메뉴 건너뛰기




Volumn 39, Issue 5, 2011, Pages 1117-1122

Quinone methide tripterine, celastrol, induces apoptosis in human myeloma cells via NF-Bκ pathway

Author keywords

Apoptosis; Celastrol; Multiple myeloma; Nuclear factor B (NF B)

Indexed keywords

CASPASE 3; CELASTROL; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN;

EID: 80053192325     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.2011.1161     Document Type: Article
Times cited : (40)

References (36)
  • 1
    • 0036884062 scopus 로고    scopus 로고
    • Molecular mechanisms of novel therapeutic approaches for multiple myeloma
    • DOI 10.1038/nrc952
    • Hideshima T and Anderson KC: Molecular mechanisms of novel therapeutic approaches for multiple myeloma. Nat Rev Cancer 2: 927-937, 2002. (Pubitemid 37328894)
    • (2002) Nature Reviews Cancer , vol.2 , Issue.12 , pp. 927-937
    • Hideshima, T.1    Anderson, K.C.2
  • 2
    • 0142117347 scopus 로고    scopus 로고
    • Thalidomide and its derivatives: New promise for multiple myeloma
    • Weber D: Thalidomide and its derivatives: new promise for multiple myeloma. Cancer Control 10: 375-383, 2003.
    • (2003) Cancer Control , vol.10 , pp. 375-383
    • Weber, D.1
  • 3
    • 74049142026 scopus 로고    scopus 로고
    • The use of novel agents in the treatment of relapsed and refractory multiple myeloma
    • Laubach JP, Mahindra A, Richardson PG, et al: The use of novel agents in the treatment of relapsed and refractory multiple myeloma. Leukemia 23: 2222-2232, 2009.
    • (2009) Leukemia , vol.23 , pp. 2222-2232
    • Laubach, J.P.1    Mahindra, A.2    Richardson, P.G.3
  • 5
    • 33645292701 scopus 로고    scopus 로고
    • Severe pulmonary complications in Japanese patients after bortezomib treatment for refractory multiple myeloma
    • Miyakoshi S, Kami M, Oshimi K, et al: Severe pulmonary complications in Japanese patients after bortezomib treatment for refractory multiple myeloma. Blood 107: 3492-3494, 2006.
    • (2006) Blood , vol.107 , pp. 3492-3494
    • Miyakoshi, S.1    Kami, M.2    Oshimi, K.3
  • 6
    • 60749134528 scopus 로고    scopus 로고
    • Mechanisms underlying chemotherapy-induced neurotoxicity and the potential for neuroprotective strategies
    • Park SB, Krishnan AV, Lin CS, Goldstein D, Friedlander M and Kiernan MC: Mechanisms underlying chemotherapy-induced neurotoxicity and the potential for neuroprotective strategies. Curr Med Chem 15: 3081-3094, 2008.
    • (2008) Curr Med Chem , vol.15 , pp. 3081-3094
    • Park, S.B.1    Krishnan, A.V.2    Lin, C.S.3    Goldstein, D.4    Friedlander, M.5    Kiernan, M.C.6
  • 7
    • 33947280591 scopus 로고    scopus 로고
    • Targeted therapy of multiple myeloma based upon tumor-microenvironmental interactions
    • Anderson KC: Targeted therapy of multiple myeloma based upon tumor-microenvironmental interactions. Exp Hematol 35 (Suppl 1): S155-S162, 2007.
    • (2007) Exp Hematol , vol.35 , Issue.SUPPL. 1
    • Anderson, K.C.1
  • 8
  • 9
    • 0036158551 scopus 로고    scopus 로고
    • Antiinflammatory constituents of Celastrus orbiculatus inhibit the NF-κB activation and NO production
    • Jin HZ, Hwang BY, Kim HS, Lee JH, Kim YH and Lee JJ: Antiinflammatory constituents of Celastrus orbiculatus inhibit the NF-κB activation and NO production. J Nat Prod 65: 89-91, 2002.
    • (2002) J Nat Prod , vol.65 , pp. 89-91
    • Jin, H.Z.1    Hwang, B.Y.2    Kim, H.S.3    Lee, J.H.4    Kim, Y.H.5    Lee, J.J.6
  • 12
  • 13
    • 33646406554 scopus 로고    scopus 로고
    • Celastrol, a triterpene extracted from the Chinese 'Thunder of God Vine', is a potent proteasome inhibitor and suppresses human prostate cancer growth in nude mice
    • Yang H, Chen D, Cui QC, Yuan X and Dou QP: Celastrol, a triterpene extracted from the Chinese 'Thunder of God Vine', is a potent proteasome inhibitor and suppresses human prostate cancer growth in nude mice. Cancer Res 66: 4758-4765, 2006.
    • (2006) Cancer Res , vol.66 , pp. 4758-4765
    • Yang, H.1    Chen, D.2    Cui, Q.C.3    Yuan, X.4    Dou, Q.P.5
  • 14
    • 0029874138 scopus 로고    scopus 로고
    • The NF-κB and IκB proteins: New discoveries and insights
    • Baldwin AS Jr: The NF-κB and IκB proteins: new discoveries and insights. Annu Rev Immunol 14: 649-683, 1996.
    • (1996) Annu Rev Immunol , vol.14 , pp. 649-683
    • Baldwin Jr., A.S.1
  • 15
    • 0031897632 scopus 로고    scopus 로고
    • NF-κB and Rel proteins: Evolutionarily conserved mediators of immune responses
    • Ghost S, Mary MJ and Kopp EB: NF-κB and Rel proteins: evolutionarily conserved mediators of immune responses. Annu Rev Immunol 16: 225-260, 1998.
    • (1998) Annu Rev Immunol , vol.16 , pp. 225-260
    • Ghost, S.1    Mary, M.J.2    Kopp, E.B.3
  • 16
    • 77951034358 scopus 로고    scopus 로고
    • Multiple myeloma: Chemotherapy or transplantation in the era of new drugs
    • Palumbo A and Rajkumar SV: Multiple myeloma: chemotherapy or transplantation in the era of new drugs. Eur J Haematol 84: 379-390, 2010.
    • (2010) Eur J Haematol , vol.84 , pp. 379-390
    • Palumbo, A.1    Rajkumar, S.V.2
  • 17
    • 41949130070 scopus 로고    scopus 로고
    • Improved survival in multiple myeloma and the impact of novel therapies
    • Kumar SK, Rajkumar SV, Dispenzieri A, et al: Improved survival in multiple myeloma and the impact of novel therapies. Blood 111: 2516-2520, 2008.
    • (2008) Blood , vol.111 , pp. 2516-2520
    • Kumar, S.K.1    Rajkumar, S.V.2    Dispenzieri, A.3
  • 18
    • 75649085683 scopus 로고    scopus 로고
    • Current multiple myeloma treatment strategies with novel agents: A European perspective
    • Ludwig H, Beksac M, Blade J, et al: Current multiple myeloma treatment strategies with novel agents: a European perspective. Oncologist 15: 6-25, 2010.
    • (2010) Oncologist , vol.15 , pp. 6-25
    • Ludwig, H.1    Beksac, M.2    Blade, J.3
  • 19
    • 77956259865 scopus 로고    scopus 로고
    • Importance of achieving a complete response in multiple myeloma, and the impact of novel agents
    • Chanan-Khan AA and Giralt S: Importance of achieving a complete response in multiple myeloma, and the impact of novel agents. J Clin Oncol 28: 1-13, 2010.
    • (2010) J Clin Oncol , vol.28 , pp. 1-13
    • Chanan-Khan, A.A.1    Giralt, S.2
  • 21
    • 0037468570 scopus 로고    scopus 로고
    • IL-6-independent expression of Mcl-1 in human multiple myeloma
    • DOI 10.1038/sj.onc.1206358
    • Zhang B, Potyagaylo V and Fenton RG: IL-6-independent expression of Mcl-1 in human multiple myeloma. Oncogene 22: 1848-1859, 2003. (Pubitemid 36513143)
    • (2003) Oncogene , vol.22 , Issue.12 , pp. 1848-1859
    • Zhang, B.1    Potyagaylo, V.2    Fenton, R.G.3
  • 22
    • 0036488643 scopus 로고    scopus 로고
    • Natural products in cancer chemotherapy: Past, present and future
    • Mann J: Natural products in cancer chemotherapy: past, present and future. Nat Rev Cancer 2: 143-148, 2002.
    • (2002) Nat Rev Cancer , vol.2 , pp. 143-148
    • Mann, J.1
  • 24
    • 20144363221 scopus 로고    scopus 로고
    • 1'-acetoxychavicol acetate is a novel nuclear factor kappaB inhibitor with significant activity against multiple myeloma in vitro and in vivo
    • DOI 10.1158/0008-5472.CAN-05-0072
    • Ito K, Nakazato T, Kizaki M, et al: 1'-acetoxychavicol acetate is a novel nuclear factor kappa B inhibitor with significant activity against multiple myeloma in vitro and in vivo. Cancer Res 65: 4417-4424, 2005. (Pubitemid 40775681)
    • (2005) Cancer Research , vol.65 , Issue.10 , pp. 4417-4424
    • Ito, K.1    Nakazato, T.2    Xian, M.J.3    Yamada, T.4    Hozumi, N.5    Murakami, A.6    Ohigashi, H.7    Ikeda, Y.8    Kizaki, M.9
  • 25
    • 15244358399 scopus 로고    scopus 로고
    • Catechin, a green tea component, rapidly induces apoptosis of myeloid leukemic cells via modulation of reactive oxygen species production in vitro and inhibits tumor growth in vivo
    • Nakazato T, Ito K, Kizaki M, et al: Catechin, a green tea component, rapidly induces apoptosis of myeloid leukemic cells via modulation of reactive oxygen species production in vitro and inhibits tumor growth in vivo. Haematologica 90: 317-325, 2005. (Pubitemid 40388981)
    • (2005) Haematologica , vol.90 , Issue.3 , pp. 317-325
    • Nakazato, T.1    Ito, K.2    Miyakawa, Y.3    Kinjo, K.4    Yamada, T.5    Hozumi, N.6    Ikeda, Y.7    Kizaki, M.8
  • 26
    • 23844541335 scopus 로고    scopus 로고
    • Green tea component, catechin, induces apoptosis of human malignant B cells via production of reactive oxygen species
    • DOI 10.1158/1078-0432.CCR-04-2273
    • Nakazato T, Ito K, Ikeda Y and Kizaki M: Green tea component, catechin, induces apoptosis of human malignant B cells via production of reactive oxygen species. Clin Cancer Res 11: 6040-6049, 2005. (Pubitemid 41170336)
    • (2005) Clinical Cancer Research , vol.11 , Issue.16 , pp. 6040-6049
    • Nakazato, T.1    Ito, K.2    Ikeda, Y.3    Kizaki, M.4
  • 27
    • 32144436448 scopus 로고    scopus 로고
    • Resveratrol induces apoptosis of human malignant B cells by activation of caspase-3 and p38 MAP kinase pathways
    • DOI 10.1016/j.bcp.2005.12.018, PII S000629520500835X
    • Shimizu T, Nakazato T, Xian MJ, Sagawa M, Ikeda Y and Kizaki M: Resveratrol induces apoptosis of human malignant B cells by activation of caspase-3 and p38 MAP kinase pathways. Biochem Pharmacol 71: 742-750, 2006. (Pubitemid 43208830)
    • (2006) Biochemical Pharmacology , vol.71 , Issue.6 , pp. 742-750
    • Shimizu, T.1    Nakazato, T.2    Xian, M.J.3    Sagawa, M.4    Ikeda, Y.5    Kizaki, M.6
  • 28
    • 33751332527 scopus 로고    scopus 로고
    • Zerumbone, a bioactive sesquiterpene, induces G2/M cell cycle arrest and apoptosis in leukemia cells via a Fas- and mitochondria-mediated pathway
    • DOI 10.1111/j.1349-7006.2006.00362.x
    • Xian M, Ito K, Kizaki M, et al: Zerumbone, a bioactive sesquiterpene, induces G2/M cell cycle arrest and apoptosis in leukemia cells via a Fas- and mitochondria-mediated pathway. Cancer Sci 98: 118-126, 2007. (Pubitemid 44803930)
    • (2007) Cancer Science , vol.98 , Issue.1 , pp. 118-126
    • Xian, M.1    Ito, K.2    Nakazato, T.3    Shimizu, T.4    Chen, C.-K.5    Yamato, K.6    Murakami, A.7    Ohigashi, H.8    Ikeda, Y.9    Kizaki, M.10
  • 30
    • 50149116996 scopus 로고    scopus 로고
    • Cantharidin induces apoptosis of human multiple myeloma cells via inhibition of the JAK/STAT pathway
    • Sagawa M, Nakazato T, Uchida H, Ikeda Y and Kizaki M: Cantharidin induces apoptosis of human multiple myeloma cells via inhibition of the JAK/STAT pathway. Cancer Sci 99: 1820-1826, 2008.
    • (2008) Cancer Sci , vol.99 , pp. 1820-1826
    • Sagawa, M.1    Nakazato, T.2    Uchida, H.3    Ikeda, Y.4    Kizaki, M.5
  • 31
    • 77649178833 scopus 로고    scopus 로고
    • Celastrol, a novel HSP90 inhibitor, depletes Bcr-Abl and induces apoptosis in imatinib-resistant chronic myelogenous leukemia cells harboring T315I mutation
    • Lu Z, Jin Y, Qiu L, Lai Y and Pan J: Celastrol, a novel HSP90 inhibitor, depletes Bcr-Abl and induces apoptosis in imatinib-resistant chronic myelogenous leukemia cells harboring T315I mutation. Cancer Lett 290: 182-191, 2010.
    • (2010) Cancer Lett , vol.290 , pp. 182-191
    • Lu, Z.1    Jin, Y.2    Qiu, L.3    Lai, Y.4    Pan, J.5
  • 32
    • 77951215549 scopus 로고    scopus 로고
    • Celastrol, a triterpene, enhances TRAIL-induced apoptosis through the downregulation of cell survival proteins and upregulation of death receptors
    • Sung B, Park B, Yadav VR and Aggarwal BB: Celastrol, a triterpene, enhances TRAIL-induced apoptosis through the downregulation of cell survival proteins and upregulation of death receptors. J Biol Chem 285: 11498-11507, 2010.
    • (2010) J Biol Chem , vol.285 , pp. 11498-11507
    • Sung, B.1    Park, B.2    Yadav, V.R.3    Aggarwal, B.B.4
  • 33
    • 85047699198 scopus 로고    scopus 로고
    • Nuclear transcription factor-κB as a target for cancer drug development
    • DOI 10.1038/sj/leu/2402482
    • Garg A and Aggarwal BB: Nuclear transcription factor-κB as a target for cancer drug development. Leukemia 16: 1053-1068, 2002. (Pubitemid 34618844)
    • (2002) Leukemia , vol.16 , Issue.6 , pp. 1053-1068
    • Garg, A.1    Aggarwal, B.B.2
  • 34
    • 34250898562 scopus 로고    scopus 로고
    • NF-κB as a potential molecular target for cancer therapy
    • Lee CH, Jeon YT, Kim SH and Song YS: NF-κB as a potential molecular target for cancer therapy. Biofactors 29: 19-35, 2007. (Pubitemid 46985299)
    • (2007) BioFactors , vol.29 , Issue.1 , pp. 19-35
    • Lee, C.H.1    Jeon, Y.-T.2    Kim, S.-H.3    Song, Y.-S.4
  • 35
    • 77950485584 scopus 로고    scopus 로고
    • Celastrol inhibits Hsp90 chaperoning of steroid receptors by inducing fibrillization of the Co-chaperone p23
    • Chadli A, Felts SJ, Mer G, et al: Celastrol inhibits Hsp90 chaperoning of steroid receptors by inducing fibrillization of the Co-chaperone p23. J Biol Chem 285: 4224-4231, 2010.
    • (2010) J Biol Chem , vol.285 , pp. 4224-4231
    • Chadli, A.1    Felts, S.J.2    Mer, G.3
  • 36
    • 72149125851 scopus 로고    scopus 로고
    • Characterization of celastrol to inhibit hsp90 and cdc37 interaction
    • Zhang T, Li Y, Yu Y, Zou P, Jiang Y and Sun D: Characterization of celastrol to inhibit hsp90 and cdc37 interaction. J Biol Chem 284: 35381-35389, 2009.
    • (2009) J Biol Chem , vol.284 , pp. 35381-35389
    • Zhang, T.1    Li, Y.2    Yu, Y.3    Zou, P.4    Jiang, Y.5    Sun, D.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.