Honokiol and magnolol stimulate glucose uptake by activating PI3K-dependent Akt in L6 myotubes

BioFactors

Volumn 38, Issue 5, 2012, Pages 372-377

  Choi, Sun Sil ^a   Cha, Byung Yoon ^a   Lee, Young Sil ^a   Yonezawa, Takayuki ^a   Teruya, Toshiaki ^a   Nagai, Kazuo ^a   Woo, Je Tae ^a,b  

^a CHUBU UNIVERSITY   (Japan)

^b Erina Co Inc   (Japan)

Author keywords

Glucose uptake; Honokiol; L6 cells; Magnolol

Indexed keywords

GLUCOSE TRANSPORTER 4; HONOKIOL; INSULIN; INSULIN RECEPTOR SUBSTRATE 1; MAGNOLOL; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; WORTMANNIN;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL SURFACE; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DOSE RESPONSE; DRUG EFFECT; DRUG POTENTIATION; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; GLUCOSE INTAKE; GLUCOSE TRANSPORT; MUSCLE CELL; MYOTUBE; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION;

ANDROSTADIENES; ANIMALS; BIOLOGICAL TRANSPORT; BIPHENYL COMPOUNDS; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION REGULATION; GLUCOSE; GLUCOSE TRANSPORTER TYPE 4; INSULIN; LIGNANS; MAGNOLIA; MUSCLE FIBERS, SKELETAL; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; PLANTS, MEDICINAL; PRIMARY CELL CULTURE; PROTEIN KINASE INHIBITORS; PROTEIN TRANSPORT; PROTO-ONCOGENE PROTEINS C-AKT; RATS; SIGNAL TRANSDUCTION;

MAGNOLIA OFFICINALIS;

EID: 84867738600     PISSN: 09516433     EISSN: 18728081     Source Type: Journal    
DOI: 10.1002/biof.1029     Document Type: Article

References (35)

1. Zaid, H., Antonescu, C. N., Randhawa, V. K., and Klip, A. (2008) Insulin action on glucose transporters through molecular switches, tracks and tethers. Biochem. J. 413, 201-215.
2. Kahn, C.R. (1994) Banting lecture. Insulin action, diabetogenes, and the cause of type II diabetes. Diabetes 43, 1066-1084.
3. Venkatesh, S., Reddy, G. D., Reddy, B. M., Ramesh, M., and Rao, A. V. (2003) Antihyperglycemic activity of Caralluma attenuata. Fitoterapia. 74, 274-279.
4. Smith, A. G. and Muscat, G. E. (2005) Skeletal muscle and nuclear hormone receptors: implications for cardiovascular and metabolic disease. Int. J. Biochem. Cell. Biol. 37, 2047-2063.
5. DeFronzon, R. A., Gunnarsson, R., Bjorkman, O., Olsson, M., and Wahren, J. (1985) Effects of insulin on peripheral and splanchnic glucose metabolism in noninsulin-dependent (type II) diabetes mellitus. J. Clin. Invest. 76, 149-155.
6. Musi, N., Hayashi, T., Fujii, N., Hirshman, M. F., Witters, L. A. et al. (2001) AMP-activated protein kinase activity and glucose uptake in rat skeletal muscle. Am. J. Physiol. Endocrinol. Metab. 280, E677-E684.
7. Zheng, D., MacLean, P. S., Pohnert, S. C., Knight, J. B., Olson, A. L., et al. (2001) Regulation of muscle GLUT-4 transcription by AMP-activated protein kinase. J. Appl. Physiol. 91, 1073-1083.
8. Saltiel, A. R. and Kahn, C. R. (2001) Insulin signalling and the regulation of glucose and lipid metabolism. Nature 414, 799-806.
9. Björnholm, M., Kawano, Y., Lehtihet, M., and Zierath, J. R. (1997) Insulin receptor substrate-1 phosphorylation and phosphatidylinositol 3-kinase activity in skeletal muscle from NIDDM subjects after in vivo insulin stimulation. Diabetes 46, 524-527.
10. Dohm, G. L., Tapscott, E. B., Pories, W. J., Dabbs, D. J., Flickinger, E. G., et al. (1988) An in vitro human muscle preparation suitable for metabolic studies. Decreased insulin stimulation of glucose transport in muscle from morbidly obese and diabetic subjects. J. Clin. Invest. 82, 486-484.
11. Towler, M. C. and Hardie, D. G. (2007) AMP-activated protein kinase in metabolic control and insulin signaling. Circ. Res. 100, 328-341.
12. Klip, A. and Leiter, L. A. (1990) Cellular mechanism of action of metformin. Diabetes Care. 13, 696-704.
13. Konrad, D., Rudich, A., Bilan, P. J., Patel, N., Richardson, C., Witters, L. A., and Klip, A. (2005) Troglitazone causes acute mitochondrial membrane depolarisation and an AMPK-mediated increase in glucose phosphorylation in muscle cells. Diabetologia 48, 954-966.
14. Lee, E. S., Uhm, K. O., Lee, Y. M., Han, M., Lee, M., et al. (2007) CAPE (caffeic acid phenethyl ester) stimulates glucose uptake through AMPK (AMP-activated protein kinase) activation in skeletal muscle cells. Biochem. Biophys. Res. Commun. 361, 854-858.
15. Breen, D. M., Sanli, T., Giacca, A., and Tsiani, E. (2008). Stimulation of muscle cell glucose uptake by resveratrol through sirtuins and AMPK. Biochem. Biophys. Res. Commun. 374, 117-122.
16. Lee, J., Jung, E., Park, J., Jung, K., Lee, S., et al. (2005) Anti-inflammatory effects of magnolol and honokiol are mediated through inhibition of the downstream pathway of MEKK-1 in NF-kappaB activation signaling. Planta Med. 71, 338-343.
17. Lo, Y. C., Teng, C. M., Chen, C. F., Chen, C. C., and Hong, C. Y. (1994) Magnolol and honokiol isolated from Magnolia officinalis protect rat heart mitochondria against lipid peroxidation. Biochem. Pharmacol. 47, 549-553.
18. Park, J., Lee, J., Jung, E., Park, Y., Kim, K., et al. (2004) In vitro antibacterial and anti-inflammatory effects of honokiol and magnolol against Propionibacterium sp. Eur. J. Pharmacol. 496, 189-195.
19. Ahn, K. S., Sethi, G., Shishodia, S., Sung, B., Arbiser, J. L., et al. (2006) Honokiol potentiates apoptosis, suppresses osteoclastogenesis, and inhibits invasion through modulation of nuclear factor-kappaB activation pathway. Mol. Cancer Res. 4, 621-633.
20. Battle, T. E., Arbiser, J., and Frank, D. A. (2005). The natural product honokiol induces caspase-dependent apoptosis in B-cell chronic lymphocytic leukemia (B-CLL) cells. Blood 106, 690-697.
21. Bai, X., Cerimele, F., Ushio-Fukai, M., Waqas, M., Campbell, P. M., et al. (2003) Honokiol, a small molecular weight natural product, inhibits angiogenesis in vitro and tumor growth in vivo. J. Biol. Chem. 278, 35501-35507.
22. Kotani, H., Tanabe, H., Mizukami, H., Makishima, M., and Inoue, M. (2010) Identification of a naturally occurring rexinoid, honokiol, that activates the retinoid X receptor. J. Nat. Prod. 27, 1332-1336.
23. Choi, S. S., Cha, B. Y., Lee, Y. S., Yonezawa, T., Teruya, T., et al. (2009) Magnolol enhances adipocyte differentiation and glucose uptake in 3T3-L1 cells. Life Sci. 84, 908-914.
24. Fakhrudin, N., Ladurner, A., Atanasov, A.G., Heiss, E. H., Baumgartner, L., et al. (2010) Computer-aided discovery, validation, and mechanistic characterization of novel neolignan activators of peroxisome proliferator-activated receptor gamma. Mol. Pharmacol. 77, 559-566.
25. Choi, S. S., Cha, B. Y., Iida, K., Sato, M., Lee, Y. S., et al. (2011) Honokiol enhances adipocyte differentiation by potentiating insulin signaling in 3T3-L1 preadipocytes. J. Nat. Med. 65, 424-430.
26. Mitsumoto Y., Burdett E, Grant A., and Klip A. (1991) Differential expression of the GLUT1 and GLUT4 glucose transporters during differentiation of L6 muscle cells. Biochem. Biophys. Res. Commun. 175, 652-659.
27. Ziel F. H., Venkatesan N., and Davidson M. B. (1988) Glucose transport is rate limiting for skeletal muscle glucose metabolism in normal and STZ-induced diabetic rats. Diabetes 37, 885-890.
28. Holmes B. F., Kurth-Kraczek E. J., and Winder W. W. (1999) Chronic activation of 5′-AMP-activated protein kinase increases GLUT-4, hexokinase, and glycogen in muscle. J. Appl. Physiol. 87, 1990-1995.
29. Farese R. V., Sajan M. P., and Standaert M. L. (2005) Insulin-sensitive protein kinases (atypical protein kinase C and protein kinase B/Akt): Actions and defects in obesity and type II diabetes. Exp. Biol. Med. (Maywood). 230, 593-605.
30. Watson, R. T. and Pessin, J. E. (2007) GLUT4 translocation: The last 200 nanometers. Cell. Signal. 19, 2209-2217.
31. Brozinick, J. T Jr., McCoid, S. C., Reynolds, T. H., Nardone, N. A., Hargrove, D. M., Stevenson, R. W., Cushman, S. W., and Gibbs, E. M. (2001) GLUT4 overexpression in db/db mice dose-dependently ameliorates diabetes but is not a lifelong cure. Diabetes 50, 593-600.
32. Minokoshi, Y., Kahn, C. R., and Kahn, B. B. (2003) Tissue-specific ablation of the GLUT4 glucose transporter or the insulin receptor challenges assumptions about insulin action and glucose homeostasis. J. Biol. Chem. 278, 33609-33612.
33. Hwang, J. T., Kwon, D. Y., and Yoon, S. H. (2009) AMP-activated protein kinase: a potential target for the diseases prevention by natural occurring polyphenols. N. Biotechnol. 26, 17-22.
34. Khan, A. H. and Pessin, J. E. (2002) Insulin regulation of glucose uptake: a complex interplay of intracellular signaling pathways. Diabetologia 45, 1475-1483.
35. Alonso-Castro, A. J., Zapata-Bustos, R., Domínguez, F., García-Carrancá, A., and Salazar-Olivo, L. A. (2011) Magnolia dealbata Zucc and its active principles honokiol and magnolol stimulate glucose uptake in murine and human adipocytes using the insulin-signaling pathway. Phytomedicine 18, 926-933.