Significant reduction of WT1 gene expression, possibly due to epigenetic alteration in Wilms' tumor

Journal of Biochemistry

Volumn 133, Issue 3, 2003, Pages 303-308

  Satoh, Yuji ^a   Nakagawachi, Tetsuji ^a   Nakadate, Hisaya ^b   Kaneko, Yasuhiko ^c   Masaki, Zenjiro ^a   Mukai, Tsunehiro ^a   Soejima, Hidenobu ^a  

^a SAGA UNIVERSITY   (Japan)

^b KITASATO UNIVERSITY HOSPITAL   (Japan)

^c SAITAMA CANCER CENTER   (Japan)

Author keywords

Epigenetics; Gene expression; Promoter methylation; Wilms' tumor; WT1

Indexed keywords

ARTICLE; CHROMOSOME 11P; GENE ACTIVITY; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE MUTATION; GENE SILENCING; HETEROZYGOSITY LOSS; HUMAN; METHYLATION; NEPHROBLASTOMA; REPORTER GENE; TUMOR SUPPRESSOR GENE; WT1 GENE;

BASE SEQUENCE; EPIGENESIS, GENETIC; FETUS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; KIDNEY NEOPLASMS; MOLECULAR SEQUENCE DATA; MUTATION; WILMS TUMOR; WT1 PROTEINS;

EID: 0037367539     PISSN: 0021924X     EISSN: None     Source Type: Journal    
DOI: 10.1093/jb/mvg041     Document Type: Article

References (35)

1. Call, K.M., Glaser, T., Ito, C.Y., Buckler, A.J., Pelletier, J., Haber, D.A., Rose, E.A., Kral, A., Yeger, H., and Lewis, W.H. (1990) Complete physical map of the WAGR region of 11p13 localizes a candidate Wilms' tumor gene. Cell 60, 509-520
2. Gessler, M., Poustka, A., Cavenee, W., Neve, R.L., Orkin, S.H., and Bruns, G.A. (1990) Homozygous deletion in Wilms' tumours of a zinc-finger gene identified by chromosome jumping. Nature 343, 774-778
3. Kreidberg, J.A., Sariola, H., Loring, J.M., Maeda, M., Pelletier, J., Housman, D., and Jaenisch, R. (1993) WT-1 is required for early kidney development. Cell 74, 679-691
4. Glaser, T., Lane, J., and Housman, D. (1990) A mouse model of the aniridia-Wilms tumor deletion syndrome. Science 250, 823-827
5. Guo, J.K., Menke, A.L., Gubler, M.C., Clarke, A.R., Harrison, D., Hammes, A., Hastie, N.D., and Schedl, A. (2002) WT1 is a key regulator of podocyte function: reduced expression levels cause crescentic glomerulonephritis and mesangial sclerosis. Hum. Mol. Genet. 11, 651-659
6. Moore, A.W., McInnes, L., Kreidberg, J., Hastie, N.D., and Schedl, A. (1998) YAC complementation shows a requirement for Wtl in the development of epicardium, adrenal gland and throughout nephrogenesis. Development 126, 1845-1857
7. Pritchard-Jones, K., Fleming, S., Davidson, D., Bickmore, W., Porteous, D., Gosden, C., Bard, J., Buckler, A., Pelletier, J., Housman, D., vanHeyningen, V., and Hastie, N. (1990) The candidate Wilms' tumour gene is involved in genitourinary development. Nature 346, 194-197
8. Miwa, H., Tomlinson, G.E., Timmons, C.F., Huff, V., Cohn, S.L., Strong, L.C., and Saunders, G.F. (1992) RNA expression of the WT1 gene in Wilms' tumors in relation to histology. J. Natl Cancer Inst. 84, 181-187
9. Menke, A.L., van der Eb, A.J., and Jochemsen, A.G. (1998) The Wilms' tumor 1 gene: oncogene or tumor suppressor gene? Int. Rev. Cytol. 181, 151-212
10. Nakadate, H., Yokomori, K., Watanabe, N., Tsuchiya, T., Namiki, T., Kobayshi, H., Suita, S., Tsunematsu, Y., Horikoshi, Y., Hatae, Y., Endo, M., Komada, Y., Eguchi, H., Toyoda, Y., Kikuta, A., Kobayashi, R., and Kaneko Y. (2001) Mutations/deletions of the WT1 gene, loss of heterozygosity on chromosome arms 11p and 11q, chromosome ploidy and histology in Wilms' tumors in Japan. Int. J. Cancer 94, 396-400
11. Baylin, B. and Herman, J.G. (2000) DNA hypermethylation in tumorigenesis: epigenetics joins genetics. Trends Genet. 16, 168-174
12. Jones, P.A. and Laird, P.W. (1999) Cancer epigenetics comes of age. Nature Genet. 21, 163-167
13. Knudson, A.G. Jr. and Strong, L.C. (1972) Mutation and cancer: a model for Wilms' tumor of the kidney. J. Natl Cancer Inst. 48, 313-324
14. Maiti, S., Alam, R., Amos, C.I., and Huff, V. (2000) Frequent association of beta-catenin and WT1 mutations in Wilms' tumors. Cancer Res. 60, 6288-6292
15. Paulin, R., Grigg, G.W., Davey, M.W., and Piper, A.A. (1998) Urea improves efficiency of bisulphite-mediated sequencing of 5′-methylcytosine in genomic DNA. Nucleic Acids Res. 26, 5009-5010
16. Zhong, Q., Chen, C.F., Chen, P.L., and Lee, W.H. (2002) BRCA1 facilitates microhomology-mediated end joining of DNA double strand breaks. J. Biol. Chem. 277, 28641-28647
17. Fraizer, G.C., Wu, Y.J., Hewitt, S.M., Maity, T., Ton, C.C., Huff, V., and Saunders, G.F. (1994) Transcriptional regulation of the human Wilms' tumor gene (WT1). Cell type-specific enhancer and promiscuous promoter. J. Biol. Chem. 269, 8892-8900
18. Yeger, H., Cullinane, C., Flenniken, A., Chilton-MacNeil, S., Campbell, C., Huang, A., Bonetta, L., Coppes, M.J., Thorner, P., and Williams, B.R. (1992) Coordinate expression of Wilms' tumor genes correlates with Wilms' tumor phenotypes. Cell Growth Differ. 3, 855-864
19. Dao, D., Walsh, C.P., Yuan, L., Gorelov, D., Feng, L., Hensle, T., Nisen, P., Yamashiro, D.J., Bestor, T.H., and Tycko, B. (1999) Multipoint analysis of human chromosome 11p15/mouse distal chromosome 7: inclusion of H19/IGF2 in the minimal WT2 region, gene specificity of H19 silencing in Wilms' tumorigenesis and methylation hyper-dependence of H19 imprinting. Hum. Mol. Genet. 8, 1337-1352
20. Pritchard-Jones, K. and Fleming, S. (1991) Cell types expressing the Wilms' tumour gene (WT1) in Wilms' tumours: implications for tumour histogenesis. Oncogene. 6, 2211-2220
21. Hsieh, C.L. (1997) Stability of patch methylation and its impact in regions of transcriptional initiation and elongation. Mol. Cell. Biol. 17, 5897-5904
22. Pogribny, I.P., Pogribna, M., Christman, J.K., and James, S.J. (2000) Single-site methylation within the p53 promoter region reduces gene expression in a reporter gene construct: possible in vivo relevance during tumorigenesis. Cancer Res. 60, 588-594
23. Bearzatto, A., Szadkowski, M., Macpherson, P., Jiricny, J., and Karran, P. (2000) Epigenetic regulation of the MGMT and hMSH6 DNA repair genes in cells resistant to methylating agents. Cancer Res. 60, 3262-3270
24. Song, S.H., Jong, H.S., Choi, H.H., Inoue, H., Tanabe, T., Kim, N.K., and Bang, Y.J. (2001) Transcriptional silencing of Cyclooxygenase-2 by hyper-methylation of the 5′ CpG island in human gastric carcinoma cells. Cancer Res. 61, 4628-4635
25. Curradi, M., Izzo, A., Badaracco, G., and Landsberger, N. (2002) Molecular mechanisms of gene silencing mediated by DNA methylation. Mol. Cell Biol. 22, 3157-3173
26. Irvine, R.A., Lin, I.G., and Hsieh, C.L. (2002) DNA methylation has a local effect on transcription and histone acetylation. Mol. Cell Biol. 22, 6689-6696
27. Grubb, G.R., Yun, K., Reeve, A.E., and Eccles, M.R. (1995) Exclusion of the Wilms tumour gene (WT1) promoter as a site of frequent mutation in Wilms tumour. Oncogene 10, 1677-1681
28. Hewitt, S.M., Fraizer, G.C., and Saunders, G.F. (1995) Transcriptional silencer of the Wilms' tumor gene WT1 contains an Alu repeat. J. Biol. Chem. 270, 17908-17912
29. Englert, C. (1998) WT1 - more than a transcription factor? Trends Biochem. Sci. 23, 389-393
30. Scholz. H., Bossone, S.A., Cohen, H.T., Akella, U., Strauss, W.M., and Sukhatm, V.P. (1997) A far upstream cis-element is required for Wilms' tumor-1 (WT1) gene expression in renal cell culture. J. Biol. Chem. 272, 32836-32846
31. Loeb, D.M., Evron, E., Patel, C.B., Sharma, P.M., Niranjan, B., Buluwela, L., Weitzman, S.A., Korz, D., and Sukumar, S. (2001) Wilms' tumor suppressor gene (WT1) is expressed in primary breast tumors despite tumor-specific promoter methylation. Cancer Res. 61, 921-925
32. Mares, J., Kriz, V., Weinhausel, A., Vodickova, S., Kodet, R., Haas, O.A., Sedlacek, Z., and Goetz, P. (2001) Methylation changes in promoter and enhancer regions of the WT1 gene in Wilms' tumours. Cancer Lett. 166, 165-171
33. Hiltunen, M.O., Koistinaho, J., Alhonen, L., Myöhänen, S., Marin, S., Kosma, V.M., Pääkkönen, M., and Jänne, J. (1997) Hypermethylation of the WT1 and calcitonin gene promoter regions at chromosome 11p in human colorectal cancer. Br. J. Cancer 76, 1124-1130
34. Laux, D.E., Curran, E.M., Welshons, W.V., Lubahn, D.B., and Huang, T.H. (1999) Hypermethylation of the Wilms' tumor suppressor gene CpG island in human breast carcinomas. Breast Cancer Res. Treat. 56, 35-43
35. Pritchard-Jones, K. (1997) Molecular genetic pathways to Wilms tumor. Crit. Rev. Oncogene 8, 1-27