메뉴 건너뛰기




Volumn 8, Issue 12, 2013, Pages

An internal ribosome entry site (IRES) mutant library for tuning expression level of multiple genes in mammalian cells

Author keywords

[No Author keywords available]

Indexed keywords

MONOCLONAL ANTIBODY; MYOSIN HEAVY CHAIN; MYOSIN LIGHT CHAIN; IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN LIGHT CHAIN;

EID: 84891939928     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0082100     Document Type: Article
Times cited : (44)

References (44)
  • 2
    • 0032422374 scopus 로고    scopus 로고
    • Regulated multicistronic expression technology for mammalian metabolic engineering
    • Fussenegger M, Moser S, Bailey JE (1998) Regulated multicistronic expression technology for mammalian metabolic engineering. Cytotechnology 28: 111-125. (Pubitemid 29188276)
    • (1998) Cytotechnology , vol.28 , Issue.1-3 , pp. 111-125
    • Fussenegger, M.1    Moser, S.2    Bailey, J.E.3
  • 4
    • 81355148543 scopus 로고    scopus 로고
    • Light it up: Highly efficient multigene delivery in mammalian cells
    • Trowitzsch S, Klumpp M, Thoma R, Carralot JP, Berger I (2011) Light it up: Highly efficient multigene delivery in mammalian cells. Bioessays 33: 946-955.
    • (2011) Bioessays , vol.33 , pp. 946-955
    • Trowitzsch, S.1    Klumpp, M.2    Thoma, R.3    Carralot, J.P.4    Berger, I.5
  • 5
    • 0031038002 scopus 로고    scopus 로고
    • Assembly of immunoglobulin light chains as a prerequisite for secretion: A model for oligomerization-dependent subunit folding
    • DOI 10.1074/jbc.272.5.3117
    • Leitzgen K, Knittler MR, Haas IG (1997) Assembly of immunoglobulin light chains as a prerequisite for secretion - A model for oligomerization-dependent subunit folding. Journal Of Biological Chemistry 272: 3117-3123. (Pubitemid 27053369)
    • (1997) Journal of Biological Chemistry , vol.272 , Issue.5 , pp. 3117-3123
    • Leitzgen, K.1    Knittler, M.R.2    Haas, I.G.3
  • 6
    • 0025789619 scopus 로고
    • Regulation of endoplasmic reticulum stress proteins in COS cells transfected with immunoglobulin μ heavy chain cDNA
    • Lenny N, Green M (1991) Regulation Of Endoplasmic-Reticulum Stress Proteins In Cos Cells Transfected With Immunoglobulin-Mu Heavy-Chain Cdna. Journal Of Biological Chemistry 266: 20532-20537. (Pubitemid 21908493)
    • (1991) Journal of Biological Chemistry , vol.266 , Issue.30 , pp. 20532-20537
    • Lenny, N.1    Green, M.2
  • 7
    • 13544259722 scopus 로고    scopus 로고
    • On the optimal ratio of heavy to light chain genes for efficient recombinant antibody production by CHO cells
    • DOI 10.1021/bp049780w
    • Schlatter S, Stansfield SH, Dinnis DM, Racher AJ, Birch JR, et al. (2005) On the optimal ratio of heavy to light chain genes for efficient recombinant antibody production by CHO cells. Biotechnology Progress 21: 122-133. (Pubitemid 40218480)
    • (2005) Biotechnology Progress , vol.21 , Issue.1 , pp. 122-133
    • Schlatter, S.1    Stansfield, S.H.2    Dinnis, D.M.3    Racher, A.J.4    Birch, J.R.5    James, D.C.6
  • 8
    • 0037019811 scopus 로고    scopus 로고
    • Generation of a synthetic mammalian promoter library by modification of sequences spacing transcription factor binding sites
    • DOI 10.1016/S0378-1119(02)00878-8, PII S0378111902008788
    • Tornoe J, Kusk P, Johansen TE, Jensen PR (2002) Generation of a synthetic mammalian promoter library by modification of sequences spacing transcription factor binding sites. Gene 297: 21-32. (Pubitemid 35217776)
    • (2002) Gene , vol.297 , Issue.1-2 , pp. 21-32
    • Tornoe, J.1    Kusk, P.2    Johansen, T.E.3    Jensen, P.R.4
  • 9
    • 21244446243 scopus 로고    scopus 로고
    • Multi-gene Gateway clone design for expression of multiple heterologous genes in living cells: Conditional gene expression at near physiological levels
    • DOI 10.1016/j.jbiotec.2005.02.020, PII S0168165605001264
    • Yahata K, Kishine H, Sone T, Sasaki Y, Hotta J, et al. (2005) Multi-gene Gateway clone design for expression of multiple heterologous genes in living cells: Conditional gene expression at near physiological levels. Journal Of Biotechnology 118: 123-134. (Pubitemid 40898238)
    • (2005) Journal of Biotechnology , vol.118 , Issue.2 , pp. 123-134
    • Yahata, K.1    Kishine, H.2    Sone, T.3    Sasaki, Y.4    Hotta, J.5    Chesnut, J.D.6    Okabe, M.7    Imamoto, F.8
  • 10
    • 60549116306 scopus 로고    scopus 로고
    • Mutated polyadenylation signals for controlling expression levels of multiple genes in mammalian cells
    • Yang YS, Mariati, Ho SCL, Yap MGS (2009) Mutated Polyadenylation Signals for Controlling Expression Levels of Multiple Genes in Mammalian Cells. Biotechnology And Bioengineering 102: 1152-1160.
    • (2009) Biotechnology and Bioengineering , vol.102 , pp. 1152-1160
    • Yang, Y.S.1    Mariati Ho, S.C.L.2    Yap, M.G.S.3
  • 11
    • 76149143390 scopus 로고    scopus 로고
    • Alternative-splicing-based bicistronic vectors for ratio-controlled protein expression and application to recombinant antibody production
    • Fallot S, Ben Naya R, Hieblot C, Mondon P, Lacazette E, et al. (2009) Alternative-splicing-based bicistronic vectors for ratio-controlled protein expression and application to recombinant antibody production. Nucleic Acids Research 37.
    • (2009) Nucleic Acids Research , vol.37
    • Fallot, S.1    Ben Naya, R.2    Hieblot, C.3    Mondon, P.4    Lacazette, E.5
  • 12
    • 60549102844 scopus 로고    scopus 로고
    • A study of monoclonal antibody-producing CHO cell lines: What makes a stable high producer?
    • Chusainow J, Yang YS, Yeo JH, Toh PC, Asvadi P, et al. (2009) A study of monoclonal antibody-producing CHO cell lines: what makes a stable high producer? Biotechnol Bioeng 102: 1182-1196.
    • (2009) Biotechnol Bioeng , vol.102 , pp. 1182-1196
    • Chusainow, J.1    Yang, Y.S.2    Yeo, J.H.3    Toh, P.C.4    Asvadi, P.5
  • 13
    • 84855237715 scopus 로고    scopus 로고
    • IRES-mediated Tricistronic vectors for enhancing generation of high monoclonal antibody expressing CHO cell lines
    • Ho SCL, Bardor M, Feng HT, Mariati, Tong YW, et al. (2012) IRES-mediated Tricistronic vectors for enhancing generation of high monoclonal antibody expressing CHO cell lines. Journal Of Biotechnology 157: 130-139.
    • (2012) Journal of Biotechnology , vol.157 , pp. 130-139
    • Ho, S.C.L.1    Bardor, M.2    Feng, H.T.3    Mariati Tong, Y.W.4
  • 14
    • 60549105996 scopus 로고    scopus 로고
    • A clone screening method using mRNA levels to determine specific productivity and product quality for monoclonal antibodies
    • Lee CJ, Seth G, Tsukuda J, Hamilton RW (2009) A clone screening method using mRNA levels to determine specific productivity and product quality for monoclonal antibodies. Biotechnology And Bioengineering 102: 1107-1118.
    • (2009) Biotechnology and Bioengineering , vol.102 , pp. 1107-1118
    • Lee, C.J.1    Seth, G.2    Tsukuda, J.3    Hamilton, R.W.4
  • 15
    • 0036135719 scopus 로고    scopus 로고
    • Transcriptional interference by independently regulated genes occurs in any relative arrangement of the genes and is influenced by chromosomal integration position
    • DOI 10.1128/MCB.22.2.469-479.2002
    • Eszterhas SK, Bouhassira EE, Martin DIK, Fiering S (2002) Transcriptional interference by independently regulated genes occurs in any relative arrangement of the genes and is influenced by chromosomal integration position. Molecular And Cellular Biology 22: 469-479. (Pubitemid 34027492)
    • (2002) Molecular and Cellular Biology , vol.22 , Issue.2 , pp. 469-479
    • Eszterhas, S.K.1    Bouhassira, E.E.2    Martin, D.I.K.3    Fiering, S.4
  • 16
    • 31444448624 scopus 로고    scopus 로고
    • E unum pluribus: Multiple proteins from a self-processing polyprotein
    • DOI 10.1016/j.tibtech.2005.12.006, PII S0167779905003288
    • de Felipe P, Luke GA, Hughes LE, Gani D, Halpin C, et al. (2006) E unum pluribus: multiple proteins from a self-processing polyprotein. Trends in Biotechnology 24: 68-75. (Pubitemid 43151978)
    • (2006) Trends in Biotechnology , vol.24 , Issue.2 , pp. 68-75
    • De Felipe, P.1    Luke, G.A.2    Hughes, L.E.3    Gani, D.4    Halpin, C.5    Ryan, M.D.6
  • 17
    • 84877962654 scopus 로고    scopus 로고
    • Comparison of internal ribosome entry site (IRES) and furin-2A (F2A) for monoclonal antibody expression level and quality in CHO cells
    • Ho SCL, Bardor M, Li B, Lee JJ, Song ZW, et al. (2013) Comparison of internal ribosome entry site (IRES) and furin-2A (F2A) for monoclonal antibody expression level and quality in CHO cells. Plos One 8: e63247.
    • (2013) Plos One , vol.8
    • Ho, S.C.L.1    Bardor, M.2    Li, B.3    Lee, J.J.4    Song, Z.W.5
  • 18
    • 76649115600 scopus 로고    scopus 로고
    • Inhibition of 2A-mediated 'cleavage' of certain artificial polyproteins bearing N-terminal signal sequences
    • De Felipe P, Luke GA, Brown JD, Ryan MD (2010) Inhibition of 2A-mediated 'cleavage' of certain artificial polyproteins bearing N-terminal signal sequences. Biotechnology Journal 5: 213-223.
    • (2010) Biotechnology Journal , vol.5 , pp. 213-223
    • De Felipe, P.1    Luke, G.A.2    Brown, J.D.3    Ryan, M.D.4
  • 19
    • 79955707349 scopus 로고    scopus 로고
    • High cleavage efficiency of a 2A peptide derived from porcine teschovirus-1 in human cell lines, zebrafish and mice
    • Kim JH, Lee SR, Li LH, Park HJ, Park JH, et al. (2011) High Cleavage Efficiency of a 2A Peptide Derived from Porcine Teschovirus-1 in Human Cell Lines, Zebrafish and Mice. Plos One 6.
    • (2011) Plos One , vol.6
    • Kim, J.H.1    Lee, S.R.2    Li, L.H.3    Park, H.J.4    Park, J.H.5
  • 20
    • 83755163734 scopus 로고    scopus 로고
    • Comparison of IRES and F2A-based locus-specific multicistronic expression in stable mouse lines
    • Chan HY, Sivakamasundari V, Xing X, Kraus P, Yap SP, et al. (2011) Comparison of IRES and F2A-based locus-specific multicistronic expression in stable mouse lines. PLoS One 6.
    • (2011) PLoS One , vol.6
    • Chan, H.Y.1    Sivakamasundari, V.2    Xing, X.3    Kraus, P.4    Yap, S.P.5
  • 21
    • 0344898562 scopus 로고    scopus 로고
    • Internal ribosome entry site biology and its use in expression vectors
    • DOI 10.1016/S0958-1669(99)00010-5
    • Martinez-Salas E (1999) Internal ribosome entry site biology and its use in expression vectors. Curr Opin Biotechnol 10: 458-464. (Pubitemid 29457271)
    • (1999) Current Opinion in Biotechnology , vol.10 , Issue.5 , pp. 458-464
    • Martinez-Salas, E.1
  • 22
    • 0028961591 scopus 로고
    • Internal ribosome entry sites and dicistronic rnas in mammalian transgenesis
    • Mountford PS, Smith AG (1995) Internal Ribosome Entry Sites And Dicistronic Rnas In Mammalian Transgenesis. Trends In Genetics 11: 179-184.
    • (1995) Trends in Genetics , vol.11 , pp. 179-184
    • Mountford, P.S.1    Smith, A.G.2
  • 23
    • 0035396727 scopus 로고    scopus 로고
    • Internal ribosome entry sites in eukaryotic mRNA molecules
    • DOI 10.1101/gad.891101
    • Hellen CUT, Sarnow P (2001) Internal ribosome entry sites in eukaryotic mRNA molecules. Genes & Development 15: 1593-1612. (Pubitemid 32702581)
    • (2001) Genes and Development , vol.15 , Issue.13 , pp. 1593-1612
    • Hellen, C.U.T.1    Sarnow, P.2
  • 24
    • 49949085914 scopus 로고    scopus 로고
    • Multi-gene gateway clone design for expression of multiple heterologous genes in living cells: Eukaryotic clones containing two and three ORF multi-gene cassettes expressed from a single promoter
    • Sasaki Y, Sone T, Yahata K, Kishine H, Hotta J, et al. (2008) Multi-gene gateway clone design for expression of multiple heterologous genes in living cells: Eukaryotic clones containing two and three ORF multi-gene cassettes expressed from a single promoter. Journal of Biotechnology 136: 103-112.
    • (2008) Journal of Biotechnology , vol.136 , pp. 103-112
    • Sasaki, Y.1    Sone, T.2    Yahata, K.3    Kishine, H.4    Hotta, J.5
  • 26
    • 34047240645 scopus 로고    scopus 로고
    • Translational efficiency of EMCV IRES in bicistronic vectors is dependent upon IRES sequence and gene location
    • 286, 288 passim
    • Bochkov YA, Palmenberg AC (2006) Translational efficiency of EMCV IRES in bicistronic vectors is dependent upon IRES sequence and gene location. Biotechniques 41: 283-284, 286, 288 passim.
    • (2006) Biotechniques , vol.41 , pp. 283-284
    • Bochkov, Y.A.1    Palmenberg, A.C.2
  • 27
    • 0030027934 scopus 로고    scopus 로고
    • Bicistronic vector for the creation of stable mammalian cell lines that predisposes all antibioticresistant cells to express recombinant protein
    • 106, 108-110
    • Rees S, Coote J, Stables J, Goodson S, Harris S, et al. (1996) Bicistronic vector for the creation of stable mammalian cell lines that predisposes all antibioticresistant cells to express recombinant protein. Biotechniques 20: 102-104, 106, 108-110.
    • (1996) Biotechniques , vol.20 , pp. 102-104
    • Rees, S.1    Coote, J.2    Stables, J.3    Goodson, S.4    Harris, S.5
  • 28
    • 36249002980 scopus 로고    scopus 로고
    • Analysis of IgG heavy chain to light chain ratio with mutant Encephalomyocarditis virus internal ribosome entry site
    • DOI 10.1093/protein/gzm038
    • Li JD, Zhang CC, Jostock T, Dubel S (2007) Analysis of IgG heavy chain to light chain ratio with mutant Encephalomyocarditis virus internal ribosome entry site. Protein Engineering Design & Selection 20: 491-496. (Pubitemid 350135560)
    • (2007) Protein Engineering, Design and Selection , vol.20 , Issue.10 , pp. 491-496
    • Li, J.1    Zhang, C.2    Jostock, T.3    Dubel, S.4
  • 29
    • 0029130733 scopus 로고
    • Picornavirus internal ribosome entry segments: Comparison of translation efficiency and the requirements for optimal internal initiation of translation in vitro
    • Borman AM, Bailly JL, Girard M, Kean KM (1995) Picornavirus internal ribosome entry segments: Comparison of translation efficiency and the requirements for optimal internal initiation of translation in vitro. Nucleic Acids Research 23: 3656-3663.
    • (1995) Nucleic Acids Research , vol.23 , pp. 3656-3663
    • Borman, A.M.1    Bailly, J.L.2    Girard, M.3    Kean, K.M.4
  • 30
    • 0030751962 scopus 로고    scopus 로고
    • Comparison of picornaviral IRES-driven internal initiation of translation in cultured cells of different origins
    • DOI 10.1093/nar/25.5.925
    • Borman AM, LeMercier P, Girard M, Kean KM (1997) Comparison of picornaviral IRES-driven internal initiation of translation in cultured cells of different origins. Nucleic Acids Research 25: 925-932. (Pubitemid 27298259)
    • (1997) Nucleic Acids Research , vol.25 , Issue.5 , pp. 925-932
    • Borman, A.M.1    Le Mercier, P.2    Girard, M.3    Kean, K.M.4
  • 31
    • 0026558056 scopus 로고
    • Sequence and structural elements that contribute to efficient encephalomyocarditis virus-RNA translation
    • Duke GM, Hoffman MA, Palmenberg AC (1992) Sequence and structural elements that contribute to efficient encephalomyocarditis virus-RNA translation. Journal of Virology 66: 1602-1609.
    • (1992) Journal of Virology , vol.66 , pp. 1602-1609
    • Duke, G.M.1    Hoffman, M.A.2    Palmenberg, A.C.3
  • 32
    • 0026533752 scopus 로고
    • The sequence context of the initiation codon in the encephalomyocarditis virus leader modulates efficiency of internal translation initiation
    • Davies MV, Kaufman RJ (1992) The Sequence Context Of The Initiation Codon In The Encephalomyocarditis Virus Leader Modulates Efficiency Of Internal Translation Initiation. Journal of Virology 66: 1924-1932.
    • (1992) Journal of Virology , vol.66 , pp. 1924-1932
    • Davies, M.V.1    Kaufman, R.J.2
  • 33
    • 0028314953 scopus 로고
    • Translation of encephalomyocarditis virus RNA: Parameters influencing the selection of the internal initiation site
    • Kaminski A, Belsham GJ, Jackson RJ (1994) Translation Of Encephalomyocarditis Virus-Rna - Parameters Influencing The Selection Of The Internal Initiation Site. Embo Journal 13: 1673-1681. (Pubitemid 24114719)
    • (1994) EMBO Journal , vol.13 , Issue.7 , pp. 1673-1681
    • Kaminski, A.1    Belsham, G.J.2    Jackson, R.J.3
  • 34
    • 0024394362 scopus 로고
    • Context effects and inefficient initiation at non-AUG codons in eucaryotic cell-free translation systems
    • Kozak M (1989) Context Effects And Inefficient Initiation At Non-Aug Codons In Eukaryotic Cell-Free Translation Systems. Molecular And Cellular Biology 9: 5073-5080. (Pubitemid 19275978)
    • (1989) Molecular and Cellular Biology , vol.9 , Issue.11 , pp. 5073-5080
    • Kozak, M.1
  • 35
    • 0024999179 scopus 로고
    • Initiation of translation at CUG, GUG, and ACG codons in mammalian cells
    • DOI 10.1016/0378-1119(90)90085-6
    • Mehdi H, Ono E, Gupta KC (1990) Initiation of translation of at CUG, GUG, and ACG codons in mammalian cells. Gene 91: 173-178. (Pubitemid 20269499)
    • (1990) Gene , vol.91 , Issue.2 , pp. 173-178
    • Mehdi, H.1    Ono, E.2    Gupta, K.C.3
  • 36
    • 0024559617 scopus 로고
    • Translation initiation at non-AUG triplets in mammalian cells
    • Peabody DS (1989) Translation initiation at non-AUG triplets in mammalian cells. Journal Of Biological Chemistry 264: 5031-5035. (Pubitemid 19092915)
    • (1989) Journal of Biological Chemistry , vol.264 , Issue.9 , pp. 5031-5035
    • Peabody, D.S.1
  • 37
    • 84877354063 scopus 로고    scopus 로고
    • Control of IgG LC:HC ratio in stably transfected CHO cells and study of the impact on expression, aggregation, glycosylation and conformation stability
    • Ho SCL, Koh EYC, van Beers M, Mueller M, Wan C, et al. (2013) Control of IgG LC:HC ratio in stably transfected CHO cells and study of the impact on expression, aggregation, glycosylation and conformation stability. Journal Of Biotechnology 165: 157-166.
    • (2013) Journal of Biotechnology , vol.165 , pp. 157-166
    • Ho, S.C.L.1    Koh, E.Y.C.2    Van Beers, M.3    Mueller, M.4    Wan, C.5
  • 38
    • 0344906094 scopus 로고    scopus 로고
    • Parameters influencing translational efficiency in aphthovirus IRES-based bicistronic expression vectors
    • DOI 10.1016/S0378-1119(98)00379-5, PII S0378111998003795
    • de Quinto SL, Martinez-Salas E (1998) Parameters in influencing translational efficiency in aphthovirus IRES-based bicistronic expression vectors. Gene 217: 51-56. (Pubitemid 28427306)
    • (1998) Gene , vol.217 , Issue.1-2 , pp. 51-56
    • Lopez De Quinto, S.1    Martinez-Salas, E.2
  • 39
    • 41149112510 scopus 로고    scopus 로고
    • Improvement of reporter activity by IRES-mediated polycistronic reporter system
    • Bouabe H, Fassler R, Heesemann J (2008) Improvement of reporter activity by IRES-mediated polycistronic reporter system. Nucleic Acids Research 36.
    • (2008) Nucleic Acids Research , vol.36
    • Bouabe, H.1    Fassler, R.2    Heesemann, J.3
  • 41
    • 0025145263 scopus 로고
    • Initiation of encephalomyocarditis virus-RNA translation-The authentic initiation site is not selected by a scanning mechanism
    • Kaminski A, Howell MT, Jackson RJ (1990) Initiation of encephalomyocarditis virus-RNA translation-The authentic initiation site is not selected by a scanning mechanism. Embo Journal 9: 3753-3759.
    • (1990) Embo Journal , vol.9 , pp. 3753-3759
    • Kaminski, A.1    Howell, M.T.2    Jackson, R.J.3
  • 42
    • 0031746507 scopus 로고    scopus 로고
    • The polypyrimidine tract binding protein (PTB) requirement for internal initiation of translation of cardiovirus RNAs is conditional rather than absolute
    • DOI 10.1017/S1355838298971898
    • Kaminski A, Jackson RJ (1998) The polypyrimidine tract binding protein (PTB) requirement for internal initiation of translation of cardiovirus RNAs is conditional rather than absolute. RNA - A Publication of the RNA Society 4: 626-638. (Pubitemid 28252745)
    • (1998) RNA , vol.4 , Issue.6 , pp. 626-638
    • Kaminski, A.1    Jackson, R.J.2
  • 43
    • 82955214824 scopus 로고    scopus 로고
    • Impact of gene vector design on the control of recombinant monoclonal antibody production by chinese hamster ovary cells
    • Davies SL, O'Callaghan PM, McLeod J, Pybus LP, Sung YH, et al. (2011) Impact of gene vector design on the control of recombinant monoclonal antibody production by chinese hamster ovary cells. Biotechnology Progress 27: 1689-1699.
    • (2011) Biotechnology Progress , vol.27 , pp. 1689-1699
    • Davies, S.L.1    O'callaghan, P.M.2    McLeod, J.3    Pybus, L.P.4    Sung, Y.H.5
  • 44
    • 0036353205 scopus 로고    scopus 로고
    • Kinetic model of BiP- and PDI-mediated protein folding and assembly
    • DOI 10.1006/jtbi.2001.2478
    • Gonzalez R, Andrews BA, Asenjo JA (2002) Kinetic model of BiP- and PDImediated protein folding and assembly. Journal Of Theoretical Biology 214: 529-537. (Pubitemid 34948525)
    • (2002) Journal of Theoretical Biology , vol.214 , Issue.4 , pp. 529-537
    • Gonzalez, R.1    Andrews, B.A.2    Asenjo, J.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.