Role of long non-coding RNA HULC in cell proliferation, apoptosis and tumor metastasis of gastric cancer: A clinical and in vitro investigation

Oncology Reports

Volumn 31, Issue 1, 2014, Pages 358-364

  Zhao, Yan ^a   Guo, Qinhao ^a   Chen, Jiejing ^a   Hu, Jun ^a   Wang, Shuwei ^a   Sun, Yueming ^a  

^a NANJING MEDICAL UNIVERSITY   (China)

Author keywords

Autophagy; Epithelial to mesenchymal transition; Gastric cancer; Highly upregulated in liver cancer; Long non coding RNA

Indexed keywords

LONG UNTRANSLATED RNA; PROTEIN HULC; TUMOR MARKER; UNCLASSIFIED DRUG;

ADULT; AGED; APOPTOSIS; ARTICLE; AUTOPHAGY; CANCER STAGING; CELL INVASION; CELL PROLIFERATION; CONTROLLED STUDY; DIAGNOSTIC TEST ACCURACY STUDY; DIAGNOSTIC VALUE; DISTANT METASTASIS; EPITHELIAL MESENCHYMAL TRANSITION; FEMALE; GAIN OF FUNCTION MUTATION; GENE OVEREXPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; LOSS OF FUNCTION MUTATION; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; PHENOTYPE; PRIORITY JOURNAL; RECEIVER OPERATING CHARACTERISTIC; RETROSPECTIVE STUDY; SENSITIVITY AND SPECIFICITY; STOMACH CANCER; STOMACH CARCINOGENESIS; VERY ELDERLY;

AGED; AGED, 80 AND OVER; APOPTOSIS; AUTOPHAGY; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; CELL TRANSFORMATION, NEOPLASTIC; EPITHELIAL-MESENCHYMAL TRANSITION; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE KNOCKDOWN TECHNIQUES; HUMANS; LYMPHATIC METASTASIS; MALE; MIDDLE AGED; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS; RNA, LONG NONCODING; STOMACH NEOPLASMS; TUMOR MARKERS, BIOLOGICAL; WOUND HEALING;

EID: 84891930833     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2013.2850     Document Type: Article

References (34)

1. Konishi H, Ichikawa D, Komatsu S, et al: Detection of gastric cancer-associated microRNAs on microRNA microarray comparing pre- and post-operative plasma. Br J Cancer 106: 740-747, 2012.
2. Cheng Y, Jin Z, Agarwal R, et al: LARP7 is a potential tumor suppressor gene in gastric cancer. Lab Invest 92: 1013-1019, 2012.
3. Costa FF: Non-coding RNAs: new players in eukaryotic biology. Gene 357: 83-94, 2005.
4. Batista PJ and Chang HY: Long noncoding RNAs: cellular address codes in development and disease. Cell 152: 1298-1307, 2013.
5. Panzitt K, Tschernatsch MM, Guelly C, et al: Characterization of HULC, a novel gene with striking up-regulation in hepatocellular carcinoma, as noncoding RNA. Gastroenterology 132: 330-342, 2007.
6. Xu D, Yang F, Yuan JH, et al: Long noncoding RNAs associated with liver regeneration 1 accelerates hepatocyte proliferation during liver regeneration by activating Wnt/β-catenin signaling. Hepatology 58: 739-751, 2013.
7. Wang J, Liu X, Wu H, et al: CREB up-regulates long non-coding RNA, HULC expression through interaction with microRNA-372 in liver cancer. Nucleic Acids Res 38: 5366-5383, 2010.
8. Matouk IJ, Abbasi I, Hochberg A, Galun E, Dweik H and Akkawi M: Highly upregulated in liver cancer noncoding RNA is overexpressed in hepatic colorectal metastasis. Eur J Gastroenterol Hepatol 21: 688-692, 2009.
9. Li J, Yang B, Zhou Q, et al: Autophagy promotes hepatocellular carcinoma cell invasion through activation of epithelial-mesenchymal transition. Carcinogenesis 34: 1343-1351, 2013.
10. Ledford H: Cancer theory faces doubts. Nature 472: 273, 2011.
11. Enomoto M, Tsuchida A, Miyazawa K, et al: Vitamin K2-induced cell growth inhibition via autophagy formation in cholangiocellular carcinoma cell lines. Int J Mol Med 20: 801-808, 2007.
12. Lv Q, Hua F and Hu ZW: DEDD, a novel tumor repressor, reverses epithelial-mesenchymal transition by activating selective autophagy. Autophagy 8: 1675-1676, 2012.
13. Akalay I, Janji B, Hasmim M, et al: Epithelial-to-mesenchymal transition and autophagy induction in breast carcinoma promote escape from T-cell-mediated lysis. Cancer Res 73: 2418-2427, 2013.
14. Nie Y, Liu X, Qu S, Song E, Zou H and Gong C: Long non-coding RNA HOTAIR is an independent prognostic marker for nasopharyngeal carcinoma progression and survival. Cancer Sci 104: 458-464, 2013.
15. Yang F, Bi J, Xue X, et al: Up-regulated long non-coding RNA H19 contributes to proliferation of gastric cancer cells. FEBS J 279: 3159-3165, 2012.
16. Yang H, Zhong Y, Xie H, et al: Induction of the liver cancer-down-regulated long noncoding RNA uc002mbe.2 mediates trichostatin-induced apoptosis of liver cancer cells. Biochem Pharmacol 85: 1761-1769, 2013.
17. Wahlestedt C: Targeting long non-coding RNA to therapeutically upregulate gene expression. Nat Rev Drug Discov 12: 433-446, 2013.
18. Liu Q, Huang J, Zhou N, et al: LncRNA loc285194 is a p53-regulated tumor suppressor. Nucleic Acids Res 41: 4976-4987, 2013.
19. Lv Q, Wang W, Xue J, et al: DEDD interacts with PI3KC3 to activate autophagy and attenuate epithelial-mesenchymal transition in human breast cancer. Cancer Res 72: 3238-3250, 2012.
20. Shin NR, Jeong EH, Choi CI, et al: Overexpression of Snail is associated with lymph node metastasis and poor prognosis in patients with gastric cancer. BMC Cancer 12: 521, 2012.
21. Lin X, Shang X, Manorek G and Howell SB: Regulation of the epithelial-mesenchymal transition by claudin-3 and claudin-4. PLoS One 8: e67496, 2013.
22. Davidson B, Trope CG and Reich R: Epithelial-mesenchymal transition in ovarian carcinoma. Front Oncol 2: 33, 2012.
23. Zeisberg M and Neilson EG: Biomarkers for epithelial-mesenchymal transitions. J Clin Invest 119: 1429-1437, 2009.
24. Kalluri R and Weinberg RA: The basics of epithelial-mesenchymal transition. J Clin Invest 119: 1420-1428, 2009.
25. Kondo Y, Kanzawa T, Sawaya R and Kondo S: The role of autophagy in cancer development and response to therapy. Nat Rev Cancer 5: 726-734, 2005.
26. Levine B and Yuan J: Autophagy in cell death: an innocent convict? J Clin Invest 115: 2679-2688, 2005.
27. He H, Zang LH, Feng YS, et al: Physalin A induces apoptotic cell death and protective autophagy in HT1080 human fibrosarcoma cells. J Nat Prod 76: 880-888, 2013.
28. Mizushima N, Levine B, Cuervo AM and Klionsky DJ: Autophagy fights disease through cellular self-digestion. Nature 451: 1069-1075, 2008.
29. Ye L, Zhao X, Lu J, Qian G, Zheng JC and Ge S: Knockdown of TIGAR by RNA interference induces apoptosis and autophagy in HepG2 hepatocellular carcinoma cells. Biochem Biophys Res Commun 437: 300-306, 2013.
30. Oh SY, Choi SJ, Kim KH, Cho EY, Kim JH and Roh CR: Autophagy-related proteins, LC3 and Beclin-1, in placentas from pregnancies complicated by preeclampsia. Reprod Sci 15: 912-920, 2008.
31. Mann SS and Hammarback JA: Molecular characterization of light chain 3. A microtubule binding subunit of MAP1A and MAP1B. J Biol Chem 269: 11492-11497, 1994.
32. Lang T, Schaeffeler E, Bernreuther D, Bredschneider M, Wolf DH and Thumm M: Aut2p and Aut7p, two novel microtubule-associated proteins are essential for delivery of autophagic vesicles to the vacuole. EMBO J 17: 3597-3607, 1998.
33. Kabeya Y, Mizushima N, Yamamoto A, Oshitani-Okamoto S, Ohsumi Y and Yoshimori T: LC3, GABARAP and GATE16 localize to autophagosomal membrane depending on form-II formation. J Cell Sci 117: 2805-2812, 2004.
34. Ying L, Huang Y, Chen H, et al: Downregulated MEG3 activates autophagy and increases cell proliferation in bladder cancer. Mol Biosyst 9: 407-411, 2013.