메뉴 건너뛰기




Volumn , Issue , 2009, Pages 33-50

Gut microbes in celiac disease pathogenesis and therapy

Author keywords

Gluten; Gut microbiota; Immunity; Intestinal barrier function; Oral tolerance; Permeability; Probiotics celiac disease

Indexed keywords


EID: 84892102488     PISSN: None     EISSN: None     Source Type: Book    
DOI: None     Document Type: Chapter
Times cited : (2)

References (78)
  • 1
    • 48649084357 scopus 로고    scopus 로고
    • Commensal bacteria trigger a full dendritic cell maturation program that promotes the expansion of non-Tr1 suppressor T cells
    • Baba, N., Samson, S., Bourdet-Sicard, R., Rubio, M. & Sarfati, M. (2008). Commensal bacteria trigger a full dendritic cell maturation program that promotes the expansion of non-Tr1 suppressor T cells. J Leukoc Biol., 84, 468-76.
    • (2008) J Leukoc Biol , vol.84 , pp. 468-476
    • Baba, N.1    Samson, S.2    Bourdet-Sicard, R.3    Rubio, M.4    Sarfati, M.5
  • 2
    • 40349098215 scopus 로고    scopus 로고
    • Parallels between pathogens and gluten peptides in celiac sprue
    • Bethune, M.T. & Khosla, C. (2008). Parallels between pathogens and gluten peptides in celiac sprue. PLoS Pathog. 4, e34.
    • (2008) PLoS Pathog , vol.4
    • Bethune, M.T.1    Khosla, C.2
  • 4
    • 0037111368 scopus 로고    scopus 로고
    • HLA-DQ determines the response to exogenous wheat proteins: a model of gluten sensitivity in transgenic knockout mice
    • Black, K.E., Murray, J.A. & David, C.S. (2002). HLA-DQ determines the response to exogenous wheat proteins: a model of gluten sensitivity in transgenic knockout mice. J. Inmunol., 169, 5595-600.
    • (2002) J. Inmunol. , vol.169 , pp. 5595-5600
    • Black, K.E.1    Murray, J.A.2    David, C.S.3
  • 7
    • 60549097418 scopus 로고    scopus 로고
    • Imbalances in faecal and duodenal Bifidobacterium species composition in active and non-active coeliac disease
    • Collado, M.C., Donat, E., Ribes-Koninckx, C., Calabuig, M. & Sanz, Y. (2008). Imbalances in faecal and duodenal Bifidobacterium species composition in active and non-active coeliac disease. BMC Microbiol. 22;8:232.
    • (2008) BMC Microbiol. 22;8 , pp. 232
    • Collado, M.C.1    Donat, E.2    Ribes-Koninckx, C.3    Calabuig, M.4    Sanz, Y.5
  • 8
    • 61849116850 scopus 로고    scopus 로고
    • Specific duodenal and faecal bacterial groups associated with paediatric coeliac disease
    • Collado MC, Donat E, Ribes-Koninckx C, Calabuig M, Sanz Y. (2009). Specific duodenal and faecal bacterial groups associated with paediatric coeliac disease. J Clin Pathol. 62, 264-9.
    • (2009) J Clin Pathol , vol.62 , pp. 264-269
    • Collado, M.C.1    Donat, E.2    Ribes-Koninckx, C.3    Calabuig, M.4    Sanz, Y.5
  • 9
    • 33947135858 scopus 로고    scopus 로고
    • Cross-talk between probiotic bacteria and the host immune system
    • Corthesy, B., Gaskins, H.R. & Mercenier, A. (2007). Cross-talk between probiotic bacteria and the host immune system. J Nutr, 137, 781-90.
    • (2007) J Nutr , vol.137 , pp. 781-790
    • Corthesy, B.1    Gaskins, H.R.2    Mercenier, A.3
  • 12
    • 30744435342 scopus 로고    scopus 로고
    • The role of NF-kappaB, IRF-1, and STAT-1alpha transcription factors in the iNOS gene induction by gliadin and IFN-gamma in RAW 264
    • De Stefano, D., Maiuri, M.C., Iovine, B., Ialenti, A., Bevilacqua, M.A. & Carnuccio, R. (2006). The role of NF-kappaB, IRF-1, and STAT-1alpha transcription factors in the iNOS gene induction by gliadin and IFN-gamma in RAW 264.7 macrophages. J Mol Med, 84, 65-74.
    • (2006) 7 macrophages. J Mol Med , vol.84 , pp. 65-74
    • De Stefano, D.1    Maiuri, M.C.2    Iovine, B.3    Ialenti, A.4    Bevilacqua, M.A.5    Carnuccio, R.6
  • 13
    • 33645118120 scopus 로고    scopus 로고
    • Epithelium derived interleukin 15 regulates intraepithelial lymphocyte Th1 cytokine production, cytotoxicity, and survival in coeliac disease
    • Di Sabatino, A., Ciccocioppo, R., Cupelli, F., Cinque, B., Millimaggi,. D, Clarkson, M.M., Paulli, M., Cifone, M.G. & Corazza, G.R. (2006). Epithelium derived interleukin 15 regulates intraepithelial lymphocyte Th1 cytokine production, cytotoxicity, and survival in coeliac disease. Gut, 55, 469-77.
    • (2006) Gut , vol.55 , pp. 469-477
    • Di Sabatino, A.1    Ciccocioppo, R.2    Cupelli, F.3    Cinque, B.4    Millimaggi, D.5    Clarkson, M.M.6    Paulli, M.7    Cifone, M.G.8    Corazza, G.R.9
  • 15
    • 27144489109 scopus 로고    scopus 로고
    • Mechanisms of disease: the role of intestinal barrier function in the pathogenesis of gastrointestinal autoimmune diseases
    • Fasano, A. & Shea-Donohue, T. (2005). Mechanisms of disease: the role of intestinal barrier function in the pathogenesis of gastrointestinal autoimmune diseases. Nat Clin Pract Gastroenterol Hepatol., 2, 416-22.
    • (2005) Nat Clin Pract Gastroenterol Hepatol , vol.2 , pp. 416-422
    • Fasano, A.1    Shea-Donohue, T.2
  • 16
    • 38349049462 scopus 로고    scopus 로고
    • Polysaccharide utilization by gut bacteria: potential for new insights from genomic analysis
    • Flint, H.J., Bayer, E.A. & Rincon, M. T. (2008). Polysaccharide utilization by gut bacteria: potential for new insights from genomic analysis, Nat Rev Microbiol., 2, 121-131.
    • (2008) Nat Rev Microbiol , vol.2 , pp. 121-131
    • Flint, H.J.1    Bayer, E.A.2    Rincon, M.T.3
  • 18
    • 23044444093 scopus 로고    scopus 로고
    • The role of gut-associated lymphoid tissues and mucosal defence
    • Forchielli, M.L.& Walker, W.A. (2005). The role of gut-associated lymphoid tissues and mucosal defence. Br J Nutr., 93, 41-8
    • (2005) Br J Nutr , vol.93 , pp. 41-48
    • Forchielli, M.L.1    Walker, W.A.2
  • 21
    • 22044446842 scopus 로고    scopus 로고
    • Adaptive and innate immune responses in celiac disease
    • Gianfrani, C., Auricchio, S. & Troncone, R. (2005). Adaptive and innate immune responses in celiac disease. Immunol Lett., 99, 141-5.
    • (2005) Immunol Lett , vol.99 , pp. 141-145
    • Gianfrani, C.1    Auricchio, S.2    Troncone, R.3
  • 22
    • 33750956239 scopus 로고    scopus 로고
    • Differences between tissue-associated intestinal microfloras of patients with Crohn's disease and ulcerative colitis
    • Gophna, U., Sommerfeld, K., Gophna, S., Doolittle, W.F. & Veldhuyzen van Zanten, S.J. (2006). Differences between tissue-associated intestinal microfloras of patients with Crohn's disease and ulcerative colitis. J Clin Microbiol., 44, 4136-41.
    • (2006) J Clin Microbiol , vol.44 , pp. 4136-4141
    • Gophna, U.1    Sommerfeld, K.2    Gophna, S.3    Doolittle, W.F.4    Veldhuyzen van Zanten, S.J.5
  • 24
    • 32944469754 scopus 로고    scopus 로고
    • Celiac disease
    • Green, P.H. & Jabri, B. (2006) Celiac disease. Annu Rev Med., 57, 207-21.
    • (2006) Annu Rev Med , vol.57 , pp. 207-221
    • Green, P.H.1    Jabri, B.2
  • 26
    • 0025264318 scopus 로고
    • Effects of six different cytokines on lymphocyte adherence to microvascular endothelium and in vivo lymphocyte migration in the rat
    • Issekutz, T.B. (1990). Effects of six different cytokines on lymphocyte adherence to microvascular endothelium and in vivo lymphocyte migration in the rat. J Immunol. 144, 2140-6.
    • (1990) J Immunol , vol.144 , pp. 2140-2146
    • Issekutz, T.B.1
  • 29
    • 3343010394 scopus 로고    scopus 로고
    • Gliadin stimulates human monocytes to production of IL-8 and TNF-alpha through a mechanism involving NF-kappaB
    • Jelínková, L., Tucková, L., Cinová, J., Flegelová, Z. & Tlaskalová-Hogenová, H. (2004). Gliadin stimulates human monocytes to production of IL-8 and TNF-alpha through a mechanism involving NF-kappaB. FEBS Lett. 571, 81-5.
    • (2004) FEBS Lett , vol.571 , pp. 81-85
    • Jelínková, L.1    Tucková, L.2    Cinová, J.3    Flegelová, Z.4    Tlaskalová-Hogenová, H.5
  • 30
    • 16244372671 scopus 로고    scopus 로고
    • Overview and pathogenesis of celiac disease
    • Kagnoff, M.F (2005) Overview and pathogenesis of celiac disease. Gastroenterology 128, S10-8.
    • (2005) Gastroenterology , vol.128
    • Kagnoff, M.F.1
  • 31
    • 34047116237 scopus 로고    scopus 로고
    • Probiotics during the first 7 years of life: a cumulative risk reduction of eczema in a randomized, placebo-controlled trial
    • Kalliomaki, M., Salminen, S., Poussa, T. & Isolauri, E. (2007). Probiotics during the first 7 years of life: a cumulative risk reduction of eczema in a randomized, placebo-controlled trial. J Allergy Clin Immunol., 119, 1019-21.
    • (2007) J Allergy Clin Immunol , vol.119 , pp. 1019-1021
    • Kalliomaki, M.1    Salminen, S.2    Poussa, T.3    Isolauri, E.4
  • 32
    • 0347756655 scopus 로고    scopus 로고
    • Commensal anaerobic gut bacteria attenuate inflammation by regulating nuclear-cytoplasmic shuttling of PPAR-gamma and RelA
    • Kelly, D., Campbell, J.I. & King, T.P. (2004). Commensal anaerobic gut bacteria attenuate inflammation by regulating nuclear-cytoplasmic shuttling of PPAR-gamma and RelA. Nature Immunology, 5, 1, 104-112.
    • (2004) Nature Immunology , vol.5 , pp. 104-112
    • Kelly, D.1    Campbell, J.I.2    King, T.P.3
  • 33
    • 0036298165 scopus 로고    scopus 로고
    • Aberrant composition of gut microbiota of allergic infants: a target of bidfidobacterial therapy at weaning?
    • Kirjavainen, P.V., Arvola, T., Salminen, S.J., & Isolauri, E. (2002).Aberrant composition of gut microbiota of allergic infants: a target of bidfidobacterial therapy at weaning? Gut, 51, 51-5.
    • (2002) Gut , vol.51 , pp. 51-55
    • Kirjavainen, P.V.1    Arvola, T.2    Salminen, S.J.3    Isolauri, E.4
  • 34
    • 34247500287 scopus 로고    scopus 로고
    • High prevalence of Escherichia coli belonging to the B2+D phylogenetic group in inflammatory bowel disease
    • Kotlowski, R., Bernstein, C.N., Sepehri, S. & Krause, D.O. (2007). High prevalence of Escherichia coli belonging to the B2+D phylogenetic group in inflammatory bowel disease. Gut, 56, 669-75.
    • (2007) Gut , vol.56 , pp. 669-675
    • Kotlowski, R.1    Bernstein, C.N.2    Sepehri, S.3    Krause, D.O.4
  • 36
    • 34548656855 scopus 로고    scopus 로고
    • Signaling pathways downstream of pattern-recognition receptors and their cross talk
    • Lee, M.S. & Kim, Y.J. (2007). Signaling pathways downstream of pattern-recognition receptors and their cross talk. Annu Rev Biochem, 76, 447-80.
    • (2007) Annu Rev Biochem , vol.76 , pp. 447-480
    • Lee, M.S.1    Kim, Y.J.2
  • 37
    • 43349099918 scopus 로고    scopus 로고
    • Live probiotic Bifidobacterium lactis bacteria inhibit the toxic effects induced by wheat gliadin in epithelial cell culture
    • Lindfors, K., Blomqvist, T., Juuti-Uusitalo, K., Stenman, S., Venäläinen, J., Mäki, M. & Kaukinen, K. (2008). Live probiotic Bifidobacterium lactis bacteria inhibit the toxic effects induced by wheat gliadin in epithelial cell culture. Clin Exp Immunol. 152, 552-8.
    • (2008) Clin Exp Immunol , vol.152 , pp. 552-558
    • Lindfors, K.1    Blomqvist, T.2    Juuti-Uusitalo, K.3    Stenman, S.4    Venäläinen, J.5    Mäki, M.6    Kaukinen, K.7
  • 38
    • 0041663833 scopus 로고    scopus 로고
    • Oral administration of probiotic Escherichia coli after birth reduces frequency of allergies and repeated infections later in life (after 10 and 20 years)
    • Lodinová-Zádníková, R., Cukrowska, B. & Tlaskalova-Hogenova, H. (2003). Oral administration of probiotic Escherichia coli after birth reduces frequency of allergies and repeated infections later in life (after 10 and 20 years). Int Arch Allergy Immunol., 131, 209-11.
    • (2003) Int Arch Allergy Immunol , vol.131 , pp. 209-211
    • Lodinová-Zádníková, R.1    Cukrowska, B.2    Tlaskalova-Hogenova, H.3
  • 39
    • 1542618118 scopus 로고    scopus 로고
    • Induction of protective IgA by intestinal dendritic cells carrying commensal bacteria
    • Macpherson, A.J. & Uhr, T. (2004) Induction of protective IgA by intestinal dendritic cells carrying commensal bacteria. Science, 303, 1662-5.
    • (2004) Science , vol.303 , pp. 1662-1665
    • Macpherson, A.J.1    Uhr, T.2
  • 40
    • 22144490199 scopus 로고    scopus 로고
    • An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune system
    • Mazmanian, S.K., Liu, C.H., Tzianabos, A.O. & Kasper, D.L. (2005) An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune system. Cell, 122, 107-18.
    • (2005) Cell , vol.122 , pp. 107-118
    • Mazmanian, S.K.1    Liu, C.H.2    Tzianabos, A.O.3    Kasper, D.L.4
  • 42
    • 36049010630 scopus 로고    scopus 로고
    • Differential immunomodulatory properties of Bifidobacterium longum strains: relevance to probiotic selection and clinical applications
    • Medina, M., Izquierdo, E., Ennahar, S. & Sanz, Y. (2007). Differential immunomodulatory properties of Bifidobacterium longum strains: relevance to probiotic selection and clinical applications. Clin Exp Immunol., 150, 531-8.
    • (2007) Clin Exp Immunol , vol.150 , pp. 531-538
    • Medina, M.1    Izquierdo, E.2    Ennahar, S.3    Sanz, Y.4
  • 43
    • 60349109220 scopus 로고    scopus 로고
    • Bifidobacterium strains suppress in vitro the pro-inflammatory milieu triggered by the large intestinal microbiota of coeliac patients
    • Medina, M., De Palma, G., Ribes-Koninckx, C., Calabuig, M. & Sanz, Y. (2008). Bifidobacterium strains suppress in vitro the pro-inflammatory milieu triggered by the large intestinal microbiota of coeliac patients. J Inflamm. 3; 5:19.
    • (2008) J Inflamm. 3; , vol.5 , pp. 19
    • Medina, M.1    De Palma, G.2    Ribes-Koninckx, C.3    Calabuig, M.4    Sanz, Y.5
  • 44
    • 26844442270 scopus 로고    scopus 로고
    • Binding of intimin with Tir on the bacterial surface is prerequisite for the barrier disruption induced by enteropathogenic Escherichia coli
    • Miyake, M., Hanajima, M., Matsuzawa, T., Kobayashi, C., Minami, M., Abe, A. & Horiguchi, Y. (2005). Binding of intimin with Tir on the bacterial surface is prerequisite for the barrier disruption induced by enteropathogenic Escherichia coli. Biochem Biophys Res Commun. 337, 922-7.
    • (2005) Biochem Biophys Res Commun , vol.337 , pp. 922-927
    • Miyake, M.1    Hanajima, M.2    Matsuzawa, T.3    Kobayashi, C.4    Minami, M.5    Abe, A.6    Horiguchi, Y.7
  • 45
    • 31844439924 scopus 로고    scopus 로고
    • Most probable origin of coeliac disease is low immune globulin A in the intestine caused by malfunction of Peyer's patches
    • Mulder, S.J, & Mulder-Bos, G.C. (2006). Most probable origin of coeliac disease is low immune globulin A in the intestine caused by malfunction of Peyer's patches. Med Hypotheses. 66, 757-62.
    • (2006) Med Hypotheses , vol.66 , pp. 757-762
    • Mulder, S.J.1    Mulder-Bos, G.C.2
  • 46
    • 37249066238 scopus 로고    scopus 로고
    • Imbalance in the composition of the duodenal microbiota of children with coeliac disease
    • Nadal, I., Donat, E., Ribes-Koninckx, C., Calabuig, M. & Sanz, Y. (2007). Imbalance in the composition of the duodenal microbiota of children with coeliac disease. J Med Microbiol. 56, 669-74.
    • (2007) J Med Microbiol , vol.56 , pp. 669-674
    • Nadal, I.1    Donat, E.2    Ribes-Koninckx, C.3    Calabuig, M.4    Sanz, Y.5
  • 47
  • 48
    • 0029995799 scopus 로고    scopus 로고
    • Experimental granulomatous colitis in mice is abrogated by induction of TGF-betamediated oral tolerance
    • Neurath, M.F., Fuss, I., Kelsall, B.L., Presky, D.H., Waegell, W. & Strober, W. (1996). Experimental granulomatous colitis in mice is abrogated by induction of TGF-betamediated oral tolerance. J Exp Med. 183, 2605-16.
    • (1996) J Exp Med , vol.183 , pp. 2605-2616
    • Neurath, M.F.1    Fuss, I.2    Kelsall, B.L.3    Presky, D.H.4    Waegell, W.5    Strober, W.6
  • 50
    • 1842583729 scopus 로고    scopus 로고
    • Mechanisms of cross hyporesponsiveness to Toll-like receptor bacterial ligands in intestinal epithelial cells
    • Otte, J.M., Cario, E. & Podolsky, D.K. (2004). Mechanisms of cross hyporesponsiveness to Toll-like receptor bacterial ligands in intestinal epithelial cells. Gastroenterology, 126, 1054-1070.
    • (2004) Gastroenterology , vol.126 , pp. 1054-1070
    • Otte, J.M.1    Cario, E.2    Podolsky, D.K.3
  • 53
    • 16244415500 scopus 로고    scopus 로고
    • Epidemiology of coeliac disease: what are the prevalence, incidence, and progression of coeliac disease?
    • Rewers, M. (2005). Epidemiology of coeliac disease: what are the prevalence, incidence, and progression of coeliac disease? Gastroenterology. 128, S47-51.
    • (2005) Gastroenterology , vol.128
    • Rewers, M.1
  • 54
    • 64749090219 scopus 로고    scopus 로고
    • Prevalence of Small Intestine Bacterial Overgrowth Diagnosed by Quantitative Culture of Intestinal Aspirate in Celiac Disease
    • Rubio-Tapia, A., Barton, S.H., Rosenblatt, J.E. & Murray, J.A. (2009). Prevalence of Small Intestine Bacterial Overgrowth Diagnosed by Quantitative Culture of Intestinal Aspirate in Celiac Disease. J Clin Gastroenterol. 43, 157-61.
    • (2009) J Clin Gastroenterol , vol.43 , pp. 157-161
    • Rubio-Tapia, A.1    Barton, S.H.2    Rosenblatt, J.E.3    Murray, J.A.4
  • 57
    • 58149508814 scopus 로고    scopus 로고
    • Reduced diversity and increased virulence-gene carriage in intestinal enterobacteria of coeliac children
    • Sánchez, E., Nadal, I., Donat, E., Ribes-Koninckx, C., Calabuig, M. & Sanz Y. (2008). Reduced diversity and increased virulence-gene carriage in intestinal enterobacteria of coeliac children. BMC Gastroenterol. 4; 8:50.
    • (2008) BMC Gastroenterol , vol.4 , Issue.8 , pp. 50
    • Sánchez, E.1    Nadal, I.2    Donat, E.3    Ribes-Koninckx, C.4    Calabuig, M.5    Sanz, Y.6
  • 58
    • 35948957475 scopus 로고    scopus 로고
    • Differences in faecal bacterial communities in coeliac and healthy children as detected by PCR and denaturing gradient gel electrophoresis
    • Sanz, Y., Sánchez, E., Marzotto, M., Calabuig, M., Torriani, S. & Dellaglio, F. (2007a). Differences in faecal bacterial communities in coeliac and healthy children as detected by PCR and denaturing gradient gel electrophoresis. FEMS Immunol Med Microbiol., 51, 562-8.
    • (2007) FEMS Immunol Med Microbiol , vol.51 , pp. 562-568
    • Sanz, Y.1    Sánchez, E.2    Marzotto, M.3    Calabuig, M.4    Torriani, S.5    Dellaglio, F.6
  • 61
    • 38649115342 scopus 로고    scopus 로고
    • Microbial influences in inflammatory bowel diseases
    • Sartor, R.B. (2008). Microbial influences in inflammatory bowel diseases. Gastroenterol., 134, 577-94.
    • (2008) Gastroenterol , vol.134 , pp. 577-594
    • Sartor, R.B.1
  • 62
    • 65349175633 scopus 로고    scopus 로고
    • Novel perspectives in celiac disease therapy
    • Sanz Y. (2009). Novel perspectives in celiac disease therapy. Mini Rev Med Chem. 9, 359-67.
    • (2009) Mini Rev Med Chem , vol.9 , pp. 359-367
    • Sanz, Y.1
  • 64
    • 42049098409 scopus 로고    scopus 로고
    • Probiotics ameliorate the hydrogen peroxide-induced epithelial barrier disruption by a PKC- and MAP kinase-dependent mechanism
    • Seth, A., Yan, F., Polk, D.B. & Rao, R.K. (2008). Probiotics ameliorate the hydrogen peroxide-induced epithelial barrier disruption by a PKC- and MAP kinase-dependent mechanism. Am J Physiol Gastrointest Liver Physiol., 294, G1060-9.
    • (2008) Am J Physiol Gastrointest Liver Physiol , vol.294
    • Seth, A.1    Yan, F.2    Polk, D.B.3    Rao, R.K.4
  • 66
    • 38749143294 scopus 로고    scopus 로고
    • Transglutaminase and the pathogenesis of coeliac disease
    • Stenberg, P., Roth, E.B. & Sjöberg, K. (2008). Transglutaminase and the pathogenesis of coeliac disease. Eur. J. Intern. Med., 19, 83-91.
    • (2008) Eur. J. Intern. Med. , vol.19 , pp. 83-91
    • Stenberg, P.1    Roth, E.B.2    Sjöberg, K.3
  • 73
    • 33745493934 scopus 로고    scopus 로고
    • Recent advances in coeliac disease
    • Van Heel D.A.& West, J. (2006). Recent advances in coeliac disease. Gut. 55, 1037-46.
    • (2006) Gut , vol.55 , pp. 1037-1046
    • Van Heel, D.A.1    West, J.2
  • 74
    • 34547672619 scopus 로고    scopus 로고
    • Intestinal epithelial cell signalling and chronic inflammation: From the proteome to specific molecular mechanisms
    • Werner, T. & Haller, D. (2007). Intestinal epithelial cell signalling and chronic inflammation: From the proteome to specific molecular mechanisms. Mutation Research., 622, 42-57.
    • (2007) Mutation Research , vol.622 , pp. 42-57
    • Werner, T.1    Haller, D.2
  • 75
    • 4644305046 scopus 로고    scopus 로고
    • Bacteroides fragilis enterotoxin induces intestinal epithelial cell secretion of interleukin8 through mitogen-activated protein kinases and a tyrosine kinase-regulated nuclear factor-kappaB pathway
    • Wu, S., Powell, J., Mathioudakis, N., Kane, S., Fernandez, E. & Sears, C.L. (2004). Bacteroides fragilis enterotoxin induces intestinal epithelial cell secretion of interleukin8 through mitogen-activated protein kinases and a tyrosine kinase-regulated nuclear factor-kappaB pathway. Infect Immun. 72, 5832-9.
    • (2004) Infect Immun , vol.72 , pp. 5832-5839
    • Wu, S.1    Powell, J.2    Mathioudakis, N.3    Kane, S.4    Fernandez, E.5    Sears, C.L.6
  • 76
    • 33748050136 scopus 로고    scopus 로고
    • The Bacteroides fragilis toxin binds to a specific intestinal epithelial cell receptor
    • Wu, S., Shin, J., Zhang, G., Cohen, M., Franco, A. & Sears, C.L. (2006). The Bacteroides fragilis toxin binds to a specific intestinal epithelial cell receptor. Infect Immun. 74, 5382-90.
    • (2006) Infect Immun , vol.74 , pp. 5382-5390
    • Wu, S.1    Shin, J.2    Zhang, G.3    Cohen, M.4    Franco, A.5    Sears, C.L.6
  • 78
    • 52149114013 scopus 로고    scopus 로고
    • Clinical trial: effect of active lactic acid bacteria on mucosal barrier function in patients with diarrheapredominant irritable bowel syndrome
    • Jul 30. [Epub ahead of print]
    • Zeng, J., Li, Y.Q., Zuo, X.L., Zhen, Y.B., Yang, J., Liu, C.H. (2008). Clinical trial: effect of active lactic acid bacteria on mucosal barrier function in patients with diarrheapredominant irritable bowel syndrome. Aliment Pharmacol Ther. Jul 30. [Epub ahead of print]
    • (2008) Aliment Pharmacol Ther
    • Zeng, J.1    Li, Y.Q.2    Zuo, X.L.3    Zhen, Y.B.4    Yang, J.5    Liu, C.H.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.