-
2
-
-
0036875211
-
Adipose tissue intracrinology: Potential importance of local androgen/estrogen metabolism in the regulation of adiposity
-
Bélanger, C., Luu-The, V., Dupont, P., and Tchernof, A. (2002) Adipose tissue intracrinology: potential importance of local androgen/estrogen metabolism in the regulation of adiposity. Horm. Metab. Res. 34, 737-745
-
(2002)
Horm. Metab. Res.
, vol.34
, pp. 737-745
-
-
Bélanger, C.1
Luu-The, V.2
Dupont, P.3
Tchernof, A.4
-
3
-
-
79951665862
-
The molecular biology, biochemistry, and physiology of human steroidogenesis and its disorders
-
Miller, W. L., and Auchus, R. J. (2011) The molecular biology, biochemistry, and physiology of human steroidogenesis and its disorders. Endocr. Rev. 32, 81-151
-
(2011)
Endocr. Rev.
, vol.32
, pp. 81-151
-
-
Miller, W.L.1
Auchus, R.J.2
-
4
-
-
0042737939
-
Peripheral-type benzodiazepine receptor: Structure and function of a cholesterol-binding protein in steroid and bile acid biosynthesis
-
Lacapère, J. J., and Papadopoulos, V. (2003) Peripheral-type benzodiazepine receptor: structure and function of a cholesterol-binding protein in steroid and bile acid biosynthesis. Steroids 68, 569-585
-
(2003)
Steroids
, vol.68
, pp. 569-585
-
-
Lacapère, J.J.1
Papadopoulos, V.2
-
5
-
-
33847039156
-
Is there a mitochondrial signaling complex facilitating cholesterol import?
-
Papadopoulos, V., Liu, J., and Culty, M. (2007) Is there a mitochondrial signaling complex facilitating cholesterol import? Mol. Cell. Endocrinol. 265, 59-64
-
(2007)
Mol. Cell. Endocrinol.
, vol.265
, pp. 59-64
-
-
Papadopoulos, V.1
Liu, J.2
Culty, M.3
-
6
-
-
0037073676
-
Transport of cholesterol into mitochondria is rate-limiting for bile acid synthesis via the alternative pathway in primary rat hepatocytes
-
Pandak, W. M., Ren, S., Marques, D., Hall, E., Redford, K., Mallonee, D., Bohdan, P., Heuman, D., Gil, G., and Hylemon, P. (2002) Transport of cholesterol into mitochondria is rate-limiting for bile acid synthesis via the alternative pathway in primary rat hepatocytes. J. Biol. Chem. 277, 48158-48164
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 48158-48164
-
-
Pandak, W.M.1
Ren, S.2
Marques, D.3
Hall, E.4
Redford, K.5
Mallonee, D.6
Bohdan, P.7
Heuman, D.8
Gil, G.9
Hylemon, P.10
-
7
-
-
0035985702
-
Oxysterols in human circulation: Which role do they have?
-
Björkhem, I., Meaney, S., and Diczfalusy, U. (2002) Oxysterols in human circulation: which role do they have? Curr. Opin. Lipidol. 13, 247-253
-
(2002)
Curr. Opin. Lipidol.
, vol.13
, pp. 247-253
-
-
Björkhem, I.1
Meaney, S.2
Diczfalusy, U.3
-
8
-
-
0035133061
-
Evidence that the major oxysterols in human circulation originate from distinct pools of cholesterol: A stable isotope study
-
Meaney, S., Hassan, M., Sakinis, A., Lütjohann, D., von Bergmann, K., Wennmalm, A., Diczfalusy, U., and Björkhem, I. (2001) Evidence that the major oxysterols in human circulation originate from distinct pools of cholesterol: a stable isotope study. J. Lipid Res. 42, 70-78
-
(2001)
J. Lipid Res.
, vol.42
, pp. 70-78
-
-
Meaney, S.1
Hassan, M.2
Sakinis, A.3
Lütjohann, D.4
Von Bergmann, K.5
Wennmalm, A.6
Diczfalusy, U.7
Björkhem, I.8
-
9
-
-
24344509286
-
Differential expression of the peripheral benzodiazepine receptor and gremlin during adipogenesis
-
Wade, F. M., Wakade, C., Mahesh, V. B., and Brann, D. W. (2005) Differential expression of the peripheral benzodiazepine receptor and gremlin during adipogenesis. Obes. Res. 13, 818-822
-
(2005)
Obes. Res.
, vol.13
, pp. 818-822
-
-
Wade, F.M.1
Wakade, C.2
Mahesh, V.B.3
Brann, D.W.4
-
10
-
-
0032508707
-
Inhibition of 3T3-L1 adipocyte differentiation by expression of acyl-CoA-binding protein antisense RNA
-
Mandrup, S., Sorensen, R. V., Helledie, T., Nohr, J., Baldursson, T., Gram, C., Knudsen, J., and Kristiansen, K. (1998) Inhibition of 3T3-L1 adipocyte differentiation by expression of acyl-CoA-binding protein antisense RNA. J. Biol. Chem. 273, 23897-23903
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 23897-23903
-
-
Mandrup, S.1
Sorensen, R.V.2
Helledie, T.3
Nohr, J.4
Baldursson, T.5
Gram, C.6
Knudsen, J.7
Kristiansen, K.8
-
11
-
-
0034648794
-
CAP defines a second signalling pathway required for insulin-stimulated glucose transport
-
Baumann, C. A., Ribon, V., Kanzaki, M., Thurmond, D. C., Mora, S., Shigematsu, S., Bickel, P. E., Pessin, J. E., and Saltiel, A. R. (2000) CAP defines a second signalling pathway required for insulin-stimulated glucose transport. Nature 407, 202-207
-
(2000)
Nature
, vol.407
, pp. 202-207
-
-
Baumann, C.A.1
Ribon, V.2
Kanzaki, M.3
Thurmond, D.C.4
Mora, S.5
Shigematsu, S.6
Bickel, P.E.7
Pessin, J.E.8
Saltiel, A.R.9
-
12
-
-
0035129323
-
Characterization of a human preadipocyte cell strain with high capacity for adipose differentiation
-
Wabitsch, M., Brenner, R. E., Melzner, I., Braun, M., Möller, P., Heinze, E., Debatin, K. M., and Hauner, H. (2001) Characterization of a human preadipocyte cell strain with high capacity for adipose differentiation. Int. J. Obes. Relat. Metab. Disord. 25, 8-15
-
(2001)
Int. J. Obes. Relat. Metab. Disord.
, vol.25
, pp. 8-15
-
-
Wabitsch, M.1
Brenner, R.E.2
Melzner, I.3
Braun, M.4
Möller, P.5
Heinze, E.6
Debatin, K.M.7
Hauner, H.8
-
13
-
-
33845977384
-
Protein-protein interactions mediate mitochondrial cholesterol transport and steroid biosynthesis
-
Liu, J., Rone, M. B., and Papadopoulos, V. (2006) Protein-protein interactions mediate mitochondrial cholesterol transport and steroid biosynthesis. J. Biol. Chem. 281, 38879-38893
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 38879-38893
-
-
Liu, J.1
Rone, M.B.2
Papadopoulos, V.3
-
14
-
-
0025615204
-
The stromavascular fraction of rat inguinal and epididymal adipose tissue and the adipoconversion of fat cell precursors in primary culture
-
Grégoire, F., Todoroff, G., Hauser, N., and Remacle, C. (1990) The stromavascular fraction of rat inguinal and epididymal adipose tissue and the adipoconversion of fat cell precursors in primary culture. Biol. Cell 69, 215-222
-
(1990)
Biol. Cell
, vol.69
, pp. 215-222
-
-
Grégoire, F.1
Todoroff, G.2
Hauser, N.3
Remacle, C.4
-
15
-
-
0025073860
-
Peripheral-type benzodiazepine receptors mediate translocation of cholesterol from outer to inner mitochondrial membranes in adrenocortical cells
-
Krueger, K. E., and Papadopoulos, V. (1990) Peripheral-type benzodiazepine receptors mediate translocation of cholesterol from outer to inner mitochondrial membranes in adrenocortical cells. J. Biol. Chem. 265, 15015-15022
-
(1990)
J. Biol. Chem.
, vol.265
, pp. 15015-15022
-
-
Krueger, K.E.1
Papadopoulos, V.2
-
16
-
-
0035970108
-
Cholesterol binding at the cholesterol recognition/interaction amino acid consensus (CRAC) of the peripheral-type benzodiazepine receptor and inhibition of steroidogenesis by an HIV TAT-CRAC peptide
-
Li, H., Yao, Z., Degenhardt, B., Teper, G., and Papadopoulos, V. (2001) Cholesterol binding at the cholesterol recognition/interaction amino acid consensus (CRAC) of the peripheral-type benzodiazepine receptor and inhibition of steroidogenesis by an HIV TAT-CRAC peptide. Proc. Natl. Acad. Sci. U.S.A. 98, 1267-1272
-
(2001)
Proc. Natl. Acad. Sci. U.S.A.
, vol.98
, pp. 1267-1272
-
-
Li, H.1
Yao, Z.2
Degenhardt, B.3
Teper, G.4
Papadopoulos, V.5
-
17
-
-
0036220150
-
Cholesterol transport, peripheral benzodiazepine receptor, and steroidogenesis in aging Leydig cells
-
Culty, M., Luo, L., Yao, Z. X., Chen, H., Papadopoulos, V., and Zirkin, B. R. (2002) Cholesterol transport, peripheral benzodiazepine receptor, and steroidogenesis in aging Leydig cells. J. Androl. 23, 439-447
-
(2002)
J. Androl.
, vol.23
, pp. 439-447
-
-
Culty, M.1
Luo, L.2
Yao, Z.X.3
Chen, H.4
Papadopoulos, V.5
Zirkin, B.R.6
-
18
-
-
0026635087
-
Regulation of pregnenolone synthesis in C6-2B glioma cells by 4-chlorodiazepam
-
Guarneri, P., Papadopoulos, V., Pan, B., and Costa, E. (1992) Regulation of pregnenolone synthesis in C6-2B glioma cells by 4-chlorodiazepam. Proc. Natl. Acad. Sci. U.S.A. 89, 5118-5122
-
(1992)
Proc. Natl. Acad. Sci. U.S.A.
, vol.89
, pp. 5118-5122
-
-
Guarneri, P.1
Papadopoulos, V.2
Pan, B.3
Costa, E.4
-
19
-
-
0032541028
-
Activities of recombinant human cytochrome P450c27 (CYP27), which produce intermediates of alternative bile acid biosynthetic pathways
-
Pikuleva, I. A., Babiker, A., Waterman, M. R., and Björkhem, I. (1998) Activities of recombinant human cytochrome P450c27 (CYP27), which produce intermediates of alternative bile acid biosynthetic pathways. J. Biol. Chem. 273, 18153-18160
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 18153-18160
-
-
Pikuleva, I.A.1
Babiker, A.2
Waterman, M.R.3
Björkhem, I.4
-
20
-
-
10344248701
-
Of mice and men: The tale of steroidogenic factor-1
-
Jameson, J. L. (2004) Of mice and men: The tale of steroidogenic factor-1. J. Clin. Endocrinol. Metab. 89, 5927-5929
-
(2004)
J. Clin. Endocrinol. Metab.
, vol.89
, pp. 5927-5929
-
-
Jameson, J.L.1
-
21
-
-
0043268895
-
DAX-1, an unusual orphan receptor at the crossroads of steroidogenic function and sexual differentiation
-
Lalli, E., and Sassone-Corsi, P. (2003) DAX-1, an unusual orphan receptor at the crossroads of steroidogenic function and sexual differentiation. Mol. Endocrinol. 17, 1445-1453
-
(2003)
Mol. Endocrinol.
, vol.17
, pp. 1445-1453
-
-
Lalli, E.1
Sassone-Corsi, P.2
-
22
-
-
33744904197
-
Expression and localization of sterol 27-hydroxylase (CYP27A1) in monkey retina
-
Lee, J. W., Fuda, H., Javitt, N. B., Strott, C. A., and Rodriguez, I. R. (2006) Expression and localization of sterol 27-hydroxylase (CYP27A1) in monkey retina. Exp. Eye Res. 83, 465-469
-
(2006)
Exp. Eye Res.
, vol.83
, pp. 465-469
-
-
Lee, J.W.1
Fuda, H.2
Javitt, N.B.3
Strott, C.A.4
Rodriguez, I.R.5
-
23
-
-
0030610365
-
7-Hydroxylation of 27-hydroxycholesterol: Biologic role in the regulation of cholesterol synthesis
-
Martin, K. O., Reiss, A. B., Lathe, R., and Javitt, N. B. (1997) 7-Hydroxylation of 27-hydroxycholesterol: biologic role in the regulation of cholesterol synthesis. J. Lipid Res. 38, 1053-1058
-
(1997)
J. Lipid Res.
, vol.38
, pp. 1053-1058
-
-
Martin, K.O.1
Reiss, A.B.2
Lathe, R.3
Javitt, N.B.4
-
24
-
-
80053631359
-
Oxysterols in bile acid metabolism
-
Crosignani, A., Zuin, M., Allocca, M., and Del Puppo, M. (2011) Oxysterols in bile acid metabolism. Clin. Chim. Acta 412, 2037-2045
-
(2011)
Clin. Chim. Acta
, vol.412
, pp. 2037-2045
-
-
Crosignani, A.1
Zuin, M.2
Allocca, M.3
Del Puppo, M.4
-
25
-
-
48749113401
-
Targeting bile-acid signalling for metabolic diseases
-
Thomas, C., Pellicciari, R., Pruzanski, M., Auwerx, J., and Schoonjans, K. (2008) Targeting bile-acid signalling for metabolic diseases. Nat. Rev. Drug Discov. 7, 678-693
-
(2008)
Nat. Rev. Drug Discov.
, vol.7
, pp. 678-693
-
-
Thomas, C.1
Pellicciari, R.2
Pruzanski, M.3
Auwerx, J.4
Schoonjans, K.5
-
26
-
-
0036250159
-
25R,26-Hydroxycholesterol revisited: Synthesis metabolism, and biologic roles
-
Javitt, N. B. (2002) 25R,26-Hydroxycholesterol revisited: synthesis, metabolism, and biologic roles. J. Lipid Res. 43, 665-670
-
(2002)
J. Lipid Res.
, vol.43
, pp. 665-670
-
-
Javitt, N.B.1
-
27
-
-
0034892932
-
Metabolism of an oxysterol, 7-ketocholesterol, by sterol 27-hydroxylase in HepG2 cells
-
Lyons, M. A., and Brown, A. J. (2001) Metabolism of an oxysterol, 7-ketocholesterol, by sterol 27-hydroxylase in HepG2 cells. Lipids 36, 701-711
-
(2001)
Lipids
, vol.36
, pp. 701-711
-
-
Lyons, M.A.1
Brown, A.J.2
-
28
-
-
0036133869
-
Neurosteroids: Biochemistry and clinical significance
-
Mellon, S. H., and Griffin, L. D. (2002) Neurosteroids: biochemistry and clinical significance. Trends Endocrinol. Metab. 13, 35-43
-
(2002)
Trends Endocrinol. Metab.
, vol.13
, pp. 35-43
-
-
Mellon, S.H.1
Griffin, L.D.2
-
29
-
-
0035232905
-
Neurosteroids: Beginning of the story
-
Baulieu, E. E., Robel, P., and Schumacher, M. (2001) Neurosteroids: beginning of the story. Int. Rev. Neurobiol. 46, 1-32
-
(2001)
Int. Rev. Neurobiol.
, vol.46
, pp. 1-32
-
-
Baulieu, E.E.1
Robel, P.2
Schumacher, M.3
-
30
-
-
0034458417
-
Steroidogenic enzyme gene expression in the human heart
-
Kayes-Wandover, K. M., and White, P. C. (2000) Steroidogenic enzyme gene expression in the human heart. J. Clin. Endocrinol. Metab. 85, 2519-2525
-
(2000)
J. Clin. Endocrinol. Metab.
, vol.85
, pp. 2519-2525
-
-
Kayes-Wandover, K.M.1
White, P.C.2
-
31
-
-
0038468629
-
Human skin is a steroidogenic tissue: Steroidogenic enzymes and cofactors are expressed in epidermis, normal sebocytes, and an immortalized sebocyte cell line (SEB-1)
-
Thiboutot, D., Jabara, S., McAllister, J. M., Sivarajah, A., Gilliland, K., Cong, Z., and Clawson, G. (2003) Human skin is a steroidogenic tissue: steroidogenic enzymes and cofactors are expressed in epidermis, normal sebocytes, and an immortalized sebocyte cell line (SEB-1). J. Invest. Dermatol. 120, 905-914
-
(2003)
J. Invest. Dermatol.
, vol.120
, pp. 905-914
-
-
Thiboutot, D.1
Jabara, S.2
McAllister, J.M.3
Sivarajah, A.4
Gilliland, K.5
Cong, Z.6
Clawson, G.7
-
32
-
-
2542520714
-
Local synthesis and dual actions of progesterone in the nervous system: Neuroprotection and myelination
-
Schumacher, M., Guennoun, R., Robert, F., Carelli, C., Gago, N., Ghoumari, A., Gonzalez Deniselle, M. C., Gonzalez, S. L., Ibanez, C., Labombarda, F., Coirini, H., Baulieu, E. E., and De Nicola, A. F. (2004) Local synthesis and dual actions of progesterone in the nervous system: neuroprotection and myelination. Growth Horm. IGF Res. 14, S18-S33
-
(2004)
Growth Horm. IGF Res.
, vol.14
-
-
Schumacher, M.1
Guennoun, R.2
Robert, F.3
Carelli, C.4
Gago, N.5
Ghoumari, A.6
Gonzalez Deniselle, M.C.7
Gonzalez, S.L.8
Ibanez, C.9
Labombarda, F.10
Coirini, H.11
Baulieu, E.E.12
De Nicola, A.F.13
-
33
-
-
12144261036
-
Brain steroidogenesis: Emerging therapeutic strategies to prevent neurodegeneration
-
Azcoitia, I., Sierra, A., Veiga, S., and Garcia-Segura, L. M. (2005) Brain steroidogenesis: emerging therapeutic strategies to prevent neurodegeneration. J. Neural. Transm. 112, 171-176
-
(2005)
J. Neural. Transm.
, vol.112
, pp. 171-176
-
-
Azcoitia, I.1
Sierra, A.2
Veiga, S.3
Garcia-Segura, L.M.4
-
34
-
-
84886601180
-
Steroidogenesis in the skin: Implications for local immune functions
-
Slominski, A., Zbytek, B., Nikolakis, G., Manna, P. R., Skobowiat, C., Zmijewski, M., Li, W., Janjetovic, Z., Postlethwaite, A., Zouboulis, C. C., and Tuckey, R. C. (2013) Steroidogenesis in the skin: implications for local immune functions. J. Steroid Biochem. Mol. Biol. 137, 107-123
-
(2013)
J. Steroid Biochem. Mol. Biol.
, vol.137
, pp. 107-123
-
-
Slominski, A.1
Zbytek, B.2
Nikolakis, G.3
Manna, P.R.4
Skobowiat, C.5
Zmijewski, M.6
Li, W.7
Janjetovic, Z.8
Postlethwaite, A.9
Zouboulis, C.C.10
Tuckey, R.C.11
-
35
-
-
0035824440
-
A transgenic model of visceral obesity and the metabolic syndrome
-
Masuzaki, H., Paterson, J., Shinyama, H., Morton, N. M., Mullins, J. J., Seckl, J. R., and Flier, J. S. (2001) A transgenic model of visceral obesity and the metabolic syndrome. Science 294, 2166-2170
-
(2001)
Science
, vol.294
, pp. 2166-2170
-
-
Masuzaki, H.1
Paterson, J.2
Shinyama, H.3
Morton, N.M.4
Mullins, J.J.5
Seckl, J.R.6
Flier, J.S.7
-
36
-
-
84860226019
-
Adipocytes produce aldosterone through calcineurin-dependent signaling pathways: Implications in diabetes mellitus-associated obesity and vascular dysfunction
-
Briones, A. M., Nguyen Dinh Cat, A., Callera, G. E., Yogi, A., Burger, D., He, Y., Corrêa, J. W., Gagnon, A. M., Gomez-Sanchez, C. E., Gomez-Sanchez, E. P., Sorisky, A., Ooi, T. C., Ruzicka, M., Burns, K. D., and Touyz, R. M. (2012) Adipocytes produce aldosterone through calcineurin-dependent signaling pathways: implications in diabetes mellitus-associated obesity and vascular dysfunction. Hypertension 59, 1069-1078
-
(2012)
Hypertension
, vol.59
, pp. 1069-1078
-
-
Briones, A.M.1
Nguyen Dinh Cat, A.2
Callera, G.E.3
Yogi, A.4
Burger, D.5
He, Y.6
Corrêa, J.W.7
Gagnon, A.M.8
Gomez-Sanchez, C.E.9
Gomez-Sanchez, E.P.10
Sorisky, A.11
Ooi, T.C.12
Ruzicka, M.13
Burns, K.D.14
Touyz, R.M.15
-
37
-
-
55949107611
-
Depot-specific steroidogenic gene transcription in human adipose tissue
-
MacKenzie, S. M., Huda, S. S., Sattar, N., Fraser, R., Connell, J. M., and Davies, E. (2008) Depot-specific steroidogenic gene transcription in human adipose tissue. Clin. Endocrinol. 69, 848-854
-
(2008)
Clin. Endocrinol.
, vol.69
, pp. 848-854
-
-
MacKenzie, S.M.1
Huda, S.S.2
Sattar, N.3
Fraser, R.4
Connell, J.M.5
Davies, E.6
-
38
-
-
42249108359
-
The orphan nuclear receptor DAX-1 acts as a novel transcriptional corepressor of PPAR
-
Kim, G. S., Lee, G. Y., Nedumaran, B., Park, Y. Y., Kim, K. T., Park, S. C., Lee, Y. C., Kim, J. B., and Choi, H. S. (2008) The orphan nuclear receptor DAX-1 acts as a novel transcriptional corepressor of PPAR. Biochem. Biophys. Res. Commun. 370, 264-268
-
(2008)
Biochem. Biophys. Res. Commun.
, vol.370
, pp. 264-268
-
-
Kim, G.S.1
Lee, G.Y.2
Nedumaran, B.3
Park, Y.Y.4
Kim, K.T.5
Park, S.C.6
Lee, Y.C.7
Kim, J.B.8
Choi, H.S.9
-
39
-
-
0026767451
-
Cholesterol side-chain cleavage by mitochondria from the human placenta. Studies using hydroxycholesterols as substrates
-
Tuckey, R. C. (1992) Cholesterol side-chain cleavage by mitochondria from the human placenta. Studies using hydroxycholesterols as substrates. J. Steroid Biochem. Mol. Biol. 42, 883-890
-
(1992)
J. Steroid Biochem. Mol. Biol.
, vol.42
, pp. 883-890
-
-
Tuckey, R.C.1
-
40
-
-
63849125216
-
Metabolism of vitamin D2 to 17 20,24-trihydroxyvitamin D2 by cytochrome p450scc (CYP11A1)
-
Nguyen, M. N., Slominski, A., Li, W., Ng, Y. R., and Tuckey, R. C. (2009) Metabolism of vitamin D2 to 17,20,24-trihydroxyvitamin D2 by cytochrome p450scc (CYP11A1). Drug Metab. Dispos. 37, 761-767
-
(2009)
Drug Metab. Dispos.
, vol.37
, pp. 761-767
-
-
Nguyen, M.N.1
Slominski, A.2
Li, W.3
Ng, Y.R.4
Tuckey, R.C.5
-
41
-
-
0344736703
-
A pathway for the metabolism of vitamin D3: Unique hydroxylated metabolites formed during catalysis with cytochrome P450scc (CYP11A1)
-
Guryev, O., Carvalho, R. A., Usanov, S., Gilep, A., and Estabrook, R. W. (2003) A pathway for the metabolism of vitamin D3: unique hydroxylated metabolites formed during catalysis with cytochrome P450scc (CYP11A1). Proc. Natl. Acad. Sci. U.S.A. 100, 14754-14759
-
(2003)
Proc. Natl. Acad. Sci. U.S.A.
, vol.100
, pp. 14754-14759
-
-
Guryev, O.1
Carvalho, R.A.2
Usanov, S.3
Gilep, A.4
Estabrook, R.W.5
-
42
-
-
23944509748
-
Enzymatic metabolism of ergosterol by cytochrome p450scc to biologically active 17,24-dihydroxyergosterol
-
Slominski, A., Semak, I., Zjawiony, J., Wortsman, J., Gandy, M. N., Li, J., Zbytek, B., Li, W., and Tuckey, R. C. (2005) Enzymatic metabolism of ergosterol by cytochrome p450scc to biologically active 17,24- dihydroxyergosterol. Chem. Biol. 12, 931-939
-
(2005)
Chem. Biol.
, vol.12
, pp. 931-939
-
-
Slominski, A.1
Semak, I.2
Zjawiony, J.3
Wortsman, J.4
Gandy, M.N.5
Li, J.6
Zbytek, B.7
Li, W.8
Tuckey, R.C.9
-
43
-
-
8644251210
-
A novel pathway for sequential transformation of 7-dehydrocholesterol and expression of the P450scc system in mammalian skin
-
Slominski, A., Zjawiony, J., Wortsman, J., Semak, I., Stewart, J., Pisarchik, A., Sweatman, T., Marcos, J., Dunbar, C., and C Tuckey, R. (2004) A novel pathway for sequential transformation of 7-dehydrocholesterol and expression of the P450scc system in mammalian skin. Eur. J. Biochem. 271, 4178-4188
-
(2004)
Eur. J. Biochem.
, vol.271
, pp. 4178-4188
-
-
Slominski, A.1
Zjawiony, J.2
Wortsman, J.3
Semak, I.4
Stewart, J.5
Pisarchik, A.6
Sweatman, T.7
Marcos, J.8
Dunbar, C.9
Tuckey R, C.10
-
44
-
-
80051975233
-
Production of 22-hydroxy metabolites of vitamin D3 by cytochrome p450scc (CYP11A1) and analysis of their biological activities on skin cells
-
Tuckey, R. C., Li, W., Shehabi, H. Z., Janjetovic, Z., Nguyen, M. N., Kim, T. K., Chen, J., Howell, D. E., Benson, H. A., Sweatman, T., Baldisseri, D. M., and Slominski, A. (2011) Production of 22-hydroxy metabolites of vitamin D3 by cytochrome p450scc (CYP11A1) and analysis of their biological activities on skin cells. Drug Metab. Dispos. 39, 1577-1588
-
(2011)
Drug Metab. Dispos.
, vol.39
, pp. 1577-1588
-
-
Tuckey, R.C.1
Li, W.2
Shehabi, H.Z.3
Janjetovic, Z.4
Nguyen, M.N.5
Kim, T.K.6
Chen, J.7
Howell, D.E.8
Benson, H.A.9
Sweatman, T.10
Baldisseri, D.M.11
Slominski, A.12
-
45
-
-
84874505939
-
Causal relationship between obesity and vitamin D status: Bi-directional Mendelian randomization analysis of multiple cohorts
-
Vimaleswaran, K. S., Berry, D. J., Lu, C., Tikkanen, E., Pilz, S., Hiraki, L. T., Cooper, J. D., Dastani, Z., Li, R., Houston, D. K., Wood, A. R., Michaëlsson, K., Vandenput, L., Zgaga, L., Yerges-Armstrong, L. M., McCarthy, M. I., Dupuis, J., Kaakinen, M., Kleber, M. E., Jameson, K., Arden, N., Raitakari, O., Viikari, J., Lohman, K. K., Ferrucci, L., Melhus, H., Ingelsson, E., Byberg, L., Lind, L., Lorentzon, M., Salomaa, V., Campbell, H., Dunlop, M., Mitchell, B. D., Herzig, K. H., Pouta, A., Hartikainen, A. L., Streeten, E. A., Theodoratou, E., Jula, A., Wareham, N. J., Ohlsson, C., Frayling, T. M., Kritchevsky, S. B., Spector, T. D., Richards, J. B., Lehtimäki, T., Ouwehand, W. H., Kraft, P., Cooper, C., Marz, W., Power, C., Loos, R. J., Wang, T. J., Jarvelin, M. R., Whittaker, J. C., Hingorani, A. D., and Hyppönen, E. (2013) Causal relationship between obesity and vitamin D status: bi-directional Mendelian randomization analysis of multiple cohorts. PLoS Med. 10, e1001383
-
(2013)
PLoS Med.
, vol.10
-
-
Vimaleswaran, K.S.1
Berry, D.J.2
Lu, C.3
Tikkanen, E.4
Pilz, S.5
Hiraki, L.T.6
Cooper, J.D.7
Dastani, Z.8
Li, R.9
Houston, D.K.10
Wood, A.R.11
Michaëlsson, K.12
Vandenput, L.13
Zgaga, L.14
Yerges-Armstrong, L.M.15
McCarthy, M.I.16
Dupuis, J.17
Kaakinen, M.18
Kleber, M.E.19
Jameson, K.20
Arden, N.21
Raitakari, O.22
Viikari, J.23
Lohman, K.K.24
Ferrucci, L.25
Melhus, H.26
Ingelsson, E.27
Byberg, L.28
Lind, L.29
Lorentzon, M.30
Salomaa, V.31
Campbell, H.32
Dunlop, M.33
Mitchell, B.D.34
Herzig, K.H.35
Pouta, A.36
Hartikainen, A.L.37
Streeten, E.A.38
Theodoratou, E.39
Jula, A.40
Wareham, N.J.41
Ohlsson, C.42
Frayling, T.M.43
Kritchevsky, S.B.44
Spector, T.D.45
Richards, J.B.46
Lehtimäki, T.47
Ouwehand, W.H.48
Kraft, P.49
Cooper, C.50
Marz, W.51
Power, C.52
Loos, R.J.53
Wang, T.J.54
Jarvelin, M.R.55
Whittaker, J.C.56
Hingorani, A.D.57
Hyppönen, E.58
more..
-
46
-
-
0026488375
-
Identification by site-directed mutagenesis of two lysine residues in cholesterol side chain cleavage cytochrome P450 that are essential for adrenodoxin binding
-
Wada, A., and Waterman, M. R. (1992) Identification by site-directed mutagenesis of two lysine residues in cholesterol side chain cleavage cytochrome P450 that are essential for adrenodoxin binding. J. Biol. Chem. 267, 22877-22882
-
(1992)
J. Biol. Chem.
, vol.267
, pp. 22877-22882
-
-
Wada, A.1
Waterman, M.R.2
-
47
-
-
0033593336
-
An additional electrostatic interaction between adrenodoxin and P450c27 (CYP27A1) results in tighter binding than between adrenodoxin and p450scc (CYP11A1)
-
Pikuleva, I. A., Cao, C., and Waterman, M. R. (1999) An additional electrostatic interaction between adrenodoxin and P450c27 (CYP27A1) results in tighter binding than between adrenodoxin and p450scc (CYP11A1). J. Biol. Chem. 274, 2045-2052
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 2045-2052
-
-
Pikuleva, I.A.1
Cao, C.2
Waterman, M.R.3
-
48
-
-
0026551710
-
Mechanism of degradation of the steroid side chain in the formation of bile acids
-
Björkhem, I. (1992) Mechanism of degradation of the steroid side chain in the formation of bile acids. J. Lipid Res. 33, 455-471
-
(1992)
J. Lipid Res.
, vol.33
, pp. 455-471
-
-
Björkhem, I.1
-
49
-
-
85047684249
-
Human cholesterol 7-hydroxylase (CYP7A1) deficiency has a hypercholesterolemic phenotype
-
Pullinger, C. R., Eng, C., Salen, G., Shefer, S., Batta, A. K., Erickson, S. K., Verhagen, A., Rivera, C. R., Mulvihill, S. J., Malloy, M. J., and Kane, J. P. (2002) Human cholesterol 7-hydroxylase (CYP7A1) deficiency has a hypercholesterolemic phenotype. J. Clin. Invest. 110, 109-117
-
(2002)
J. Clin. Invest.
, vol.110
, pp. 109-117
-
-
Pullinger, C.R.1
Eng, C.2
Salen, G.3
Shefer, S.4
Batta, A.K.5
Erickson, S.K.6
Verhagen, A.7
Rivera, C.R.8
Mulvihill, S.J.9
Malloy, M.J.10
Kane, J.P.11
-
50
-
-
77950599782
-
Marked accumulation of 27-hydroxycholesterol in SPG5 patients with hereditary spastic paresis
-
Schüle, R., Siddique, T., Deng, H. X., Yang, Y., Donkervoort, S., Hansson, M., Madrid, R. E., Siddique, N., Schöls, L., and Björkhem, I. (2010) Marked accumulation of 27-hydroxycholesterol in SPG5 patients with hereditary spastic paresis. J. Lipid Res. 51, 819-823
-
(2010)
J. Lipid Res.
, vol.51
, pp. 819-823
-
-
Schüle, R.1
Siddique, T.2
Deng, H.X.3
Yang, Y.4
Donkervoort, S.5
Hansson, M.6
Madrid, R.E.7
Siddique, N.8
Schöls, L.9
Björkhem, I.10
-
51
-
-
84877576592
-
Expression of vitamin D-metabolizing enzyme in human adipose tissue-The effect of obesity and diet-induced weight joss
-
Wamberg, L., Christiansen, T., Paulsen, S. K., Fisker, S., Rask, P., Rejnmark, L., Richelsen, B., and Pedersen, S. B. (2013) Expression of vitamin D-metabolizing enzyme in human adipose tissue-the effect of obesity and diet-induced weight joss. Int. J. Obes. 37, 651-657
-
(2013)
Int. J. Obes.
, vol.37
, pp. 651-657
-
-
Wamberg, L.1
Christiansen, T.2
Paulsen, S.K.3
Fisker, S.4
Rask, P.5
Rejnmark, L.6
Richelsen, B.7
Pedersen, S.B.8
-
52
-
-
0034504237
-
Subcutaneous and visceral adipose tissue: Their relation to the metabolic syndrome
-
Wajchenberg, B. L. (2000) Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome. Endocr. Rev. 21, 697-738
-
(2000)
Endocr. Rev.
, vol.21
, pp. 697-738
-
-
Wajchenberg, B.L.1
-
53
-
-
44849132591
-
Dynamics of fat cell turnover in humans
-
Spalding, K. L., Arner, E., Westermark, P. O., Bernard, S., Buchholz, B. A., Bergmann, O., Blomqvist, L., Hoffstedt, J., Näslund, E., Britton, T., Concha, H., Hassan, M., Rydén, M., Frisén, J., and Arner, P. (2008) Dynamics of fat cell turnover in humans. Nature 453, 783-787
-
(2008)
Nature
, vol.453
, pp. 783-787
-
-
Spalding, K.L.1
Arner, E.2
Westermark, P.O.3
Bernard, S.4
Buchholz, B.A.5
Bergmann, O.6
Blomqvist, L.7
Hoffstedt, J.8
Näslund, E.9
Britton, T.10
Concha, H.11
Hassan, M.12
Rydén, M.13
Frisén, J.14
Arner, P.15
-
54
-
-
3242804594
-
Oxysterols regulate differentiation of mesenchymal stem cells: Pro-bone and anti-fat
-
Kha, H. T., Basseri, B., Shouhed, D., Richardson, J., Tetradis, S., Hahn, T. J., and Parhami, F. (2004) Oxysterols regulate differentiation of mesenchymal stem cells: pro-bone and anti-fat. J. Bone Miner. Res. 19, 830-840
-
(2004)
J. Bone Miner. Res.
, vol.19
, pp. 830-840
-
-
Kha, H.T.1
Basseri, B.2
Shouhed, D.3
Richardson, J.4
Tetradis, S.5
Hahn, T.J.6
Parhami, F.7
-
55
-
-
19944427358
-
Role of CYP27A in cholesterol and bile acid metabolism
-
Dubrac, S., Lear, S. R., Ananthanarayanan, M., Balasubramaniyan, N., Bollineni, J., Shefer, S., Hyogo, H., Cohen, D. E., Blanche, P. J., Krauss, R. M., Batta, A. K., Salen, G., Suchy, F. J., Maeda, N., and Erickson, S. K. (2005) Role of CYP27A in cholesterol and bile acid metabolism. J. Lipid Res. 46, 76-85
-
(2005)
J. Lipid Res.
, vol.46
, pp. 76-85
-
-
Dubrac, S.1
Lear, S.R.2
Ananthanarayanan, M.3
Balasubramaniyan, N.4
Bollineni, J.5
Shefer, S.6
Hyogo, H.7
Cohen, D.E.8
Blanche, P.J.9
Krauss, R.M.10
Batta, A.K.11
Salen, G.12
Suchy, F.J.13
Maeda, N.14
Erickson, S.K.15
-
56
-
-
84871330823
-
The cholesterol derivative 27-hydroxycholesterol reduces steatohepatitis in mice
-
Bieghs, V., Hendrikx, T., van Gorp, P. J., Verheyen, F., Guichot, Y. D., Walenbergh, S. M., Jeurissen, M. L., Gijbels, M., Rensen, S. S., Bast, A., Plat, J., Kalhan, S. C., Koek, G. H., Leitersdorf, E., Hofker, M. H., Lutjohann, D., and Shiri-Sverdlov, R. (2013) The cholesterol derivative 27-hydroxycholesterol reduces steatohepatitis in mice. Gastroenterology 144, 167-178
-
(2013)
Gastroenterology
, vol.144
, pp. 167-178
-
-
Bieghs, V.1
Hendrikx, T.2
Van Gorp, P.J.3
Verheyen, F.4
Guichot, Y.D.5
Walenbergh, S.M.6
Jeurissen, M.L.7
Gijbels, M.8
Rensen, S.S.9
Bast, A.10
Plat, J.11
Kalhan, S.C.12
Koek, G.H.13
Leitersdorf, E.14
Hofker, M.H.15
Lutjohann, D.16
Shiri-Sverdlov, R.17
-
57
-
-
84870816481
-
Non-alcoholic fatty liver disease and obesity: Not all about body mass index
-
Pagadala, M. R., and McCullough, A. J. (2012) Non-alcoholic fatty liver disease and obesity: not all about body mass index. Am. J. Gastroenterol. 107, 1859-1861
-
(2012)
Am. J. Gastroenterol.
, vol.107
, pp. 1859-1861
-
-
Pagadala, M.R.1
McCullough, A.J.2
-
58
-
-
70350245011
-
Harmonizing the metabolic syndrome: A joint interim statement of the international diabetes federation task force on epidemiology and prevention
-
National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity
-
Alberti, K. G., Eckel, R. H., Grundy, S. M., Zimmet, P. Z., Cleeman, J. I., Donato, K. A., Fruchart, J. C., James, W. P., Loria, C. M., and Smith, S. C., Jr. (2009) Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity. Circulation 120, 1640-1645
-
(2009)
Circulation
, vol.120
, pp. 1640-1645
-
-
Alberti, K.G.1
Eckel, R.H.2
Grundy, S.M.3
Zimmet, P.Z.4
Cleeman, J.I.5
Donato, K.A.6
Fruchart, J.C.7
James, W.P.8
Loria, C.M.9
Smith Jr., S.C.10
-
59
-
-
14444285707
-
Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway
-
Lehmann, J. M., Kliewer, S. A., Moore, L. B., Smith-Oliver, T. A., Oliver, B. B., Su, J. L., Sundseth, S. S., Winegar, D. A., Blanchard, D. E., Spencer, T. A., and Willson, T. M. (1997) Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway. J. Biol. Chem. 272, 3137-3140
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 3137-3140
-
-
Lehmann, J.M.1
Kliewer, S.A.2
Moore, L.B.3
Smith-Oliver, T.A.4
Oliver, B.B.5
Su, J.L.6
Sundseth, S.S.7
Winegar, D.A.8
Blanchard, D.E.9
Spencer, T.A.10
Willson, T.M.11
-
60
-
-
0037312554
-
On the role of liver X receptors in lipid accumulation in adipocytes
-
Juvet, L. K., Andresen, S. M., Schuster, G. U., Dalen, K. T., Tobin, K. A., Hollung, K., Haugen, F., Jacinto, S., Ulven, S. M., Bamberg, K., Gustafsson, J. A., and Nebb, H. I. (2003) On the role of liver X receptors in lipid accumulation in adipocytes. Mol. Endocrinol. 17, 172-182
-
(2003)
Mol. Endocrinol.
, vol.17
, pp. 172-182
-
-
Juvet, L.K.1
Andresen, S.M.2
Schuster, G.U.3
Dalen, K.T.4
Tobin, K.A.5
Hollung, K.6
Haugen, F.7
Jacinto, S.8
Ulven, S.M.9
Bamberg, K.10
Gustafsson, J.A.11
Nebb, H.I.12
-
61
-
-
11144356074
-
Activated liver X receptors stimulate adipocyte differentiation through induction of peroxisome proliferatoractivated receptor expression
-
Seo, J. B., Moon, H. M., Kim, W. S., Lee, Y. S., Jeong, H. W., Yoo, E. J., Ham, J., Kang, H., Park, M. G., Steffensen, K. R., Stulnig, T. M., Gustafsson, J. A., Park, S. D., and Kim, J. B. (2004) Activated liver X receptors stimulate adipocyte differentiation through induction of peroxisome proliferatoractivated receptor expression. Mol. Cell. Biol. 24, 3430-3444
-
(2004)
Mol. Cell. Biol.
, vol.24
, pp. 3430-3444
-
-
Seo, J.B.1
Moon, H.M.2
Kim, W.S.3
Lee, Y.S.4
Jeong, H.W.5
Yoo, E.J.6
Ham, J.7
Kang, H.8
Park, M.G.9
Steffensen, K.R.10
Stulnig, T.M.11
Gustafsson, J.A.12
Park, S.D.13
Kim, J.B.14
-
62
-
-
1642465503
-
Liver X receptors are regulators of adipocyte gene expression but not differentiation: Identification of apoD as a direct target
-
Hummasti, S., Laffitte, B. A., Watson, M. A., Galardi, C., Chao, L. C., Ramamurthy, L., Moore, J. T., and Tontonoz, P. (2004) Liver X receptors are regulators of adipocyte gene expression but not differentiation: identification of apoD as a direct target. J. Lipid Res. 45, 616-625
-
(2004)
J. Lipid Res.
, vol.45
, pp. 616-625
-
-
Hummasti, S.1
Laffitte, B.A.2
Watson, M.A.3
Galardi, C.4
Chao, L.C.5
Ramamurthy, L.6
Moore, J.T.7
Tontonoz, P.8
-
63
-
-
0036318980
-
Microarray analyses during adipogenesis: Understanding the effects of Wnt signaling on adipogenesis and the roles of liver X receptor-in adipocyte metabolism
-
Ross, S. E., Erickson, R. L., Gerin, I., DeRose, P. M., Bajnok, L., Longo, K. A., Misek, D. E., Kuick, R., Hanash, S. M., Atkins, K. B., Andresen, S. M., Nebb, H. I., Madsen, L., Kristiansen, K., and MacDougald, O. A. (2002) Microarray analyses during adipogenesis: understanding the effects of Wnt signaling on adipogenesis and the roles of liver X receptor-in adipocyte metabolism. Mol. Cell. Biol. 22, 5989-5999
-
(2002)
Mol. Cell. Biol.
, vol.22
, pp. 5989-5999
-
-
Ross, S.E.1
Erickson, R.L.2
Gerin, I.3
Derose, P.M.4
Bajnok, L.5
Longo, K.A.6
Misek, D.E.7
Kuick, R.8
Hanash, S.M.9
Atkins, K.B.10
Andresen, S.M.11
Nebb, H.I.12
Madsen, L.13
Kristiansen, K.14
MacDougald, O.A.15
-
64
-
-
38449113816
-
20(S)-hydroxycholesterol inhibits PPAR expression and adipogenic differentiation of bone marrow stromal cells through a hedgehogdependent mechanism
-
Kim, W. K., Meliton, V., Amantea, C. M., Hahn, T. J., and Parhami, F. (2007) 20(S)-hydroxycholesterol inhibits PPAR expression and adipogenic differentiation of bone marrow stromal cells through a hedgehogdependent mechanism. J. Bone Miner. Res. 22, 1711-1719
-
(2007)
J. Bone Miner. Res.
, vol.22
, pp. 1711-1719
-
-
Kim, W.K.1
Meliton, V.2
Amantea, C.M.3
Hahn, T.J.4
Parhami, F.5
-
65
-
-
79953160837
-
27-Hydroxycholesterol: The first identified endogenous SERM
-
Umetani, M., and Shaul, P. W. (2011) 27-Hydroxycholesterol: the first identified endogenous SERM. Trends Endocrinol. Metab. 22, 130-135
-
(2011)
Trends Endocrinol. Metab.
, vol.22
, pp. 130-135
-
-
Umetani, M.1
Shaul, P.W.2
-
66
-
-
1442349778
-
Evidence for functional estrogen receptors and in human adipose cells: Regional specificities and regulation by estrogens
-
Dieudonn, M. N., Leneveu, M. C., Giudicelli, Y., and Pecquery, R. (2004) Evidence for functional estrogen receptors and in human adipose cells: regional specificities and regulation by estrogens. Am. J. Physiol. Cell Physiol. 286, C655-C661
-
(2004)
Am. J. Physiol. Cell Physiol.
, vol.286
-
-
Dieudonn, M.N.1
Leneveu, M.C.2
Giudicelli, Y.3
Pecquery, R.4
|