TRANSFER; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPERLEPTINEMIA; IMMUNOPRECIPITATION; INTERVERTEBRAL DISK DEGENERATION; INTRACELLULAR SIGNALING; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEUS PULPOSUS; OBESITY; PHOSPHORYLATION; PROTEIN EXPRESSION; WESTERN BLOTTING;

ACTIN CYTOSKELETON; ADULT; COFILIN 2; FEMALE; HUMANS; INTERVERTEBRAL DISC; LEPTIN; LIM KINASES; MALE; RHO-ASSOCIATED KINASES; RHOA GTP-BINDING PROTEIN; SCOLIOSIS; SIGNAL TRANSDUCTION;

EID: 84892603904     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms15011176     Document Type: Article

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