Ox-LDL downregulates eNOS activity via LOX-1-mediated endoplasmic reticulum stress

International Journal of Molecular Medicine

Volumn 32, Issue 6, 2013, Pages 1442-1450

  Zhou, Jie ^a   Abid, Morad Dirhem Naji ^a   Xiong, Yufang ^a   Chen, Qing ^a   Chen, Juan ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Akt; Endoplasmic reticulum stress; Endothelial nitric oxide synthase; Lectin like oxidized low density lipoprotein receptor 1; Oxidized low density lipoprotein

Indexed keywords

4 PHENYLBUTYRIC ACID; BLOCKING ANTIBODY; BREFELDIN A; ENDOTHELIAL NITRIC OXIDE SYNTHASE; GLUCOSE REGULATED PROTEIN 78; JTX 20; OXIDIZED LOW DENSITY LIPOPROTEIN; OXIDIZED LOW DENSITY LIPOPROTEIN RECEPTOR 1; PHOSPHATIDYLINOSITOL 3 KINASE; PROLINE RICH EXTENSIN LIKE RECEPTOR KINASE; PROTEIN KINASE B; PROTEIN TYROSINE KINASE; SERINE; THREONINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BOVINE AORTIC ENDOTHELIAL CELL; CONTROLLED STUDY; DEPHOSPHORYLATION; DOWN REGULATION; ENDOPLASMIC RETICULUM STRESS; ENDOTHELIUM CELL; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; ENZYME REGULATION; EXPOSURE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ANTIBODIES, BLOCKING; AORTA; BREFELDIN A; CATTLE; DOWN-REGULATION; ENDOPLASMIC RETICULUM STRESS; ENDOTHELIAL CELLS; ENZYME ACTIVATION; LIPOPROTEINS, LDL; NITRIC OXIDE SYNTHASE TYPE III; PHENYLBUTYRATES; PHOSPHOPROTEIN PHOSPHATASES; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; SCAVENGER RECEPTORS, CLASS E;

EID: 84892160432     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm.2013.1513     Document Type: Article

References (39)

1. Ross R: The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature 362: 801-809, 1993.
2. Stocker R and Keaney JF Jr: Role of oxidative modifications in atherosclerosis. Physiol Rev 84: 1381-1478, 2004.
3. Griffith OW and Stuehr DJ: Nitric oxide synthases: properties and catalytic mechanism. Annu Rev Physiol 57: 707-736, 1995.
4. Cheng J, Ou JS, Singh H, et al: 20-hydroxyeicosatetraenoic acid causes endothelial dysfunction via eNOS uncoupling. Am J Physiol Heart Circ Physiol 294: H1018-H1026, 2008.
5. Sawamura T, Kume N, Aoyama T, et al: An endothelial receptor for oxidized low-density lipoprotein. Nature 386: 73-77, 1997.
6. Sugimoto K, Ishibashi T, Sawamura T, et al: LOX-1-MT1-MMP axis is crucial for RhoA and Rac1 activation induced by oxidized low-density lipoprotein in endothelial cells. Cardiovasc Res 84: 127-136, 2009.
7. Ogura S, Kakino A, Sato Y, et al: Lox-1: the multifunctional receptor underlying cardiovascular dysfunction. Circ J 73: 1993-1999, 2009.
8. Fulton D, Gratton JP, McCabe TJ, et al: Regulation of endothelium-derived nitric oxide production by the protein kinase Akt. Nature 399: 597-601, 1999.
9. Dimmeler S, Fleming I, Fisslthaler B, et al: Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation. Nature 399: 601-605, 1999.
10. Sanson M, Auge N, Vindis C, et al: Oxidized low-density lipoproteins trigger endoplasmic reticulum stress in vascular cells: prevention by oxygen-regulated protein 150 expression. Circ Res 104: 328-336, 2009.
11. Tu BP and Weissman JS: Oxidative protein folding in eukaryotes: mechanisms and consequences. J Cell Biol 164: 341-346, 2004.
12. Banhegyi G, Csala M, Szarka A, et al: Role of ascorbate in oxidative protein folding. Biofactors 17: 37-46, 2003.
13. Zhou J, Werstuck GH, Lhotak S, et al: Association of multiple cellular stress pathways with accelerated atherosclerosis in hyperhomocysteinemic apolipoprotein E-deficient mice. Circulation 110: 207-213, 2004.
14. Myoishi M, Hao H, Minamino T, et al: Increased endoplasmic reticulum stress in atherosclerotic plaques associated with acute coronary syndrome. Circulation 116: 1226-1233, 2007.
15. Xu C, Bailly-Maitre B and Reed JC: Endoplasmic reticulum stress: cell life and death decisions. J Clin Invest 115: 2656-2664, 2005.
16. Dong Y, Zhang M, Liang B, et al: Reduction of AMP-activated protein kinase alpha2 increases endoplasmic reticulum stress and atherosclerosis in vivo. Circulation 121: 792-803, 2010.
17. Hyoda K, Hosoi T, Horie N, et al: PI3K-Akt inactivation induced CHOP expression in endoplasmic reticulum-stressed cells. Biochem Biophys Res Commun 340: 286-290, 2006.
18. Sessa WC, Harrison JK, Luthin DR, et al: Genomic analysis and expression patterns reveal distinct genes for endothelial and brain nitric oxide synthase. Hypertension 21: 934-938, 1993.
19. Sessa WC, Barber CM and Lynch KR: Mutation of N-myristoylation site converts endothelial cell nitric oxide synthase from a membrane to a cytosolic protein. Circ Res 72: 921-924, 1993.
20. Rosenkranz-Weiss P, Sessa WC, Milstien S, et al: Regulation of nitric oxide synthesis by proinflammatory cytokines in human umbilical vein endothelial cells. Elevations in tetrahydrobiopterin levels enhance endothelial nitric oxide synthase specific activity. J Clin Invest 93: 2236-2243, 1994.
21. Wei Q and Xia Y: Proteasome inhibition down-regulates endothelial nitric-oxide synthase phosphorylation and function. J Biol Chem 281: 21652-21659, 2006.
22. Doms RW, Lamb RA, Rose JK and Helenius A: Folding and assembly of viral membrane proteins. Virology 193: 545-562, 1993.
23. Greif DM, Kou R and Michel T: Site-specific dephosphorylation of endothelial nitric oxide synthase by protein phosphatase 2A: evidence for crosstalk between phosphorylation sites. Biochemistry 41: 15845-15853, 2002.
24. Millward TA, Zolnierowicz S and Hemmings BA: Regulation of protein kinase cascades by protein phosphatase 2A. Trends Biochem Sci 24: 186-191, 1999.
25. Kaufman RJ: Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls. Genes Dev 13: 1211-1233, 1999.
26. Mehta JL, Li DY, Chen HJ, et al: Inhibition of LOX-1 by statins may relate to upregulation of eNOS. Biochem Biophys Res Commun 289: 857-861, 2001.
27. Aoyama T, Sawamura T, Furutani Y, et al: Structure and chromosomal assignment of the human lectin-like oxidized low-density-lipoprotein receptor-1 (LOX-1) gene. Biochem J 339: 177-184, 1999.
28. Li D, Yang B and Mehta JL: Ox-LDL induces apoptosis in human coronary artery endothelial cells: role of PKC, PTK, bcl-2, and Fas. Am J Physiol 275: H568-H576, 1998.
29. Li D and Mehta JL: Upregulation of endothelial receptor for oxidized LDL (LOX-1) by oxidized LDL and implications in apoptosis of human coronary artery endothelial cells: evidence from use of antisense LOX-1 mRNA and chemical inhibitors. Arterioscler Thromb Vasc Biol 20: 1116-1122, 2000.
30. Oka K, Sawamura T, Kikuta K, et al: Lectin-like oxidized low-density lipoprotein receptor 1 mediates phagocytosis of aged/apoptotic cells in endothelial cells. Proc Natl Acad Sci USA 95: 9535-9540, 1998.
31. Mehta JL and Li DY: Identification and autoregulation of receptor for OX-LDL in cultured human coronary artery endothelial cells. Biochem Biophys Res Commun 248: 511-514, 1998.
32. Shiojima I and Walsh K: Role of Akt signaling in vascular homeostasis and angiogenesis. Circ Res 90: 1243-1250, 2002.
33. Wang X and Robbins J: Heart failure and protein quality control. Circ Res 99: 1315-1328, 2006.
34. Glembotski CC: Endoplasmic reticulum stress in the heart. Circ Res 101: 975-984, 2007.
35. Lai E, Teodoro T and Volchuk A: Endoplasmic reticulum stress: signaling the unfolded protein response. Physiology (Bethesda) 22: 193-201, 2007.
36. Schroder M and Kaufman RJ: The mammalian unfolded protein response. Annu Rev Biochem 74: 739-789, 2005.
37. Yamaguchi H and Wang HG: CHOP is involved in endoplasmic reticulum stress-induced apoptosis by enhancing DR5 expression in human carcinoma cells. J Biol Chem 279: 45495-45502, 2004.
38. Ma Y, Brewer JW, Diehl JA and Hendershot LM: Two distinct stress signaling pathways converge upon the CHOP promoter during the mammalian unfolded protein response. J Mol Biol 318: 1351-1365, 2002.
39. Ron D and Habener JF: CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C/EBP and LAP and functions as a dominant-negative inhibitor of gene transcription. Genes Dev 6: 439-453, 1992.