Glucose Metabolism, Insulin Sensitivity and β-Cell Function in Type A Insulin Resistance Syndrome Around Puberty: A 9-Year Follow-up

Hormone and Metabolic Research

Volumn 46, Issue 1, 2014, Pages 65-72

  Huang, Z ^a   Liu, J ^a   Ma, L ^a   Wan, X ^a   He, X ^a   Fang, D ^a   Liao, Z ^a   Li, Y ^a  

^a THE FIRST AFFILIATED HOSPITAL OF SUN YAT SEN UNIVERSITY   (China)

Author keywords

compensation; diabetes mellitus; insulin resistance; intramyocellular lipid; puberty

Indexed keywords

C PEPTIDE; HEMOGLOBIN A1C; INSULIN;

ADOLESCENT; ADULT; ARTICLE; CELL FUNCTION; FEMALE; FOLLOW UP; GENE MUTATION; GLUCOSE BLOOD LEVEL; GLUCOSE METABOLISM; GLUCOSE TOLERANCE; HUMAN; INSULIN RESISTANCE; INSULIN SENSITIVITY; MAJOR CLINICAL STUDY; MALE; METABOLIC SYNDROME X; NON INSULIN DEPENDENT DIABETES MELLITUS; ORAL GLUCOSE TOLERANCE TEST; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PUBERTY; YOUNG ADULT;

ADOLESCENT; ADULT; AMINO ACID SUBSTITUTION; BLOOD GLUCOSE; C-PEPTIDE; CHILD; DIABETES MELLITUS, TYPE 2; FEMALE; FOLLOW-UP STUDIES; GLUCOSE TOLERANCE TEST; HUMANS; INSULIN; INSULIN RESISTANCE; INSULIN-SECRETING CELLS; LIPID METABOLISM; MALE; PUBERTY; RECEPTOR, INSULIN; SYNDROME; TWINS; YOUNG ADULT;

EID: 84892499093     PISSN: 00185043     EISSN: 14394286     Source Type: Journal    
DOI: 10.1055/s-0033-1357193     Document Type: Article

References (31)

1. Weyer C., Bogardus C., Mott D. M., Pratley R. E. The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes mellitus. J Clin Invest: 1999; 104 787 794
2. Kahn S. E. The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of type 2 diabetes. Diabetologia: 2003; 46 3 19
3. Steil G. M., Trivedi N., Jonas J. C., Hasenkamp W. M., Sharma A., Bonner-Weir S., Weir G. C. Adaptation of beta-cell mass to substrate oversupply: enhanced function with normal gene expression. Am J Physiol Endocrinol Metab: 2001; 280 E788 E796
4. Jetton T. L., Lausier J., LaRock K., Trotman W. E., Larmie B., Habibovic A., Peshavaria M., Leahy J. L. Mechanisms of compensatory beta-cell growth in insulin-resistant rats: roles of Akt kinase. Diabetes: 2005; 54 2294 2304
5. Liu Y. Q., Jetton T. L., Leahy J. L. Beta cell adaptation to insulin resistance. Increased pyruvate carboxylase and malate-pyruvate shuttle activity in islets of nondiabetic Zucker fatty rats. J Biol Chem: 2002; 277 39163 39168
6. Bonner-Weir S., Deery D., Leahy J. L., Weir G. C. Compensatory growth of pancreatic beta-cells in adult rats after short-term glucose infusion. Diabetes: 1989; 38 49 53
7. Chang-Chen K. J., Mullur R., Bernal-Mizrachi E. β-cell failure as a complication of diabetes. Rev Endocr Metab Disord: 2008; 9 329 343
8. Taylor S. I. Lilly Lecture: Molecular mechanisms of insulin resistance. Lessons from patients with mutations in the insulin-receptor gene. Diabetes: 1992; 41 1473 1490
9. Huang Z., Li Y., Tang T., Xu W., Liao Z., Yao B., Hu G., Weng J. Hyperinsulinaemic hypoglycaemia associated with a heterozygous missense mutation of R1174W in the insulin receptor (IR) gene. Clin Endocrinol (Oxf): 2009; 71 659 665
10. Salgin B., Sleigh A. J., Williams R. M., Jackson S. J., Bluck L. J., Murgatroyd P. R., Humphreys S. M., Harding S., Carpenter T. A., Dunger D. B. Intramyocellular lipid levels are associated with peripheral, but not hepatic, insulin sensitivity in normal healthy subjects. Clinical Science: 2009; 117 111 118
11. van Loon L. J., Koopman R., Manders R., van der Weegen W., van Kranenburg G. P., Keizer HA. Intramyocellular lipid content in type 2 diabetes patients compared with overweight sedentary men and highly trained endurance athletes. Am J Physiol Endocrinol Metab: 2004; 287 E558 E665
12. Moran A., Jacobs D. R. Jr, Steinberger J., Hong C. P., Prineas R., Luepker R., Sinaiko A. R. Insulin resistance during puberty: results from clamp studies in 357 children. Diabetes: 1999; 48 2039 2044
13. Goran M. I., Gower BA. Longitudinal study on pubertal insulin resistance. Diabetes: 2001; 50 2444 2450
14. Inagaki K. A Familial insulin-like growth factor-I receptor mutant leads to short stature: clinical and biochemical characterization. J Clin Endocrinol Metab: 2007; 92 1542 1548
15. Wallborn T., Wuller S., Klammt J., Kruis T., Kratzsch J., Schmidt G. A heterozygous mutation of the insulin-like growth factor-I receptor causes retention of the nascent protein in the endoplasmic reticulum and results in intrauterine and postnatal growth retardation. J Clin Endocrinol Metab: 2010; 95 2316 2324
16. Woods K. A., Camacho-Hubner C., Savage M. O., Clark A. J. Intrauterine growth retardation and postnatal growth failure associated with deletion of the insulin-like growth factor I gene. N Engl J Med: 1996; 335 1363 1367
17. Walenkamp M. J., Karperien M., Pereira A. M., Hilhorst-Hofstee Y., van Doorn J., Chen J. W., Mohan S., Denley A., Forbes B., van Duyvenvoorde H. A., van Thiel S. W., Sluimers C. A., Bax J. J., de Laat J. A., Breuning M. B., Romijn J. A., Wit J. M. Homozygous and heterozygous expression of a novel insulin-like growth factor-I mutation. J Clin Endocrinol Metab: 2005; 90 2855 2864
18. Rother K. I., Imai Y., Caruso M., Beguinot F., Formisano P., Accili D. Evidence that IRS-2 phosphorylation is required for insulin action in hepatocytes. J Biol Chem: 1998; 273 17491 17497
19. Rother K. I., Accili D. Role of insulin receptors and IGF receptors in growth and development. Pediatr Nephrol: 2000; 14 558 561
20. Cinti S., Eberbach S., Castellucci M., Accili D. Lack of insulin receptors affects the formation of white adipose tissue in mice. A morphometric and ultrastructural analysis. Diabetologia: 1998; 41 171 177
21. Rau H., Kocova M., O'Rahilly S., Whitehead J. P. Naturally occurring amino acid substitutions at Arg1174 in the human insulin receptor result in differential effects on receptor biosynthesis and hybrid formation, leading to discordant clinical phenotypes. Diabetes: 2000; 49 1264 1268
22. Prato S. D., Marchetti P., Bonadonna R. C. Phasic insulin release and metabolic regulation in type 2 diabetes. Diabetes: 2002; 51 S109 S116
23. Rave K., Sidharta P. N., Dingemanse J., Heinemann L., Roggen K. First-phase insulin secretion has limited impact on postprandial glycaemia in subjects with type 2 diabetes: correlations between hyperglycemic glucose clamp and meal test. Diabetes Technol Ther: 2010; 12 117 123
24. Del Prato S., Marchetti P. Beta- and alpha-cell dysfunction in type 2 diabetes. Horm Metab Res: 2004; 36 775 781
25. Berrish T. S., Hetherington C. S., Alberti K. G., Walker M. Peripheral and hepatic insulin sensitivity in subjects with impaired glucose tolerance. Diabetologia: 1995; 38 699 704
26. Vambergue A., Lautier C., Valat A. S., Cortet-Rudelli C., Grigorescu F., Dewailly D. Follow-up study of two sisters with type A syndrome of severe insulin resistance gives a new insight into PCOS pathogenesis in relation to puberty and pregnancy outcome: a case report. Hum Reprod: 2006; 21 1274 1278
27. Musso C., Cochran E., Moran S. A., Skarulis M. C., Oral E. A., Taylor S., Gorden P. Clinical course of genetic diseases of the insulin receptor (type A and Rabson-Mendenhall syndromes): a 30-year prospective. Medicine (Baltimore): 2004; 83 209 222
28. Menendez J. A., Vazquez-Martin A., Ortega F. J., Fernandez-Real J. M. Fatty acid synthase: association with insulin resistance, type 2 diabetes, and cancer. Clin Chem: 2009; 55 425 438
29. Poitout V., Robertson R. P. Glucolipotoxicity: fuel excess and beta-cell dysfunction. Endocr Rev: 2008; 29 351 366
30. Del Prato S. Role of glucotoxicity and lipotoxicity in the pathophysiology of type 2 diabetes mellitus and emerging treatment strategies. Diabet Med: 2009; 26 1185 1192
31. Kashyap S., Belfort R., Gastaldelli A., Pratipanawatr T., Berria R., Pratipanawatr W., Bajaj M., Mandarino L., DeFronzo R., Cusi K. A sustained increase in plasma free fatty acids impairs insulin secretion in nondiabetic subjects genetically predisposed to develop type 2 diabetes. Diabetes: 2003; 52 2461 2474