Evaluation of the antihypertensive properties of yellow passion fruit pulp (passiflora edulis sims f. flavicarpa deg.) in spontaneously hypertensive rats

Phytotherapy Research

Volumn 28, Issue 1, 2014, Pages 28-32

  Konta, Eliziane Mieko ^a   Almeida, Mara Ribeiro ^b   Amaral, Cátia Lira Do ^b   Darin, Joana Darc Castania ^b   De Rosso, Veridiana V ^c   Mercadante, Adriana Zerlotti ^d   Antunes, Lusânia Maria Greggi ^b   Bianchi, Maria Lourdes Pires ^b  

^a SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

^c FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^d UNIVERSITY OF CAMPINAS   (Brazil)

Author keywords

carotenoids; hypertension; micronuclei; passion fruit; phenolic compounds; renal function

Indexed keywords

ASCORBIC ACID; CAROTENOID; CISPLATIN; FLAVONOID; GLUTATHIONE; HERBACEOUS AGENT; THIOBARBITURIC ACID REACTIVE SUBSTANCE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIHYPERTENSIVE ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; BODY WEIGHT; BONE MARROW CELL; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DOSE RESPONSE; DOWN REGULATION; DRUG DOSE COMPARISON; FRUIT (STRUCTURE); FRUIT PULP; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYPERTENSION; KIDNEY FUNCTION; KIDNEY MASS; MALE; MICRONUCLEUS TEST; MUTAGENICITY; NEPHROTOXICITY; NONHUMAN; PASSION FRUIT; PHYTOCHEMISTRY; PROTEINURIA; RAT; SPONTANEOUSLY HYPERTENSIVE RAT; SYSTOLIC BLOOD PRESSURE; TANDEM MASS SPECTROMETRY; TOXICITY TESTING; UPREGULATION; URINE FLOW RATE;

PASSIFLORA; PASSIFLORA EDULIS; RATTUS;

CAROTENOIDS; HYPERTENSION; MICRONUCLEI; PASSION FRUIT; PHENOLIC COMPOUNDS; RENAL FUNCTION;

ANIMALS; ANTIHYPERTENSIVE AGENTS; ANTIOXIDANTS; ASCORBIC ACID; BLOOD PRESSURE; BONE MARROW; CAROTENOIDS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CREATININE; FLAVONOIDS; FRUIT; GLUTATHIONE; HYPERTENSION; KIDNEY; MALE; OXIDATIVE STRESS; PASSIFLORA; PHENOLS; RATS; RATS, INBRED SHR; RATS, WISTAR; TANDEM MASS SPECTROMETRY; THIOBARBITURIC ACID REACTIVE SUBSTANCES;

EID: 84892432432     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.4949     Document Type: Article

References (35)

1. Appel K, Rose T, Fiebich B, Kammler T, Hoffmann C, Weiss G,. 2011. Modulation of the γ-aminobutyric acid (GABA) system by Passiflora incarnata L. Phytother. Res. 25: 838-843.
2. Biswas SK, De Faria JBL,. 2007. Which comes first: Renal inflammation or oxidative stress in spontaneously hypertensive rats? Free Radic. Res. 41: 216-224.
3. Boeira JM, Fenner R, Betti AH,. 2010. Toxicity and genotoxicity evaluation of Passiflora alata Curtis (Passifloraceae). J. Ethnopharmacol. 128: 526-532.
4. Bradford MM,. 1976. A rapid sensitive method for the quantitation of microgram quantities on protein utilizing the principle or protein-dye binding. Eur. J. Anaesthesiol. 25: 248-256.
5. Chen D, Coffman TM,. 2012. The Kidney and Hypertension: Lessons From Mouse Models. Can. J. Cardiol. 28: 305-310.
6. De Rosso VV, Mercadante AZ,. 2007a. The high ascorbic acid content is the main cause of the low stability of anthocyanin extracts from acerola. Food Chem. 103: 935-943.
7. De Rosso VV, Mercadante AZ,. 2007b. Identification and quantification of carotenoids, by HPLC-PDA-MS/MS, from amazonian fruits. J. Agric. Food Chem. 55: 5062-5072.
8. Dhawan K, Dhawan S, Sharma A,. 2004. Passiflora: a review update. J. Ethnopharmacol. 94: 1-23.
9. Dornas WC, Silva ME,. 2011. Animal models for the study of arterial hypertension. J. Biosci. 36: 731-737.
10. Duarte J, Perez-Vizcaino F, Zarzuelo A, Jimenez J, Tamargo J,. 1993. Vasodilator effects of quercetin in isolated rat vascular smooth muscle. Eur. J. Pharmacol. 239: 1-7.
11. Duarte J, Perez-Palencia R, Vargas F,. 2001. Antihypertensive effects of the flavonoid quercetin in spontaneously hypertensive rats. Br. J. Pharmacol. 133: 117-124.
12. Evangelista CM, Antunes LM, Francescato HD, Bianchi ML,. 2004. Effects of the olive, extra virgin olive and canola oils on cisplatin-induced clastogenesis in Wistar rats. Food Chem. Toxicol. 42: 1291-1297.
13. Harrison DG, Gongora MC,. 2009. Oxidative stress and hypertension. Med. Clin. North Am. 93: 621-635.
14. Hartree EF,. 1972. Determination of protein: a modification of the Lowry method that gives a linear photometric response. Anal. Biochem. 48: 422-427.
15. Hayashi M, MacGregor JT, Gatehouse DG,. 2000. In vivo rodent erythrocyte micronucleus assay. II. Some aspects of protocol design including repeated treatments, integration with toxicity testing, and automated scoring. Environ. Mol. Mutagen. 35: 234-252.
16. Houston MC,. 2010. The role of cellular micronutrient analysis, nutraceuticals, vitamins, antioxidants and minerals in the prevention and treatment of hypertension and cardiovascular disease. Ther. Adv. Cardiovasc. Dis. 4: 165-183.
17. Ichimura T, Yamanaka A, Ichiba T,. 2006. Antihypertensive effect of an extract of Passiflora edulis rind in spontaneously hypertensive rats. Biosci. Biotechnol. Biochem. 70: 718-721.
18. Kizhakekuttu TJ, Widlansky ME,. 2010. Natural antioxidants and hypertension: promise and challenges. Cardiovasc. Ther. 28: e20-e32.
19. Macgregor JT, Heddle JA, Hite M,. 1987. Guidelines for the Conduct of Micronucleus Assays in Mammalian Bone-Marrow Erythrocytes. Mutat. Res. 189: 103-112.
20. Mercadante AZ, Britton G, Rodriguez-Amaya DB,. 1998. Carotenoids from yellow passion fruit (Passiflora edulis). J. Agric. Food Chem. 46: 4102-4106.
21. Montezano AC, Touyz RM,. 2012. Molecular Mechanisms of Hypertension-Reactive Oxygen Species and Antioxidants: A Basic Science Update for the Clinician. Can. J. Cardiol. 28: 288-295.
22. Ngan A, Conduit R,. 2011. A double-blind, placebo-controlled investigation of the effects of Passiflora incarnata (passionflower) herbal tea on subjective sleep quality. Phytother. Res. 25: 1153-1159.
23. Palm F, Nordquist L,. 2011. Renal oxidative stress, oxygenation, and hypertension. Am. J. Physiol. Regul. Integr. Comp. Physiol. 301: R1229-R1241.
24. Reginatto FH, De-Paris F, Petry RD,. 2006. Evaluation of anxiolytic activity of spray dried powders of two South Brazilian Passiflora species. Phytother. Res. 20: 348-351.
25. Rodrigo R, Gil D, Miranda-Merchak A, Kalantzidis G,. 2012. Antihypertensive role of polyphenols. Adv. Clin. Chem. 58: 225-254.
26. Sdlak J, Lindsay RH,. 1968. Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent. Anal. Biochem. 24: 192-205.
27. Singleton VL, Rossi-Jr JA,. 1965. Colorimetry of total phenolics with phosphomolybdic-phosphotungstic acid reagents. Am. J. Enol. Vitic. 16: 144-158.
28. de Souza MDS, Barbalho SM, Damasceno DC,. 2012. Effects of Passiflora edulis (Yellow Passion) on Serum Lipids and Oxidative Stress Status of Wistar Rats. J. Med. Food 15: 78-82.
29. Uchiyama M, Mihara M,. 1978. Determination of Malonaldehyde Precursor in Tissues by Thiobarbituric Acid Test. Anal. Biochem. 86: 271-278.
30. Vasdev S, Ford CA, Parai S, Longerich L, Gadag V,. 2001. Dietary vitamin C supplementation lowers blood pressure in spontaneously hypertensive rats. Mol. Cell. Biochem. 218: 97-103.
31. Vianna LM, Paiva ACM, Paiva TB,. 1992. Treatment with Vitamin-D3 Reduces Blood-Pressure of Spontaneously Hypertensive Rats. Genetic Hypertension 218: 589-591.
32. Wolfsegger MJ, Jaki T, Dietrich B, Kunzler JA, Barker K,. 2009. A note on statistical analysis of organ weights in non-clinical toxicological studies. Toxicol. Appl. Pharmacol. 240: 117-122.
33. Yeh C-T, Huang W-H, Yen G-C,. 2009. Antihypertensive effects of Hsian-tsao and its active compound in spontaneously hypertensive rats. J. Nutr. Biochem. 20: 866-875.
34. Zhishen J, Mengcheng T, Jianming W,. 1999. The determination of flavonoid contents in mulberry and their scavenging effects on superoxide radicals. Food Chem. 64: 555-559.
35. Zibadi S, Farid R, Moriguchi S,. 2007. Oral administration of purple passion fruit peel extract attenuates blood pressure in female spontaneously hypertensive rats and humans. Nutr. Res. 27: 408-416.