An anthelmintic drug, pyrvinium pamoate, thwarts fibrosis and ameliorates myocardial contractile dysfunction in a mouse model of myocardial infarction

PLoS ONE

Volumn 8, Issue 11, 2013, Pages

  Murakoshi, Motoaki ^a   Saiki, Kyohei ^a   Urayama, Kyoji ^a   Sato, Thomas N ^a,b,c  

^a NARA INSTITUTE OF SCIENCE AND TECHNOLOGY   (Japan)

^b Cornell University   (United States)

^c CENTENARY INSTITUTE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ANTHELMINTIC AGENT; GLUCOSE; OXYGEN; PYRVINIUM EMBONATE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL STRESS; CELL SURVIVAL; CELL TRANSFORMATION; CONTROLLED STUDY; DRUG MECHANISM; FIBROBLAST; HEART CONTRACTION; HEART DISEASE; HEART INFARCTION; HEART MUSCLE CELL; HEART MUSCLE CONTRACTILITY; HEART MUSCLE FIBROSIS; MALE; METABOLIC STRESS; MOUSE; MYOCARDIAL CONTRACTILE DYSFUNCTION; NONHUMAN; NUTRIENT; SCAR FORMATION;

ANIMALS; ANTHELMINTICS; CELL SURVIVAL; DISEASE MODELS, ANIMAL; FIBROBLASTS; FIBROSIS; MALE; MICE; MUSCLE CONTRACTION; MYOCARDIAL INFARCTION; MYOCARDIUM; PYRVINIUM COMPOUNDS;

EID: 84892577861     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0079374     Document Type: Article

References (22)

1. Leask A (2010) Potential therapeutic targets for cardiac fibrosis: TGFbeta, angiotensin, endothelin, CCN2, and PDGF, partners in fibroblast activation. Circ Res 106: 1675-1680. doi:10.1161/CIRCRESAHA.110.217737. PubMed: 20538689.
2. van den Borne SW, Diez J, Blankesteijn WM, Verjans J, Hofstra L et al. (2010) Myocardial remodeling after infarction: the role of myofibroblasts. Nat. Rev Cardiol 7: 30-37. doi:10.1038/nrcardio.2009.199.
3. De Mello WC, Specht P (2006) Chronic blockade of angiotensin II AT1-receptors increased cell-to-cell communication, reduced fibrosis and improved impulse propagation in the failing heart. J Renin Angiotensin Aldosterone Syst 7: 201-205. doi:10.3317/jraas.2006.038. PubMed: 17318788.
4. Shibasaki Y, Nishiue T, Masaki H, Tamura K, Matsumoto N et al. (2005) Impact of the angiotensin II receptor antagonist, losartan, on myocardial fibrosis in patients with end-stage renal disease: assessment by ultrasonic integrated backscatter and biochemical markers. Hypertens Res 28: 787-795. doi:10.1291/hypres.28.787. PubMed: 16471172.
5. Sakai C, Tomitsuka E, Esumi H, Harada S, Kita K (2012) Mitochondrial fumarate reductase as a target of chemotherapy: from parasites to cancer cells. Biochim Biophys Acta 1820: 643-651. doi:10.1016/j.bbagen.2011.12.013. PubMed: 22226661.
6. Deng L, Lei Y, Liu R, Li J, Yuan K et al. (2013) Pyrvinium targets autophagy addiction to promote cancer cell death. Cell Death. Drosophila Inf Serv 4: e614.
7. Jones JO, Bolton EC, Huang Y, Feau C, Guy RK et al. (2009) Non-competitive androgen receptor inhibition in vitro and in vivo. Proc Natl Acad Sci U S A 106: 7233-7238. doi:10.1073/pnas.0807282106. PubMed: 19363158.
8. Thorne CA, Hanson AJ, Schneider J, Tahinci E, Orton D et al. (2010) Small-molecule inhibition of Wnt signaling through activation of casein kinase 1alpha. Nat Chem Biol 6: 829-836. doi:10.1038/nchembio.453. PubMed: 20890287.
9. Yu DH, Macdonald J, Liu G, Lee AS, Ly M et al. (2008) Pyrvinium targets the unfolded protein response to hypoglycemia and its antitumor activity is enhanced by combination therapy. PLOS ONE 3: e3951. doi:10.1371/journal.pone. 0003951. PubMed: 19079611.
10. Jones JO, Diamond MI (2008) A cellular conformation-based screen for androgen receptor inhibitors. ACS Chem Biol 3: 412-418. doi:10.1021/cb800054w. PubMed: 18582038.
11. Esumi H, Lu J, Kurashima Y, Hanaoka T (2004) Antitumor activity of pyrvinium pamoate, 6-(dimethylamino)-2-[2-(2,5-dimethyl-1-phenyl-1H-pyrrol-3-yl) ethenyl]-1-methyl-qu inolinium pamoate salt, showing preferential cytotoxicity during glucose starvation. Cancer Sci 95: 685-690. doi:10.1111/j.1349-7006.2004. tb03330.x. PubMed: 15298733.
12. Harada Y, Ishii I, Hatake K, Kasahara T (2012) Pyrvinium pamoate inhibits proliferation of myeloma/erythroleukemia cells by suppressing mitochondrial respiratory complex I and STAT3. Cancer Lett 319: 83-88. doi:10.1016/j.canlet. 2011.12.034. PubMed: 22210382.
13. Tomitsuka E, Kita K, Esumi H (2012) An anticancer agent, pyrvinium pamoate inhibits the NADH-fumarate reductase system - a unique mitochondrial energy metabolism in tumour microenvironments. J Biochem 152: 171-183. doi:10.1093/jb/mvs041. PubMed: 22528668.
14. Saraswati S, Alfaro MP, Thorne CA, Atkinson J, Lee E et al. (2010) Pyrvinium, a potent small molecule Wnt inhibitor, promotes wound repair and post-MI cardiac remodeling. PLOS ONE 5: e15521. doi: 10.1371/journal.pone. 0015521. PubMed: 21170416.
15. Ishii I, Harada Y, Kasahara T (2012) Reprofiling a classical anthelmintic, pyrvinium pamoate, as an anti-cancer drug targeting mitochondrial respiration. Front Oncol 2: 137. PubMed: 23061049.
16. Ikeda Y, Aihara K, Sato T, Akaike M, Yoshizumi M et al. (2005) Androgen receptor gene knockout male mice exhibit impaired cardiac growth and exacerbation of angiotensin II-induced cardiac fibrosis. J Biol Chem 280: 29661-29666. doi:10.1074/jbc.M411694200. PubMed: 15961403.
17. Chun MG, Shaw RJ (2013) Cancer metabolism in breadth and depth. Nat Biotechnol 31: 505-507. doi:10.1038/nbt.2611. PubMed: 23752435.
18. Hu J, Locasale JW, Bielas JH, O'Sullivan J, Sheahan K et al. (2013) Heterogeneity of tumor-induced gene expression changes in the human metabolic network. Nat Biotechnol 31: 522-529. doi:10.1038/nbt.2530. PubMed: 23604282.
19. Ma L, Tao Y, Duran A, Llado V, Galvez A et al. (2013) Control of nutrient stress-induced metabolic reprogramming by PKCzeta in tumorigenesis. Cell 152: 599-611. doi:10.1016/j.cell.2012.12.028. PubMed: 23374352.
20. Ward PS, Thompson CB (2012) Metabolic reprogramming: a cancer hallmark even warburg did not anticipate. Cancer Cell 21: 297-308. doi:10.1016/j.ccr. 2012.02.014. PubMed: 22439925.
21. Kobayashi K, Luo M, Zhang Y, Wilkes DC, Ge G et al. (2009) Secreted Frizzled-related protein 2 is a procollagen C proteinase enhancer with a role in fibrosis associated with myocardial infarction. Nat Cell Biol 11: 46-55. doi:10.1038/ncb1811. PubMed: 19079247.
22. Visconti RP, Richardson CD, Sato TN (2002) Orchestration of angiogenesis and arteriovenous contribution by angiopoietins and vascular endothelial growth factor (VEGF). Proc Natl Acad Sci U S A 99: 8219-8224. doi:10.1073/pnas. 122109599. PubMed: 12048246.