Translational induction of VEGF internal ribosome entry site elements during the early response to ischemic stress

Circulation Research

Volumn 100, Issue 3, 2007, Pages 305-308

  Bornes, Stéphanie ^a   Prado Lourenco, Leonel ^a,b   Bastide, Amandine ^a   Zanibellato, Catherine ^a   Iacovoni, Jason S ^a   Lacazette, Eric ^a   Prats, Anne Catherine ^a   Touriol, Christian ^a   Prats, Hervé ^a  

^a INSERM   (France)

^b MilleGen   (France)

Author keywords

Internal ribosome entry site; Ischemia; Transgenic mice; Translation; VEGF

Indexed keywords

MESSENGER RNA; VASCULOTROPIN;

5' UNTRANSLATED REGION; ANGIOGENESIS; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; EMBRYO; ENVIRONMENTAL STRESS; HEART MUSCLE ISCHEMIA; HUMAN; HYPOXIA; IN VIVO STUDY; INTERNAL RIBOSOME ENTRY SITE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; REPORTER GENE; TRANSGENIC MOUSE; TRANSLATION INITIATION;

5' UNTRANSLATED REGIONS; ACUTE DISEASE; ANIMALS; BASE SEQUENCE; CODON, INITIATOR; GENE EXPRESSION REGULATION; HINDLIMB; HUMANS; ISCHEMIA; L CELLS (CELL LINE); MALE; MICE; MICE, TRANSGENIC; MOLECULAR SEQUENCE DATA; MUSCLE, SKELETAL; NEOVASCULARIZATION, PHYSIOLOGIC; NIH 3T3 CELLS; ORGAN SPECIFICITY; PROTEIN BIOSYNTHESIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, NUCLEIC ACID; SPECIES SPECIFICITY; STRESS; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 33847058369     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.0000258873.08041.c9     Document Type: Article

References (12)

1. Shweiki D, Itin A, Soffer D, Keshet E. Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis. Nature. 1992;359:843-845.
2. Banai S, Shweiki D, Pinson A, Chandra M, Lazarovici G, Keshet E. Upregulation of vascular endothelial growth factor expression induced by myocardial ischaemia: implications for coronary angiogenesis. Cardiovasc Res. 1994;28:1176-1179.
3. Rissanen TT, Vajanto I, Hiltunen MO, Rutanen J, Kettunen MI, Niemi M, Leppanen P, Turunen MP, Markkanen JE, Arve K, Alhava E, Kauppinen RA, Yla-Herttuala S. Expression of vascular endothelial growth factor and vascular endothelial growth factor receptor-2 (KDR/Flk-1) in ischemic skeletal muscle and its regeneration. Am J Pathol. 2002;160:1393-1403.
4. Huez I, Creancier L, Audigier S, Gensac MC, Prats AC, Prats H. Two independent internal ribosome entry sites are involved in translation initiation of vascular endothelial growth factor mRNA. Mol Cell Biol. 1998;18:6178-6190.
5. Huez I, Bornes S, Bresson D, Creancier L, Prats H. New vascular endothelial growth factor isoform generated by internal ribosome entry site-driven CUG translation initiation. Mol Endocrinol. 2001;15:2197-2210.
6. Bornes S, Boulard M, Hieblot C, Zanibellato C, Iacovoni JS, Prats H, Touriol C. Control of the vascular endothelial growth factor internal ribosome entry site (IRES) activity and translation initiation by alternatively spliced coding sequences. J Biol Chem. 2004;279:18717-18726.
7. Stein I, Itin A, Einat P, Skaliter R, Grossman Z, Keshet E. Translation of vascular endothelial growth factor mRNA by internal ribosome entry: implications for translation under hypoxia. Mol Cell Biol. 1998;18:3112-3119.
8. Creancier L, Morello D, Mercier P, Prats AC. Fibroblast growth factor 2 internal ribosome entry site (IRES) activity ex vivo and in transgenic mice reveals a stringent tissue-specific regulation. J Cell Biol. 2000;150:275-281.
9. Teshima-Kondo S, Kondo K, Prado-Lourenco L, Gonzalez-Herrera IG, Rokutan K, Bayard F, Arnal JF, Prats AC. Hyperglycemia upregulates translation of the fibroblast growth factor 2 mRNA in mouse aorta via internal ribosome entry site. FASEB J. 2004;18:1583-1585.
10. Creancier L, Mercier P, Prats AC, Morello D. c-myc internal ribosome entry site activity is developmentally controlled and subjected to a strong translational repression in adult transgenic mice. Mol Cell Biol. 2001;21:1833-1840.
11. Bonheur JA, Albadawi H, Patton GM, Watkins MT. A noninvasive murine model of hind limb ischemia-reperfusion injury. J Surg Res. 2004;116:55-63.
12. Akiri G, Nahari D, Finkelstein Y, Le SY, Elroy-Stein O, Levi BZ. Regulation of vascular endothelial growth factor (VEGF) expression is mediated by internal initiation of translation and alternative initiation of transcription. Oncogene. 1998;17:227-236.