Binder addition methods and binder distribution in high shear and fluidised bed granulation

Chemical Engineering Research and Design

Volumn 89, Issue 5, 2011, Pages 553-559

  Osborne, James D ^a   Sochon, Robert P J ^a,b   Cartwright, James J ^b   Doughty, David G ^b   Hounslow, Michael J ^a   Salman, Agba D ^a  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

^b GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Binder addition; Binder distribution; Fluidised bed; Granulation; High shear mixer

Indexed keywords

ADDITION METHOD; BINDER CONTENT; BINDER DISTRIBUTION; DIFFERENT SIZES; FLUIDISED BED; HIGH SHEAR; HIGH SHEAR MIXER; HIGH SHEAR MIXERS; IMPELLER FORCE; MEAN SIZE; NONUNIFORMITY; SIZE CLASS; ULTRA-VIOLET;

FLUIDIZATION; FLUIDIZED BEDS; GRANULATION; MIXERS (MACHINERY); MIXING;

BINDERS;

EID: 79956116614     PISSN: 02638762     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cherd.2010.08.006     Document Type: Article

References (21)

1. Abberger T. Influence of binder properties, method of addition, powder type and operating conditions on fluid bed melt granulation and resulting tablet properties. Pharmazie 2001, 56(12):949-952.
2. Abberger T., Seo A., Schaefer T. The effect of droplet size and powder particle size on the mechanisms of nucleation and growth in fluid bed melt agglomeration. International Journal of Pharmaceutics 2002, 249:185-197.
3. Biggs C.A., Sanders C., Scott A.C., Willemse A.W., Hoffman A.C., Instone T., Salman A.D., Hounslow M.J. Coupling granule properties and granulation rates in high shear granulation. Powder Technology 2003, 130:162-168.
4. Chen Y., Yang J., Dave R.N., Pfeffer R. Granulation of cohesive Geldart group C powders in a mini-Glatt fluidized bed by pre-coating with nanoparticles. Powder Technology 2009, 191:206-217.
5. Gao J.Z.H., Jain A., Motheram R., Gray D.B., Hussain M.A. Fluid bed granulation of a poorly water soluble, low density, micronized drug: comparison with high shear granulation. International Journal of Pharmaceutics 2002, 237:1-14.
6. Hapgood K.P, Litster J.D., Smith R. Nucleation regime map for liquid bound granules. AIChE 2003, 350-361.
7. Hemati M., Cherif R., Saleh K., Pont V. Fluidised bed coating and granulation: influence of process-related variables and physiochemical properties on the growth kinetics. Powder Technology 2003, 130:18-34.
8. Iveson S.M., Litster J.D., Hapgood K.P., Ennis B.J. Nucleation, growth and breakage phenomena in agitated wet granulation processes: a review. Powder Technology 2001, 117:3-39.
9. Johansen A, Schaefer T. Effects of interactions between powder particle size and binder viscosity on agglomerate growth mechanisms in a high shear mixer. European Journal of Pharmaceutical Sciences 2001, 12:297-305.
10. Knight P.C., Instone T., Pearson J.M.K., Hounslow M.J. An investigation into the kinetics of liquid distribution and growth in high shear mixer agglomeration. Powder Technology 1998, 97:246-257.
11. Reynolds G.K, Biggs C.A., Salman A.D., Hounslow M.J. Non-uniformity of binder distribution in high-shear granulation. Powder Technology 2004, 140:203-208.
12. Reynolds G.K., Fu J.S., Cheong Y.S., Hounslow M.J., Salman A.D. Breakage in granulation: a review. Chemical Engineering Science 2005, 60:3969-3992.
13. Rahmanian N., Ghadiri M., Jia X., Stepanek F. Characterisation of granule structure and strength made in a high shear granulator. Powder Technology 2009, 192:184-194.
14. Schaafsma S.H., Vonk P., Kossen N.W.F. Fluid bed agglomeration with a narrow droplet size distribution. International Journal of Pharmaceutics 2000, 193:175-187.
15. Schaefer T., Mathiesen C. Melt pelletization in a high shear mixer. IX. Effects of binder particle size. International Journal of Pharmaceutics 1996, 139:139-148.
16. Scott A.C., Hounslow M.J., Instone T. Direct evidence of heterogeneity during high shear granulation. Powder Technology 2000, 113:205-213.
17. Seo A., Holm P., Schaefer T. Effects of droplet size and type of binder on the agglomerate growth mechanisms by melt agglomeration in a fluidised bed. European Journal of Pharmaceutical Science 2002, 16:95-105.
18. Smith P.G., Nienow A.W. Particle growth mechanisms in fluidised bed granulation - I. The effect of process variables. Chemical Engineering Science 1983, 38(8):1223-1231.
19. Sochon, R., Zomer, S., Cartwright, J., Salman, A., in press. The variability in pharmaceutical granulation, Chemical Engineering Journal.
20. Tan H.S., Salman A.D., Hounslow M.J. Kinetics of fluidized bed granulation - I. The effect of process variables. Chemical Engineering Science 2006, 61:1585-1601.
21. Walker G.M., Andrews G., Jones D. Effect of process parameters on the melt granulation of pharmaceutical powders. Powder Technology 2006, 165:161-166.