메뉴 건너뛰기




Volumn 91, Issue 2, 2014, Pages 300-314

A Francisella virulence factor catalyses an essential reaction of biotin synthesis

Author keywords

[No Author keywords available]

Indexed keywords

ASPARTIC ACID; BIOJ PROTEIN; BIOTIN; HISTIDINE; HYDROLASE; SERINE; UNCLASSIFIED DRUG; VIRULENCE FACTOR;

EID: 84891956554     PISSN: 0950382X     EISSN: 13652958     Source Type: Journal    
DOI: 10.1111/mmi.12460     Document Type: Article
Times cited : (53)

References (53)
  • 1
    • 84867903878 scopus 로고    scopus 로고
    • Structure of the enzyme-acyl carrier protein (ACP) substrate gatekeeper complex required for biotin synthesis
    • Agarwal, V., Lin, S., Lukk, T., Nair, S.K., and Cronan, J.E. (2012) Structure of the enzyme-acyl carrier protein (ACP) substrate gatekeeper complex required for biotin synthesis. Proc Natl Acad Sci USA 109: 17406-17411.
    • (2012) Proc Natl Acad Sci USA , vol.109 , pp. 17406-17411
    • Agarwal, V.1    Lin, S.2    Lukk, T.3    Nair, S.K.4    Cronan, J.E.5
  • 2
    • 59249084463 scopus 로고    scopus 로고
    • Glutathione provides a source of cysteine essential for intracellular multiplication of Francisella tularensis
    • Alkhuder, K., Meibom, K.L., Dubail, I., Dupuis, M., and Charbit, A. (2009) Glutathione provides a source of cysteine essential for intracellular multiplication of Francisella tularensis. PLoS Pathog 5: e1000284.
    • (2009) PLoS Pathog , vol.5
    • Alkhuder, K.1    Meibom, K.L.2    Dubail, I.3    Dupuis, M.4    Charbit, A.5
  • 3
    • 77955249234 scopus 로고    scopus 로고
    • Molecular complexity orchestrates modulation of phagosome biogenesis and escape to the cytosol of macrophages by Francisella tularensis
    • Asare, R., and Abu Kwaik, Y. (2010) Molecular complexity orchestrates modulation of phagosome biogenesis and escape to the cytosol of macrophages by Francisella tularensis. Environ Microbiol 12: 2559-2586.
    • (2010) Environ Microbiol , vol.12 , pp. 2559-2586
    • Asare, R.1    Abu Kwaik, Y.2
  • 4
    • 0036183336 scopus 로고    scopus 로고
    • Chemical and catalytic mechanisms of carboxyl transfer reactions in biotin-dependent enzymes
    • Attwood, P.V., and Wallace, J.C. (2002) Chemical and catalytic mechanisms of carboxyl transfer reactions in biotin-dependent enzymes. Acc Chem Res 35: 113-120.
    • (2002) Acc Chem Res , vol.35 , pp. 113-120
    • Attwood, P.V.1    Wallace, J.C.2
  • 5
    • 72049089849 scopus 로고    scopus 로고
    • The Francisella tularensis pathogenicity island encodes a secretion system that is required for phagosome escape and virulence
    • Barker, J.R., Chong, A., Wehrly, T.D., Yu, J.J., Rodriguez, S.A., Liu, J., etal. (2009) The Francisella tularensis pathogenicity island encodes a secretion system that is required for phagosome escape and virulence. Mol Microbiol 74: 1459-1470.
    • (2009) Mol Microbiol , vol.74 , pp. 1459-1470
    • Barker, J.R.1    Chong, A.2    Wehrly, T.D.3    Yu, J.J.4    Rodriguez, S.A.5    Liu, J.6
  • 6
    • 41449084503 scopus 로고    scopus 로고
    • Biotin sensing: universal influence of biotin status on transcription
    • Beckett, D. (2007) Biotin sensing: universal influence of biotin status on transcription. Annu Rev Genet 41: 443-464.
    • (2007) Annu Rev Genet , vol.41 , pp. 443-464
    • Beckett, D.1
  • 7
    • 58649116254 scopus 로고    scopus 로고
    • Biotin sensing at the molecular level
    • Beckett, D. (2009) Biotin sensing at the molecular level. J Nutr 139: 167-170.
    • (2009) J Nutr , vol.139 , pp. 167-170
    • Beckett, D.1
  • 9
    • 80053605687 scopus 로고    scopus 로고
    • Antimicrobial peptides important in innate immunity
    • Cederlund, A., Gudmundsson, G.H., and Agerberth, B. (2011) Antimicrobial peptides important in innate immunity. FEBS J 278: 3942-3951.
    • (2011) FEBS J , vol.278 , pp. 3942-3951
    • Cederlund, A.1    Gudmundsson, G.H.2    Agerberth, B.3
  • 10
    • 84879000118 scopus 로고    scopus 로고
    • Mechanisms of Francisella tularensis intracellular pathogenesis
    • Celli, J., and Zahrt, T.C. (2013) Mechanisms of Francisella tularensis intracellular pathogenesis. Cold Spring Harb Perspect Med 3: a010314.
    • (2013) Cold Spring Harb Perspect Med , vol.3
    • Celli, J.1    Zahrt, T.C.2
  • 11
    • 0000695637 scopus 로고
    • Evaluation of live Tularemia vaccine prepared in a chemically defined medium
    • Chamberlain, R.E. (1965) Evaluation of live Tularemia vaccine prepared in a chemically defined medium. Appl Microbiol 13: 232-235.
    • (1965) Appl Microbiol , vol.13 , pp. 232-235
    • Chamberlain, R.E.1
  • 12
    • 0033199782 scopus 로고    scopus 로고
    • The enzymatic biotinylation of proteins: a post-translational modification of exceptional specificity
    • Chapman-Smith, A., and Cronan, J.E. (1999) The enzymatic biotinylation of proteins: a post-translational modification of exceptional specificity. Trends Biochem Sci 24: 359-363.
    • (1999) Trends Biochem Sci , vol.24 , pp. 359-363
    • Chapman-Smith, A.1    Cronan, J.E.2
  • 13
    • 70449715726 scopus 로고    scopus 로고
    • A novel role for plasmin-mediated degradation of opsonizing antibody in the evasion of host immunity by virulent, but not attenuated, Francisella tularensis
    • Crane, D.D., Warner, S.L., and Bosio, C.M. (2009) A novel role for plasmin-mediated degradation of opsonizing antibody in the evasion of host immunity by virulent, but not attenuated, Francisella tularensis. J Immunol 183: 4593-4600.
    • (2009) J Immunol , vol.183 , pp. 4593-4600
    • Crane, D.D.1    Warner, S.L.2    Bosio, C.M.3
  • 14
    • 79957971951 scopus 로고    scopus 로고
    • Synthesis of the alpha,omega-dicarboxylic acid precursor of biotin by the canonical fatty acid biosynthetic pathway
    • Cronan, J.E., and Lin, S. (2010) Synthesis of the alpha, omega-dicarboxylic acid precursor of biotin by the canonical fatty acid biosynthetic pathway. Curr Opin Chem Biol 15: 407-413.
    • (2010) Curr Opin Chem Biol , vol.15 , pp. 407-413
    • Cronan, J.E.1    Lin, S.2
  • 15
    • 70350376747 scopus 로고    scopus 로고
    • Escherichia coli unsaturated fatty acid synthesis: complex transcription of the fabA gene and in vivo identification of the essential reaction catalyzed by FabB
    • Feng, Y., and Cronan, J.E. (2009) Escherichia coli unsaturated fatty acid synthesis: complex transcription of the fabA gene and in vivo identification of the essential reaction catalyzed by FabB. J Biol Chem 284: 29526-29535.
    • (2009) J Biol Chem , vol.284 , pp. 29526-29535
    • Feng, Y.1    Cronan, J.E.2
  • 16
    • 77956544826 scopus 로고    scopus 로고
    • Overlapping repressor binding sites result in additive regulation of Escherichia coli FadH by FadR and ArcA
    • Feng, Y., and Cronan, J.E. (2010) Overlapping repressor binding sites result in additive regulation of Escherichia coli FadH by FadR and ArcA. J Bacteriol 192: 4289-4299.
    • (2010) J Bacteriol , vol.192 , pp. 4289-4299
    • Feng, Y.1    Cronan, J.E.2
  • 17
    • 79953063344 scopus 로고    scopus 로고
    • Complex binding of the FabR repressor of bacterial unsaturated fatty acid biosynthesis to its cognate promoters
    • Feng, Y., and Cronan, J.E. (2011a) Complex binding of the FabR repressor of bacterial unsaturated fatty acid biosynthesis to its cognate promoters. Mol Microbiol 80: 195-218.
    • (2011) Mol Microbiol , vol.80 , pp. 195-218
    • Feng, Y.1    Cronan, J.E.2
  • 18
    • 80051556512 scopus 로고    scopus 로고
    • The Vibrio cholerae fatty acid regulatory protein, FadR, represses transcription of plsB, the gene encoding the first enzyme of membrane phospholipid biosynthesis
    • Feng, Y., and Cronan, J.E. (2011b) The Vibrio cholerae fatty acid regulatory protein, FadR, represses transcription of plsB, the gene encoding the first enzyme of membrane phospholipid biosynthesis. Mol Microbiol 81: 1020-1033.
    • (2011) Mol Microbiol , vol.81 , pp. 1020-1033
    • Feng, Y.1    Cronan, J.E.2
  • 19
    • 84880693039 scopus 로고    scopus 로고
    • Brucella BioR regulator defines a complex regulatory mechanism for bacterial biotin metabolism
    • Feng, Y., Xu, J., Zhang, H., Chen, Z., and Srinivas, S. (2013a) Brucella BioR regulator defines a complex regulatory mechanism for bacterial biotin metabolism. J Bacteriol 195: 3451-3467.
    • (2013) J Bacteriol , vol.195 , pp. 3451-3467
    • Feng, Y.1    Xu, J.2    Zhang, H.3    Chen, Z.4    Srinivas, S.5
  • 20
    • 84875594599 scopus 로고    scopus 로고
    • Profligate biotin synthesis in alpha-proteobacteria - a developing or degenerating regulatory system?
    • Feng, Y., Zhang, H., and Cronan, J.E. (2013b) Profligate biotin synthesis in alpha-proteobacteria - a developing or degenerating regulatory system? Mol Microbiol 88: 77-92.
    • (2013) Mol Microbiol , vol.88 , pp. 77-92
    • Feng, Y.1    Zhang, H.2    Cronan, J.E.3
  • 21
    • 84863655274 scopus 로고    scopus 로고
    • Evolution of a new function in an esterase: simple amino acid substitutions enable the activity present in the larger paralog, BioH
    • Flores, H., Lin, S., Contreras-Ferrat, G., Cronan, J.E., and Morett, E. (2012) Evolution of a new function in an esterase: simple amino acid substitutions enable the activity present in the larger paralog, BioH. Protein Eng Des Sel 25: 387-395.
    • (2012) Protein Eng Des Sel , vol.25 , pp. 387-395
    • Flores, H.1    Lin, S.2    Contreras-Ferrat, G.3    Cronan, J.E.4    Morett, E.5
  • 22
    • 79959484170 scopus 로고    scopus 로고
    • Phagocytic receptors dictate phagosomal escape and intracellular proliferation of Francisella tularensis
    • Geier, H., and Celli, J. (2011) Phagocytic receptors dictate phagosomal escape and intracellular proliferation of Francisella tularensis. Infect Immun 79: 2204-2214.
    • (2011) Infect Immun , vol.79 , pp. 2204-2214
    • Geier, H.1    Celli, J.2
  • 23
    • 0033153557 scopus 로고    scopus 로고
    • Of barn owls and bankers: a lush variety of alpha/beta hydrolases
    • Heikinheimo, P., Goldman, A., Jeffries, C., and Ollis, D.L. (1999) Of barn owls and bankers: a lush variety of alpha/beta hydrolases. Structure 7: R141-R146.
    • (1999) Structure , vol.7
    • Heikinheimo, P.1    Goldman, A.2    Jeffries, C.3    Ollis, D.L.4
  • 26
    • 84866340552 scopus 로고    scopus 로고
    • Repression of bacterial lipoprotein production by Francisella novicida facilitates evasion of innate immune recognition
    • Jones, C.L., Sampson, T.R., Nakaya, H.I., Pulendran, B., and Weiss, D.S. (2012b) Repression of bacterial lipoprotein production by Francisella novicida facilitates evasion of innate immune recognition. Cell Microbiol 14: 1531-1543.
    • (2012) Cell Microbiol , vol.14 , pp. 1531-1543
    • Jones, C.L.1    Sampson, T.R.2    Nakaya, H.I.3    Pulendran, B.4    Weiss, D.S.5
  • 27
    • 77951260924 scopus 로고    scopus 로고
    • The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors
    • Kawai, T., and Akira, S. (2010) The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Nat Immunol 11: 373-384.
    • (2010) Nat Immunol , vol.11 , pp. 373-384
    • Kawai, T.1    Akira, S.2
  • 28
    • 0024315260 scopus 로고
    • The mechanism of biotin-dependent enzymes
    • Knowles, J.R. (1989) The mechanism of biotin-dependent enzymes. Annu Rev Biochem 58: 195-221.
    • (1989) Annu Rev Biochem , vol.58 , pp. 195-221
    • Knowles, J.R.1
  • 29
    • 13944273799 scopus 로고    scopus 로고
    • The complete genome sequence of Francisella tularensis, the causative agent of tularemia
    • Larsson, P., Oyston, P.C., Chain, P., Chu, M.C., Duffield, M., Fuxelius, H.H., etal. (2005) The complete genome sequence of Francisella tularensis, the causative agent of tularemia. Nat Genet 37: 153-159.
    • (2005) Nat Genet , vol.37 , pp. 153-159
    • Larsson, P.1    Oyston, P.C.2    Chain, P.3    Chu, M.C.4    Duffield, M.5    Fuxelius, H.H.6
  • 30
    • 79956086881 scopus 로고    scopus 로고
    • Closing in on complete pathways of biotin biosynthesis
    • Lin, S., and Cronan, J.E. (2010) Closing in on complete pathways of biotin biosynthesis. Mol Biosyst 7: 1811-1821.
    • (2010) Mol Biosyst , vol.7 , pp. 1811-1821
    • Lin, S.1    Cronan, J.E.2
  • 31
    • 84868232323 scopus 로고    scopus 로고
    • The BioC O-methyltransferase catalyzes methyl esterification of malonyl-acyl carrier protein, an essential step in biotin synthesis
    • Lin, S., and Cronan, J.E. (2012) The BioC O-methyltransferase catalyzes methyl esterification of malonyl-acyl carrier protein, an essential step in biotin synthesis. J Biol Chem 287: 37010-37020.
    • (2012) J Biol Chem , vol.287 , pp. 37010-37020
    • Lin, S.1    Cronan, J.E.2
  • 32
    • 77955927354 scopus 로고    scopus 로고
    • Biotin synthesis begins by hijacking the fatty acid synthetic pathway
    • Lin, S., Hanson, R.E., and Cronan, J.E. (2010) Biotin synthesis begins by hijacking the fatty acid synthetic pathway. Nat Chem Biol 6: 682-688.
    • (2010) Nat Chem Biol , vol.6 , pp. 682-688
    • Lin, S.1    Hanson, R.E.2    Cronan, J.E.3
  • 33
    • 80052479082 scopus 로고    scopus 로고
    • Macrophage replication screen identifies a novel Francisella hydroperoxide resistance protein involved in virulence
    • Llewellyn, A.C., Jones, C.L., Napier, B.A., Bina, J.E., and Weiss, D.S. (2011) Macrophage replication screen identifies a novel Francisella hydroperoxide resistance protein involved in virulence. PLoS ONE 6: e24201.
    • (2011) PLoS ONE , vol.6
    • Llewellyn, A.C.1    Jones, C.L.2    Napier, B.A.3    Bina, J.E.4    Weiss, D.S.5
  • 35
    • 4544341163 scopus 로고    scopus 로고
    • A Francisella tularensis pathogenicity island required for intramacrophage growth
    • Nano, F.E., Zhang, N., Cowley, S.C., Klose, K.E., Cheung, K.K., Roberts, M.J., etal. (2004) A Francisella tularensis pathogenicity island required for intramacrophage growth. J Bacteriol 186: 6430-6436.
    • (2004) J Bacteriol , vol.186 , pp. 6430-6436
    • Nano, F.E.1    Zhang, N.2    Cowley, S.C.3    Klose, K.E.4    Cheung, K.K.5    Roberts, M.J.6
  • 38
    • 64749104915 scopus 로고    scopus 로고
    • Life on the inside: the intracellular lifestyle of cytosolic bacteria
    • Ray, K., Marteyn, B., Sansonetti, P.J., and Tang, C.M. (2009) Life on the inside: the intracellular lifestyle of cytosolic bacteria. Nat Rev Microbiol 7: 333-340.
    • (2009) Nat Rev Microbiol , vol.7 , pp. 333-340
    • Ray, K.1    Marteyn, B.2    Sansonetti, P.J.3    Tang, C.M.4
  • 39
    • 0036797992 scopus 로고    scopus 로고
    • Conservation of the biotin regulon and the BirA regulatory signal in Eubacteria and Archaea
    • Rodionov, D.A., Mironov, A.A., and Gelfand, M.S. (2002) Conservation of the biotin regulon and the BirA regulatory signal in Eubacteria and Archaea. Genome Res 12: 1507-1516.
    • (2002) Genome Res , vol.12 , pp. 1507-1516
    • Rodionov, D.A.1    Mironov, A.A.2    Gelfand, M.S.3
  • 40
    • 39549114621 scopus 로고    scopus 로고
    • Comparison of Francisella tularensis genomes reveals evolutionary events associated with the emergence of human pathogenic strains
    • Rohmer, L., Fong, C., Abmayr, S., Wasnick, M., Larson Freeman, T.J., Radey, M., etal. (2007) Comparison of Francisella tularensis genomes reveals evolutionary events associated with the emergence of human pathogenic strains. Genome Biol 8: R102.
    • (2007) Genome Biol , vol.8
    • Rohmer, L.1    Fong, C.2    Abmayr, S.3    Wasnick, M.4    Larson Freeman, T.J.5    Radey, M.6
  • 41
    • 26844548098 scopus 로고    scopus 로고
    • The role of the complement system in innate immunity
    • Rus, H., Cudrici, C., and Niculescu, F. (2005) The role of the complement system in innate immunity. Immunol Res 33: 103-112.
    • (2005) Immunol Res , vol.33 , pp. 103-112
    • Rus, H.1    Cudrici, C.2    Niculescu, F.3
  • 42
    • 84877782955 scopus 로고    scopus 로고
    • A CRISPR/Cas system mediates bacterial innate immune evasion and virulence
    • Sampson, T.R., Saroj, S.D., Llewellyn, A.C., Tzeng, Y.L., and Weiss, D.S. (2013) A CRISPR/Cas system mediates bacterial innate immune evasion and virulence. Nature 497: 254-257.
    • (2013) Nature , vol.497 , pp. 254-257
    • Sampson, T.R.1    Saroj, S.D.2    Llewellyn, A.C.3    Tzeng, Y.L.4    Weiss, D.S.5
  • 43
    • 0038168191 scopus 로고    scopus 로고
    • Integrating structure, bioinformatics, and enzymology to discover function: BioH, a new carboxylesterase from Escherichia coli
    • Sanishvili, R., Yakunin, A.F., Laskowski, R.A., Skarina, T., Evdokimova, E., Doherty-Kirby, A., etal. (2003) Integrating structure, bioinformatics, and enzymology to discover function: BioH, a new carboxylesterase from Escherichia coli. J Biol Chem 278: 26039-26045.
    • (2003) J Biol Chem , vol.278 , pp. 26039-26045
    • Sanishvili, R.1    Yakunin, A.F.2    Laskowski, R.A.3    Skarina, T.4    Evdokimova, E.5    Doherty-Kirby, A.6
  • 44
    • 34548411393 scopus 로고    scopus 로고
    • A Francisella tularensis pathogenicity island protein essential for bacterial proliferation within the host cell cytosol
    • Santic, M., Molmeret, M., Barker, J.R., Klose, K.E., Dekanic, A., Doric, M., and Abu Kwaik, Y. (2007) A Francisella tularensis pathogenicity island protein essential for bacterial proliferation within the host cell cytosol. Cell Microbiol 9: 2391-2403.
    • (2007) Cell Microbiol , vol.9 , pp. 2391-2403
    • Santic, M.1    Molmeret, M.2    Barker, J.R.3    Klose, K.E.4    Dekanic, A.5    Doric, M.6    Abu Kwaik, Y.7
  • 45
    • 77957730038 scopus 로고    scopus 로고
    • The fslE homolog, FTL_0439 (fupA/B), mediates siderophore-dependent iron uptake in Francisella tularensis LVS
    • Sen, B., Meeker, A., and Ramakrishnan, G. (2010) The fslE homolog, FTL_0439 (fupA/B), mediates siderophore-dependent iron uptake in Francisella tularensis LVS. Infect Immun 78: 4276-4285.
    • (2010) Infect Immun , vol.78 , pp. 4276-4285
    • Sen, B.1    Meeker, A.2    Ramakrishnan, G.3
  • 46
    • 84869034598 scopus 로고    scopus 로고
    • Remarkable diversity in the enzymes catalyzing the last step in synthesis of the pimelate moiety of biotin
    • Shapiro, M.M., Chakravartty, V., and Cronan, J.E. (2012) Remarkable diversity in the enzymes catalyzing the last step in synthesis of the pimelate moiety of biotin. PLoS ONE 7: e49440.
    • (2012) PLoS ONE , vol.7
    • Shapiro, M.M.1    Chakravartty, V.2    Cronan, J.E.3
  • 47
    • 34249868441 scopus 로고    scopus 로고
    • Genome-wide identification of Francisella tularensis virulence determinants
    • Su, J., Yang, J., Zhao, D., Kawula, T.H., Banas, J.A., and Zhang, J.R. (2007) Genome-wide identification of Francisella tularensis virulence determinants. Infect Immun 75: 3089-3101.
    • (2007) Infect Immun , vol.75 , pp. 3089-3101
    • Su, J.1    Yang, J.2    Zhao, D.3    Kawula, T.H.4    Banas, J.A.5    Zhang, J.R.6
  • 48
    • 0016227934 scopus 로고
    • Iron and susceptibility to infectious disease
    • Weinberg, E.D. (1974) Iron and susceptibility to infectious disease. Science 184: 952-956.
    • (1974) Science , vol.184 , pp. 952-956
    • Weinberg, E.D.1
  • 49
    • 34347270217 scopus 로고    scopus 로고
    • In vivo negative selection screen identifies genes required for Francisella virulence
    • Weiss, D.S., Brotcke, A., Henry, T., Margolis, J.J., Chan, K., and Monack, D.M. (2007) In vivo negative selection screen identifies genes required for Francisella virulence. Proc Natl Acad Sci USA 104: 6037-6042.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 6037-6042
    • Weiss, D.S.1    Brotcke, A.2    Henry, T.3    Margolis, J.J.4    Chan, K.5    Monack, D.M.6
  • 50
    • 70350437274 scopus 로고    scopus 로고
    • Francisella tularensis induces ubiquitin-dependent major histocompatibility complex class II degradation in activated macrophages
    • Wilson, J.E., Katkere, B., and Drake, J.R. (2009) Francisella tularensis induces ubiquitin-dependent major histocompatibility complex class II degradation in activated macrophages. Infect Immun 77: 4953-4965.
    • (2009) Infect Immun , vol.77 , pp. 4953-4965
    • Wilson, J.E.1    Katkere, B.2    Drake, J.R.3
  • 51
    • 80053459537 scopus 로고    scopus 로고
    • Evaluating the sensitivity of Mycobacterium tuberculosis to biotin deprivation using regulated gene expression
    • Woong Park, S., Klotzsche, M., Wilson, D.J., Boshoff, H.I., Eoh, H., Manjunatha, U., etal. (2011) Evaluating the sensitivity of Mycobacterium tuberculosis to biotin deprivation using regulated gene expression. PLoS Pathog 7: e1002264.
    • (2011) PLoS Pathog , vol.7
    • Woong Park, S.1    Klotzsche, M.2    Wilson, D.J.3    Boshoff, H.I.4    Eoh, H.5    Manjunatha, U.6
  • 53
    • 3843146246 scopus 로고    scopus 로고
    • An efficient one-step site-directed and site-saturation mutagenesis protocol
    • Zheng, L., Baumann, U., and Reymond, J.L. (2004) An efficient one-step site-directed and site-saturation mutagenesis protocol. Nucleic Acids Res 32: e115.
    • (2004) Nucleic Acids Res , vol.32
    • Zheng, L.1    Baumann, U.2    Reymond, J.L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.