Position of the academy of nutrition and dietetics: Nutritional genomics

Journal of the Academy of Nutrition and Dietetics

Volumn 114, Issue 2, 2014, Pages 299-312

  Camp, Kathryn M ^a   Trujillo, Elaine ^b  

^a Kelly Government Solutions   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL; ARTICLE; DIET; DIETETICS; EDUCATION; EPIGENETICS; ETHICS; EVIDENCE BASED MEDICINE; GENE EXPRESSION; GENETIC SCREENING; GENETIC VARIABILITY; GENETICS; GENOTYPE; HEALTH CARE POLICY; HUMAN; HUMAN GENOME PROJECT; LEGAL ASPECT; NUTRIGENOMICS; NUTRITION; ORGANIZATION; PERSONALIZED MEDICINE; PHENOTYPE; UNITED STATES;

ACADEMIES AND INSTITUTES; ANIMALS; DIET; DIETETICS; EPIGENOMICS; EVIDENCE-BASED MEDICINE; GENE EXPRESSION; GENETIC TESTING; GENETIC VARIATION; GENOTYPE; HUMAN GENOME PROJECT; HUMANS; INDIVIDUALIZED MEDICINE; NUTRIGENOMICS; NUTRITION POLICY; NUTRITIONAL PHYSIOLOGICAL PHENOMENA; PHENOTYPE; UNITED STATES;

EID: 84892521234     PISSN: 22122672     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jand.2013.12.001     Document Type: Article

References (85)

1. German J.B., Zivkovic A.M., Dallas D.C., Smilowitz J.T. Nutrigenomics and personalized diets: What will they mean for food?. Annu Rev Food Sci Technol 2011, 2:97-123.
2. National Human Genome Research Institute. An overview of the Human Genome Project. Reviewed November 8, 2012. Accessed August 26, 2013. http://www.genome.gov/12011238.
3. Broad Institute. Elephant Genome Project. Accessed August 26, 2013. http://www.broadinstitute.org/science/projects/mammals-models/elephant/elephant-genome-project.
4. National Human Genome Research Institute. DNA sequencing costs: Data from NHGRI Large-Scale Genome Sequencing Program (GSP): Overview. Updated October 29, 2013. Accessed November 18, 2013. http://www.genome.gov/sequencingcosts.
5. National Human Genome Research Institute. DNA sequencing costs: Data from NHGRI Large-Scale Genome Sequencing Program (GSP): Cost categories. Updated October 29, 2013. Accessed November 18, 2013. http://www.genome.gov/sequencingcosts/.
6. Cordero P., Ashley E.A. Whole-genome sequencing in personalized therapeutics. Clin Pharmacol Ther 2012, 91(6):1001-1009.
7. US National Library of Medicine. Cells and DNA. November 12, 2013. Accessed November 18, 2013. http://ghr.nlm.nih.gov/handbook/basics?show=all.
8. US National Library of Medicine. How genes work. November 12, 2013. Accessed November 18, 2013. http://ghr.nlm.nih.gov/handbook/howgeneswork?show=all.
9. Schneider M.V., Orchard S. Omics technologies, data and bioinformatics principles. Methods Mol Biol 2011, 719:3-30.
10. Rimbach G., Minihane A.M. Nutrigenetics and personalised nutrition: How far have we progressed and are we likely to get there?. Proc Nutr Soc 2009, 68(2):162-172.
11. Panagiotou G., Nielsen J. Nutritional systems biology: Definitions and approaches. Annu Rev Nutr 2009, 29:329-339.
12. Simopoulos A.P. Nutrigenetics/nutrigenomics. Annu Rev Public Health 2010, 31:53-68.
13. Corella D., Ordovas J.M. Nutrigenomics in cardiovascular medicine. Circ Cardiovasc Genet 2009, 2(6):637-651.
14. Clarke R., Bennett D.A., Parish S., et al. Homocysteine and coronary heart disease: Meta-analysis of MTHFR case-control studies, avoiding publication bias. PLoS Med 2012, 9(2):e1001177.
15. Yang Q., Bailey L., Clarke R., et al. Prospective study of methylenetetrahydrofolate reductase (MTHFR) variant C677T and risk of all-cause and cardiovascular disease mortality among 6000 US adults. Am J Clin Nutr 2012, 95(5):1245-1253.
16. Zeisel S.H. Metabolic crosstalk between choline/1-carbon metabolism and energy homeostasis. Clin Chem Lab Med 2012, 0(0):1-9.
17. Zeisel S.H. Nutritional genomics: Defining the dietary requirement and effects of choline. J Nutr 2011, 141(3):531-534.
18. Bennet A.M., Di Angelantonio E., Ye Z., et al. Association of apolipoprotein E genotypes with lipid levels and coronary risk. JAMA 2007, 298(11):1300-1311.
19. Song Y., Stampfer M.J., Liu S. Meta-analysis: Apolipoprotein E genotypes and risk for coronary heart disease. Ann Intern Med 2004, 141(2):137-147.
20. Wilson P.W., Schaefer E.J., Larson M.G., Ordovas J.M. Apolipoprotein E alleles and risk of coronary disease. A meta-analysis. Arterioscler Thromb Vasc Biol 1996, 16(10):1250-1255.
21. Lai C.Q., Corella D., Demissie S., et al. Dietary intake of n-6 fatty acids modulates effect of apolipoprotein A5 gene on plasma fasting triglycerides, remnant lipoprotein concentrations, and lipoprotein particle size: The Framingham Heart Study. Circulation 2006, 113(17):2062-2070.
22. Curti M.L., Jacob P., Borges M.C., Rogero M.M., Ferreira S.R. Studies of gene variants related to inflammation, oxidative stress, dyslipidemia, and obesity: Implications for a nutrigenetic approach. J Obes 2011, 2011:497401.
23. Hetherington M.M., Cecil J.E. Gene-environment interactions in obesity. Forum Nutr 2010, 63:195-203.
24. Herrera B.M., Lindgren C.M. The genetics of obesity. Curr Diab Rep 2010, 10(6):498-505.
25. Frayling T.M., Timpson N.J., Weedon M.N., et al. A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science 2007, 316(5826):889-894.
26. Cecil J.E., Tavendale R., Watt P., Hetherington M.M., Palmer C.N. An obesity-associated FTO gene variant and increased energy intake in children. N Engl J Med 2008, 359(24):2558-2566.
27. Wardle J., Carnell S., Haworth C.M., Plomin R. Evidence for a strong genetic influence on childhood adiposity despite the force of the obesogenic environment. Am J Clin Nutr 2008, 87(2):398-404.
28. Kallio P., Kolehmainen M., Laaksonen D.E., et al. Dietary carbohydrate modification induces alterations in gene expression in abdominal subcutaneous adipose tissue in persons with the metabolic syndrome: The FUNGENUT Study. Am J Clin Nutr 2007, 85(5):1417-1427.
29. Dahlman I., Linder K., Arvidsson Nordstrom E., et al. Changes in adipose tissue gene expression with energy-restricted diets in obese women. Am J Clin Nutr 2005, 81(6):1275-1285.
30. Rudkowska I., Perusse L. Individualized weight management: What can be learned from nutrigenomics and nutrigenetics?. Prog Mol Biol Transl Sci 2012, 108:347-382.
31. Ornish D., Magbanua M.J., Weidner G., et al. Changes in prostate gene expression in men undergoing an intensive nutrition and lifestyle intervention. Proc Natl Acad Sci U S A 2008, 105(24):8369-8374.
32. Magbanua M.J., Roy R., Sosa E.V., et al. Gene expression and biological pathways in tissue of men with prostate cancer in a randomized clinical trial of lycopene and fish oil supplementation. PLoS One 2011, 6(9):e24004.
33. Link A., Balaguer F., Goel A. Cancer chemoprevention by dietary polyphenols: Promising role for epigenetics. Biochem Pharmacol 2010, 80(12):1771-1792.
34. Fenech M., El-Sohemy A., Cahill L., et al. Nutrigenetics and nutrigenomics: Viewpoints on the current status and applications in nutrition research and practice. J Nutrigenet Nutrigenomics 2011, 4(2):69-89.
35. Kauwell G.P. Epigenetics: What it is and how it can affect dietetics practice. J Am Diet Assoc 2008, 108(6):1056-1059.
36. Ho E., Beaver L.M., Williams D.E., Dashwood R.H. Dietary factors and epigenetic regulation for prostate cancer prevention. Adv Nutr 2011, 2(6):497-510.
37. Waterland R.A., Jirtle R.L. Transposable elements: Targets for early nutritional effects on epigenetic gene regulation. Mol Cell Biol 2003, 23(15):5293-5300.
38. Dolinoy D.C., Weidman J.R., Waterland R.A., Jirtle R.L. Maternal genistein alters coat color and protects Avy mouse offspring from obesity by modifying the fetal epigenome. Environ Health Perspect 2006, 114(4):567-572.
39. Heijmans B.T., Tobi E.W., Stein A.D., et al. Persistent epigenetic differences associated with prenatal exposure to famine in humans. Proc Natl Acad Sci U S A 2008, 105(44):17046-17049.
40. Roseboom T., de Rooij S., Painter R. The Dutch famine and its long-term consequences for adult health. Early Hum Dev 2006, 82(8):485-491.
41. Campion J., Milagro F., Martinez J.A. Epigenetics and obesity. Prog Mol Biol Transl Sci 2010, 94:291-347.
42. Milagro F.I., Campion J., Cordero P., et al. A dual epigenomic approach for the search of obesity biomarkers: DNA methylation in relation to diet-induced weight loss. FASEB J 2011, 25(4):1378-1389.
43. Askree S.H., Dharamrup S., Hjelm L.N., Coffee B. Parent-of-origin testing for 15q11-q13 gains by quantitative DNA methylation analysis. J Mol Diagn 2012, 14(3):192-198.
44. Jana N.R. Understanding the pathogenesis of Angelman syndrome through animal models. Neural Plast 2012, 2012:710943.
45. Berg A.O., Baird M.A., Botkin J.R., et al. National Institutes of Health State-of-the-Science Conference Statement: Family history and improving health. Ann Intern Med 2009, 151(12):872-877.
46. Pyeritz R.E. The family history: The first genetic test, and still useful after all those years?. Genet Med 2012, 14(1):3-9.
47. Ogino S., Nishihara R., Lochhead P., et al. Prospective study of family history and colorectal cancer risk by tumor LINE-1 methylation level. J Natl Cancer Inst 2013, 105(2):130-140.
48. Recommendations from the EGAPP Working Group: Genetic testing strategies in newly diagnosed individuals with colorectal cancer aimed at reducing morbidity and mortality from Lynch syndrome in relatives. Genet Med 2009, 11(1):35-41.
49. Recommendations from the EGAPP Working Group: Genomic profiling to assess cardiovascular risk to improve cardiovascular health. Genet Med 2010, 12(12):839-843.
50. Khoury M.J., Gwinn M., Bowen M.S., Dotson W.D. Beyond base pairs to bedside: A population perspective on how genomics can improve health. Am J Public Health 2012, 102(1):34-37.
51. Fraker M., Mazza A. Direct-to-Consumer Genetic Testing: Summary of a Workshop 2010, National Academies Press, Washington, DC.
52. Hopkins P.N., Toth P.P., Ballantyne C.M., Rader D.J. Familial hypercholesterolemias: Prevalence, genetics, diagnosis and screening recommendations from the National Lipid Association Expert Panel on Familial Hypercholesterolemia. J Clin Lipidol 2011, 5(3 suppl):S9-S17.
53. Centers for Disease Control and Prevention. Genomic tests and family history by levels of evidence. Updated April 15, 2013. Accessed August 26, 2013. http://www.cdc.gov/genomics/gtesting/tier.htm.
54. US Preventive Servies Task Force homepage. Accessed August 26, 2013. http://www.uspreventiveservicestaskforce.org/index.html.
55. US Department of Health and Human Services, Secretary's Advisory Committee on Genetics, Health, and Society, US System of Oversight of Genetic Testing: A Response to the Charge of the Secretary of Health and Human Services; 2008. Accessed December 19, 2013. http://oba.od.nih.gov/oba/SACGHS/reports/SACGHS_oversight_report.pdf.
56. Katsnelson A. Genetics tells tall tales. Nature 2010, 465(7301):998.
57. Caulfield T., McGuire A.L. Direct-to-consumer genetic testing: perceptions, problems, and policy responses. Annu Rev Med 2012, 63:23-33.
58. Myers M.F., Bernhardt B.A. Direct-to-consumer genetic testing: Introduction to the Special Issue. J Genet Couns 2012, 21(3):357-360.
59. Saukko P.M., Reed M., Britten N., Hogarth S. Negotiating the boundary between medicine and consumer culture: Online marketing of nutrigenetic tests. Soc Sci Med 2010, 70(5):744-753.
60. Hall T.O., Renz A.D., Snapinn K.W., Bowen D.J., Edwards K.L. Awareness and uptake of direct-to-consumer genetic testing among cancer cases, their relatives, and controls: The Northwest Cancer Genetics Network. Genet Test Mol Biomarkers 2012, 16(7):744-748.
61. Spencer D.H., Lockwood C., Topol E., et al. Direct-to-consumer genetic testing: Reliable or risky?. Clin Chem 2011, 57(12):1641-1644.
62. Kutz G. Direct-To-Consumer Genetic Tests: Misleading Test Results are Further Complicated by Deceptive Marketing and Other Questionable Practices 2010, 1-33. Government Accountability Office, Washington, DC.
63. Saukko P. State of play in direct-to-consumer genetic testing for lifestyle-related diseases: Market, marketing content, user experiences and regulation. Proc Nutr Soc 2013, 72(1):53-60.
64. Schlanger S.J. Putting together the pieces: Recent proposals to fill in the genetic testing regulatory puzzle. Ann Health Law 2012, 21(2):383-405.
65. US Departmentt of Health and Human Services. Summary from the Molecular & Clinical Genetics Panel Meeting - March 8-9, 2011. Accessed August 26, 2013. http://www.fda.gov/downloads/AdvisoryCommittees/CommitteesMeetingMaterials/MedicalDevices/MedicalDevicesAdvisoryCommittee/MolecularandClinicalGeneticsPanel/UCM246907.pdf?utm_campaign=Google2%26utm_source=fdaSearch%26utm_medium=website%26utm_term=geneticpanel%26utm_content=3.
66. Code of Federal Regulations, Title 45. Public Welfare. Department of Health and Human Services. Part 46. Protection of Human Subjects; 2009. Accessed December 19, 2013. http://www.hhs.gov/ohrp/policy/ohrpregulations.pdf.
67. Bergmann M.M., Gorman U., Mathers J.C. Bioethical considerations for human nutrigenomics. Annu Rev Nutr 2008, 28:447-467.
68. Zimmern R.L., Khoury M.J. The impact of genomics on public health practice: The case for change. Public Health Genomics 2012, 15(3-4):118-124.
69. Reilly P.R., Debusk R.M. Ethical and legal issues in nutritional genomics. J Am Diet Assoc 2008, 108(1):36-40.
70. Castle D., Ries N.M. Ethical, legal and social issues in nutrigenomics: The challenges of regulating service delivery and building health professional capacity. Mutat Res 2007, 622(1-2):138-143.
71. Vickery C.E., Cotugna N. Incorporating human genetics into dietetics curricula remains a challenge. J Am Diet Assoc 2005, 105(4):583-588.
72. Rosen R., Earthman C., Marquart L., Reicks M. Continuing education needs of registered dietitians regarding nutrigenomics. J Am Diet Assoc 2006, 106(8):1242-1245.
73. Whelan K., McCarthy S., Pufulete M. Genetics and diet-gene interactions: Involvement, confidence and knowledge of dietitians. Br J Nutr 2008, 99(1):23-28.
74. McCarthy S., Pufulete M., Whelan K. Factors associated with knowledge of genetics and nutritional genomics among dietitians. J Hum Nutr Diet 2008, 21(6):547-554.
75. Prasad C., Imrhan V., Rew M. Introducing nutritional genomics teaching in undergraduate dietetic curricula. J Nutrigenet Nutrigenomics 2011, 4(3):165-172.
76. Chen R., Mias G.I., Li-Pook-Than J., et al. Personal omics profiling reveals dynamic molecular and medical phenotypes. Cell 2012, 148(6):1293-1307.
77. Rhea M., Bettles C. Future changes driving dietetics workforce supply and demand: Future scan 2012-2022. J Acad Nutr Diet 2012, 112(3 suppl):S10-S24.
78. Singh R.H., Kaczmarczyk M.M. Standards of professional practice for genetic metabolic dietitians. Genet Med 2008, 10(4):290-293.
79. Camp K., Rohr F.J. Advanced practitioners and what they do that is different, roles in genetics. Top Clni Nutr 2009, 23(3):219-230.
80. Ford D., Raj S., Batheja R.K., et al. American Dietetic Association: Standards of Practice and Standards of Professional Performance for registered dietitians (competent, proficient, and expert) in integrative and functional medicine. J Am Diet Assoc 2011, 111(6):902-913. e901-923.
81. de Vrieze J., Bouwman L., Komduur R., et al. Nutrition tailored to the individual? Not just yet-Realigning nutrigenomic science with contemporary society. J Nutrigenet Nutrigenomics 2009, 2(4-5):184-188.
82. US National Library of Medicine. Genetics home reference: Glossary. Accessed July 31, 2013. http://ghr.nlm.nih.gov/glossary/browse/.
83. US Department of Energy. Human Genome Project information archive 1990-2003. Modified July 23, 2013. Accessed July 31, 2013. http://www.ornl.gov/hgmis.
84. US National Library of Medicine. Genetics home reference: MTHFR. Reviewed July 2011. Accessed July 31, 2013. http://ghr.nlm.nih.gov/gene/MTHFR.
85. Yang J. Human Microbiome Project: Extending the definition of what constitutes a human. National Human Genome Research Institute website. Published July 16, 2012. Accessed August 7, 2013. http://www.genome.gov/27549400.%20Accessed%20August%207.