Protective effects of Notoginsenoside R1 on intestinal ischemia-reperfusion injury in rats

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 306, Issue 2, 2014, Pages

  Li, Chong ^a,b   Li, Quan ^a,b,c   Liu, Yu Ying ^a,b,c   Wang, Ming Xia ^a,b,c   Pan, Chun Shui ^a,b,c   Yan, Li ^a,b,c   Chen, Yuan Yuan ^a,b   Fan, Jing Yu ^a,b,c   Han, Jing Yan ^a,b,c  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

^b State Administration of Traditional Chinese Medicine   (China)

^c The Key Lab of TCM Information Engineering of State Administration of Traditional Chinese Medicine   (China)

Author keywords

Adenosine 5' triphosphate; Inflammation; Microcirculation; Nuclear factor B; Tight junction

Indexed keywords

ADENOSINE DIPHOSPHATE; ADENOSINE PHOSPHATE; ADENOSINE TRIPHOSPHATE; ATP5D PROTEIN; CD68 ANTIGEN; CYTOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MYELOPEROXIDASE; NOTOGINSENOSIDE R1; PROTEIN; TIGHT JUNCTION PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BIOLOGICAL ACTIVITY; BLOOD VESSEL PERMEABILITY; CELL INFILTRATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENERGY METABOLISM; ENZYME LINKED IMMUNOSORBENT ASSAY; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; INTESTINE BLOOD FLOW; INTESTINE ISCHEMIA; INTESTINE MUCOSA; JEJUNUM; LEUKOCYTE; MALE; MICROCIRCULATION; NONHUMAN; PRIORITY JOURNAL; PROTECTION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; REPERFUSION INJURY; SHAM PROCEDURE; SUPERIOR MESENTERIC ARTERY; TISSUE INJURY; WESTERN BLOTTING;

ADENOSINE 5′-TRIPHOSPHATE; INFLAMMATION; MICROCIRCULATION; NUCLEAR FACTOR-ΚB; TIGHT JUNCTION;

ANIMALS; APOPTOSIS; BLOTTING, WESTERN; CAPILLARY PERMEABILITY; ENERGY METABOLISM; GINSENOSIDES; INTESTINAL DISEASES; INTESTINES; JEJUNUM; MALE; MALONDIALDEHYDE; MICROCIRCULATION; NEUTROPHIL INFILTRATION; PEROXIDASE; RATS; RATS, SPRAGUE-DAWLEY; REGIONAL BLOOD FLOW; REPERFUSION INJURY; TIGHT JUNCTIONS;

EID: 84892600718     PISSN: 01931857     EISSN: 15221547     Source Type: Journal    
DOI: 10.1152/ajpgi.00123.2013     Document Type: Article

References (32)

1. Acosta S. Epidemiology of mesenteric vascular disease: clinical implications. Semin Vasc Surg 23: 4-8, 2010.
2. Alfieri A, Watson JJ, Kammerer RA, Tasab M, Progias P, Reeves K, Brown NJ, Brookes ZL. Angiopoietin-1 variant reduces LPS-induced microvascular dysfunction in a murine model of sepsis (Abstract). Crit Care 16: R182, 2012.
3. Campolo M, Di Paola R, Impellizzeri D, Crupi R, Morittu VM, Procopio A, Perri E, Britti D, Peli A, Esposito E, Cuzzocrea S. Effects of a polyphenol present in olive oil, oleuropein aglycone, in a murine model of intestinal ischemia/reperfusion injury. J Leukoc Biol 93: 277-287, 2013.
4. Cerqueira NF, Hussni CA, Yoshida WB. Pathophysiology of mesenteric ischemia/reperfusion: a review. Acta Cir Bras 20: 336-343, 2005.
5. Chen WX, Wang F, Liu YY, Zeng QJ, Sun K, Xue X, Li X, Yang JY, An LH, Hu BH, Yang JH, Wang CS, Li ZX, Liu LY, Li Y, Zheng J, Liao FL, Han D, Fan JY, Han JY. Effect of notoginsenoside R1 on hepatic microcirculation disturbance induced by gut ischemia and reperfusion. World J Gastroenterol 14: 29-37, 2008.
6. Fasano A. Regulation of intercellular tight junctions by zonula occludens toxin and its eukaryotic analogue zonulin. Ann NY Acad Sci 915: 214-222, 2000.
7. Grootjans J, Lenaerts K, Derikx JP, Matthijsen RA, de Bruïne AP, van Bijnen AA, van Dam RM, Dejong CH, Buurman WA. Human intestinal ischemia-reperfusion-induced inflammation characterized: experiences from a new translational model. Am J Pathol 176: 2283-2291, 2010.
8. Lin SQ, Wei XH, Huang P, Liu YY, Zhao N, Li Q, Pan CS, Hu BH, Chang X, Fan JY, Yang XY, Wang CS, Liu HN, Han JY. QiShenYiQi Pills® prevents cardiac ischemia-reperfusion injury via energy modulation. Int J Cardiol. doi:10.1016/j.ijcard.2012.10.042.
9. Liu KX, Li YS, Huang WQ, Chen SQ, Wang ZX, Liu JX, Xia Z. Immediate postconditioning during reperfusion attenuates intestinal injury. Intensive Care Med 35: 933-942, 2009.
10. Liu KX, Li YS, Huang WQ, Li C, Liu JX, Li Y. Immediate but not delayed postconditioning during reperfusion attenuates acute lung injury induced by intestinal ischemia/reperfusion in rats: comparison with ischemic preconditioning. J Surg Res 157: e55-e62, 2009.
11. Liu KX, Chen SQ, Huang WQ, Li YS, Irwin MG, Xia Z. Propofol pretreatment reduces ceramide production and attenuates intestinal mucosal apoptosis induced by intestinal ischemia/reperfusion in rats. Anesth Analg 107: 1884-1891, 2008.
12. Liu WJ, Tang HT, Jia YT, Ma B, Fu JF, Wang Y, Lv KY, Xia ZF. Notoginsenoside R1 attenuates renal ischemia-reperfusion injury in rats. Shock 34: 314-320, 2010.
13. Mallick IH, Yang W, Winslet MC, Seifalian AM. Ischemia-reperfusion injury of the intestine and protective strategies against injury. Dig Dis Sci 49: 1359-1377, 2004.
14. Menconi MJ, Salzman AL, Unno N, Ezzel RM, Casey DM, Fink MP. Acidosis induces hyperpermeability in Caco-2BBe cultured intestinal epithelial monolayers. Am J Physiol Gastrointest Liver Physiol 272: G1007-G1021, 1997.
15. Olanders K, Sun Z, Börjesson A, Dib M, Andersson E, Lasson A, Ohlsson T, Andersson R. The effect of intestinal ischemia and reperfusion injury on ICAM-1 expression, endothelial barrier function, neutrophil tissue influx, and protease inhibitor levels in rats. Shock 18: 86-92, 2002.
16. Pierro A, Eaton S. Intestinal ischemia reperfusion injury and multisystem organ failure. Semin Pediatr Surg 13: 11-17, 2004.
17. Salehi P, Madsen K, Zhu J, Castillo E, Avila J, Lakey JR, Churchill TA. Alleviating ischemia-reperfusion injury in small bowel. Am J Transplant 4: 728-737, 2004.
18. Sato A, Kuwabara Y, Sugiura M, Seo Y, Fujii Y. Intestinal energy metabolism during ischemia and reperfusion. J Surg Res 82: 261-267, 1999.
19. Schoenberg MH, Poch B, Younes M, Schwarz A, Baczako K, Lundberg C, Haglund U, Beger HG. Involvement of neutrophils in postischaemic damage to the small intestine. Gut 32: 905-912, 1991.
20. Spehlmann ME, Eckmann L. Nuclear factor-kappa B in intestinal protection and destruction. Curr Opin Gastroenterol 25: 92-99, 2009.
21. Sun B, Xiao J, Sun XB, Wu Y. Notoginsenoside R1 attenuates cardiac dysfunction in endotoxemic mice: an insight into oestrogen receptor activation and PI3K/Akt signaling. Br J Pharmacol 168: 1758-1770, 2013.
22. Sun Z, Wang X, Deng X, Lasson A, Soltesz V, Börjesson A, Andersson R. Beneficial effects of lexipafant, a PAF antagonist on gut barrier dysfunction caused by intestinal ischemia and reperfusion in rats. Dig Surg 17: 57-65, 2000.
23. Turner JR. Intestinal mucosal barrier function in health and disease. Nat Rev Immunol 9: 799-809, 2009.
24. Unno N, Menconi MJ, Salzman AL, Smith M, Hagen S, Ezzell RM, Ge Y, Fink MP. Hyperpemeability and ATP depletion induced by chronic hypoxia or glycolytic inhibition in Caco-2BBe monolayers. Am J Physiol Gastrointest Liver Physiol 270: G1010-G1021, 1996.
25. Vollmar B, Menger MD. Intestinal ischemia/reperfusion: microcirculatory pathology and functional consequences. Langenbecks Arch Surg 396: 13-29, 2011.
26. Wattanasirichaigoon S, Menconi MJ, Delude RL, Fink MP. Effect of mesenteric ischemia and reperfusion or hemorrhagic shock on intestinal mucosal permeability and ATP content in rats. Shock 12: 127-133, 1999.
27. Yamada T, Taguchi T, Suita S. Energy metabolism and tissue blood flow as parameters for assessment of graft viability in rat small bowel transplantation. J Pediatr Surg 31: 1475-1481, 1996.
28. Yasuhara H. Acute mesenteric ischemia: the challenge of gastroenterology. Surg Today 35: 185-195, 2005.
29. Zhang HS, Wang SQ. Notoginsenoside R1 inhibits TNF-alpha-induced fibronectin production in smooth muscle cells via the ROS/ERK pathway. Free Radic Biol Med 40: 1664-1674, 2006.
30. Zhang WJ, Wojta J, Binder BR. Notoginsenoside R1 counteracts endotoxin-induced activation of endothelial cells in vitro and endotoxininduced lethality in mice in vivo. Arterioscler Thromb Vasc Biol 17: 465-474, 1997.
31. Zhao N, Liu YY, Wang F, Hu BH, Sun K, Chang X, Pan CS, Fan JY, Wei XH, Li X, Wang CS, Guo ZX, Han JY. Cardiotonic pills, a compound Chinese medicine, protects ischemia-reperfusion-induced microcirculatory disturbance and myocardial damage in rats. Am J Physiol Heart Circ Physiol 298: H1166-H1176, 2010.
32. Zhao X, Town JR, Yang A, Zhang X, Paur N, Sawicki G, Gordon JR. A novel ELR-CXC chemokine antagonist reduces intestinal ischemia reperfusion-induced mortality, and local and remote organ injury. J Surg Res 162: 264-273, 2010.