The Kidney and Hypertension: Lessons From Mouse Models

Canadian Journal of Cardiology

Volumn 28, Issue 3, 2012, Pages 305-310

  Chen, Daian ^a   Coffman, Thomas M ^a,b  

^a DURHAM VA MEDICAL CENTER   (United States)

^b DUKE NUS MEDICAL SCHOOL   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

ALDOSTERONE; ANGIOTENSIN RECEPTOR; EPITHELIAL SODIUM CHANNEL; PROTEIN KINASE WNK1; PROTEIN KINASE WNK4; RENIN;

BARTTER SYNDROME; BLOOD PRESSURE; FAMILIAL DISEASE; FLUID BALANCE; GAIN OF FUNCTION MUTATION; GENE LOCUS; GENETIC REGULATION; GITELMAN SYNDROME; GORDON SYNDROME; HUMAN; HUMAN GENETICS; HYPERCALCIURIA; HYPERKALEMIA; HYPERTENSION; HYPERVOLEMIA; HYPOCALCIURIA; HYPOKALEMIA; HYPOTENSION; KIDNEY FUNCTION; LIDDLE SYNDROME; METABOLIC ALKALOSIS; NEPHRON; NONHUMAN; PATHOGENESIS; PSEUDOHYPOALDOSTERONISM; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; REVIEW; SALT WASTING;

ANIMALS; ARTHROGRYPOSIS; BLOOD PRESSURE DETERMINATION; CLEFT PALATE; CLUBFOOT; DISEASE MODELS, ANIMAL; GENETIC PREDISPOSITION TO DISEASE; GITELMAN SYNDROME; HAND DEFORMITIES, CONGENITAL; HUMANS; HYPERTENSION; KIDNEY; KIDNEY FUNCTION TESTS; MICE; MICE, TRANSGENIC; NATRIURESIS; RENIN-ANGIOTENSIN SYSTEM; SPECIES SPECIFICITY;

EID: 84860919462     PISSN: 0828282X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cjca.2012.01.002     Document Type: Review

References (56)

1. Sarafidis P.A., Bakris G.L. Resistant hypertension: an overview of evaluation and treatment. J Am Coll Cardiol 2008, 52:1749-1757.
2. Hajjar I., Kotchen T.A. Trends in prevalence, awareness, treatment, and control of hypertension in the United States, 1988-2000. JAMA 2003, 290:199-206.
3. Rabi D.M., Daskalopoulou S.S., Padwal R.S., et al. The 2011 Canadian Hypertension Education Program recommendations for the management of hypertension: blood pressure measurement, diagnosis, assessment of risk, and therapy. Can J Cardiol 2011, 27:415-433.e1-2.
4. Bronson S.K., Smithies O. Altering mice by homologous recombination using embryonic stem cells. J Biol Chem 1994, 269:27155-27158.
5. Goldblatt H., Lynch J., Hanzal R.F., Summerville W.W. Studies on experimental hypertension I. The production of persistent elevation of systolic blood pressure by means of renal ischemia. J Exp Med 1934, 59:347-379.
6. Bianchi G., Tenconi L.T., Lucca R. Effect in the conscious dog of constriction of the renal artery to a sole remaining kidney on haemodynamics, sodium balance, body fluid volumes, plasma renin concentration and pressor responsiveness to angiotensin. Clin Sci 1970, 38:741-766.
7. Ledingham J.M., Cohen R.D. Changes in the extracellular fluid volume and cardiac output during the development of experimental renal hypertension. Can Med Assoc J 1964, 90:292-294.
8. Crawford M.P., Richardson T.Q., Guyton A.C. Renal servocontrol of arterial blood pressure. J Appl Physiol 1967, 22:139-142.
9. Guyton A.C., Coleman T.G., Cowley A.V., et al. Arterial pressure regulation. Overriding dominance of the kidneys in long-term regulation and in hypertension. Am J Med 1972, 52:584-594.
10. Lifton R.P., Gharavi A.G., Geller D.S. Molecular mechanisms of human hypertension. Cell 2001, 104:545-556.
11. Wirth A., Benyo Z., Lukasova M., et al. G12-G13-LARG-mediated signaling in vascular smooth muscle is required for salt-induced hypertension. Nat Med 2008, 14:64-68.
12. Michael S.K., Surks H.K., Wang Y., et al. High blood pressure arising from a defect in vascular function. Proc Natl Acad Sci U S A 2008, 105:6702-6707.
13. Guilluy C., Bregeon J., Toumaniantz G., et al. The Rho exchange factor Arhgef1 mediates the effects of angiotensin II on vascular tone and blood pressure. Nat Med 2010, 16:183-190.
14. Sasamura H., Hein L., Krieger J.E., et al. Cloning, characterization, and expression of two angiotensin receptor (AT-1) isoforms from the mouse genome. Biochem Biophys Res Commun 1992, 185:253-259.
15. Burson J.M., Aguilera G., Gross K.W., Sigmund C.D. Differential expression of angiotensin receptor 1A and 1B in mouse. Am J Physiol 1994, 267:E260-E267.
16. Shanmugam S., Sandberg K. Ontogeny of angiotensin II receptors. Cell Biol Int 1996, 20:169-176.
17. Ito M., Oliverio M.I., Mannon P.J., et al. Regulation of blood pressure by the type 1A angiotensin II receptor gene. Proc Natl Acad Sci U S A 1995, 92:3521-3525.
18. Oliverio M.I., Best C.F., Smithies O., Coffman T.M. Regulation of sodium balance and blood pressure by the AT(1A) receptor for angiotensin II. Hypertension 2000, 35:550-554.
19. Kobori H., Harrison-Bernard L.M., Navar L.G. Expression of angiotensinogen mRNA and protein in angiotensin II-dependent hypertension. J Am Soc Nephrol 2001, 12:431-439.
20. Navar L.G., Kobori H., Prieto M.C., Gonzalez-Villalobos R.A. Intratubular renin-angiotensin system in hypertension. Hypertension 2011, 57:355-362.
21. Zhuo J.L., Li X.C. New insights and perspectives on intrarenal renin-angiotensin system: focus on intracrine/intracellular angiotensin II. Peptides 2011, 32:1551-1565.
22. Ichikawa I., Brenner B.M. Importance of efferent arteriolar vascular tone in regulation of proximal tubule fluid reabsorption and glomerulotubular balance in the rat. J Clin Invest 1980, 65:1192-1201.
23. Navar L.G., Carmines P.K., Huang W.C., Mitchell K.D. The tubular effects of angiotensin II. Kidney Int Suppl 1987, 20:S81-S88.
24. Cogan M.G. Angiotensin II: a powerful controller of sodium transport in the early proximal tubule. Hypertension 1990, 15:451-458.
25. Peti-Peterdi J., Warnock D.G., Bell P.D. Angiotensin II directly stimulates ENaC activity in the cortical collecting duct via AT(1) receptors. J Am Soc Nephrol 2002, 13:1131-1135.
26. Crowley S.D., Gurley S.B., Oliverio M.I., et al. Distinct roles for the kidney and systemic tissues in blood pressure regulation by the renin-angiotensin system. J Clin Invest 2005, 115:1092-1099.
27. Crowley S.D., Gurley S.B., Herrera M.J., et al. Angiotensin II causes hypertension and cardiac hypertrophy through its receptors in the kidney. Proc Natl Acad Sci U S A 2006, 103:17985-17990.
28. Gurley S.B., Riquier-Brison A.D., Schnermann J., et al. AT1A angiotensin receptors in the renal proximal tubule regulate blood pressure. Cell Metab 2011, 13:469-475.
29. Li H., Weatherford E.T., Davis D.R., et al. Renal proximal tubule angiotensin AT1A receptors regulate blood pressure. Am J Physiol Regul Integr Comp Physiol 2011, 301:R1067-R1077.
30. Ding Y., Davisson R.L., Hardy D.O., et al. The kidney androgen-regulated protein promoter confers renal proximal tubule cell-specific and highly androgen-responsive expression on the human angiotensinogen gene in transgenic mice. J Biol Chem 1997, 272:28142-28148.
31. Mercier-Zuber A., O'Shaughnessy K.M. Role of SPAK and OSR1 signalling in the regulation of NaCl cotransporters. Curr Opin Nephrol Hypertens 2011, 20:534-540.
32. Pradervand S., Wang Q., Burnier M., et al. A mouse model for Liddle's syndrome. J Am Soc Nephrol 1999, 10:2527-2533.
33. Lalioti M.D., Zhang J., Volkman H.M., et al. Wnk4 controls blood pressure and potassium homeostasis via regulation of mass and activity of the distal convoluted tubule. Nat Genet 2006, 38:1124-1132.
34. Yang S.S., Morimoto T., Rai T., et al. Molecular pathogenesis of pseudohypoaldosteronism type II: generation and analysis of a Wnk4(D561A/+) knockin mouse model. Cell Metab 2007, 5:331-344.
35. Takahashi N., Chernavvsky D.R., Gomez R.A., et al. Uncompensated polyuria in a mouse model of Bartter's syndrome. Proc Natl Acad Sci U S A 2000, 97:5434-5439.
36. Schultheis P.J., Lorenz J.N., Meneton P., et al. Phenotype resembling Gitelman's syndrome in mice lacking the apical Na+-Cl- cotransporter of the distal convoluted tubule. J Biol Chem 1998, 273:29150-29155.
37. Yang S.S., Lo Y.F., Wu C.C., et al. SPAK-knockout mice manifest Gitelman syndrome and impaired vasoconstriction. J Am Soc Nephrol 2010, 21:1868-1877.
38. Rafiqi F.H., Zuber A.M., Glover M., et al. Role of the WNK-activated SPAK kinase in regulating blood pressure. EMBO Mol Med 2010, 2:63-75.
39. Bobulescu I.A., Moe O.W. Luminal Na(+)/H(+) exchange in the proximal tubule. Pflugers Arch 2009, 458:5-21.
40. Liddle G.W., Bledsoe T., Coppage W.S.J. A familial renal disorder simulating primary aldosteronism but with negligible aldosterone secretion. Trans Assoc Am Physician 1963, 76:199-213.
41. Warnock D.G. Liddle syndrome: an autosomal dominant form of human hypertension. Kidney Int 1998, 53:18-24.
42. Hansson J.H., Nelson-Williams C., Suzuki H., et al. Hypertension caused by a truncated epithelial sodium channel gamma subunit: genetic heterogeneity of Liddle syndrome. Nat Genet 1995, 11:76-82.
43. Hansson J.H., Schild L., Lu Y., et al. A de novo missense mutation of the beta subunit of the epithelial sodium channel causes hypertension and Liddle syndrome, identifying a proline-rich segment critical for regulation of channel activity. Proc Natl Acad Sci U S A 1995, 92:11495-11499.
44. Bartter F.C., Pronove P., Gill J.R., Maccardle R.C. Hyperplasia of the juxtaglomerular complex with hyperaldosteronism and hypokalemic alkalosis. A new syndrome. Am J Med 1962, 33:811-828.
45. Gitelman H.J., Graham J.B., Welt L.G. A new familial disorder characterized by hypokalemia and hypomagnesemia. Trans Assoc Am Physicians 1966, 79:221-235.
46. Simon D.B., Karet F.E., Hamdan J.M., et al. Bartter's syndrome, hypokalaemic alkalosis with hypercalciuria, is caused by mutations in the Na-K-2Cl cotransporter NKCC2. Nat Genet 1996, 13:183-188.
47. Simon D.B., Nelson-Williams C., Bia M.J., et al. Gitelman's variant of Bartter's syndrome, inherited hypokalaemic alkalosis, is caused by mutations in the thiazide-sensitive Na-Cl cotransporter. Nat Genet 1996, 12:24-30.
48. Loffing J., Vallon V., Loffing-Cueni D., et al. Altered renal distal tubule structure and renal Na(+) and Ca(2+) handling in a mouse model for Gitelman's syndrome. J Am Soc Nephrol 2004, 15:2276-2288.
49. Wilson F.H., Disse-Nicodeme S., Choate K.A., et al. Human hypertension caused by mutations in WNK kinases. Science 2001, 293:1107-1112.
50. Uchida S. Pathophysiological roles of WNK kinases in the kidney. Pflugers Arch 2010, 460:695-702.
51. Disse-Nicodeme S., Achard J.M., Desitter I., et al. A new locus on chromosome 12p13.3 for pseudohypoaldosteronism type II, an autosomal dominant form of hypertension. Am J Hum Genet 2000, 67:302-310.
52. Mansfield T.A., Simon D.B., Farfel Z., et al. Multilocus linkage of familial hyperkalaemia and hypertension, pseudohypoaldosteronism type II, to chromosomes 1q31-42 and 17p11-q21. Nat Genet 1997, 16:202-205.
53. Wulff P., Vallon V., Huang D.Y., et al. Impaired renal Na(+) retention in the sgk1-knockout mouse. J Clin Invest 2002, 110:1263-1268.
54. Vallon V., Schroth J., Lang F., Kuhl D., Uchida S. Expression and phosphorylation of the Na+-Cl- cotransporter NCC in vivo is regulated by dietary salt, potassium, and SGK1. Am J Physiol Renal Physiol 2009, 297:F704-F712.
55. Fejes-Toth G., Frindt G., Naray-Fejes-Toth A., Palmer L.G. Epithelial Na+ channel activation and processing in mice lacking SGK1. Am J Physiol Renal Physiol 2008, 294:F1298-F1305.
56. Reiche J., Theilig F., Rafiqi F.H., et al. SORLA/SORL1 functionally interacts with SPAK to control renal activation of Na(+)-K(+)-Cl(-) cotransporter 2. Mol Cell Biol 2010, 30:3027-3037.