Lung Stem and Progenitor Cells in Tissue Homeostasis and Disease

Current Topics in Developmental Biology

Volumn 107, Issue , 2014, Pages 207-233

  Leeman, Kristen T ^a,b,c   Fillmore, Christine M ^a,b,c   Kim, Carla F ^a,b,c  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b HARVARD STEM CELL INSTITUTE   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Cell based therapy; Embryonic stem cells; IPS cells; Lung cancer; Lung cancer stem cells; Lung stem cells; Mesenchymal stromal cells

Indexed keywords

BIOLOGICAL MARKER;

ANIMAL; ARTICLE; BIOLOGICAL MODEL; CELL DIFFERENTIATION; CELL LINEAGE; CELL-BASED THERAPY; CYTOLOGY; EMBRYONIC STEM CELL; HOMEOSTASIS; HUMAN; IPS CELLS; LUNG; LUNG CANCER; LUNG CANCER STEM CELLS; LUNG STEM CELLS; LUNG TUMOR; MESENCHYMAL STROMA CELL; METABOLISM; METHODOLOGY; MOUSE; PATHOPHYSIOLOGY; PHYSIOLOGY; STEM CELL; STEM CELL TRANSPLANTATION;

CELL-BASED THERAPY; EMBRYONIC STEM CELLS; IPS CELLS; LUNG CANCER; LUNG CANCER STEM CELLS; LUNG STEM CELLS; MESENCHYMAL STROMAL CELLS;

ANIMALS; BIOLOGICAL MARKERS; CELL DIFFERENTIATION; CELL LINEAGE; HOMEOSTASIS; HUMANS; LUNG; LUNG NEOPLASMS; MESENCHYMAL STROMAL CELLS; MICE; MODELS, BIOLOGICAL; STEM CELL TRANSPLANTATION; STEM CELLS;

EID: 84892475171     PISSN: 00702153     EISSN: None     Source Type: Book Series    
DOI: 10.1016/B978-0-12-416022-4.00008-1     Document Type: Chapter

References (129)

1. Adamson I., Bowden D. The type 2 cell as progenitor of alveolar epithelial regeneration. A cytodynamic study in mice after exposure to oxygen. Laboratory Investigation 1974, 30:35-42.
2. Aguilar S., Scotton C., McNutty K., Nye E., Stamp G., Laurent G., et al. Bone marrow stem cells expressing keratinocyte growth factor via an inducible lentivirus protects against bleomycin-induced pulmonary fibrosis. PLoS One 2009, 4(11):e8013.
3. Aslam M., Baveja R., Liang O., Fernandez-Gonzalez A., Lee C., Mitsialis S., et al. Bone marrow stromal cells attenuate lung injury in a murine model of neonatal chronic lung disease. American Journal of Respiratory and Critical Care Medicine 2009, 180(11):1122-1130.
4. Aso Y., Yoneda K., Kikkawa Y. Morphologic and biochemical study of pulmonary changes induced by bleomycin in mice. Laboratory Investigation 1976, 35:558-568.
5. Baber S., Deng W., Master R., Bunnell B., Taylor B., Murthy S., et al. Intratracheal mesenchymal stem cell administration attenuates monocrotaline-induced pulmonary hypertension and endothelial dysfunction. American Journal of Physiology. Heart and Circulatory Physiology 2007, 292(2):H1120-H1128.
6. Balasubramaniam V., Ryan S., Seedorf G., Roth E., Heumann T., Yoder M., et al. Bone marrow-derived angiogenic cells restore lung alveolar and vascular structure after neonatal hyperoxia in infant mice. American Journal of Physiology. Lung Cellular and Molecular Physiology 2010, 298(3):L315-L323.
7. Barbie D.A., Tamayo P., Boehm J.S., Kim S.Y., Moody S.E., Dunn I.F., et al. Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1. Nature 2009, 462(7269):108-112.
8. Barkauskas C., Cronce M., Rackley C., Bowie E., Keene D., Stripp B., et al. Type 2 alveolar cells are stem cells in adult lung. The Journal of Clinical Investigation 2013, 123(7):3025-3036.
9. Bass A.J., Watanabe H., Mermel C.H., Yu S., Perner S., Verhaak R.G., et al. SOX2 is an amplified lineage-survival oncogene in lung and esophageal squamous cell carcinomas. Nature Genetics 2009, 41(11):1238-1242.
10. Bentley J., Popova A., Bozyk P., Linn M., Baek A., Lei J., et al. Ovalbumin sensitization and challenge increases the number of lung cells possessing a mesenchymal stromal cell phenotype. Respiratory Research 2010, 11:127.
11. Bertolini G., Roz L., Perego P., Tortoreto M., Fontanella E., Gatti L., et al. Highly tumorigenic lung cancer CD133+ cells display stem-like features and are spared by cisplatin treatment. Proceedings of the National Academy of Sciences 2009, 106(38):16281-16286.
12. Bertoncello I., McQualter J. Lung stem cells: Do they exist?. Respirology 2013, 18(4):587-595.
13. Borthwick D., Shahbazian M., Krantz Q., Dorin J., Randell S. Evidence for stem-cell niches in the tracheal epithelium. American Journal of Respiratory Cell and Molecular Biology 2001, 24:662-670.
14. Carretero J., Shimamura T., Rikova K., Jackson A.L., Wilkerson M.D., Borgman C.L., et al. Integrative Genomic and Proteomic Analyses Identify Targets for Lkb1-Deficient Metastatic Lung Tumors. Cancer Cell 2010, 17(6):547-559.
15. Chapman H., Li X., Alexander J., Brumwell A., Lorizio W., Tan K., et al. Integrin α6β4 identifies an adult distal lung epithelial population with regenerative potential in mice. The Journal of Clinical Investigation 2011, 121(7):2855-2862.
16. Clevers H. Stem cells: A unifying theory for the crypt. Nature 2013, 495(7439):53-54.
17. Curtis S.J., Sinkevicius K.W., Li D., Lau A.N., Roach R.R., Zamponi R., et al. Primary tumor genotype is an important determinant in identification of lung cancer propagating cells. Cell Stem Cell 2010, 7(1):127-133.
18. De Langhe S., Carraro G., Warburton D., Hajihosseini M., Bellusci S. Levels of mesenchymal FGFR2 signaling modulate smooth muscle progenitor cell commitment in the lung. Developmental Biology 2006, 299(1):52-62.
19. Ding B., Nolan D., Guo P., Babazadeh A., Cao Z., Rosenwaks Z., et al. Endothelial-derived angiocrine signals induce and sustain regenerative lung alveolarization. Cell 2011, 147(3):539-553.
20. Dominici M., Le Blanc K., Mueller I., Slaper-Cortenbach I., Marini F., Krause D., et al. Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy 2006, 8(4):315-317.
21. Duong H., Erzurum S., Asosingh K. Pro-angiogenic hematopoietic progenitor cells and endothelial colony-forming cells in pathological angiogenesis of bronchial and pulmonary circulation. Angiogenesis 2011, 14:411-422.
22. Eramo A., Lotti F., Sette G., Pilozzi E., Biffoni M., Di Virgilio A., et al. Identification and expansion of the tumorigenic lung cancer stem cell population. Cell Death Differ 2008, 15(3):504-514.
23. Ettinger D.S., Akerley W., Borghaei H., Chang A.C., Cheney R.T., Chirieac L.R., et al. Non-small cell lung cancer, version 2.2013. Journal of the National Comprehensive Cancer Network 2013, 11(6):645-653.
24. Evans M., Cabral L., Stephens R., Freeman G. Transformation of alveolar type 2 cells to type 1 cells following exposure to NO2. Experimental and Molecular Pathology 1975, 22(1):142-150.
25. Evans M., Cabral-Anderson L., Freeman G. Role of the Clara cell in renewal of the bronchiolar epithelium. Laboratory Investigation 1978, 38(6):648-653.
26. Evans M., Johnson L., Stephens R., Freeman G. Renewal of the terminal bronchiolar epithelium in the rat following exposure to NO2 or O3. Laboratory Investigation 1976, 35(3):246-257.
27. Evans M., Shami S., Cabral-Anderson L., Dekker N. Role of nonciliated cells in renewal of the bronchial epithelium of rats exposed to NO2. The American Journal of Pathology 1986, 123(1):126-133.
28. Fulcher M., Gabriel S., Burns K., Yankaskas J., Randell S. Well-differentiated human airway epithelial cell cultures. Methods in Molecular Medicine 2005, 107:183-206.
29. Gazdar A.F., Girard L., Lockwood W.W., Lam W.L., Minna J.D. Lung cancer cell lines as tools for biomedical discovery and research. Journal of the National Cancer Institute 2010, 102(17):1310-1321.
30. Ghanta S., Leeman K., Christou H. An update on pharmacologic approaches to bronchopulmonary dysplasia. Seminars in Perinatology 2013, 37(2):115-123.
31. Giangreco A., Reynolds S., Stripp B. Terminal bronchioles harbor a unique airway stem cell population that localizes to the bronchioalveolar duct junction. The American Journal of Pathology 2002, 161(1):173-182.
32. Giordano A., Galderisi U., Marino I. From the laboratory bench to the patient's bedside: An update on clinical trials with mesenchymal stem cells. Journal of Cellular Physiology 2007, 211:27-35.
33. Green M., Chen A., Nostro M., d'Souza S., Lemischka I., Gouon-Evans V., et al. Generation of anterior foregut endoderm from human embryonic and induced pluripotent stem cells. Nature Biotechnology 2011, 29(3):267-272.
34. Govindan R., Ding L., Griffith M., Subramanian J., Dees N.D., Kanchi K.L., et al. Genomic Landscape of Non-Small Cell Lung Cancer in Smokers and Never-Smokers. Cell 2012, 150(6):1121-1134.
35. Gupta N., Su X., Popov B., Lee J., Serikov V., Matthay M. Intrapulmonary delivery of bone marrow-derived mesenchymal stem cells improves survival and attenuates endotoxin-induced acute lung injury in mice. The Journal of Immunology 2007, 179:1855-1863.
36. Hegab A., Ha V., Gilbert J., Zhang K., Malkoski S., Chon A., et al. Novel stem/progenitor cell population from murine tracheal submucosal gland ducts with multipotent regenerative potential. Stem Cells 2011, 29(8):1283-1293.
37. Hegab A., Nickerson D., Ha V., Darmawan D., Gomperts B. Repair and regeneration of tracheal surface epithelium and submucosal glands in a mouse model of hypoxic-ischemic injury. Respirology 2012, 17(7):1101-1113.
38. Hennrick K., Keeton A., Nanua S., Kijek T., Goldsmith A., Sajjan U., et al. Lung cells from neonates show a mesenchymal stem cell phenotype. American Journal of Respiratory and Critical Care Medicine 2007, 175(11):1158-1164.
39. Herbst R.S., Heymach J.V., Lippman S.M. Lung cancer. New England Journal of Medicine 2008, 359(13):1367-1380.
40. Hoffman A., Paxson J., Mazan M., Davis A., Tyagi S., Murthy S., et al. Lung-derived mesenchymal stromal cell post-transplantation survival, persistence, paracrine expression, and repair of elastase-injured lung. Stem Cells and Development 2011, 20(10):1779-1792.
41. Hong K., Reynolds S., Giangreco A., Hurley C., Stripp B. Clara cell secretory protein-expressing cells of the airway neuroepithelial body microenvironment include a label-retaining subset and are critical for epithelial renewal after progenitor cell depletion. American Journal of Respiratory Cell and Molecular Biology 2001, 24(6):671-681.
42. Imielinski M., Berger A.H., Hammerman P.S., Hernandez B., Pugh T.J., Hodis E., et al. Mapping the Hallmarks of Lung Adenocarcinoma with Massively Parallel Sequencing. Cell 2012, 150(6):1107-1120.
43. Islam M., Das S., Emin M., Wei M., Sun L., Westphalen K., et al. Mitochondrial transfer from bone marrow derived stromal cells to pulmonary alveoli protects against acute lung injury. Nature Medicine 2012, 18:759-765.
44. Jackson E.L., Willis N., Mercer K., Bronson R.T., Crowley D., Montoya R., et al. Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras. Genes & Development 2001, 15(24):3243-3248.
45. Jackson E.L., Olive K.P., Tuveson D.A., Bronson R., Crowley D., Brown M., et al. The Differential Effects of Mutant p53 Alleles on Advanced Murine Lung Cancer. Cancer Research 2005, 65(22):10280-10288.
46. Ji H., Li D., Chen L., Shimamura T., Kobayashi S., McNamara K., et al. The impact of human EGFR kinase domain mutations on lung tumorigenesis and in vivo sensitivity to EGFR-targeted therapies. Cancer Cell 2006, 9(6):485-495.
47. Ji H., Ramsey M.R., Hayes D.N., Fan C., McNamara K., Kozlowski P., et al. LKB1 modulates lung cancer differentiation and metastasis. Nature 2007, 448(7155):807-810.
48. Jiang F., Qiu Q., Khanna A., Todd N.W., Deepak J., Xing L., et al. Aldehyde dehydrogenase 1 is a tumor stem cell-associated marker in lung cancer. Molecular Cancer Research 2009, 7(3):330-338.
49. Johnson L., Mercer K., Greenbaum D., Bronson R.T., Crowley D., Tuveson D.A., et al. Somatic activation of the K-ras oncogene causes early onset lung cancer in mice. Nature 2001, 410(6832):1111-1116.
50. Kajstura J., Rota M., Hall S.R., Hosoda T., D'Amario D., Sanada F., et al. Evidence for human lung stem cells. The New England Journal of Medicine 2011, 364(19):1795-1806.
51. Kanki-Horimoto S., Horimoto H., Mieno S., Kishida K., Watanabe F., Furuya E., et al. Implantation of mesenchymal stem cells overexpressing endothelial nitric oxide synthase improves right ventricular impairments caused by pulmonary hypertension. Circulation 2006, 114:I181-I185.
52. Karoubi G., Cortes-Dericks L., Breyer I., Schmid R., Dutly A. Identification of mesenchymal stromal cells in human lung parenchyma capable of differentiating into aquaporin 5-expressing cells. Laboratory Investigation 2009, 89:1100-1114.
53. Kim C., Jackson E., Woolfenden A., Lawrence S., Babar I., Vogel S., et al. Identification of bronchioalveolar stem cells in normal lung and lung cancer. Cell 2005, 121(6):823-835.
54. Kimura S., Hara Y., Pineau T., Fernandez-Salguero P., Fox C., Ward J., et al. The T/ebp null mouse: Thyroid-specific enhancer-binding protein is essential for the organogenesis of the thyroid, lung, ventral forebrain, and pituitary. Genes & Development 1996, 10:60-69.
55. Kolios G., Moodley Y. Introduction to stem cells and regenerative medicine. Respiration 2013, 85:3-10.
56. Kumamoto M., Nishiwaki T., Matsuo N., Kimura H., Matsushima K. Minimally cultured bone marrow mesenchymal stem cells ameliorate fibrotic lung injury. The European Respiratory Journal 2009, 34:740-748.
57. Kumar P.A., Hu Y., Yamamoto Y., Hoe N.B., Wei T.S., Mu D., et al. Distal airway stem cells yield alveoli in vitro and during lung regeneration following H1N1 influenza infection. Cell 2011, 147(3):525-538.
58. Lazzaro D., Price M., de Felice M., Di Lauro R. The transcription factor TTF-1 is expressed at the onset of thyroid and lung morphogenesis and in restricted regions of the foetal brain. Development 1991, 113(4):1093-1104.
59. Lee J., Fang X., Gupta N., Serikov V., Matthay M. Allogenic human mesenchymal stem cells for treatment of E. coli endotoxin-induced acute lung injury in the ex vivo perfused human lung. Proceedings of the National Academy of Sciences of the United States of America 2009, 106(38):16357-16362.
60. Lee J., Fang X., Krasnodembskaya A., Howard J., Matthay M. Concise review: Mesenchymal stem cells for acute lung injury: Role of paracrine soluble factors. Stem Cells 2011, 29(6):913-919.
61. Lee J.H., Kim J., Gludish D., Roach R.R., Saunders A.H., Barrios J., et al. Surfactant protein C chromatin-bound green fluorescence protein reporter mice reveal heterogeneity of surfactant protein C expressing lung cells. American Journal of Respiratory Cell and Molecular Biology 2013, 48(3):288-298.
62. Lee C., Mitsialis S., Aslam M., Vitali S., Vergadi E., Konstantinou G., et al. Exosomes mediate the cytoprotective action of mesenchymal stromal cells on hypoxia-induced pulmonary hypertension. Circulation 2012, 126(22):2601-2611.
63. Li F., Tiede B., Massague J., Kang Y. Beyond tumorigenesis: Cancer stem cells in metastasis. Cell Research 2007, 17(1):3-14.
64. Liang O., Mitsialis S., Chang M., Vergadi E., Lee C., Aslam M., et al. Mesenchymal stromal cells expressing heme oxygenase-1 reverse pulmonary hypertension. Stem Cells 2011, 29(1):99-107.
65. Longmire T., Ikonomou L., Hawkins F., Christodoulou C., Cao Y., Jean J., et al. Efficient derivation of purified lung and thyroid progenitors from embryonic stem cells. Cell Stem Cell 2012, 10(4):398-411.
66. Lu Y., Futtner C., Rock J.R., Xu X., Whitworth W., Hogan B.L.M., et al. Evidence that Sox2 overexpression is oncogenic in the lung. PLoS One 2010, 5(6):e11022.
67. Mailleux A., Kelly R., Veltmaat J., De Langhe S., Zaffran S., Thiery J., et al. Fgf10 expression identifies parabronchial smooth muscle cell progenitors and is required for their entry into the smooth muscle cell lineage. Development 2005, 132(9):2157-2166.
68. Martin J., Helm K., Ruegg P., Varella-Garcia M., Burnham E., Majka S. Adult lung side populations have mesenchymal stem cell potential. Cytotherapy 2008, 10:140-151.
69. McQualter J., Brouard N., Williams B., Baird B., Sims-Lucas S., Yuan K., et al. Endogenous fibroblastic progenitor cells in the adult mouse lung are highly enriched in the sca-1 positive cell fraction. Stem Cells 2009, 27(3):623-633.
70. McQualter J., Yuen K., Williams B., Bertoncello I. Evidence of an epithelial stem/progenitor cell hierarchy in the adult mouse lung. Proceedings of the National Academy of Sciences of the United States of America 2010, 107(4):1414-1419.
71. Mei S., McCarter S., Deng Y., Parker C., Liles W., Stewart D. Prevention of LPS-induced acute lung injury in mice by mesenchymal stem cells overexpressing angiopoietin 1. PLoS Medicine 2007, 4:e269.
72. Meng X., Li M., Wang X., Wang Y., Ma D. Both CD133+ and CD133- subpopulations of A549 and H446 cells contain cancer-initiating cells. Cancer Science 2009, 100(6):1040-1046.
73. Minoo P., Su G., Drum H., Bringas P., Kimura S. Defects in tracheoesophageal and lung morphogenesis in Nkx2.1 (-/-) mouse embryos. Developmental Biology 1999, 209(1):60-71.
74. Morrisey E., Hogan B. Preparing for the first breath: Genetic and cellular mechanisms in lung development. Developmental Cell 2010, 18:8-23.
75. Mou H., Zhao R., Sherwood R., Ahfeldt T., Lapey A., Wain J., et al. Generation of multipotent lung and airway progenitors from mouse ESCs and patient-specific cystic fibrosis iPSCs. Cell Stem Cell 2012, 10(4):385-397.
76. Nguyen L.V., Vanner R., Dirks P., Eaves C.J. Cancer stem cells: An evolving concept. Nature Reviews. Cancer 2012, 12(2):133-143.
77. Odorico J., Kaufman D., Thomson J. Multilineage differentiation from human embryonic stem cell lines. Stem Cells 2001, 19:193-204.
78. Oeztuerk-Winder F., Guinot A., Ochalek A., Ventura J. Regulation of human lung alveolar multipotent cells by a novel p38alpha MAPK/mir-17-92 axis. The EMBO Journal 2012, 31(16):3431-3441.
79. Oliver T.G., Mercer K.L., Sayles L.C., Burke J.R., Mendus D., Lovejoy K.S., et al. Chronic cisplatin treatment promotes enhanced damage repair and tumor progression in a mouse model of lung cancer. Genes & Development 2010, 24(8):837-852.
80. Ortiz L., Gambelli F., McBride C., Gaupp D., Baddoo M., Kaminski N., et al. Mesenchymal stem cell engraftment in lung is enhanced in response to bleomycin exposure and ameliorates its fibrotic effects. Proceedings of the National Academy of Sciences of the United States of America 2003, 100:8407-8411.
81. Park K.-S., Liang M.-C., Raiser D.M., Zamponi R., Roach R.R., Curtis S.J., et al. Characterization of the cell of origin for small cell lung cancer. Cell Cycle 2011, 10(16):2806-2815.
82. Perl A., Kist R., Shan Z., Scherer G., Whitsett J. Normal lung development and function after Sox9 inactivation in the respiratory epithelium. Genesis 2005, 41:23-32.
83. Politi K., Zakowski M.F., Fan P.-D., Schonfeld E.A., Pao W., Varmus H.E. Lung adenocarcinomas induced in mice by mutant EGF receptors found in human lung cancers respond to a tyrosine kinase inhibitor or to down-regulation of the receptors. Genes & Development 2006, 20(11):1496-1510.
84. Potten C., Loeffler M. Stem cells: Attributes, cycles, spirals, pitfalls and uncertainties. Lessons for and from the crypt. Development 1990, 110:1001-1020.
85. Que J., Luo X., Schwartz R., Hogan B. Multiple roles for Sox2 in the developing and adult mouse trachea. Development 2009, 136(11):1899-1907.
86. Raiser D., Zacharek S., Roach R., Curtis S., Sinkevicius K., Gludish D., et al. Stem cell biology in the lung and lung cancers: Using pulmonary context and classic approaches. Cold Spring Harbor Symposia on Quantitative Biology 2008, 73:479-490.
87. Rawlins E., Clark C., Xue Y., Hogan B. The Id2+ distal tip lung epithelium contains individual multipotent embryonic progenitor cells. Development 2009, 136(22):3741-3745.
88. Rawlins E., Hogan B. Epithelial stem cells of the lung: Privileged few or opportunities for many?. Development 2006, 133(13):2455-2465.
89. Rawlins E., Hogan B. Ciliated epithelial cell lifespan in the mouse trachea and lung. American Journal of Physiology. Lung Cellular and Molecular Physiology 2008, 295:L231-L234.
90. Rawlins E., Okubo T., Xue Y., Brass D., Auten R., Hasegawa H., et al. The role of Scgb1a1+ Clara cells in the long-term maintenance and repair of lung airway, but not alveolar epithelium. Cell Stem Cell 2009, 4(6):525-534.
91. Reynolds S., Giangreco A., Power J., Stripp B. Neuroepithelial bodies of pulmonary airways serve as a reservoir of progenitor cells capable of epithelial regeneration. The American Journal of Pathology 2000, 156(1):269-278.
92. Rock J., Barkauskas C., Cronce M., Xue Y., Harris J., Liang J., et al. Multiple stromal populations contribute to pulmonary fibrosis without evidence for epithelial to mesenchymal transition. Proceedings of the National Academy of Sciences of the United States of America 2011, 108(52):E1475-E1483.
93. Rock J., Hogan B. Epithelial progenitor cells in lung development, maintenance, repair, and disease. Annual Review of Cell and Developmental Biology 2011, 27:493-512.
94. Rock J., Onaitis M., Rawlins E., Lu Y., Clark C., Xue Y., et al. Basal cells as stem cells of the mouse trachea and human airway epithelium. Proceedings of the National Academy of Sciences of the United States of America 2009, 106(31):12771-12775.
95. Rock J., Randell S., Hogan B. Airway basal stem cells: A perspective on their roles in epithelial homeostasis and remodeling. Disease Models & Mechanisms 2010, 3(9-10):545-556.
96. Shan L., Subramaniam M., Emanuel R., Degan S., Johnston P., Tefft D., et al. Centrifugal migration of mesenchymal cells in the embryonic lung. Developmental Dynamics 2008, 237(3):750-757.
97. Sharma S.V., Lee D.Y., Li B., Quinlan M.P., Takahashi F., Maheswaran S., et al. A chromatin-mediated reversible drug-tolerant state in cancer cell subpopulations. Cell 2010, 141(1):69-80.
98. Shu W., Lu M., Zhang Y., Tucker P., Zhou D., Morrisey E. Foxp2 and Foxp1 cooperatively regulate lung and esophagus development. Development 2007, 134:1991-2000.
99. Song H., Yao E., Lin C., Gacayan R., Chen M.-H., Chuang P.-T. Functional characterization of pulmonary neuroendocrine cells in lung development, injury, and tumorigenesis. Proceedings of the National Academy of Sciences of the United States of America 2012, 109(43):17531-17536.
100. Sullivan J.P., Spinola M., Dodge M., Raso M.G., Behrens C., Gao B., et al. Aldehyde dehydrogenase activity selects for lung adenocarcinoma stem cells dependent on notch signaling. Cancer Research 2010, 70(23):9937-9948.
101. Summer R., Fitzsimmons K., Dwyer D., Murphy J., Fine A. Isolation of an adult mouse lung mesenchymal progenitor cell population. American Journal of Respiratory Cell and Molecular Biology 2007, 37:152-159.
102. Sun S., Schiller J.H., Gazdar A.F. Lung cancer in never smokers - a different disease. Nat Rev Cancer 2007, 7(10):778-790.
103. Sutherland K.D., Proost N., Brouns I., Adriaensen D., Song J.-Y., Berns A. Cell of origin of small cell lung cancer: Inactivation of Trp53 and Rb1 in distinct cell types of adult mouse lung. Cancer Cell 2011, 19(6):754-764.
104. Takahashi K., Tanabe K., Ohnuki M., Narita M., Ichisaka T., Tomoda K., et al. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 2007, 131(5):861-872.
105. Takahashi K., Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 2006, 126:663-676.
106. Tanaka H., Yanagisawa K., Shinjo K., Taguchi A., Maeno K., Tomida S., et al. Lineage-specific dependency of lung adenocarcinomas on the lung development regulator TTF-1. Cancer Research 2007, 67(13):6007-6011.
107. TCGA Comprehensive genomic characterization of squamous cell lung cancers. Nature 2012, 489(7417):519-525.
108. Teisanu R., Lagasse E., Whitesides J., Stripp B. Prospective isolation of bronchiolar stem cells based upon immunophenotypic and autofluorescence characteristics. Stem Cells 2009, 27(3):612-622.
109. Travis W.D., Brambilla E., Riely G.J. New pathologic classification of lung cancer: Relevance for clinical practice and clinical trials. Journal of Clinical Oncology 2013, 31(8):992-1001.
110. Tropea K., Leder E., Aslam M., Lau A., Raiser D., Lee J., et al. Bronchioalveolar stem cells increase after mesenchymal stromal cell treatment in a mouse model of bronchopulmonary dysplasia. American Journal of Physiology. Lung Cellular and Molecular Physiology 2012, 302(9):L829-L837.
111. Uccelli A., Moretta L., Pistoia V. Mesenchymal stem cells in health and disease. Nature Reviews. Immunology 2008, 8:726-736.
112. van Haaften T., Byrne R., Bonnet S., Rochefort G., Akabutu J., Bouchentouf M., et al. Airway delivery of mesenchymal stem cells prevents arrested alveolar growth in neonatal lung injury in rats. American Journal of Respiratory and Critical Care Medicine 2009, 180(11):1131-1142.
113. Van Haute L., De Block G., Liebaers I., Sermon K., DeRycke M. Generation of lung epithelial-like tissue from human embryonic stem cells. Respiratory Research 2009, 5(10):105.
114. Van Lommel A. Pulmonary neuroendocrine cells (PNEC) and neuroepithelial bodies (NEB): Chemoreceptors and regulators of lung development. Paediatric Respiratory Reviews 2001, 2:171-176.
115. Visvader J.E. Cells of origin in cancer. Nature 2011, 469(7330):314-322.
116. Vosdoganes P., Lim R., Moss T., Wallace E. Cell therapy: A novel treatment approach for bronchopulmonary dysplasia. Pediatrics 2012, 130:727-737.
117. Weiss D., Casaburi R., Flannery R., Leroux-Williams M., Tashkin D. A placebo-controlled, randomized trial of mesenchymal stem cells in COPD. Chest 2013, 143(6):1590-1598.
118. Wilkerson M.D., Yin X., Hoadley K.A., Liu Y., Hayward M.C., Cabanski C.R., et al. Lung squamous cell carcinoma mRNA expression subtypes are reproducible, clinically important, and correspond to normal cell types. Clinical Cancer Research 2010, 16(19):4864-4875.
119. Winslow M.M., Dayton T.L., Verhaak R.G.W., Kim-Kiselak C., Snyder E.L., Feldser D.M., et al. Suppression of lung adenocarcinoma progression by Nkx2-1. Nature 2011, 473(7345):101-104.
120. Wistuba I.I., Bryant D., Behrens C., Milchgrub S., Virmani A.K., Ashfaq R., et al. Comparison of features of human lung cancer cell lines and their corresponding tumors. Clinical Cancer Research 1999, 5(5):991-1000.
121. Wong A., Bear C., Chin S., Pasceri P., Thompson T., Huan L., et al. Directed differentiation of human pluripotent stem cells into mature airway epithelia expressing functional CFTR protein. Nature Biotechnology 2012, 9:876-882.
122. Xiao Z., Jiang Q., Willette-Brown J., Xi S., Zhu F., Burkett S., et al. The pivotal role of IKKα in the development of spontaneous lung squamous cell carcinomas. Cancer Cell 2013, 23(4):527-540.
123. Xu X., Rock J.R., Lu Y., Futtner C., Schwab B., Guinney J., et al. Evidence for type II cells as cells of origin of K-Ras-induced distal lung adenocarcinoma. Proceedings of the National Academy of Sciences of the United States of America 2012, 109(13):4910-4915.
124. Xu J., Woods C., Mora A., Joodi R., Brigham K., Iyer S., et al. Prevention of endotoxin-induced systemic response by bone marrow derived mesenchymal stem cells in mice. American Journal of Physiology. Lung Cellular and Molecular Physiology 2007, 293(1):L131-L141.
125. Yamamoto H., Yun E., Gerber H., Ferrara N., Whitsett J., Vu T. Epithelial-vascular cross talk mediated by VEGF-A and HGF signaling directs primary septae formation during distal lung morphogenesis. Developmental Biology 2007, 308(1):44-53.
126. Yu J., Vodyanik M., Smuga-Otto K., Antosiewicz-Bourget J., Frane J., Tian S., et al. Induced pluripotent stem cell lines derived from human somatic cells. Science 2007, 318(5858):1917-1920.
127. Zacharek S., Fillmore C., Lau A., Gludish D., Chou A., Ho J., et al. Lung stem cell self-renewal relies on BMI1-dependent control of expression at imprinted loci. Cell Stem Cell 2011, 9(3):272-281.
128. Zhang W.C., Shyh-Chang N., Yang H., Rai A., Umashankar S., Ma S., et al. Glycine decarboxylase activity drives non-small cell lung cancer tumor-initiating cells and tumorigenesis. Cell 2012, 148(1-2):259-272.
129. Zhou W., Ercan D., Chen L., Yun C.-H., Li D., Capelletti M., et al. Novel mutant-selective EGFR kinase inhibitors against EGFR T790M. Nature 2009, 462(7276):1070-1074.