A new methodology for high drug loading wet granulation formulation development

International Journal of Pharmaceutics

Volumn 441, Issue 1-2, 2013, Pages 790-800

  Cai, Lixia ^a   Farber, Leon ^a   Zhang, Dina ^a   Li, Feng ^a   Farabaugh, Julianne ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

High drug loading; High shear wet granulation; Polymeric binders

Indexed keywords

ETORICOXIB; METFORMIN; POLYMER; SIMVASTATIN;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; COMPRESSION; DOG; DRUG COMPACTIBILITY; DRUG DISTRIBUTION; DRUG FLOWABILITY; DRUG FORMULATION; DRUG GRANULATION; DRUG GRANULE; DRUG LOADING WET GRANULATION; DRUG SOLUBILITY; IN VIVO STUDY; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; PARTICLE SIZE; PHARMACOLOGICAL PARAMETERS; PRIORITY JOURNAL; SCANNING ELECTRON MICROSCOPY; WETTABILITY;

ANIMALS; DOGS; DRUG COMPOUNDING; EXCIPIENTS; METFORMIN; PARTICLE SIZE; POLYMERS; PYRIDINES; SIMVASTATIN; SOLUBILITY; SULFONES; WETTABILITY;

EID: 84872810627     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2012.09.052     Document Type: Article

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