Transcriptional repression of tumor suppressor CDC73, encoding an RNA polymerase II interactor, by Wilms Tumor 1 protein (WT1) promotes cell proliferation:Implication for cancer therapeutics

Journal of Biological Chemistry

Volumn 289, Issue 2, 2014, Pages 968-976

  Rather, Mohammad Iqbal ^a   Swamy, Shivananda ^b   Gopinath, Kodaganur S ^b   Kumar, Arun ^a  

^a INDIAN INSTITUTE OF SCIENCE   (India)

^b HCG Bangalore Institute of Oncology   (India)

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROLIFERATION; FUNCTIONAL POLYMERS; SIGNAL ENCODING;

CANCER THERAPEUTICS; DOWN-REGULATION; NEOPLASTIC TRANSFORMATION; RNA POLYMERASE II; TRANSCRIPTIONAL REPRESSION; TUMOR SUPPRESSORS; UP-REGULATION; WILMS TUMORS;

TUMORS;

AZACITIDINE; CELL CYCLE PROTEIN 37; RNA POLYMERASE II; WT1 PROTEIN;

APOPTOSIS; ARTICLE; BIOINFORMATICS; CARCINOGENICITY; CDC73 GENE; CELL PROLIFERATION; CONTROLLED STUDY; CORRELATION ANALYSIS; DOWN REGULATION; EMBRYO; GENE CONTROL; GENE EXPRESSION REGULATION; GENE REPRESSION; HUMAN; HUMAN CELL; MOUTH SQUAMOUS CELL CARCINOMA; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN ANALYSIS; PROTEIN DNA BINDING; PROTEIN TARGETING; RECEPTOR BINDING; TUMOR SUPPRESSOR GENE; UPREGULATION;

APOPTOSIS; CANCER PREVENTION; CDC73; HRPT2; ONCOGENE; OSCC; PARAFIBROMIN; TRANSCRIPTION PROMOTER; TUMOR SUPPRESSOR GENE; WT1;

ADULT; AGED; BASE SEQUENCE; BLOTTING, WESTERN; CARCINOMA, SQUAMOUS CELL; CELL LINE, TUMOR; CELL PROLIFERATION; DNA METHYLATION; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HEK293 CELLS; HUMANS; MALE; MIDDLE AGED; MOLECULAR SEQUENCE DATA; MOUTH NEOPLASMS; MUTATION; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SEQUENCE HOMOLOGY, NUCLEIC ACID; TUMOR SUPPRESSOR PROTEINS; WT1 PROTEINS;

EID: 84891961093     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.483255     Document Type: Article

References (34)

1. Carpten, J. D., Robbins, C. M., Villablanca, A., Forsberg, L., Presciuttini, S., Bailey-Wilson, J., Simonds, W. F., Gillanders, E. M., Kennedy, A. M., Chen, J. D., Agarwal, S. K., Sood, R., Jones, M. P., Moses, T. Y., Haven, C., Petillo, D., Leotlela, P. D., Harding, B., Cameron, D., Pannett, A. A., Höög, A., Heath, H., 3rd, James-Newton, L. A., Robinson, B., Zarbo, R. J., Cavaco, B. M., Wassif, W., Perrier, N. D., Rosen, I. B., Kristoffersson, U., Turnpenny, P. D., Farnebo, L. O., Besser, G. M., Jackson, C. E., Morreau, H., Trent, J. M., Thakker, R. V., Marx, S. J., Teh, B. T., Larsson, C., and Hobbs, M. R. (2002) HRPT2, encoding parafibromin, is mutated in hyperparathyroidism-jaw tumour syndrome. Nat. Genet. 32, 676-680
2. Cetani, F., Pardi, E., Borsari, S., Viacava, P., Dipollina, G., Cianferotti, L., Ambrogini, E., Gazzerro, E., Colussi, G., Berti, P., Miccoli, P., Pinchera, A., and Marcocci, C. (2004) Genetic analyses of the HRPT2 gene in primary hyperparathyroidism: germ line and somatic mutations in familial and sporadic parathyroid tumors. J. Clin. Endocrinol. Metab. 89, 5583-5591
3. Krogan, N. J., Dover, J., Wood, A., Schneider, J., Heidt, J., Boateng, M. A., Dean, K., Ryan, O. W., Golshani, A., Johnston, M., Greenblatt, J. F., and Shilatifard, A. (2003) The Paf1 complex is required for histone H3 methylation by COMPASS and Dot1p: linking transcriptional elongation to histone methylation. Mol. Cell 11, 721-729
4. Wood, A., Krogan, N. J., Dover, J., Schneider, J., Heidt, J., Boateng, M. A., Dean, K., Golshani, A., Zhang, Y., Greenblatt, J. F., Johnston, M., and Shilatifard, A. (2003) Bre1, an E3 ubiquitin ligase required for recruitment and substrate selection of Rad6 at a promoter. Mol. Cell 11, 267-274
5. Rozenblatt-Rosen, O., Hughes, C. M., Nannepaga, S. J., Shanmugam, K. S., Copeland, T. D., Guszczynski, T., Resau, J. H., and Meyerson, M. (2005) The parafibromin tumour suppressor protein is part of a human Paf1 complex. Mol. Cell. Biol. 25, 612-620
6. Yart, A., Gstaiger, M., Wirbelauer, C., Pecnik, M., Anastasiou, D., Hess, D., and Krek, W. (2005) The HRPT2 tumour suppressor gene product parafibromin associates with human PAF1 and RNA polymerase II. Mol. Cell. Biol. 25, 5052-5060
7. Zhang, C., Kong, D., Tan, M. H., Pappas, D. L., Jr., Wang, P. F., Chen, J., Farber, L., Zhang, N., Koo, H. M., Weinreich, M., Williams, B. O., and Teh, B. T. (2006) Parafibromin inhibits cancer cell growth and causes G1 phase arrest. Biochem. Biophys. Res. Commun. 350, 17-24
8. Selvarajan, S., Sii, L. H., Lee, A., Yip, G., Bay, B. H., Tan, M. H., Teh, B. T., and Tan, P. H. (2008) Parafibromin expression in breast cancer: a novel marker for prognostication? J. Clin. Pathol. 61, 64-67
9. Zheng, H. C., Takahashi, H., Li, X. H., Hara, T., Masuda, S., Guan, Y. F., and Takano, Y. (2008) Down-regulated parafibromin expression is a promising marker for pathogenesis, invasion, metastasis and prognosis of gastric carcinomas. Virchows Arch. 452, 147-155
10. James, R. G., Biechele, T. L., Conrad, W. H., Camp, N. D., Fass, D. M., Major, M. B., Sommer, K., Yi, X., Roberts, B. S., Cleary, M. A., Arthur, W. T., MacCoss, M., Rawlings, D. J., Haggarty, S. J., and Moon, R.T. (2009) Bruton's tyrosine kinase revealed as a negative regulator of Wnt-catenin signaling. Sci. Signal. 2, ra25
11. Shattuck, T. M., Välimäki, S., Obara, T., Gaz, R. D., Clark, O. H., Shoback, D., Wierman, M. E., Tojo, K., Robbins, C. M., Carpten, J. D., Farnebo, L. O., Larsson, C., and Arnold, A. (2003) Somatic and germ-line mutations of the HRPT2 gene in sporadic parathyroid carcinoma. N. Engl. J. Med. 349, 1722-1729
12. Hewitt, K. M., Sharma, P. K., Samowitz, W., and Hobbs, M. (2007) Aberrant methylation of the HRPT2 gene in parathyroid carcinoma. Ann. Otol. Rhinol. Laryngol. 116, 928-933
13. Hahn, M. A., Howell, V. M., Gill, A. J., Clarkson, A., Weaire-Buchanan, G., Robinson, B. G., Delbridge, L., Gimm, O., Schmitt, W. D., Teh, B. T., and Marsh, D. J. (2010) CDC73/HRPT2 CpG island hypermethylation and mutation of 5-untranslated sequence are uncommon mechanisms of silencing parafibromin in parathyroid tumors. Endocr. Relat. Cancer 17, 273-282
14. Rather, M. I., Nagashri, M. N., Swamy, S. S., Gopinath, K. S., and Kumar A. (2013) Oncogenic microRNA-155 down-regulates tumor suppressor CDC73 and promotes oral squamous cell carcinoma cell proliferation: implications for cancer therapeutics. J. Biol. Chem. 288, 608-618
15. Sobin, L. H., and Fleming, I. D. (1997) TNM classification of malignant tumors, fifth edition. Cancer 80, 1803-1804
16. Zhao, F., Xuan, Z., Liu, L., and Zhang, M. Q. (2005) TRED: a transcriptional regulatory element database and a platform for in silico gene regulation studies. Nucleic Acids Res. 33, D103-D107
17. Livak, K. J., and Schmittgen, T. D. (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2CT method. Methods 25, 402-408.
18. Chakraborty, S., Mohiyuddin, S. M., Gopinath, K. S., and Kumar, A. (2008) Involvement of TSC genes and differential expression of other members of the mTOR signaling pathway in oral squamous cell carcinoma. BMC Cancer 8, 163
19. Satoh, Y., Nakagawachi, T., Nakadate, H., Kaneko, Y., Masaki, Z., Mukai, T., and Soejima, H. (2003) Significant reduction of WT1 gene expression, possibly due to epigenetic alteration in Wilms' tumor. J. Biochem. 133, 303-308
20. Bajaj, V., Singhmar, P., and Kumar, A. (2008) Promoter characterization and regulation of expression of an imprinted gene SLC22A18AS. Gene 424, 40-47
21. Reddy, J. C., Hosono, S., and Licht, J. D. (1995) The transcriptional effect of WT1 is modulated by choice of expression vector. J. Biol. Chem. 270, 29976-29982
22. Han, Y., San-Marina, S., Liu, J., and Minden, M. D. (2004) Transcriptional activation of c-Myc proto-oncogene by WT1 protein. Oncogene 23, 6933-6941
23. Pannone, G., Bufo, P., Santoro, A., Franco, R., Aquino, G., Longo, F., Botti, G., Serpico, R., Cafarelli, B., Abbruzzese, A., Caraglia, M., Papagerakis, S., and Lo Muzio, L. (2010) WNT pathway in oral cancer: epigenetic inactivation of WNT inhibitors. Oncol. Rep. 24, 1035-1041
24. Yang, L., Han, Y., Saurez Saiz, F., and Minden, M. D. (2007) A tumor suppressor and oncogene: the WT1 story. Leukemia 21, 868-876
25. Oji, Y., Ogawa, H., Tamaki, H., Oka, Y., Tsuboi, A., Kim, E. H., Soma, T., Tatekawa, T., Kawakami, M., Asada, M., Kishimoto, T., and Sugiyama, H. (1999) Expression of the Wilms' tumor gene WT1 in solid tumors and its involvement in tumor cell growth. Jpn. J. Cancer Res. 90, 194-204
26. Osaka, M., Koami, K., and Sugiyama, T. (1997) WT1 contributes to leukemogenesis: expression patterns in 7,12-dimethylbenz[a]anthracene (DMBA)-induced leukemia. Int. J. Cancer 72, 696-699
27. Inoue, K., Tamaki, H., Ogawa, H., Oka, Y., Soma, T., Tatekawa, T., Oji, Y., Tsuboi, A., Kim, E. H., Kawakami, M., Akiyama, T., Kishimoto, T., and Sugiyama, H. (1998) Wilms' tumor gene (WT1) competes with differentiation- inducing signal in hematopoietic progenitor cells. Blood 91, 2969-2976
28. Loeb, D. M., Evron, E., Patel, C. B., Sharma, P. M., Niranjan, B., Buluwela, L., Weitzman, S. A., Korz, D., and Sukumar, S. (2001) Wilms' tumor suppressor gene (WT1) is expressed in primary breast tumors despite tumorspecific promoter methylation. Cancer Res. 61, 921-925
29. Mikami, T., Hada, T., Chosa, N., Ishisaki, A., Mizuki, H., and Takeda, Y. (2013) Expression of Wilms' tumor 1 (WT1) in oral squamous cell carcinoma. J. Oral Pathol. Med. 42, 133-139
30. Yamagami, T., Sugiyama, H., Inoue, K., Ogawa, H., Tatekawa, T., Hirata, M., Kudoh, T., Akiyama, T., Murakami, A., and Maekawa, T. (1996) Growth inhibition of human leukemic cells by WT1 (Wilms' tumor gene) antisense oligodeoxynucleotides: implications for the involvement of WT1 in leukemogenesis. Blood 87, 2878-2884
31. Tsuboi, A., Oka, Y., Ogawa, H., Elisseeva, O. A., Tamaki, H., Oji Y., Kim, E. H., Soma, T., Tatekawa, T., Kawakami, M., Kishimoto, T., and Sugiyama, H. (1999) Constitutive expression of the Wilms' tumor gene WT1 inhibits the differentiation of myeloid progenitor cells but promotes their proliferation in response to granulocyte-colony stimulating factor (G-CSF). Leuk. Res. 23, 499-505
32. Oka, Y., Elisseeva, O. A., Tsuboi, A., Ogawa, H., Tamaki, H., Li, H., Oji, Y., Kim, E. H., Soma, T., Asada, M., Ueda, K., Maruya, E., Saji, H., Kishimoto, T., Udaka, K., and Sugiyama, H. (2000) Human cytotoxic T-lymphocyte responses specific for peptides of the wild-type Wilms' tumor gene (WT1) product. Immunogenetics 51, 99-107
33. Oka, Y., Tsuboi, A., Taguchi, T., Osaki, T., Kyo, T., Nakajima, H., Elisseeva, O. A., Oji, Y., Kawakami, M., Ikegame, K., Hosen, N., Yoshihara, S., Wu, F., Fujiki, F., Murakami, M., Masuda, T., Nishida, S., Shirakata, T., Nakatsuka, S., Sasaki, A., Udaka, K., Dohy, H., Aozasa, K., Noguchi, S., Kawase, I., and Sugiyama, H. (2004) Induction of WT1 (Wilms' tumor gene)-specific cytotoxic T lymphocytes by WT1 peptide vaccine and the resultant cancer regression. Proc. Natl. Acad. Sci. U.S.A. 101, 13885-13890
34. Mayo, M. W., Wang, C. Y., Drouin, S. S., Madrid, L. V., Marshall, A. F., Reed, J. C., Weissman, B. E., and Baldwin, A. S. (1999) WT1 modulates apoptosis by transcriptionally up-regulating the bcl-2 proto-oncogene. EMBO J. 18, 3990-4003