Hydroxylation of DHEA and its analogues by Absidia coerulea AM93. Can an inducible microbial hydroxylase catalyze 7α- and 7β-hydroxylation of 5-ene and 5α-dihydro C19-steroids?

Bioorganic and Medicinal Chemistry

Volumn 22, Issue 2, 2014, Pages 883-891

  Milecka Tronina, Natalia ^a   Kołek, Teresa ^a   Świzdor, Alina ^a   Panek, Anna ^a  

^a WROC AW UNIVERSITY OF ENVIRONMENTAL AND LIFE SCIENCES   (Poland)

Author keywords

Absidia coerulea; Dehydroepiandrosterone 7 hydroxylase; DHEA metabolism; Enzymatic steroid hydroxylation; Hydroxy DHEA; Hydroxy epiandrosterone

Indexed keywords

11ALPHA HYDROXY 5ALPHA ANDROSTAN 3,17 DIONE; 11ALPHA HYDROXYEPIANDROSTERONE; 3BETA,11ALPHA DIHYDROXY 5ALPHA ANDROSTAN 17 ONE; 3BETA,17BETA DIHYDROXYANDROST 5 EN 7 ONE; 3BETA,17BETA TRIHYDROXYANDROST 5 ENE; 3BETA,7ALPHA DIHYDROXY 5ALPHA ANDROSTAN 17 ONE; 3BETA,7ALPHA,17BETA TRIHYDROXYANDROST 5 ENE; 3BETA,7BETA DIHYDROXY 5ALPHA ANDROSTAN 17 ONE; 3BETA,7BETA,17BETA TRIHYDROXYANDROST 5 ENE; 3BETA,9ALPHA DIHYDROXY 5ALPHA ANDROSTAN 17 ONE; 7 OXO HYDROXYANDROST 5 EN 17 ONE; 7ALPHA HYDROXY 5ALPHA ANDROSTAN 3,17 DIONE; 7ALPHA HYDROXYEPIANDROSTERONE; 7BETA HYDROXY 5ALPHA ANDROSTAN 3,17 DIONE; 7BETA HYDROXYANDROST 5 EN 17 ONE; 7BETA HYDROXYEPIANDROSTERONE; 9ALPHA HYDROXY 5ALPHA ANDROSTAN 3,17 DIONE; 9ALPHA HYDROXYEPIANDROSTERONE; ANDROSTANEDIONE; ANDROSTENEDIOL; CYCLOHEXIMIDE; DIKETONE; EPIANDROSTERONE; KETOL; OXYGEN; OXYGENASE; PRASTERONE; PRASTERONE DERIVATIVE; UNCLASSIFIED DRUG; MIXED FUNCTION OXIDASE; STEROID;

ABSIDIA; ABSIDIA COERULEA; ARTICLE; BIOTRANSFORMATION; CELL PH; CONTROLLED STUDY; ENZYME INHIBITION; ENZYME MECHANISM; ENZYME SUBSTRATE; ENZYME SUBSTRATE COMPLEX; FUNGAL CELL; HYDROGEN BOND; NONHUMAN; OXIDATION; STEROID HYDROXYLATION; BIOCATALYSIS; CHEMICAL STRUCTURE; CHEMISTRY; ENZYMOLOGY; HYDROXYLATION; METABOLISM; PH; TIME;

ABSIDIA COERULEA;

ABSIDIA; BIOCATALYSIS; DEHYDROEPIANDROSTERONE; HYDROGEN-ION CONCENTRATION; HYDROXYLATION; MIXED FUNCTION OXYGENASES; MOLECULAR STRUCTURE; STEROIDS; TIME FACTORS;

EID: 84892370086     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2013.11.050     Document Type: Article

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