β2-Adrenergic and M2-muscarinic receptors decrease basal t-tubular L-type Ca2+ channel activity and suppress ventricular contractility in heart failure

European Journal of Pharmacology

Volumn 724, Issue 1, 2014, Pages 122-131

  Kashihara, Toshihide ^a   Hirose, Masamichi ^b   Shimojo, Hisashi ^a   Nakada, Tsutomu ^a   Gomi, Simmon ^a   Hongo, Minoru ^c   Yamada, Mitsuhiko ^a  

^a SHINSHU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b IWATE MEDICAL UNIVERSITY   (Japan)

^c SHINSHU UNIVERSITY   (Japan)

Author keywords

2 adrenergic receptor; A 1 adenosine receptor; Heart failure; L type Ca2+ channels; M2 muscarinic receptor; Protein phosphatase

Indexed keywords

3 ISOPROPYLAMINO 1 (7 METHYL 4 INDANYLOXY) 2 BUTANOL; 8 CYCLOPENTYL 1,3 DIPROPYLXANTHINE; ADENOSINE A1 RECEPTOR; ATROPINE; BETA 2 ADRENERGIC RECEPTOR; CALCIUM CHANNEL L TYPE; G PROTEIN COUPLED RECEPTOR; ISOPRENALINE; MUSCARINIC M2 RECEPTOR; PHOSPHOPROTEIN PHOSPHATASE 2A;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE LENGTH; CELL DENSITY; CONTROLLED STUDY; HEART LEFT VENTRICLE CONTRACTILITY; HEART LEFT VENTRICLE ENDDIASTOLIC PRESSURE; HEART LEFT VENTRICLE FAILURE; HEART LEFT VENTRICLE MUSCLE; HEART MUSCLE CELL; LUNG WEIGHT; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; TIBIA; TRANSVERSE TUBULAR SYSTEM;

A(1)-ADENOSINE RECEPTOR; HEART FAILURE; L-TYPE CA(2+) CHANNELS; M(2)-MUSCARINIC RECEPTOR; PROTEIN PHOSPHATASE; Β(2)-ADRENERGIC RECEPTOR;

ADENOSINE A1 RECEPTOR ANTAGONISTS; ADRENERGIC BETA-ANTAGONISTS; ANIMALS; ATROPINE; CALCIUM CHANNELS, L-TYPE; ENZYME INHIBITORS; HEART FAILURE; MALE; MICE; MICE, INBRED C57BL; MUSCARINIC ANTAGONISTS; MYOCARDIAL CONTRACTION; OKADAIC ACID; PHOSPHOPROTEIN PHOSPHATASES; PROPANOLAMINES; RECEPTOR, MUSCARINIC M2; RECEPTORS, ADRENERGIC, BETA-2; VENTRICULAR FUNCTION, LEFT; XANTHINES;

EID: 84892416681     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2013.12.037     Document Type: Article

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