Use of concatemers of ligand-gated ion channel subunits to study mechanisms of steroid potentiation

Anesthesiology

Volumn 115, Issue 6, 2011, Pages 1328-1337

  Steinbach, Joe Henry ^a   Akk, Gustav ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; AMINO ACID; ESTRADIOL; ION CHANNEL; LIGAND GATED ION CHANNEL SUBUNIT; NEUROSTEROID; NEUROTRANSMITTER; NICOTINIC RECEPTOR ALPHA4BETA2; PROTEIN SUBUNIT; UNCLASSIFIED DRUG;

ALPHA CHAIN; AMINO TERMINAL SEQUENCE; ANESTHESIOLOGY; BETA CHAIN; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CHANNEL GATING; CONCATEMER; DRUG MECHANISM; HORMONE RECEPTOR INTERACTION; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN STRUCTURE; REVIEW; SIGNAL TRANSDUCTION; VOLTAGE CLAMP; XENOPUS;

BINDING SITES; DRUG SYNERGISM; ESTRADIOL; HUMANS; LIGAND-GATED ION CHANNELS; NEUROTRANSMITTER AGENTS; RECEPTORS, GABA-A; RECEPTORS, NICOTINIC; STEROIDS; SYNAPTIC TRANSMISSION;

EID: 81855206093     PISSN: 00033022     EISSN: 15281175     Source Type: Journal    
DOI: 10.1097/ALN.0b013e318233046a     Document Type: Review

References (58)

1. Isacoff EY, Jan YN, Jan LY: Evidence for the formation of heteromultimeric potassium channels in Xenopus oocytes. Nature 1990; 345:530-4
2. A receptor subunit requires a monomeric subunit of α6 or β2. J Biol Chem 1995; 270:26063-6
3. Varnum MD, Zagotta WN: Subunit interactions in the activation of cyclic nucleotide-gated ion channels. Biophys J 1996; 70:2667-79
4. + channels. Pflugers Arch 2002; 445: 423-30
5. Wang R, Zhang X, Cui N, Wu J, Piao H, Wang X, Su J, Jiang C: Subunit-stoichiometric evidence for kir6.2 channel gating, ATP binding, and binding-gating coupling. Mol Pharmacol 2007; 71:1646-56
6. Baumann SW, Baur R, Sigel E: Subunit arrangement of γ-aminobutyric acid type A receptors. J Biol Chem 2001; 276: 36275-80
7. Groot-Kormelink PJ, Broadbent SD, Boorman JP, Sivilotti LG: Incomplete incorporation of tandem subunits in recombinant neuronal nicotinic receptors. J Gen Physiol 2004; 123: 697-708
8. Zhou Y, Nelson ME, Kuryatov A, Choi C, Cooper J, Lindstrom J: Human α4β2 acetylcholine receptors formed from linked subunits. J Neurosci 2003; 23:9004-15
9. A receptor-associated protein. J Neurosci 2005; 25:11219-30
10. Zerhusen B, Zhao J, Xie J, Davis PB, Ma J: A single conductance pore for chloride ions formed by two cystic fibrosis transmembrane conductance regulator molecules. J Biol Chem 1999; 274:7627-30
11. Schorge S, Elenes S, Colquhoun D: Maximum likelihood fitting of single channel NMDA activity with a mechanism composed of independent dimers of subunits. J Physiol 2005; 569:395-418
12. Selye H: The anesthetic effects of steroid hormones. Proc Soc Exp Biol Med 1941; 46:116-21
13. Harrison NL, Vicini S, Barker JL: A steroid anesthetic prolongs inhibitory postsynaptic currents in cultured rat hippocampal neurons. J Neurosci 1987; 7:604-9
14. Majewska MD, Harrison NL, Schwartz RD, Barker JL, Paul SM: Steroid hormone metabolites are barbiturate-like modulators of the GABA receptor. Science 1986; 232:1004-7
15. A receptors. Psychoneuroendocrinology 2009; 34(Suppl 1): S48-58
16. A receptors. Pharmacol Ther 2007; 116:35-57
17. A receptors. J Physiol 2004; 558:59-74
18. A receptor. J Neurosci 2005; 25:11605-13
19. A receptor potentiation. J Physiol 2007; 584:789-800
20. A receptors through two discrete transmembrane sites. Nature 2006; 444:486-9
21. A receptors. Neuropharmacology 2009; 56:149-54
22. A receptors. Mol Pharmacol 2006; 69:2015-26
23. Paradiso K, Sabey K, Evers AS, Zorumski CF, Covey DF, Steinbach JH: Steroid inhibition of rat neuronal nicotinic α4β2 receptors expressed in HEK 293 cells. Mol Pharmacol 2000; 58:341-51
24. Paradiso K, Zhang J, Steinbach JH: The C terminus of the human nicotinic α4β2 receptor forms a binding site required for potentiation by an estrogenic steroid. J Neurosci 2001; 21:6561-8
25. Curtis L, Buisson B, Bertrand S, Bertrand D: Potentiation of human α4β2 neuronal nicotinic acetylcholine receptor by estradiol. Mol Pharmacol 2002; 61:127-35
26. Carbone AL, Moroni M, Groot-Kormelink PJ, Bermudez I: Pentameric concatenated (α4)(2)(β2)(3) and (α4)(3)(β2)(2) nicotinic acetylcholine receptors: Subunit arrangement determines functional expression. Br J Pharmacol 2009; 156: 970-81
27. Kuryatov A, Lindstrom J: Expression of functional human α6β2β3* acetylcholine receptors in Xenopus laevis oocytes achieved through subunit chimeras and concatamers. Mol Pharmacol 2011; 79:126-40
28. A receptors. Insight into the absolute arrangement J Biol Chem 2002; 277:46020-5
29. A receptor of defined subunit composition and positioning: Concatenation of five subunits. FEBS Lett 2006; 580:1616-20
30. Groot-Kormelink PJ, Broadbent S, Beato M, Sivilotti LG: Constraining the expression of nicotinic acetylcholine receptors by using pentameric constructs. Mol Pharmacol 2006; 69: 558-63
31. A receptor biogenesis. Mol Cell Neurosci 2008; 37:610-21
32. A receptors: Comparison with α1β3δ and α6β3δ receptors. J Biol Chem 2010; 285:17398-405
33. A receptors. J Neurosci 2003; 23:11158-66
34. A receptors induced by either agonist binding site. Mol Pharmacol 2005; 67:1005-8
35. A receptors expressed in human embryonic kidney cells. Mol Pharmacol 2009; 75: 1400-11
36. Halevi S, McKay J, Palfreyman M, Yassin L, Eshel M, Jorgensen E, Treinin M: The C. elegans ric-3 gene is required for maturation of nicotinic acetylcholine receptors. Embo J 2002; 21:1012-20
37. Lansdell SJ, Gee VJ, Harkness PC, Doward AI, Baker ER, Gibb AJ, Millar NS: RIC-3 enhances functional expression of multiple nicotinic acetylcholine receptor subtypes in mammalian cells. Mol Pharmacol 2005; 68:1431-8
38. Jeanclos EM, Lin L, Treuil MW, Rao J, DeCoster MA, Anand R: The chaperone protein 14-3-3eta interacts with the nicotinic acetylcholine receptor α4 subunit. Evidence for a dynamic role in subunit stabilization J Biol Chem 2001; 276: 28281-90
39. Srinivasan R, Pantoja R, Moss FJ, Mackey ED, Son CD, Miwa J, Lester HA: Nicotine up-regulates α4β2 nicotinic receptors and ER exit sites via stoichiometry-dependent chaperoning. J Gen Physiol 2011; 137:59-79
40. + channel subunits does not ensure the stoichiometry of expressed channels. Biophys J 1992; 63:1406-11
41. A receptor function. Mol Pharmacol 2009; 75:973-81
42. Jin X, Steinbach JH: A portable site: A binding element for 17β-estradiol can be placed on any subunit of a nicotinic α4β2 receptor. J Neurosci 2011; 31:5045-54
43. Sack JT, Shamotienko O, Dolly JO: How to validate a heteromeric ion channel drug target: Assessing proper expression of concatenated subunits. J Gen Physiol 2008; 131:415-20
44. Barrera NP, Edwardson JM: The subunit arrangement and assembly of ionotropic receptors. Trends Neurosci 2008; 31:569-76
45. White MM: Pretty subunits all in a row: Using concatenated subunit constructs to force the expression of receptors with defined subunit stoichiometry and spatial arrangement. Mol Pharmacol 2006; 69:407-10
46. Minier F, Sigel E: Techniques: Use of concatenated subunits for the study of ligand-gated ion channels. Trends Pharmacol Sci 2004; 25:499-503
47. A receptor induced from either transmitter binding site. Mol Pharmacol 2011; 80:79-86
48. A receptor needs two homologous domains of the β-subunit for activation by GABA but not by pentobarbital. Nature 1993; 366:565-9
49. Revah F, Bertrand D, Galzi JL, Devillers-Thiéry A, Mulle C, Hussy N, Bertrand S, Ballivet M, Changeux JP: Mutations in the channel domain alter desensitization of a neuronal nicotinic receptor. Nature 1991; 353:846-9
50. Chang Y, Weiss DS: Allosteric activation mechanism of the α1β2γ2 γ-aminobutyric acid type A receptor revealed by mutation of the conserved M2 leucine. Biophys J 1999; 77:2542-51
51. Moroni M, Zwart R, Sher E, Cassels BK, Bermudez I: α4β2 nicotinic receptors with high and low acetylcholine sensitivity: Pharmacology, stoichiometry, and sensitivity to long-term exposure to nicotine. Mol Pharmacol 2006; 70:755-68
52. A and glycine receptors. Nature 1997; 389:385-9
53. A receptor beta subunit controls a binding cavity for propofol and other alkylphenol general anesthetics. Neuropharmacology 2001; 41:952-64
54. A receptor. Mol Pharmacol 2004; 65:68-76
55. A receptor anesthetic binding site at subunit interfaces by photolabeling with an etomidate analog. J Neurosci 2006; 26:11599-605
56. Belelli D, Lambert JJ, Peters JA, Wafford K, Whiting PJ: The interaction of the general anesthetic etomidate with the γ-aminobutyric acid type A receptor is influenced by a single amino acid. Proc Natl Acad Sci U S A 1997; 94:11031-6
57. Akk G, Steinbach LH: Structural studies of the actions of anesthetic drugs on the γ-aminobutyric acid type A receptor. ANESTHESIOLOGY. 2011; in press
58. A receptor macroscopic kinetics. Neuropharmacology 2003; 44: 1003-12