Investigation of high shear wet granulation processes using different parameters and formulations

Chemical and Pharmaceutical Bulletin

Volumn 56, Issue 1, 2008, Pages 22-27

  Wang, Siling ^a   Ye, Guanhao ^a   Heng, Paul Wan Sia ^b   Ma, Mingxin ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Flow pattern; Granule characteristics; High shear granulation; Process parameter

Indexed keywords

ALPHA LACTOSE; MICROCRYSTALLINE CELLULOSE; STARCH; WATER;

ANALYSIS OF VARIANCE; ARTICLE; DRUG FORMULATION; DRUG GRANULATION; DRUG RESEARCH; EQUILIBRIUM CONSTANT; IMPELLER; INTERMETHOD COMPARISON; PARTICLE SIZE; SCANNING ELECTRON MICROSCOPY; ALGORITHM; INSTRUMENTATION; METHODOLOGY; PHARMACEUTICS; SHEAR STRENGTH;

ALGORITHMS; SHEAR STRENGTH; STARCH; TECHNOLOGY, PHARMACEUTICAL; WATER;

EID: 38049179025     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.56.22     Document Type: Article

References (12)

1. Parikh D. M., "Handbook of Pharmaceutical Granulation Technology," Marcel Dekker, Inc., New York, 1997, pp. 152-204.
2. Vonk P., Guillaume C. P. F., Ramaker J. S., Vromans H., Kossen N. W. F., Int. J. Pharm., 157, 93-102 (1997).
3. Franke G., Steffens K. J., Pharm. Ind., 61, 861-865 (1999).
4. Ameye D., Keleb E., Vervaet C., Remon J. P., Adams E., Massart D. L., Eur. J. Pharm. Sci., 17, 247-251 (2002).
5. Bock T. K., Krass U., Eur. J. Pharm. Biopharm., 52, 297-303 (2001).
6. Fekete R., Marton S., Farkas E., Racz I., Die Pharmazie, 54, 200-202 (1999).
7. Hamdani J., Moes A. J., Amighi K., Int. J. Pharm., 245, 167-177 (2002).
8. Voinovich D., Moneghini M., Perissutti B., Franceschinis E., Eur. J. Pharm. Biopharm., 52, 305-313 (2001).
9. Vojnovic D., Selenati P., Rubessa F., Moneghini M., Zanchetta A., Drug Dev. Ind. Pharm., 18, 961-972 (1992).
10. Ramaker J. S., Jelgersma M. A., Vonk V., Kossen N. W. F., Int. J. Pharm., 166, 89-97 (1998).
11. Zhou F., Veraet C., Remon J. P., Int. J. Pharm., 147, 23-30 (1997).
12. Faure A., Grimsey I. M., Rowe R. C., York P., Cliff M. J., Eur. J. Pharm. Sci., 8, 85-93 (1999).