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Volumn 31, Issue 1, 2014, Pages 488-496

Purified vitexin compound 1 induces apoptosis through activation of FOXO3a in hepatocellular carcinoma

Author keywords

AKT; Apoptosis; ERK; FOXO3a; Hepatocellular carcinoma; Purified vitexin compound 1

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; CASPASE 3; CASPASE 8; CASPASE 9; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROPIDIUM IODIDE; PROTEIN KINASE B; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR FKHRL1; UNCLASSIFIED DRUG; VITEXIN; VITEXIN COMPOUND 1;

EID: 84891932499     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2013.2855     Document Type: Article
Times cited : (20)

References (45)
  • 1
    • 84864480565 scopus 로고    scopus 로고
    • Molecularly targeted therapy for advanced hepatocellular carcinoma in 2012: Current status and future perspectives
    • Zhu AX: Molecularly targeted therapy for advanced hepatocellular carcinoma in 2012: current status and future perspectives. Semin Oncol 39: 493-502, 2012.
    • (2012) Semin Oncol , vol.39 , pp. 493-502
    • Zhu, A.X.1
  • 3
    • 73449129338 scopus 로고    scopus 로고
    • Liver tumor ablation: Percutaneous and open approaches
    • Padma S, Martinie JB and Iannitti DA: Liver tumor ablation: percutaneous and open approaches. J Surg Oncol 100: 619-634, 2009.
    • (2009) J Surg Oncol , vol.100 , pp. 619-634
    • Padma, S.1    Martinie, J.B.2    Iannitti, D.A.3
  • 4
    • 0030444731 scopus 로고    scopus 로고
    • The medical management of hepatocellular carcinoma (HCC) in Japan: A review with implications for HCC seen in the west
    • Ichida T, Van Thiel DH and Hassanein T: The medical management of hepatocellular carcinoma (HCC) in Japan: a review with implications for HCC seen in the west. Hepatogastroenterology 43: 1575-1583, 1996.
    • (1996) Hepatogastroenterology , vol.43 , pp. 1575-1583
    • Ichida, T.1    Van Thiel, D.H.2    Hassanein, T.3
  • 5
    • 28844480321 scopus 로고    scopus 로고
    • Management of hepatocellular carcinoma
    • Practice Guidelines Committee, American Association for the Study of Liver Diseases
    • Bruix J, Sherman M; Practice Guidelines Committee, American Association for the Study of Liver Diseases: Management of hepatocellular carcinoma. Hepatology 42: 1208-1236, 2005.
    • (2005) Hepatology , vol.42 , pp. 1208-1236
    • Bruix, J.1    Sherman, M.2
  • 6
    • 0037129704 scopus 로고    scopus 로고
    • Arterial embolisation or chemoembolisation versus symptomatic treatment in patients with unresectable hepatocellular carcinoma: A randomised controlled trial
    • Llovet JM, Real MI, Montaña X, et al: Arterial embolisation or chemoembolisation versus symptomatic treatment in patients with unresectable hepatocellular carcinoma: a randomised controlled trial. Lancet 359: 1734-1739, 2002.
    • (2002) Lancet , vol.359 , pp. 1734-1739
    • Llovet, J.M.1    Real, M.I.2    Montaña, X.3
  • 7
    • 84863985161 scopus 로고    scopus 로고
    • Vitexin and isovitexin from the leaves of Ficus deltoidea with in-vivo α-glucosidase inhibition
    • Choo CY, Sulong NY, Man F and Wong TW: Vitexin and isovitexin from the leaves of Ficus deltoidea with in-vivo α-glucosidase inhibition. J Ethnopharmacol 142: 776-781, 2012.
    • (2012) J Ethnopharmacol , vol.142 , pp. 776-781
    • Choo, C.Y.1    Sulong, N.Y.2    Man, F.3    Wong, T.W.4
  • 8
    • 84864116943 scopus 로고    scopus 로고
    • An evaluation of the inhibitory effects against rotavirus infection of edible plant extracts
    • Knipping K, Garssen J and van't Land B: An evaluation of the inhibitory effects against rotavirus infection of edible plant extracts. Virol J 9: 137, 2012.
    • (2012) Virol J , vol.9 , pp. 137
    • Knipping, K.1    Garssen, J.2    Van't Land, B.3
  • 10
    • 84866439177 scopus 로고    scopus 로고
    • Apoptosis triggered by vitexin in U937 human leukemia cells via a mitochondrial signaling pathway
    • Lee CY, Chien YS, Chiu TH, et al: Apoptosis triggered by vitexin in U937 human leukemia cells via a mitochondrial signaling pathway. Oncol Rep 28: 1883-1888, 2012.
    • (2012) Oncol Rep , vol.28 , pp. 1883-1888
    • Lee, C.Y.1    Chien, Y.S.2    Chiu, T.H.3
  • 11
    • 84873744604 scopus 로고    scopus 로고
    • Vitexin-2-O-xyloside, raphasatin and (-)-epigallocatechin-3-gallate synergistically affect cell growth and apoptosis of colon cancer cells
    • Papi A, Farabegoli F, Iori R, et al: Vitexin-2-O-xyloside, raphasatin and (-)-epigallocatechin-3-gallate synergistically affect cell growth and apoptosis of colon cancer cells. Food Chem 138: 1521-1530, 2013.
    • (2013) Food Chem , vol.138 , pp. 1521-1530
    • Papi, A.1    Farabegoli, F.2    Iori, R.3
  • 12
    • 84876415784 scopus 로고    scopus 로고
    • Lignans extracted from Vitex negundo possess cytotoxic activity by G2/M phase cell cycle arrest and apoptosis induction
    • Xin H, Kong Y, Wang Y, et al: Lignans extracted from Vitex negundo possess cytotoxic activity by G2/M phase cell cycle arrest and apoptosis induction. Phytomedicine 20: 640-647, 2013.
    • (2013) Phytomedicine , vol.20 , pp. 640-647
    • Xin, H.1    Kong, Y.2    Wang, Y.3
  • 13
    • 69349085413 scopus 로고    scopus 로고
    • Vitexins, nature-derived lignan compounds, induce apoptosis and suppress tumor growth
    • Zhou Y, Liu YE, Cao J, et al: Vitexins, nature-derived lignan compounds, induce apoptosis and suppress tumor growth. Clin Cancer Res 15: 5161-5169, 2009.
    • (2009) Clin Cancer Res , vol.15 , pp. 5161-5169
    • Zhou, Y.1    Liu, Y.E.2    Cao, J.3
  • 14
    • 84863298521 scopus 로고    scopus 로고
    • Purified vitexin compound 1 suppresses tumor growth and induces cell apoptosis in a mouse model of human choriocarcinoma
    • Tan Z, Zhang Y, Deng J, Zeng G and Zhang Y: Purified vitexin compound 1 suppresses tumor growth and induces cell apoptosis in a mouse model of human choriocarcinoma. Int J Gynecol Cancer 22: 360-366, 2012.
    • (2012) Int J Gynecol Cancer , vol.22 , pp. 360-366
    • Tan, Z.1    Zhang, Y.2    Deng, J.3    Zeng, G.4    Zhang, Y.5
  • 15
    • 84868628069 scopus 로고    scopus 로고
    • Mutations and deregulation of Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascades which alter therapy response
    • McCubrey JA, Steelman LS, Chappell WH, et al: Mutations and deregulation of Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascades which alter therapy response. Oncotarget 3: 954-987, 2012.
    • (2012) Oncotarget , vol.3 , pp. 954-987
    • McCubrey, J.A.1    Steelman, L.S.2    Chappell, W.H.3
  • 18
    • 84866890498 scopus 로고    scopus 로고
    • The heme oxygenase 1 inducer (CoPP) protects human cardiac stem cells against apoptosis through activation of the extracellular signal-regulated kinase (ERK)/NRF2 signaling pathway and cytokine release
    • Cai C, Teng L, Vu D, et al: The heme oxygenase 1 inducer (CoPP) protects human cardiac stem cells against apoptosis through activation of the extracellular signal-regulated kinase (ERK)/NRF2 signaling pathway and cytokine release. J Biol Chem 287: 33720-33732, 2012.
    • (2012) J Biol Chem , vol.287 , pp. 33720-33732
    • Cai, C.1    Teng, L.2    Vu, D.3
  • 19
    • 84873344263 scopus 로고    scopus 로고
    • Hepatitis B virus X protein represses miRNA-148a to enhance tumorigenesis
    • Xu X, Fan Z, Kang L, et al: Hepatitis B virus X protein represses miRNA-148a to enhance tumorigenesis. J Clin Invest 123: 630-645, 2013.
    • (2013) J Clin Invest , vol.123 , pp. 630-645
    • Xu, X.1    Fan, Z.2    Kang, L.3
  • 20
    • 79960026150 scopus 로고    scopus 로고
    • Deciphering the role of forkhead transcription factors in cancer therapy
    • Yang JY and Hung MC: Deciphering the role of forkhead transcription factors in cancer therapy. Curr Drug Targets 12: 1284-1290, 2011.
    • (2011) Curr Drug Targets , vol.12 , pp. 1284-1290
    • Yang, J.Y.1    Hung, M.C.2
  • 21
    • 33747370384 scopus 로고    scopus 로고
    • Multiple roles of FOXO transcription factors in mammalian cells point to multiple roles in cancer
    • Arden KC: Multiple roles of FOXO transcription factors in mammalian cells point to multiple roles in cancer. Exp Gerontol 41: 709-717, 2006.
    • (2006) Exp Gerontol , vol.41 , pp. 709-717
    • Arden, K.C.1
  • 22
    • 11144357466 scopus 로고    scopus 로고
    • IκB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a
    • Hu MC, Lee DF, Xia W, et al: IκB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a. Cell 117: 225-237, 2004.
    • (2004) Cell , vol.117 , pp. 225-237
    • Hu, M.C.1    Lee, D.F.2    Xia, W.3
  • 23
    • 24644519938 scopus 로고    scopus 로고
    • Involvement of Foxo transcription factors in angiogenesis and postnatal neovascularization
    • Potente M, Urbich C, Sasaki K, et al: Involvement of Foxo transcription factors in angiogenesis and postnatal neovascularization. J Clin Invest 115: 2382-2392, 2005.
    • (2005) J Clin Invest , vol.115 , pp. 2382-2392
    • Potente, M.1    Urbich, C.2    Sasaki, K.3
  • 24
    • 0033582929 scopus 로고    scopus 로고
    • Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor
    • Brunet A, Bonni A, Zigmond MJ, et al: Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell 96: 857-868, 1999.
    • (1999) Cell , vol.96 , pp. 857-868
    • Brunet, A.1    Bonni, A.2    Zigmond, M.J.3
  • 25
    • 38849139580 scopus 로고    scopus 로고
    • ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation
    • Yang JY, Zong CS, Xia W, et al: ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation. Nat Cell Biol 10: 138-148, 2008.
    • (2008) Nat Cell Biol , vol.10 , pp. 138-148
    • Yang, J.Y.1    Zong, C.S.2    Xia, W.3
  • 26
    • 67249165389 scopus 로고    scopus 로고
    • VEGF siRNA delivery system using arginine-grafted bioreducible poly(disulfide amine)
    • Kim SH, Jeong JH, Kim TI, Kim SW and Bull DA: VEGF siRNA delivery system using arginine-grafted bioreducible poly(disulfide amine). Mol Pharm 6: 718-726, 2009.
    • (2009) Mol Pharm , vol.6 , pp. 718-726
    • Kim, S.H.1    Jeong, J.H.2    Kim, T.I.3    Kim, S.W.4    Bull, D.A.5
  • 27
    • 79958094337 scopus 로고    scopus 로고
    • Effective inhibition of foot-and-mouth disease virus (FMDV) replication in vitro by vector-delivered microRNAs targeting the 3D gene
    • Du J, Gao S, Luo J, et al: Effective inhibition of foot-and-mouth disease virus (FMDV) replication in vitro by vector-delivered microRNAs targeting the 3D gene. Virol J 8: 292, 2011.
    • (2011) Virol J , vol.8 , pp. 292
    • Du, J.1    Gao, S.2    Luo, J.3
  • 28
    • 84891957841 scopus 로고    scopus 로고
    • Promotion of caspase activation by caspase-9-mediated feedback amplification of mitochondrial damage
    • pii: 1000126
    • Guerrero AD, Schmitz I, Chen M and Wang J: Promotion of caspase activation by caspase-9-mediated feedback amplification of mitochondrial damage. J Clin Cell Immunol 3: pii: 1000126, 2012.
    • (2012) J Clin Cell Immunol , vol.3
    • Guerrero, A.D.1    Schmitz, I.2    Chen, M.3    Wang, J.4
  • 29
    • 84866421259 scopus 로고    scopus 로고
    • Apoptotic potential of Fas-associated death domain on regulation of cell death regulatory protein cFLIP and death receptor mediated apoptosis in HEK 293T cells
    • Ranjan K, Surolia A and Pathak C: Apoptotic potential of Fas-associated death domain on regulation of cell death regulatory protein cFLIP and death receptor mediated apoptosis in HEK 293T cells. J Cell Commun Signal 6: 155-168, 2012.
    • (2012) J Cell Commun Signal , vol.6 , pp. 155-168
    • Ranjan, K.1    Surolia, A.2    Pathak, C.3
  • 30
    • 84862726489 scopus 로고    scopus 로고
    • Important role of β1-integrin in fucoidan-induced apoptosis via caspase-8 activation
    • Yamasaki Y, Yamasaki M, Tachibana H and Yamada K: Important role of β1-integrin in fucoidan-induced apoptosis via caspase-8 activation. Biosci Biotechnol Biochem 76: 1163-1168, 2012.
    • (2012) Biosci Biotechnol Biochem , vol.76 , pp. 1163-1168
    • Yamasaki, Y.1    Yamasaki, M.2    Tachibana, H.3    Yamada, K.4
  • 31
    • 77949717502 scopus 로고    scopus 로고
    • Highly phosphorylated FOXO3A is an adverse prognostic factor in acute myeloid leukemia
    • Kornblau SM, Singh N, Qiu Y, Chen W, Zhang N and Coombes KR: Highly phosphorylated FOXO3A is an adverse prognostic factor in acute myeloid leukemia. Clin Cancer Res 16: 1865-1874, 2010.
    • (2010) Clin Cancer Res , vol.16 , pp. 1865-1874
    • Kornblau, S.M.1    Singh, N.2    Qiu, Y.3    Chen, W.4    Zhang, N.5    Coombes, K.R.6
  • 32
    • 84886375160 scopus 로고    scopus 로고
    • Role of PI3K-AKT-mTOR and Wnt signaling pathways in transition of G1-S phase of cell cycle in cancer cells
    • Vadlakonda L, Pasupuleti M and Pallu R: Role of PI3K-AKT-mTOR and Wnt signaling pathways in transition of G1-S phase of cell cycle in cancer cells. Front Oncol 3: 85, 2013.
    • (2013) Front Oncol , vol.3 , pp. 85
    • Vadlakonda, L.1    Pasupuleti, M.2    Pallu, R.3
  • 33
    • 41949089154 scopus 로고    scopus 로고
    • FOXO transcription factors are mechanosensitive and their regulation is altered with aging in the respiratory pump
    • Pardo PS, Lopez MA and Boriek AM: FOXO transcription factors are mechanosensitive and their regulation is altered with aging in the respiratory pump. Am J Physiol Cell Physiol 294: C1056-C1066, 2008.
    • (2008) Am J Physiol Cell Physiol , vol.294
    • Pardo, P.S.1    Lopez, M.A.2    Boriek, A.M.3
  • 34
    • 80055025175 scopus 로고    scopus 로고
    • Pathological alteration of FoxO3a activity promotes idiopathic pulmonary fibrosis fibroblast proliferation on type I collagen matrix
    • Nho RS, Hergert P, Kahm J, Jessurun J and Henke C: Pathological alteration of FoxO3a activity promotes idiopathic pulmonary fibrosis fibroblast proliferation on type I collagen matrix. Am J Pathol 179: 2420-2430, 2011.
    • (2011) Am J Pathol , vol.179 , pp. 2420-2430
    • Nho, R.S.1    Hergert, P.2    Kahm, J.3    Jessurun, J.4    Henke, C.5
  • 35
    • 84155184198 scopus 로고    scopus 로고
    • A pathway from JNK through decreased ERK and Akt activities for FOXO3a nuclear translocation in response to UV irradiation
    • Wang X, Chen WR and Xing D: A pathway from JNK through decreased ERK and Akt activities for FOXO3a nuclear translocation in response to UV irradiation. J Cell Physiol 227: 1168-1178, 2012.
    • (2012) J Cell Physiol , vol.227 , pp. 1168-1178
    • Wang, X.1    Chen, W.R.2    Xing, D.3
  • 36
    • 84864004532 scopus 로고    scopus 로고
    • Upregulator of cell proliferation predicts poor prognosis in hepatocellular carcinoma and contributes to hepatocarcinogenesis by downregulating FOXO3a
    • Xie C, Song LB, Wu JH, et al: Upregulator of cell proliferation predicts poor prognosis in hepatocellular carcinoma and contributes to hepatocarcinogenesis by downregulating FOXO3a. PLoS One 7: e40607, 2012.
    • (2012) PLoS One , vol.7
    • Xie, C.1    Song, L.B.2    Wu, J.H.3
  • 37
    • 84862996844 scopus 로고    scopus 로고
    • CHOP potentially co-operates with FOXO3a in neuronal cells to regulate PUMA and BIM expression in response to ER stress
    • Ghosh AP, Klocke BJ, Ballestas ME and Roth KA: CHOP potentially co-operates with FOXO3a in neuronal cells to regulate PUMA and BIM expression in response to ER stress. PLoS One 7: e39586, 2012.
    • (2012) PLoS One , vol.7
    • Ghosh, A.P.1    Klocke, B.J.2    Ballestas, M.E.3    Roth, K.A.4
  • 38
    • 84872731452 scopus 로고    scopus 로고
    • Regulation of the FOXO3a/Bim signaling pathway by 5,7-dihydroxy-8- nitrochrysin in MDA-MB-453 breast cancer cells
    • Zhao XC, Cao XC, Liu F, Quan MF, Ren KQ and Cao JG: Regulation of the FOXO3a/Bim signaling pathway by 5,7-dihydroxy-8-nitrochrysin in MDA-MB-453 breast cancer cells. Oncol Lett 5: 929-934, 2013.
    • (2013) Oncol Lett , vol.5 , pp. 929-934
    • Zhao, X.C.1    Cao, X.C.2    Liu, F.3    Quan, M.F.4    Ren, K.Q.5    Cao, J.G.6
  • 39
    • 84868013359 scopus 로고    scopus 로고
    • Death protein 5 and p53-upregulated modulator of apoptosis mediate the endoplasmic reticulum stress-mitochondrial dialog triggering lipotoxic rodent and human β-cell apoptosis
    • Cunha DA, Igoillo-Esteve M, Gurzov EN, et al: Death protein 5 and p53-upregulated modulator of apoptosis mediate the endoplasmic reticulum stress-mitochondrial dialog triggering lipotoxic rodent and human β-cell apoptosis. Diabetes 61: 2763-2775, 2012.
    • (2012) Diabetes , vol.61 , pp. 2763-2775
    • Cunha, D.A.1    Igoillo-Esteve, M.2    Gurzov, E.N.3
  • 40
    • 84872872078 scopus 로고    scopus 로고
    • Casticin induces growth suppression and cell cycle arrest through activation of FOXO3a in hepatocellular carcinoma
    • He L, Yang X, Cao X, Liu F, Quan M and Cao J: Casticin induces growth suppression and cell cycle arrest through activation of FOXO3a in hepatocellular carcinoma. Oncol Rep 29: 103-108, 2013.
    • (2013) Oncol Rep , vol.29 , pp. 103-108
    • He, L.1    Yang, X.2    Cao, X.3    Liu, F.4    Quan, M.5    Cao, J.6
  • 41
    • 78650774201 scopus 로고    scopus 로고
    • Resveratrol induces growth arrest and apoptosis through activation of FOXO transcription factors in prostate cancer cells
    • Chen Q, Ganapathy S, Singh KP, Shankar S and Srivastava RK: Resveratrol induces growth arrest and apoptosis through activation of FOXO transcription factors in prostate cancer cells. PLoS One 5: e15288, 2010.
    • (2010) PLoS One , vol.5
    • Chen, Q.1    Ganapathy, S.2    Singh, K.P.3    Shankar, S.4    Srivastava, R.K.5
  • 42
    • 79953293746 scopus 로고    scopus 로고
    • Pancreatic tumor suppression by benzyl isothiocyanate is associated with inhibition of PI3K/AKT/FOXO pathway
    • Boreddy SR, Pramanik KC and Srivastava SK: Pancreatic tumor suppression by benzyl isothiocyanate is associated with inhibition of PI3K/AKT/FOXO pathway. Clin Cancer Res 17: 1784-1795, 2011.
    • (2011) Clin Cancer Res , vol.17 , pp. 1784-1795
    • Boreddy, S.R.1    Pramanik, K.C.2    Srivastava, S.K.3
  • 43
    • 77954675751 scopus 로고    scopus 로고
    • Inhibition of PI3K/AKT and MAPK/ERK pathways causes activation of FOXO transcription factor, leading to cell cycle arrest and apoptosis in pancreatic cancer
    • Roy SK, Srivastava RK and Shankar S: Inhibition of PI3K/AKT and MAPK/ERK pathways causes activation of FOXO transcription factor, leading to cell cycle arrest and apoptosis in pancreatic cancer. J Mol Signal 5: 10, 2010.
    • (2010) J Mol Signal , vol.5 , pp. 10
    • Roy, S.K.1    Srivastava, R.K.2    Shankar, S.3
  • 44
    • 84870476514 scopus 로고    scopus 로고
    • EGCG inhibits growth of human pancreatic tumors orthotopically implanted in Balb C nude mice through modulation of FKHRL1/FOXO3a and neuropilin
    • Shankar S, Marsh L and Srivastava RK: EGCG inhibits growth of human pancreatic tumors orthotopically implanted in Balb C nude mice through modulation of FKHRL1/FOXO3a and neuropilin. Mol Cell Biochem 372: 83-94, 2013.
    • (2013) Mol Cell Biochem , vol.372 , pp. 83-94
    • Shankar, S.1    Marsh, L.2    Srivastava, R.K.3
  • 45
    • 77949658533 scopus 로고    scopus 로고
    • FOXO transcription factors and VEGF neutralizing antibody enhance antiangiogenic effects of resveratrol
    • Srivastava RK, Unterman TG and Shankar S: FOXO transcription factors and VEGF neutralizing antibody enhance antiangiogenic effects of resveratrol. Mol Cell Biochem 337: 201-212, 2010.
    • (2010) Mol Cell Biochem , vol.337 , pp. 201-212
    • Srivastava, R.K.1    Unterman, T.G.2    Shankar, S.3


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