Enhanced susceptibility to kainate-induced seizures, neuronal apoptosis, and death in mice lacking gangliotetraose gangliosides: Protection with LIGA 20, a membrane-permeant analog of GM1

Journal of Neuroscience

Volumn 25, Issue 47, 2005, Pages 11014-11022

  Wu, Gusheng ^a   Lu, Zi Hua ^a   Wang, Jianfeng ^a   Wang, Yvette ^a   Xie, Xin ^a   Meyenhofer, Markus F ^a   Ledeen, Robert W ^a  

^a RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

Author keywords

Epilepsy; Ganglioside GM1; Ganglioside knock out mouse; Kainate induced seizures; LIGA 20; Nuclear calcium; Nuclear sodium calcium exchanger; Sodium calcium exchanger

Indexed keywords

GANGLIOSIDE; GANGLIOSIDE GM1; KAINIC ACID; LIGA 20; N ACETYLGALACTOSAMINYLTRANSFERASE; SODIUM CALCIUM EXCHANGE PROTEIN; UNCLASSIFIED DRUG; URIDINE DIPHOSPHATE N ACETYLGALACTOSAMINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CALCIUM TRANSPORT; CELL NUCLEUS MEMBRANE; CONTROLLED STUDY; DISEASE PREDISPOSITION; DISEASE SEVERITY; DRUG ABSORPTION; DRUG PENETRATION; DRUG POTENCY; DRUG STRUCTURE; EPILEPTIC STATE; GENE DISRUPTION; GENOTYPE; HETEROZYGOTE; HIPPOCAMPUS; KNOCKOUT MOUSE; MEMBRANE PERMEABILITY; MOUSE; NEUROPROTECTION; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; PYRAMIDAL NERVE CELL; SEIZURE;

ANIMALS; APOPTOSIS; BRAIN; DISEASE SUSCEPTIBILITY; G(M1) GANGLIOSIDE; GANGLIOSIDES; HIPPOCAMPUS; KAINIC ACID; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; N-ACETYLGALACTOSAMINYLTRANSFERASES; NEURONS; NEUROPROTECTIVE AGENTS; OLIGOSACCHARIDES; SEIZURES; SODIUM-CALCIUM EXCHANGER; SPHINGOSINE; STATUS EPILEPTICUS; TIME FACTORS;

EID: 28044454975     PISSN: 02706474     EISSN: 02706474     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.3635-05.2005     Document Type: Article

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