Neuronal expression of GalNAc transferase is sufficient to prevent the age-related neurodegenerative phenotype of complex ganglioside-deficient mice

Journal of Neuroscience

Volumn 34, Issue 3, 2014, Pages 880-891

  Yao, Denggao ^a   McGonigal, Rhona ^a   Barrie, Jennifer A ^a   Cappell, Joanna ^a   Cunningham, Madeleine E ^a   Meehan, Gavin R ^a   Fewou, Simon N ^a   Edgar, Julia M ^a   Rowan, Edward ^b   Ohmi, Yuhsuke ^c   Furukawa, Keiko ^c   Furukawa, Koichi ^c   Brophy, Peter J ^d   Willison, Hugh J ^a  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

^b UNIVERSITY OF STRATHCLYDE   (United Kingdom)

^c NAGOYA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^d UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

Ganglioside; Glycosyltransferase; Neurodegeneration; Transgenic

Indexed keywords

BETA 1,4 N ACETYLGALACTOSAMINYLTRANSFERASE 1; GANGLIOSIDE; GANGLIOSIDE GD3; N ACETYLGALACTOSAMINYLTRANSFERASE; UNCLASSIFIED DRUG;

AGING; ANIMAL TISSUE; ARTICLE; ATAXIA; BEHAVIOR DISORDER; BRAIN ELECTROPHYSIOLOGY; DEMYELINATION; ELECTRON MICROSCOPY; ENZYME ACTIVITY; GLIA CELL; GRIP STRENGTH; IMMUNOHISTOCHEMISTRY; MORPHOMETRICS; MOUSE; NERVE CELL; NERVE CONDUCTION; NERVE DEGENERATION; NERVE FIBER DEGENERATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SCIATIC NERVE; TANDEM MASS SPECTROMETRY; THIN LAYER CHROMATOGRAPHY; TRANSGENIC MOUSE; TREMOR; ULTRASTRUCTURE;

GANGLIOSIDE; GLYCOSYLTRANSFERASE; NEURODEGENERATION; TRANSGENIC;

AGING; ANIMALS; AXONS; GANGLIOSIDES; GENE EXPRESSION REGULATION, ENZYMOLOGIC; MALE; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; N-ACETYLGALACTOSAMINYLTRANSFERASES; NEURODEGENERATIVE DISEASES; NEURONS; PHENOTYPE;

EID: 84892427814     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.3996-13.2014     Document Type: Article

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