Replication-dependent and transcription-dependent mechanisms of DNA double-strand break induction by the topoisomerase 2-targeting drug etoposide

PLoS ONE

Volumn 8, Issue 11, 2013, Pages

  Tammaro, Margaret ^a   Barr, Peri ^a   Ricci, Brett ^a   Yan, Hong ^a  

^a FOX CHASE CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; DNA TOPOISOMERASE (ATP HYDROLYSING); ETOPOSIDE; REPLICATION FACTOR A; TOPOISOMERASE 2ALPHA; TOPOISOMERASE 2BETA; UNCLASSIFIED DRUG;

ARTICLE; CELL CYCLE G2 PHASE; CELL CYCLE S PHASE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA REPLICATION; DNA TRANSCRIPTION; DOUBLE STRANDED DNA BREAK; HUMAN; HUMAN CELL; OSTEOSARCOMA CELL; PROTEIN DEGRADATION;

ANTIGENS, NEOPLASM; CELL LINE, TUMOR; DNA; DNA BREAKS, DOUBLE-STRANDED; DNA REPLICATION; DNA TOPOISOMERASES, TYPE II; DNA-BINDING PROTEINS; ETOPOSIDE; HUMANS; ISOENZYMES; TOPOISOMERASE II INHIBITORS; TRANSCRIPTION, GENETIC;

EID: 84892387968     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0079202     Document Type: Article

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