Honokiol trimers and dimers via biotransformation catalyzed by Momordica charantia peroxidase: Novel and potent α-glucosidase inhibitors

Bioorganic and Medicinal Chemistry

Volumn 22, Issue 2, 2014, Pages 762-771

  He, Ye ^a   Wang, Xiao Bing ^a   Fan, Bo Yi ^a   Kong, Ling Yi ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Glucosidase inhibitor; Biotransformation; Dimers; Honokiol; Momordica charantia peroxidase; Trimers

Indexed keywords

3',3''',3''''',5,5'',5'''' HEXAALLYL [1,1':3',1'':3'',1'':5''',1'''':3'''',1''''' SEXIPHENYL] 2,2'',2'''',4,4''',4''''' HEXOL; 3',3''',3''''',5,5'',5'''' HEXAALLYL [1,1':3',1'':3'',1'':5''',1'''':5'''',1''''' SEXIPHENYL] 2',2'',2'''',2''''',4,4''' HEXOL; 3',3''',3''''',5,5'',5'''' HEXAALLYL [1,1':5',1'':3'',1'':5''',1'''':3'''',1''''' SEXIPHENYL] 2,2'',2'''',4',4''',4''''' HEXOL; 3',3''',3''''',5,5'',5'''' HEXAALLYL [1,1':5',1'':3'',1'':5''',1'''':5'''',1''''' SEXIPHENYL] 2,2'',2'''',2''''',4',4''' HEXOL; 3',5 DIALLYL 3 [[3',5 DIALLYL 4' HYDROXY (1,1' BIPHENYL) 2 YL]OXY] [1,1' BIPHENYL] 2,4' DIOL; 3',5 DIALLYL 3 [[3,5' DIALLYL 2' HYDROXY (1,1' BIPHENYL) 4 YL]OXY] [1,1' BIPHENYL] 2,4' DIOL; 3',5 DIALLYL 5' [[3',5 DIALLYL 4' HYDROXY (1,1' BIPHENYL) 2 YL]OXY] [1,1' BIPHENYL] 2,4' DIOL; 3,3''',5',5'' TETRAALLYL [1,1':3',1'':3'',1''' QUATERPHENYL] 2',2'',4,4''' TETRAOL; ALPHA GLUCOSIDASE; ALPHA GLUCOSIDASE INHIBITOR; HONOKIOL; MOMORDICA CHARANTIA EXTRACT; MOMORDICA CHARANTIA PEROXIDASE; PEROXIDASE; POLYMER; UNCLASSIFIED DRUG; BIPHENYL DERIVATIVE; ENZYME INHIBITOR; LIGNAN;

ARTICLE; BIOCATALYSIS; CIRCULAR DICHROISM; DRUG TRANSFORMATION; ENZYME CONFORMATION; ENZYME INHIBITION; ENZYME STRUCTURE; IC 50; IN VITRO STUDY; INHIBITION KINETICS; MOLECULAR MECHANICS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; DIMERIZATION; DOSE RESPONSE; ENZYMOLOGY; METABOLISM; MOMORDICA CHARANTIA; SACCHAROMYCES CEREVISIAE; STRUCTURE ACTIVITY RELATION;

MOMORDICA CHARANTIA;

ALPHA-GLUCOSIDASES; BIOCATALYSIS; BIPHENYL COMPOUNDS; DIMERIZATION; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; LIGNANS; MOLECULAR STRUCTURE; MOMORDICA CHARANTIA; PEROXIDASE; SACCHAROMYCES CEREVISIAE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84892371929     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2013.12.005     Document Type: Article

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