메뉴 건너뛰기




Volumn 117, Issue 3, 2009, Pages 111-118

Intramyocellular lipid levels are associated with peripheral, but not hepatic, insulin sensitivity in normal healthy subjects

Author keywords

1H magnetic resonance spectroscopy; Glucose stable isotope; Hyperinsulinaemic euglycaemic clamp; Insulin sensitivity; Intramyocellular lipid

Indexed keywords

ABDOMINAL FAT; ADULT; ARTICLE; BODY COMPOSITION; BODY FAT; CELL LEVEL; CONTROLLED STUDY; FEMALE; GLUCONEOGENESIS; GLUCOSE CLAMP TECHNIQUE; HUMAN; INSULIN SENSITIVITY; INTRAMYOCELLULAR LIPID LEVEL; LIPID TRANSPORT; MALE; NORMAL HUMAN; PRIORITY JOURNAL; ADIPOSE TISSUE; BIOSYNTHESIS; BODY MASS; GLUCOSE BLOOD LEVEL; LIPID METABOLISM; LIVER; METABOLISM; PHOTON ABSORPTIOMETRY; PHYSIOLOGY;

EID: 70149091505     PISSN: 01435221     EISSN: None     Source Type: Journal    
DOI: 10.1042/CS20080563     Document Type: Article
Times cited : (8)

References (54)
  • 1
    • 0345086474 scopus 로고    scopus 로고
    • Free fatty acid-induced insulin resistance is associated with activation of protein kinase Cθ and alterations in the insulin signaling cascade
    • Griffin, M. E., Marcucci, M. J., Cline, G.W., Bell, K., Barucci, N., Lee, D., Goodyear, L. J., Kraegen, E. W., White, M. F. and Shulman, G. I. (1999) Free fatty acid-induced insulin resistance is associated with activation of protein kinase Cθ and alterations in the insulin signaling cascade. Diabetes 48, 1270-1274
    • (1999) Diabetes , vol.48 , pp. 1270-1274
    • Griffin, M.E.1    Marcucci, M.J.2    Cline, G.W.3    Bell, K.4    Barucci, N.5    Lee, D.6    Goodyear, L.J.7    Kraegen, E.W.8    White, M.F.9    Shulman, G.I.10
  • 2
    • 0027762766 scopus 로고
    • Insulin resistance and insulin secretory dysfunction as precursors of non-insulin-dependent diabetes mellitus. Prospective studies of Pima Indians
    • Lillioja, S., Mott, D. M., Spraul, M., Ferraro, R., Foley, J. E., Ravussin, E., Knowler, W. C., Bennett, P. H. and Bogardus, C. (1993) Insulin resistance and insulin secretory dysfunction as precursors of non-insulin-dependent diabetes mellitus. Prospective studies of Pima Indians. N. Engl. J. Med. 329, 1988-1992
    • (1993) N. Engl. J. Med , vol.329 , pp. 1988-1992
    • Lillioja, S.1    Mott, D.M.2    Spraul, M.3    Ferraro, R.4    Foley, J.E.5    Ravussin, E.6    Knowler, W.C.7    Bennett, P.H.8    Bogardus, C.9
  • 3
    • 0025663581 scopus 로고
    • Slow glucose removal rate and hyperinsulinemia precede the development of type II diabetes in the offspring of diabetic parents
    • Warram, J. H., Martin, B. C., Krolewski, A. S., Soeldner, J. S. and Kahn, C. R. (1990) Slow glucose removal rate and hyperinsulinemia precede the development of type II diabetes in the offspring of diabetic parents. Ann. Intern. Med. 113, 909-915
    • (1990) Ann. Intern. Med , vol.113 , pp. 909-915
    • Warram, J.H.1    Martin, B.C.2    Krolewski, A.S.3    Soeldner, J.S.4    Kahn, C.R.5
  • 4
    • 0036724346 scopus 로고    scopus 로고
    • Preservation of pancreatic β-cell function and prevention of type 2 diabetes by pharmacological treatment of insulin resistance in high-risk hispanic women
    • Buchanan, T. A., Xiang, A. H., Peters, R. K., Kjos, S. L., Marroquin, A., Goico, J., Ochoa, C., Tan, S., Berkowitz, K., Hodis, H. N. and Azen, S. P. (2002) Preservation of pancreatic β-cell function and prevention of type 2 diabetes by pharmacological treatment of insulin resistance in high-risk hispanic women. Diabetes 51, 2796-2803
    • (2002) Diabetes , vol.51 , pp. 2796-2803
    • Buchanan, T.A.1    Xiang, A.H.2    Peters, R.K.3    Kjos, S.L.4    Marroquin, A.5    Goico, J.6    Ochoa, C.7    Tan, S.8    Berkowitz, K.9    Hodis, H.N.10    Azen, S.P.11
  • 5
    • 33748748206 scopus 로고    scopus 로고
    • Effect of rosiglitazone on the frequency of diabetes in patients with impaired glucose tolerance or impaired fasting glucose: A randomised controlled trial
    • Gerstein, H. C., Yusuf, S., Bosch, J., Pogue, J., Sheridan, P., Dinccag, N., Hanefeld, M., Hoogwerf, B., Laakso, M., Mohan, V. et al. (2006) Effect of rosiglitazone on the frequency of diabetes in patients with impaired glucose tolerance or impaired fasting glucose: a randomised controlled trial. Lancet 368, 1096-1105
    • (2006) Lancet , vol.368 , pp. 1096-1105
    • Gerstein, H.C.1    Yusuf, S.2    Bosch, J.3    Pogue, J.4    Sheridan, P.5    Dinccag, N.6    Hanefeld, M.7    Hoogwerf, B.8    Laakso, M.9    Mohan, V.10
  • 7
    • 0030946601 scopus 로고    scopus 로고
    • In vivo determination of intra-myocellular lipids in human muscle by means of localized 1H-MR-spectroscopy
    • Boesch, C., Slotboom, J., Hoppeler, H. and Kreis, R. (1997) In vivo determination of intra-myocellular lipids in human muscle by means of localized 1H-MR-spectroscopy. Magn. Reson. Med. 37, 484-493
    • (1997) Magn. Reson. Med , vol.37 , pp. 484-493
    • Boesch, C.1    Slotboom, J.2    Hoppeler, H.3    Kreis, R.4
  • 9
    • 0027457161 scopus 로고
    • Comparison of localized proton NMR signals of skeletal muscle and fat tissue in vivo: Two lipid compartments in muscle tissue
    • Schick, F., Eismann, B., Jung, W. I., Bongers, H., Bunse, M. and Lutz, O. (1993) Comparison of localized proton NMR signals of skeletal muscle and fat tissue in vivo: two lipid compartments in muscle tissue. Magn. Reson. Med. 29, 158-167
    • (1993) Magn. Reson. Med , vol.29 , pp. 158-167
    • Schick, F.1    Eismann, B.2    Jung, W.I.3    Bongers, H.4    Bunse, M.5    Lutz, O.6
  • 10
    • 0032934826 scopus 로고    scopus 로고
    • Intramyocellular lipid concentrations are correlated with insulin sensitivity in humans: A 1H NMR spectroscopy study
    • Krssak, M., Falk Petersen, K., Dresner, A., DiPietro, L., Vogel, S. M., Rothman, D. L., Roden, M. and Shulman, G. I. (1999) Intramyocellular lipid concentrations are correlated with insulin sensitivity in humans: a 1H NMR spectroscopy study. Diabetologia 42, 113-116
    • (1999) Diabetologia , vol.42 , pp. 113-116
    • Krssak, M.1    Falk Petersen, K.2    Dresner, A.3    DiPietro, L.4    Vogel, S.M.5    Rothman, D.L.6    Roden, M.7    Shulman, G.I.8
  • 12
    • 0035487317 scopus 로고    scopus 로고
    • Intramyocellular lipid is associated with resistance to in vivo insulin actions on glucose uptake, antilipolysis, and early insulin signaling pathways in human skeletal muscle
    • Virkamaki, A., Korsheninnikova, E., Seppala-Lindroos, A., Vehkavaara, S., Goto, T., Halavaara, J., Hakkinen, A. M. and Yki-Jarvinen, H. (2001) Intramyocellular lipid is associated with resistance to in vivo insulin actions on glucose uptake, antilipolysis, and early insulin signaling pathways in human skeletal muscle. Diabetes 50, 2337-2343
    • (2001) Diabetes , vol.50 , pp. 2337-2343
    • Virkamaki, A.1    Korsheninnikova, E.2    Seppala-Lindroos, A.3    Vehkavaara, S.4    Goto, T.5    Halavaara, J.6    Hakkinen, A.M.7    Yki-Jarvinen, H.8
  • 13
    • 0035515278 scopus 로고    scopus 로고
    • Effects of intravenous and dietary lipid challenge on intramyocellular lipid content and the relation with insulin sensitivity in humans
    • Bachmann, O. P., Dahl, D. B., Brechtel, K., Machann, J., Haap, M., Maier, T., Loviscach, M., Stumvoll, M., Claussen, C. D., Schick, F. et al. (2001) Effects of intravenous and dietary lipid challenge on intramyocellular lipid content and the relation with insulin sensitivity in humans. Diabetes 50, 2579-2584
    • (2001) Diabetes , vol.50 , pp. 2579-2584
    • Bachmann, O.P.1    Dahl, D.B.2    Brechtel, K.3    Machann, J.4    Haap, M.5    Maier, T.6    Loviscach, M.7    Stumvoll, M.8    Claussen, C.D.9    Schick, F.10
  • 14
    • 0032960890 scopus 로고    scopus 로고
    • Association of increased intramyocellular lipid content with insulin resistance in lean nondiabetic offspring of type 2 diabetic subjects
    • Jacob, S., Machann, J., Rett, K., Brechtel, K., Volk, A., Renn, W., Maerker, E., Matthaei, S., Schick, F., Claussen, C. D. and Haring, H. U. (1999) Association of increased intramyocellular lipid content with insulin resistance in lean nondiabetic offspring of type 2 diabetic subjects. Diabetes 48, 1113-1119
    • (1999) Diabetes , vol.48 , pp. 1113-1119
    • Jacob, S.1    Machann, J.2    Rett, K.3    Brechtel, K.4    Volk, A.5    Renn, W.6    Maerker, E.7    Matthaei, S.8    Schick, F.9    Claussen, C.D.10    Haring, H.U.11
  • 17
    • 14644435731 scopus 로고    scopus 로고
    • Reversal of nonalcoholic hepatic steatosis, hepatic insulin resistance, and hyperglycemia by moderate weight reduction in patients with type 2 diabetes
    • Petersen, K. F., Dufour, S., Befroy, D., Lehrke, M., Hendler, R. E. and Shulman, G. I. (2005) Reversal of nonalcoholic hepatic steatosis, hepatic insulin resistance, and hyperglycemia by moderate weight reduction in patients with type 2 diabetes. Diabetes 54, 603-608
    • (2005) Diabetes , vol.54 , pp. 603-608
    • Petersen, K.F.1    Dufour, S.2    Befroy, D.3    Lehrke, M.4    Hendler, R.E.5    Shulman, G.I.6
  • 23
    • 70349398225 scopus 로고    scopus 로고
    • Reference deleted
    • Reference deleted
  • 24
    • 0346308381 scopus 로고    scopus 로고
    • Improved method for accurate and efficient quantification of MRS data with use of prior knowledge
    • Vanhamme, L., van den Boogaart, A. and Van Huffel, S. (1997) Improved method for accurate and efficient quantification of MRS data with use of prior knowledge. J. Magn. Reson. 129, 35-43
    • (1997) J. Magn. Reson , vol.129 , pp. 35-43
    • Vanhamme, L.1    van den Boogaart, A.2    Van Huffel, S.3
  • 25
    • 0842264091 scopus 로고    scopus 로고
    • Distribution of intramyocellular lipids in human calf muscles as determined by MR spectroscopic imaging
    • Vermathen, P., Kreis, R. and Boesch, C. (2004) Distribution of intramyocellular lipids in human calf muscles as determined by MR spectroscopic imaging. Magn. Reson. Med. 51, 253-262
    • (2004) Magn. Reson. Med , vol.51 , pp. 253-262
    • Vermathen, P.1    Kreis, R.2    Boesch, C.3
  • 26
    • 0036032990 scopus 로고    scopus 로고
    • Measurement of insulin sensitivity indices using 13C-glucose and gas chromatography/ combustion/isotope ratio mass spectrometry
    • Clapperton, A. T., Coward, W. A. and Bluck, L. J. (2002) Measurement of insulin sensitivity indices using 13C-glucose and gas chromatography/ combustion/isotope ratio mass spectrometry. Rapid Commun. Mass Spectrom. 16, 2009-2014
    • (2002) Rapid Commun. Mass Spectrom , vol.16 , pp. 2009-2014
    • Clapperton, A.T.1    Coward, W.A.2    Bluck, L.J.3
  • 27
    • 34548606458 scopus 로고    scopus 로고
    • A single glucose derivative suitable for gas chromatography/mass spectrometry and gas chromatography/combustion/isotope ratio mass spectrometry
    • Jackson, S. J., Waterhouse, J. S. and Bluck, L. J. (2007) A single glucose derivative suitable for gas chromatography/mass spectrometry and gas chromatography/combustion/isotope ratio mass spectrometry. Rapid Commun. Mass Spectrom. 21, 3123-3128
    • (2007) Rapid Commun. Mass Spectrom , vol.21 , pp. 3123-3128
    • Jackson, S.J.1    Waterhouse, J.S.2    Bluck, L.J.3
  • 28
    • 0036313839 scopus 로고    scopus 로고
    • Adjustment of fat-free mass and fat mass for height in children aged 8 years
    • Wells, J. C. and Cole, T. J. (2002) Adjustment of fat-free mass and fat mass for height in children aged 8 years. Int. J. Obes. Relat. Metab. Disord. 26, 947-952
    • (2002) Int. J. Obes. Relat. Metab. Disord , vol.26 , pp. 947-952
    • Wells, J.C.1    Cole, T.J.2
  • 30
    • 0000648085 scopus 로고
    • Influences of glucose loading and of injected insulin on hepatic glucose output
    • Steele, R. (1959) Influences of glucose loading and of injected insulin on hepatic glucose output. Ann. N. Y. Acad. Sci. 82, 420-430
    • (1959) Ann. N. Y. Acad. Sci , vol.82 , pp. 420-430
    • Steele, R.1
  • 31
    • 0023245416 scopus 로고
    • Estimation of endogenous glucose production during hyperinsulinemic-euglycemic glucose clamps. Comparison of unlabeled and labeled exogenous glucose infusates
    • Finegood, D. T., Bergman, R. N. and Vranic, M. (1987) Estimation of endogenous glucose production during hyperinsulinemic-euglycemic glucose clamps. Comparison of unlabeled and labeled exogenous glucose infusates. Diabetes 36, 914-924
    • (1987) Diabetes , vol.36 , pp. 914-924
    • Finegood, D.T.1    Bergman, R.N.2    Vranic, M.3
  • 33
    • 0026712138 scopus 로고
    • Estimation of the rate of appearance in the non-steady state with a two-compartment model
    • Mari, A. (1992) Estimation of the rate of appearance in the non-steady state with a two-compartment model. Am. J. Physiol. 263, E400-E415
    • (1992) Am. J. Physiol , vol.263
    • Mari, A.1
  • 34
    • 37149001609 scopus 로고    scopus 로고
    • Increased intrahepatic triglyceride is associated with peripheral insulin resistance: In vivo MR imaging and spectroscopy studies
    • Hwang, J. H., Stein, D. T., Barzilai, N., Cui, M. H., Tonelli, J., Kishore, P. and Hawkins, M. (2007) Increased intrahepatic triglyceride is associated with peripheral insulin resistance: in vivo MR imaging and spectroscopy studies. Am. J. Physiol. Endocrinol. Metab. 293, E1663-E1669
    • (2007) Am. J. Physiol. Endocrinol. Metab , vol.293
    • Hwang, J.H.1    Stein, D.T.2    Barzilai, N.3    Cui, M.H.4    Tonelli, J.5    Kishore, P.6    Hawkins, M.7
  • 35
    • 0035217707 scopus 로고    scopus 로고
    • Skeletal muscle lipid content and insulin resistance: Evidence for a paradox in endurance-trained athletes
    • Goodpaster, B. H., He, J., Watkins, S. and Kelley, D. E. (2001) Skeletal muscle lipid content and insulin resistance: evidence for a paradox in endurance-trained athletes. J. Clin. Endocrinol. Metab. 86, 5755-5761
    • (2001) J. Clin. Endocrinol. Metab , vol.86 , pp. 5755-5761
    • Goodpaster, B.H.1    He, J.2    Watkins, S.3    Kelley, D.E.4
  • 36
    • 3543008339 scopus 로고    scopus 로고
    • The role of lipid accumulation in liver and muscle for insulin resistance and type 2 diabetes mellitus in humans
    • Krssak, M. and Roden, M. (2004) The role of lipid accumulation in liver and muscle for insulin resistance and type 2 diabetes mellitus in humans. Rev. Endocr. Metab. Disord. 5, 127-134
    • (2004) Rev. Endocr. Metab. Disord , vol.5 , pp. 127-134
    • Krssak, M.1    Roden, M.2
  • 37
    • 50549202600 scopus 로고
    • The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus
    • Randle, P. J., Garland, P. B., Hates, C. N. and Newsholme E. A. (1963) The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. Lancet 1, 785-789
    • (1963) Lancet , vol.1 , pp. 785-789
    • Randle, P.J.1    Garland, P.B.2    Hates, C.N.3    Newsholme, E.A.4
  • 40
    • 0023908033 scopus 로고
    • Effect of elevated free fatty acids on glucose oxidation in normal humans
    • Wolfe, B. M., Klein, S., Peters, E. J., Schmidt, B. F. and Wolfe, R. R. (1988) Effect of elevated free fatty acids on glucose oxidation in normal humans. Metabolism 37, 323-329
    • (1988) Metabolism , vol.37 , pp. 323-329
    • Wolfe, B.M.1    Klein, S.2    Peters, E.J.3    Schmidt, B.F.4    Wolfe, R.R.5
  • 41
    • 8844255630 scopus 로고    scopus 로고
    • Free fatty acids in obesity and type 2 diabetes: Defining their role in the development of insulin resistance and β-cell dysfunction
    • Boden, G. and Shulman, G. I. (2002) Free fatty acids in obesity and type 2 diabetes: defining their role in the development of insulin resistance and β-cell dysfunction. Eur. J. Clin. Invest. 32, 14-23
    • (2002) Eur. J. Clin. Invest , vol.32 , pp. 14-23
    • Boden, G.1    Shulman, G.I.2
  • 42
    • 0033927667 scopus 로고    scopus 로고
    • Cellular mechanisms of insulin resistance
    • Shulman, G. I. (2000) Cellular mechanisms of insulin resistance. J. Clin. Invest. 106, 171-176
    • (2000) J. Clin. Invest , vol.106 , pp. 171-176
    • Shulman, G.I.1
  • 43
    • 0031943479 scopus 로고    scopus 로고
    • Regulation of the insulin signalling pathway by cellular protein-tyrosine phosphatases
    • Goldstein, B. J., Ahmad, F., Ding, W., Li, P. M. and Zhang, W. R. (1998) Regulation of the insulin signalling pathway by cellular protein-tyrosine phosphatases. Mol. Cell. Biochem. 182, 91-99
    • (1998) Mol. Cell. Biochem , vol.182 , pp. 91-99
    • Goldstein, B.J.1    Ahmad, F.2    Ding, W.3    Li, P.M.4    Zhang, W.R.5
  • 44
    • 0030926433 scopus 로고    scopus 로고
    • Role of the glucosamine pathway in fat-induced insulin resistance
    • Hawkins, M., Barzilai, N., Liu, R., Hu, M., Chen, W. and Rossetti, L. (1997) Role of the glucosamine pathway in fat-induced insulin resistance. J. Clin. Invest. 99, 2173-2182
    • (1997) J. Clin. Invest , vol.99 , pp. 2173-2182
    • Hawkins, M.1    Barzilai, N.2    Liu, R.3    Hu, M.4    Chen, W.5    Rossetti, L.6
  • 45
    • 0032900343 scopus 로고    scopus 로고
    • Multiple sites of insulin resistance: Muscle, liver and adipose tissue
    • Stumvoll, M. and Jacob, S. (1999) Multiple sites of insulin resistance: muscle, liver and adipose tissue. Exp. Clin. Endocrinol. Diabetes. 107, 107-110
    • (1999) Exp. Clin. Endocrinol. Diabetes , vol.107 , pp. 107-110
    • Stumvoll, M.1    Jacob, S.2
  • 46
    • 0033817811 scopus 로고    scopus 로고
    • Failure of adipocyte differentiation causes type II diabetes mellitus?
    • Danforth, Jr, E. (2000) Failure of adipocyte differentiation causes type II diabetes mellitus? Nat. Genet. 26, 13
    • (2000) Nat. Genet , vol.26 , pp. 13
    • Danforth Jr, E.1
  • 47
    • 0036381998 scopus 로고    scopus 로고
    • Adipose tissue as a buffer for daily lipid flux
    • Frayn, K. N. (2002) Adipose tissue as a buffer for daily lipid flux. Diabetologia 45, 1201-1210
    • (2002) Diabetologia , vol.45 , pp. 1201-1210
    • Frayn, K.N.1
  • 48
    • 0034033372 scopus 로고    scopus 로고
    • Visceral fat and insulin resistance-causative or correlative?
    • Frayn, K. N. (2000) Visceral fat and insulin resistance-causative or correlative? Br. J. Nutr. 83, S71-S77
    • (2000) Br. J. Nutr , vol.83
    • Frayn, K.N.1
  • 49
    • 0034119138 scopus 로고    scopus 로고
    • The perils of portliness: Causes and consequences of visceral adiposity
    • Montague, C. T. and O'Rahilly, S. (2000) The perils of portliness: causes and consequences of visceral adiposity. Diabetes 49, 883-888
    • (2000) Diabetes , vol.49 , pp. 883-888
    • Montague, C.T.1    O'Rahilly, S.2
  • 50
    • 0032990467 scopus 로고    scopus 로고
    • Catecholamine-induced lipolysis in obesity
    • Arner, P. (1999) Catecholamine-induced lipolysis in obesity. Int. J. Obes. Relat. Metab. Disord. 23, 10-13
    • (1999) Int. J. Obes. Relat. Metab. Disord , vol.23 , pp. 10-13
    • Arner, P.1
  • 51
    • 0024253488 scopus 로고
    • Lipolysis in human adipocytes, effects of cell size, age and of regional differences
    • Engfeldt, P. and Arner, P. (1988) Lipolysis in human adipocytes, effects of cell size, age and of regional differences. Horm. Metab. Res. Suppl. 19, 26-29
    • (1988) Horm. Metab. Res. Suppl , vol.19 , pp. 26-29
    • Engfeldt, P.1    Arner, P.2
  • 52
    • 0023182306 scopus 로고
    • Heterogeneous distribution of β and α-2 adrenoceptor binding sites in human fat cells from various fat deposits: Functional consequences
    • Mauriege, P., Galitzky, J., Berlan, M. and Lafontan, M. (1987) Heterogeneous distribution of β and α-2 adrenoceptor binding sites in human fat cells from various fat deposits: functional consequences. Eur. J. Clin. Invest. 17, 156-165
    • (1987) Eur. J. Clin. Invest , vol.17 , pp. 156-165
    • Mauriege, P.1    Galitzky, J.2    Berlan, M.3    Lafontan, M.4
  • 53
    • 0018596025 scopus 로고
    • Regional differences in the control of lipolysis in human adipose tissue
    • Ostman, J., Arner, P., Engfeldt, P. and Kager, L. (1979) Regional differences in the control of lipolysis in human adipose tissue. Metabolism 28, 1198-1205
    • (1979) Metabolism , vol.28 , pp. 1198-1205
    • Ostman, J.1    Arner, P.2    Engfeldt, P.3    Kager, L.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.