Distribution of a viscous binder during high shear granulation - Sensitivity to the method of delivery and its impact on product properties

International Journal of Pharmaceutics

Volumn 460, Issue 1-2, 2014, Pages 255-263

  Tan, Bernice Mei Jin ^a   Loh, Zhi Hui ^a   Soh, Josephine Lay Peng ^b   Liew, Celine Valeria ^a   Heng, Paul Wan Sia ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b Novartis Singapore Pharmaceuticals Ltd   (Singapore)

Author keywords

Binder distribution; Binder flow rate; Granule growth; Granule rheology; High shear granulation; Pressure pot

Indexed keywords

PARACETAMOL; PHOSPHORIC ACID; POTASSIUM DIHYDROGEN PHOSPHATE;

ARTICLE; BULK DENSITY; CONTROLLED STUDY; CORRELATION COEFFICIENT; CRUSHING STRENGTH; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG GRANULATION; FLOW RATE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MEMBRANE FILTER; PARTICLE SIZE; POWDER; PRESSURE; PRIORITY JOURNAL; REPRODUCIBILITY; SENSITIVITY ANALYSIS; TABLET COMPRESSION; TABLET DISINTEGRATION; TABLET DISINTEGRATION TIME; TABLET HARDNESS; TABLET THICKNESS;

BINDER DISTRIBUTION; BINDER FLOW RATE; GRANULE GROWTH; GRANULE RHEOLOGY; HIGH SHEAR GRANULATION; PRESSURE POT;

ACETAMINOPHEN; CELLULOSE; CHLORPHENIRAMINE; DRUG COMPOUNDING; EXCIPIENTS; HARDNESS; POWDERS; STARCH; TABLETS; TECHNOLOGY, PHARMACEUTICAL; VISCOSITY;

EID: 84892444732     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2013.11.020     Document Type: Article

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