Evaluation of anxiolytic activity of spray dried powders of two south Brazilian Passiflora species

Phytotherapy Research

Volumn 20, Issue 5, 2006, Pages 348-351

  Reginatto, Flávio H ^a,b   De Paris, Fernanda ^a   Petry, Raquel D ^a   Quevedo, João ^a   Ortega, George González ^a   Gosmann, Grace ^a   Schenkel, Eloir P ^a  

^a FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

^b UNIVERSITY OF PASSO FUNDO   (Brazil)

Author keywords

Anxiolytic activity; Maracuj ; Passiflora; Passifloraceae; Plus maze test; Rats; Spray dried powders

Indexed keywords

DIAZEPAM; PASSIFLORA ALATA EXTRACT; PASSIFLORA EDULIS EXTRACT; PLANT EXTRACT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BRAZIL; CONTROLLED STUDY; DOSE RESPONSE; DRUG SYNTHESIS; LABORATORY TEST; MALE; MAZE TEST; NONHUMAN; PASSION FRUIT; RAT; SPRAY DRYING; TRANQUILIZING ACTIVITY;

ADMINISTRATION, ORAL; ANIMALS; ANTI-ANXIETY AGENTS; BEHAVIOR, ANIMAL; BRAZIL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG COMPOUNDING; MALE; MAZE LEARNING; MEDICINE, TRADITIONAL; PASSIFLORA; PHYTOTHERAPY; PLANT EXTRACTS; PLANT LEAVES; RATS; RATS, WISTAR;

ANIMALIA; PASSIFLORA; PASSIFLORA ALATA; PASSIFLORA EDULIS; PASSIFLORACEAE;

EID: 33646475465     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.1853     Document Type: Article

References (35)

1. Akhondzadeh S, Naghavi HR, Vazirian M, Shayeganpour A, Rashidi H, Khani M. 2001. Passionflower in the treatment of generalized anxiety: a pilot double blind randomized controlled trial with oxazepam. J Clin Pharm Ther 26: 363-367.
2. Ang HH, Cheang HS. 1999. Studies on the anxiolytic activity of Eurycoma longifolia Jack roots in mice. Jpn J Pharmacol 49: 497-500.
3. ANVISA, Agência Nacional de Vigilância Sanitária. 2004. Ministério da Saúde, Brazil. www.anvisa.gov.br/bancodedados.
4. Birk CD, Provensi G, Reginatto FH, Schenkel EP, Gosmann G. 2005. TLC fingerprint of flavonoids and saponins from Passiflora species. J Liq Chromatogr Rel Technol 28: 2285-2291.
5. British Herbal Pharmacopoeia. 1983. British Herbal Medicine Society: Exeter.
6. Carvalho-Freitas MIR, Costa M. 2002. Anxiolytic and sedative effects of extracts and essential oil from Citrus aurantium L. Biol Pharm Bull 25: 1629-1633.
7. De Souza KCB, Petrovick PR, Bassani VL, Gonzalez Ortega G. 2000. The adjuvants Aerosil 200 and Gelita-Sol-P influence on the technological characteristics of spray-dried powders from Passiflore edulis var. flavicarpa. Drug Dev Ind Pharm 26: 331-336.
8. De-Paris F, Petry RD, Reginatto FH, Gosmann G, Quevedo J, Salgueiro JB, Kapczinski F, González-Ortega G, Schenkel EP. 2002. Pharmacochemical study of aqueous extracts of Passiflora alata Dryander and Passiflora edulis Sims. Acta Far Bonaerense 21: 5-8.
9. DerMarderosian A, Beutler JA (eds). 2002. The Review of Natural Products®, 3rd edn. Facts and Comparisons®: St Louis, 547-550.
10. Dhawan K, Kumar S, Sharma A. 2001a. Comparative biological activity study on Passiflora incarnata and P. edulis. Fitoterapia 72: 698-702.
11. Dhawan K, Kumar S, Sharma A. 2001b. Anti-anxiety studies on extracts of Passiflora incarnata Linneaus. J Ethnopharmacol 78: 165-170.
12. Dhawan K, Kumar S, Sharma A. 2004. Passiflora: a review update. J Ethnopharmacol 94: 1-23.
13. Farmacopéia Brasileira, 1977. 3rd edn. Andrei: São Paulo. 1231p
14. González Ortega G. 1993. Trockenextrakte aus Passionsblumenkraut- Herstelleung, Standardisierung und Wirkungsnachweis. PhD Thesis. Eberhar-Karls-Universität: Tübingen.
15. Gonzáles Ortega G, Schmidt PC. 1995. Stability studies on dried extracts of passion flower (Passiflora incarnata L.). STP Pharm Sci 5: 385-389.
16. Grice ID, Ferreira LA, Griffiths LR. 2001. Identification and simultaneous analysis of harmane, harmine, harmol, isovitexin, and vitexin in Passiflora incarnata extracts with a novel HPLC method. J Liq Chromatogr Relat Technol 24: 2513-2523.
17. Kuribara H, Iwata H, Tomioka H, Takahashi R, Goto K, Murohashi N, Koya S. 2001. The anxiolytic effect of sho-jusen, a Japanese herbal medicine, assessed by an elevated plus-maze test in mice. Phytother Res 15: 142-147.
18. Kuribara H, Stavinoha WB, Maruyama Y. 1998. Behavioural pharmacological characteristics of honokiol, an anxiolytic agent present in extracts of Magnolia bark, evaluated by an elevated plus-maze test in mice. J Pharm Pharmacol 50: 819-826.
19. Medina JH, Paladini AC, Wolfman C, LevideStein M, Calvo D, Diaz LE, Pena C. 1990. Chrysin (5,7-di-OH-flavone) a naturally occurring ligand for benzodiazepine receptors, with anticonvulsant properties. Biochem Pharmacol 40: 2227-2231.
20. Parfitt K. 1999. Martindale: The Complete Drug Reference. Royal Pharmaceutical Society-Pharmaceutical Press: London.
21. Pellow S, Chopin P, File SE, Briley M. 1985. Validation of open:closed arm entries in an elevated plus-maze as a measure of anxiety in the rat. J Neurosci Methods 14: 149-167.
22. Pellow S, File SE. 1986. Anxiolytic and anxiogenic drug effects on exploratory activity in an elevated plus-maze: a novel test of anxiety in the rat. Pharmacol Biochem Behav 24: 525-529.
23. Petry RD, Reginatto FH, De-Paris F, Gosmann G, Salgueiro JB, Quevedo J, Kapczinski F, González-Ortega G, Schenkel EP. 2001. Comparative pharmacological study of hydroethanol extracts of Passiflora alata and Passiflora edulis leaves. Phytother Res 15: 162-164.
24. Reginatto FH, Gosmann G, Schripsema J, Schenkel EP. 2004. Assay of quadranguloside, the major saponin of leaves of Passiflora alata, by HPLC-UV. Phytochem Anal 15: 195-197.
25. Reginatto FH, Kauffmann C, Schripsema J, Guillaume D, Gosmann G, Schenkel EP. 2001. Steroidal and triterpenoidal glucosides from Passiflora alata. J Braz Chem Soc 12: 32-36.
26. Ross MSF, Anderson A. 1986. Selection of plants for phytopharmacological study based on modernal herbal practice. Int J Crude Drug Res 24: 1-6.
27. Senna EL, Petrovick PR, Gonzales Ortega G, Bassani VL. 1997. Preparation and characterization of spray-dried powders from Achyrocline satureioides (Lam.) DC extracts. Phytother Res 11: 123-127.
28. Soulimani R, Younos C, Jarmouni S, Bousta D, Misslin R, Mortier F. 1997. Behavioural effects of Passiflora incarnata L. and its indole alkaloid and flavonoid derivatives and maltol in the mouse. J Ethnopharmacol 57: 11-20.
29. Speroni E, Billi R, Mercati V, Boncompagni E, Toja E. 1996a. Sedative effects of crude extract of Passiflora incarnata after oral administration. Phytother Res 10: S92-S94.
30. Speroni E, Billi R, Perellino NC, Minghetti A. 1996b. Role of chrysin in the sedative effects of Passiflora incarnata L. Phytother Res 10: S98-S100.
31. Sukma M, Chaichantipyuth C, Murakami Y, Tohda M, Matsumoto K, Watanabe H. 2002. CNS inhibitory effects of barakol, a constituent of Cassia siamia Lamk. J Ethnopharmacol 83: 87-94.
32. Ulubelen A, Oksuz S, Mabry TJ, Dellamonica G, Chopin J. 1982. C-glycosylflavonoids from Passiflora pittieri, P. alata, P. ambigua and Adenia manii. J Nat Prod 45: 783.
33. WHO. 1994. Research Guidelines for Evaluating the Safety and Efficacy of Herbal Medicines. World Health Organization - Regional Office for the Western Pacific: Manila.
34. Yoshikawa K, Katsuta S, Mizumori J, Arihara S. 2000a. Four cycloartane triterpenoids and six related saponins from Passiflora edulis. J Nat Prod 63: 1229-1234.
35. Yoshikawa K, Katsuta S, Mizumori J, Arihara S. 2000b. New cycloartane triterpenoids from Passiflora edulis. J Nat Prod 63: 1377-1380.