Lignans extracted from Vitex negundo possess cytotoxic activity by G2/M phase cell cycle arrest and apoptosis induction

Phytomedicine

Volumn 20, Issue 7, 2013, Pages 640-647

  Xin, Hong ^a   Kong, Ying ^a   Wang, Yong ^c   Zhou, Yingjun ^b   Zhu, Yizhun ^a   Li, Dapeng ^d   Tan, Wenfu ^a  

^a FUDAN UNIVERSITY   (China)

^b CENTRAL SOUTH UNIVERSITY   (China)

^c SANJIU Medical and Pharmaceutical Co Ltd   (China)

^d SHANGHAI JIAO TONG UNIVERSITY   (China)

Author keywords

Apoptosis; Cytotoxic activity; G2 M phase; Lignans; Vitex negundo

Indexed keywords

3,4 METHYLENEDIOXYAMPHETAMINE; 4',6 DIAMIDINO 2 PHENYLINDOLE; CELL CYCLE PROTEIN 25; CELL MEMBRANE PROTEIN; CYCLIN B1; CYCLIN DEPENDENT KINASE 1; EVN 50; HISTONE H3; LIGNAN; TYROSINE; UNCLASSIFIED DRUG; VB1;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL CYCLE M PHASE; CHINESE MEDICINE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG SCREENING; DRUG SENSITIVITY; G2 PHASE CELL CYCLE CHECKPOINT; HISTONE PHOSPHORYLATION; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; LIVER CANCER; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; VITEX NEGUNDO; WESTERN BLOTTING;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CDC2 PROTEIN KINASE; CDC25 PHOSPHATASES; CELL LINE, TUMOR; CYCLIN B1; DRUG SCREENING ASSAYS, ANTITUMOR; FEMALE; G2 PHASE CELL CYCLE CHECKPOINTS; HUMANS; INHIBITORY CONCENTRATION 50; LIGNANS; M PHASE CELL CYCLE CHECKPOINTS; PHOSPHORYLATION; PLANTS, MEDICINAL; TYROSINE; VITEX;

VITEX NEGUNDO;

EID: 84876415784     PISSN: 09447113     EISSN: 1618095X     Source Type: Journal    
DOI: 10.1016/j.phymed.2013.02.002     Document Type: Article

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