Etomidate produces similar allosteric modulation in α1β3δ and α1β3γ2L GABAA receptors

British Journal of Pharmacology

Volumn 171, Issue 3, 2014, Pages 789-798

  Feng, H J ^a   Jounaidi, Y ^a   Haburcak, M ^a   Yang, X ^a   Forman, S A ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

subunits; allosteric modulation; concatenated subunit assemblies; electrophysiology; etomidate; GABAA receptors; general anaesthetics

Indexed keywords

4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID A RECEPTOR ALPHA1; 4 AMINOBUTYRIC ACID A RECEPTOR BETA3; 4 AMINOBUTYRIC ACID A RECEPTOR DELTA; 4 AMINOBUTYRIC ACID A RECEPTOR GAMMA2; ETOMIDATE; MESSENGER RNA; UNCLASSIFIED DRUG;

ALLOSTERISM; ANIMAL CELL; ARTICLE; CONCENTRATION RESPONSE; DRUG EFFECT; DRUG POTENTIATION; DRUG RECEPTOR BINDING; ELECTROPHYSIOLOGY; NONHUMAN; OOCYTE; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN LOCALIZATION; PROTEIN MODIFICATION; PROTEIN STRUCTURE; PROTEIN SUBUNIT; XENOPUS;

ALLOSTERIC MODULATION; CONCATENATED SUBUNIT ASSEMBLIES; ELECTROPHYSIOLOGY; ETOMIDATE; GABAA RECEPTORS; GENERAL ANAESTHETICS; Δ SUBUNITS;

ALLOSTERIC REGULATION; ANESTHETICS, GENERAL; ANIMALS; CELL MEMBRANE; DRUG PARTIAL AGONISM; ETOMIDATE; FEMALE; GABA-A RECEPTOR AGONISTS; HUMANS; MODELS, MOLECULAR; NERVE TISSUE PROTEINS; OOCYTES; PATCH-CLAMP TECHNIQUES; PROTEIN SUBUNITS; RATS; RECEPTORS, GABA-A; RECOMBINANT PROTEINS; RNA, MESSENGER; XENOPUS;

EID: 84892398622     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/bph.12507     Document Type: Article

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