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Volumn 1843, Issue 3, 2014, Pages 652-663

Heterodimerization of Mouse Orexin type 2 receptor variants and the effects on signal transduction

Author keywords

BRET; GPCR; Heterodimerization; Hypocretin (Orexin); MOX2 R; MOX2 R

Indexed keywords

CALCIUM ION; CYCLIC AMP DEPENDENT PROTEIN KINASE; HETERODIMER; LUCIFERASE; MITOGEN ACTIVATED PROTEIN KINASE; OREXIN 2 ALPHA RECEPTOR; OREXIN 2 BETA RECEPTOR; OREXIN 2 RECEPTOR; PROTEIN KINASE C INHIBITOR; PROTEIN VARIANT; UNCLASSIFIED DRUG;

EID: 84891928355     PISSN: 01674889     EISSN: 18792596     Source Type: Journal    
DOI: 10.1016/j.bbamcr.2013.12.010     Document Type: Article
Times cited : (26)

References (49)
  • 1
    • 77955982118 scopus 로고    scopus 로고
    • Applications of fluorescence and bioluminescence resonance energy transfer to drug discovery at G protein coupled receptors
    • Alvarez-Curto E., Pediani J.D., Milligan G. Applications of fluorescence and bioluminescence resonance energy transfer to drug discovery at G protein coupled receptors. Anal. Bioanal. Chem. 2010, 398:167-180.
    • (2010) Anal. Bioanal. Chem. , vol.398 , pp. 167-180
    • Alvarez-Curto, E.1    Pediani, J.D.2    Milligan, G.3
  • 3
    • 29444436827 scopus 로고    scopus 로고
    • OX1 orexin receptors activate extracellular signal-regulated kinase in Chinese hamster ovary cells via multiple mechanisms: the role of Ca2+ influx in OX1 receptor signaling
    • Ammoun S., Johansson L., Ekholm M.E., Holmqvist T., Danis A.S., Korhonen L., Sergeeva O.A., Haas H.L., Akerman K.E., Kukkonen J.P. OX1 orexin receptors activate extracellular signal-regulated kinase in Chinese hamster ovary cells via multiple mechanisms: the role of Ca2+ influx in OX1 receptor signaling. Mol. Endocrinol. 2006, 20:80-99.
    • (2006) Mol. Endocrinol. , vol.20 , pp. 80-99
    • Ammoun, S.1    Johansson, L.2    Ekholm, M.E.3    Holmqvist, T.4    Danis, A.S.5    Korhonen, L.6    Sergeeva, O.A.7    Haas, H.L.8    Akerman, K.E.9    Kukkonen, J.P.10
  • 4
    • 33644856430 scopus 로고    scopus 로고
    • G-protein-coupled OX1 Orexin/hcrtr-1 hypocretin receptors induce caspase-dependent and -independent cell death through p38 mitogen-/stress-activated protein kinase
    • Ammoun S., Lindholm D., Wootz H., Åkerman K.E.O., Kukkonen J.P. G-protein-coupled OX1 Orexin/hcrtr-1 hypocretin receptors induce caspase-dependent and -independent cell death through p38 mitogen-/stress-activated protein kinase. J. Biol. Chem. 2006, 281:834-842.
    • (2006) J. Biol. Chem. , vol.281 , pp. 834-842
    • Ammoun, S.1    Lindholm, D.2    Wootz, H.3    Åkerman, K.E.O.4    Kukkonen, J.P.5
  • 5
    • 0028227013 scopus 로고
    • Structure and function of receptors coupled to G proteins
    • Baldwin J.M. Structure and function of receptors coupled to G proteins. Curr. Opin. Cell Biol. 1994, 6:180-190.
    • (1994) Curr. Opin. Cell Biol. , vol.6 , pp. 180-190
    • Baldwin, J.M.1
  • 6
    • 14644387575 scopus 로고    scopus 로고
    • Emerging role of homo- and heterodimerization in G-protein-coupled receptor biosynthesis and maturation
    • Bulenger S., Marullo S., Bouvier M. Emerging role of homo- and heterodimerization in G-protein-coupled receptor biosynthesis and maturation. Trends Pharmacol. Sci. 2005, 26:131-137.
    • (2005) Trends Pharmacol. Sci. , vol.26 , pp. 131-137
    • Bulenger, S.1    Marullo, S.2    Bouvier, M.3
  • 7
    • 48349121168 scopus 로고    scopus 로고
    • Mycobacterium tuberculosis antigen Wag31 induces expression of C-chemokine XCL2 in macrophages
    • Cao W., Tang S., Yuan H., Wang H., Zhao X., Lu H. Mycobacterium tuberculosis antigen Wag31 induces expression of C-chemokine XCL2 in macrophages. Curr. Microbiol. 2008, 57:189-194.
    • (2008) Curr. Microbiol. , vol.57 , pp. 189-194
    • Cao, W.1    Tang, S.2    Yuan, H.3    Wang, H.4    Zhao, X.5    Lu, H.6
  • 8
    • 0142149074 scopus 로고    scopus 로고
    • Dimers of class A G protein-coupled receptors function via agonist-mediated trans-activation of associated G proteins
    • Carrillo J.J., Pediani J., Milligan G. Dimers of class A G protein-coupled receptors function via agonist-mediated trans-activation of associated G proteins. J. Biol. Chem. 2003, 278:42578-42587.
    • (2003) J. Biol. Chem. , vol.278 , pp. 42578-42587
    • Carrillo, J.J.1    Pediani, J.2    Milligan, G.3
  • 10
    • 33746062450 scopus 로고    scopus 로고
    • Differential expression of mouse orexin receptor type-2 (OX2R) variants in the mouse brain
    • Chen J., Karteris E., Collins D., Randeva H.S. Differential expression of mouse orexin receptor type-2 (OX2R) variants in the mouse brain. Brain Res. 2006, 1103:20-24.
    • (2006) Brain Res. , vol.1103 , pp. 20-24
    • Chen, J.1    Karteris, E.2    Collins, D.3    Randeva, H.S.4
  • 11
    • 8344259802 scopus 로고    scopus 로고
    • Genomic organization of mouse orexin receptors: characterization of two novel tissue-specific splice variants
    • Chen J., Randeva H.S. Genomic organization of mouse orexin receptors: characterization of two novel tissue-specific splice variants. Mol. Endocrinol. 2004, 18:2790-2804.
    • (2004) Mol. Endocrinol. , vol.18 , pp. 2790-2804
    • Chen, J.1    Randeva, H.S.2
  • 12
    • 77951246071 scopus 로고    scopus 로고
    • Genomic organization and regulation of the human orexin (hypocretin) receptor 2 gene: identification of alternative promoters
    • Chen J., Randeva H.S. Genomic organization and regulation of the human orexin (hypocretin) receptor 2 gene: identification of alternative promoters. Biochem. J. 2010, 427:377-390.
    • (2010) Biochem. J. , vol.427 , pp. 377-390
    • Chen, J.1    Randeva, H.S.2
  • 14
    • 26444473715 scopus 로고    scopus 로고
    • Changes in alternative splicing of human and mouse genes are accompanied by faster evolution of constitutive exons
    • Cusack B.P., Wolfe K.H. Changes in alternative splicing of human and mouse genes are accompanied by faster evolution of constitutive exons. Mol. Biol. Evol. 2005, 22:2198-2208.
    • (2005) Mol. Biol. Evol. , vol.22 , pp. 2198-2208
    • Cusack, B.P.1    Wolfe, K.H.2
  • 15
    • 0030760634 scopus 로고    scopus 로고
    • Dimerization of the δ opioid receptor: implication for a role in receptor internalization
    • Cvejic S., Devi L.A. Dimerization of the δ opioid receptor: implication for a role in receptor internalization. J. Biol. Chem. 1997, 272:26959-26964.
    • (1997) J. Biol. Chem. , vol.272 , pp. 26959-26964
    • Cvejic, S.1    Devi, L.A.2
  • 16
    • 0032736148 scopus 로고    scopus 로고
    • The hypocretins/orexins: novel hypothalamic neuropeptides involved in different physiological systems
    • De Lecea L., Sutcliffe J.G. The hypocretins/orexins: novel hypothalamic neuropeptides involved in different physiological systems. Cell. Mol. Life Sci. 1999, 56:473-480.
    • (1999) Cell. Mol. Life Sci. , vol.56 , pp. 473-480
    • De Lecea, L.1    Sutcliffe, J.G.2
  • 17
    • 80054790607 scopus 로고    scopus 로고
    • Dynein light chain Tctex-type 1 modulates orexin signaling through its interaction with orexin 1 receptor
    • Duguay D., B Langer-Nelson E., Mongrain V., Beben A., Khatchadourian A., Cermakian N. Dynein light chain Tctex-type 1 modulates orexin signaling through its interaction with orexin 1 receptor. PLoS ONE 2011, 6:e26430.
    • (2011) PLoS ONE , vol.6
    • Duguay, D.1    Langer-Nelson, B.E.2    Mongrain, V.3    Beben, A.4    Khatchadourian, A.5    Cermakian, N.6
  • 19
    • 4644253963 scopus 로고    scopus 로고
    • The role of subtype-specific ligand binding and the C-tail domain in dimer formation of human somatostatin receptors
    • Grant M., Patel R.C., Kumar U. The role of subtype-specific ligand binding and the C-tail domain in dimer formation of human somatostatin receptors. J. Biol. Chem. 2004, 279:38636-38643.
    • (2004) J. Biol. Chem. , vol.279 , pp. 38636-38643
    • Grant, M.1    Patel, R.C.2    Kumar, U.3
  • 20
    • 28444493656 scopus 로고    scopus 로고
    • Crosstalk in G protein-coupled receptors: changes at the transmembrane homodimer interface determine activation
    • Guo W., Shi L., Filizola M., Weinstein H., Javitch J.A. Crosstalk in G protein-coupled receptors: changes at the transmembrane homodimer interface determine activation. Proc. Natl. Acad. Sci. U. S. A. 2005, 102:17495-17500.
    • (2005) Proc. Natl. Acad. Sci. U. S. A. , vol.102 , pp. 17495-17500
    • Guo, W.1    Shi, L.2    Filizola, M.3    Weinstein, H.4    Javitch, J.A.5
  • 21
    • 84864312233 scopus 로고    scopus 로고
    • OX2R activation induces PKC-mediated ERK and CREB phosphorylation
    • Guo Y., Feng P. OX2R activation induces PKC-mediated ERK and CREB phosphorylation. Exp. Cell Res. 2012, 318:2004-2013.
    • (2012) Exp. Cell Res. , vol.318 , pp. 2004-2013
    • Guo, Y.1    Feng, P.2
  • 23
    • 0033550889 scopus 로고    scopus 로고
    • Effect of lateral cerebroventricular injection of the appetite-stimulating neuropeptide, orexin and neuropeptide Y, on the various behavioral activities of rats
    • Ida T., Nakahara K., Katayama T., Murakami N., Nakazato M. Effect of lateral cerebroventricular injection of the appetite-stimulating neuropeptide, orexin and neuropeptide Y, on the various behavioral activities of rats. Brain Res. 1999, 821:526-529.
    • (1999) Brain Res. , vol.821 , pp. 526-529
    • Ida, T.1    Nakahara, K.2    Katayama, T.3    Murakami, N.4    Nakazato, M.5
  • 24
    • 47249088189 scopus 로고    scopus 로고
    • Melatonin receptors, heterodimerization, signal transduction and binding sites: what's new?
    • Jockers R., Maurice P., Boutin J.A., Delagrange P. Melatonin receptors, heterodimerization, signal transduction and binding sites: what's new?. Br. J. Pharmacol. 2008, 154:1182-1195.
    • (2008) Br. J. Pharmacol. , vol.154 , pp. 1182-1195
    • Jockers, R.1    Maurice, P.2    Boutin, J.A.3    Delagrange, P.4
  • 25
    • 1942440473 scopus 로고    scopus 로고
    • Expression of human prepro-orexin and signaling characteristics of orexin receptors in the male reproductive system
    • Karteris E., Chen J., Randeva H.S. Expression of human prepro-orexin and signaling characteristics of orexin receptors in the male reproductive system. J. Clin. Endocrinol. Metab. 2004, 89:1957-1962.
    • (2004) J. Clin. Endocrinol. Metab. , vol.89 , pp. 1957-1962
    • Karteris, E.1    Chen, J.2    Randeva, H.S.3
  • 26
    • 17844410926 scopus 로고    scopus 로고
    • Concurrent stimulation of cannabinoid CB1 and dopamine D2 receptors enhances heterodimer formation: a mechanism for receptor cross-talk?
    • Kearn C.S., Blake-Palmer K., Daniel E., Mackie K., Glass M. Concurrent stimulation of cannabinoid CB1 and dopamine D2 receptors enhances heterodimer formation: a mechanism for receptor cross-talk?. Mol. Pharmacol. 2005, 67:1697-1704.
    • (2005) Mol. Pharmacol. , vol.67 , pp. 1697-1704
    • Kearn, C.S.1    Blake-Palmer, K.2    Daniel, E.3    Mackie, K.4    Glass, M.5
  • 27
    • 44449096273 scopus 로고    scopus 로고
    • Modulation of extracellular signal-regulated kinase (ERK) by opioid and cannabinoid receptors that are expressed in the same cell
    • Korzh A., Keren O., Gafni M., Bar-Josef H., Sarne Y. Modulation of extracellular signal-regulated kinase (ERK) by opioid and cannabinoid receptors that are expressed in the same cell. Brain Res. 2008, 1189:23-32.
    • (2008) Brain Res. , vol.1189 , pp. 23-32
    • Korzh, A.1    Keren, O.2    Gafni, M.3    Bar-Josef, H.4    Sarne, Y.5
  • 28
    • 84862831340 scopus 로고    scopus 로고
    • Heterodimerization of human apelin and kappa opioid receptors: roles in signal transduction
    • Li Y., Chen J., Bai B., Du H., Liu Y., Liu H. Heterodimerization of human apelin and kappa opioid receptors: roles in signal transduction. Cell. Signal. 2012, 24:991-1001.
    • (2012) Cell. Signal. , vol.24 , pp. 991-1001
    • Li, Y.1    Chen, J.2    Bai, B.3    Du, H.4    Liu, Y.5    Liu, H.6
  • 30
    • 0036848635 scopus 로고    scopus 로고
    • Hypocretins (orexins) regulate serotonin neurons in the dorsal raphe nucleus by excitatory direct and inhibitory indirect actions
    • Liu R.J., Van Den Pol A.N., Aghajanian G.K. Hypocretins (orexins) regulate serotonin neurons in the dorsal raphe nucleus by excitatory direct and inhibitory indirect actions. J. Neurosci. 2002, 22:9453-9464.
    • (2002) J. Neurosci. , vol.22 , pp. 9453-9464
    • Liu, R.J.1    Van Den Pol, A.N.2    Aghajanian, G.K.3
  • 31
    • 0032545511 scopus 로고    scopus 로고
    • Independent feeding and metabolic actions of orexins in mice
    • Lubkin M., Stricker-Krongrad A. Independent feeding and metabolic actions of orexins in mice. Biochem. Biophys. Res. Commun. 1998, 253:241-245.
    • (1998) Biochem. Biophys. Res. Commun. , vol.253 , pp. 241-245
    • Lubkin, M.1    Stricker-Krongrad, A.2
  • 33
    • 0032705117 scopus 로고    scopus 로고
    • Orexins stimulate corticosterone secretion of rat adrenocortical cells, through the activation of the adenylate cyclase-dependent signaling cascade
    • Malendowicz L.K., Tortorella C., Nussdorfer G.G. Orexins stimulate corticosterone secretion of rat adrenocortical cells, through the activation of the adenylate cyclase-dependent signaling cascade. J. Steroid Biochem. Mol. Biol. 1999, 70:185-188.
    • (1999) J. Steroid Biochem. Mol. Biol. , vol.70 , pp. 185-188
    • Malendowicz, L.K.1    Tortorella, C.2    Nussdorfer, G.G.3
  • 34
    • 1442309077 scopus 로고    scopus 로고
    • Applications of bioluminescence- and fluorescence resonance energy transfer to drug discovery at G protein-coupled receptors
    • Milligan G. Applications of bioluminescence- and fluorescence resonance energy transfer to drug discovery at G protein-coupled receptors. Eur. J. Pharm. Sci. 2004, 21:397-405.
    • (2004) Eur. J. Pharm. Sci. , vol.21 , pp. 397-405
    • Milligan, G.1
  • 36
    • 77957072436 scopus 로고    scopus 로고
    • Dimerization of G protein-coupled purinergic receptors: increasing the diversity of purinergic receptor signal responses and receptor functions
    • Nakata H., Suzuki T., Namba K., Oyanagi K. Dimerization of G protein-coupled purinergic receptors: increasing the diversity of purinergic receptor signal responses and receptor functions. J. Recept. Signal Transduct. Res. 2010, 30:337-346.
    • (2010) J. Recept. Signal Transduct. Res. , vol.30 , pp. 337-346
    • Nakata, H.1    Suzuki, T.2    Namba, K.3    Oyanagi, K.4
  • 39
    • 0036829815 scopus 로고    scopus 로고
    • The extracellular N-terminal domain and transmembrane domains 1 and 2 mediate oligomerization of a yeast G protein-coupled receptor
    • Overton M.C., Blumer K.J. The extracellular N-terminal domain and transmembrane domains 1 and 2 mediate oligomerization of a yeast G protein-coupled receptor. J. Biol. Chem. 2002, 277:41463-41472.
    • (2002) J. Biol. Chem. , vol.277 , pp. 41463-41472
    • Overton, M.C.1    Blumer, K.J.2
  • 40
    • 77951582541 scopus 로고    scopus 로고
    • Functional diversity of signaling pathways through G protein-coupled receptor heterodimerization with a species-specific orphan receptor subtype
    • Sakai T., Aoyama M., Kusakabe T., Tsuda M., Satake H. Functional diversity of signaling pathways through G protein-coupled receptor heterodimerization with a species-specific orphan receptor subtype. Mol. Biol. Evol. 2010, 27:1097-1106.
    • (2010) Mol. Biol. Evol. , vol.27 , pp. 1097-1106
    • Sakai, T.1    Aoyama, M.2    Kusakabe, T.3    Tsuda, M.4    Satake, H.5
  • 42
    • 0037318470 scopus 로고    scopus 로고
    • Ala/Thr(201) in extracellular loop 2 and Leu/Phe(290) in transmembrane domain 6 of type 1 frog gonadotropin-releasing hormone receptor confer differential ligand sensitivity and signal transduction
    • Seong J.Y., Wang L., Oh D.Y., Yun O., Maiti K., Li J.H., Soh J.M., Choi H.S., Kim K., Vaudry H., Kwon H.B. Ala/Thr(201) in extracellular loop 2 and Leu/Phe(290) in transmembrane domain 6 of type 1 frog gonadotropin-releasing hormone receptor confer differential ligand sensitivity and signal transduction. Endocrinology 2003, 144:454-466.
    • (2003) Endocrinology , vol.144 , pp. 454-466
    • Seong, J.Y.1    Wang, L.2    Oh, D.Y.3    Yun, O.4    Maiti, K.5    Li, J.H.6    Soh, J.M.7    Choi, H.S.8    Kim, K.9    Vaudry, H.10    Kwon, H.B.11
  • 43
    • 22844446949 scopus 로고    scopus 로고
    • Orexins modulate the growth of cultured rat adrenocortical cells, acting through type 1 and type 2 receptors coupled to the MAPK p42/p44- and p38-dependent cascades
    • Spinazzi R., Ziolkowska A., Neri G., Nowak M., Rebuffat P., Nussdorfer G.G., Andreis P.G., Malendowicz L.K. Orexins modulate the growth of cultured rat adrenocortical cells, acting through type 1 and type 2 receptors coupled to the MAPK p42/p44- and p38-dependent cascades. Int. J. Mol. Med. 2005, 15:847-852.
    • (2005) Int. J. Mol. Med. , vol.15 , pp. 847-852
    • Spinazzi, R.1    Ziolkowska, A.2    Neri, G.3    Nowak, M.4    Rebuffat, P.5    Nussdorfer, G.G.6    Andreis, P.G.7    Malendowicz, L.K.8
  • 44
    • 0033608174 scopus 로고    scopus 로고
    • Stimulation of gastric acid secretion by centrally administered orexin-A in conscious rats
    • Takahashi N., Okumura T., Yamada H., Kohgo Y. Stimulation of gastric acid secretion by centrally administered orexin-A in conscious rats. Biochem. Biophys. Res. Commun. 1999, 254:623-627.
    • (1999) Biochem. Biophys. Res. Commun. , vol.254 , pp. 623-627
    • Takahashi, N.1    Okumura, T.2    Yamada, H.3    Kohgo, Y.4
  • 45
    • 0032189780 scopus 로고    scopus 로고
    • Presynaptic and postsynaptic actions and modulation of neuroendocrine neurons by a new hypothalamic peptide, hypocretin/orexin
    • Van Den Pol A.N., Gao X.B., Obrietan K., Kilduff T.S., Belousov A.B. Presynaptic and postsynaptic actions and modulation of neuroendocrine neurons by a new hypothalamic peptide, hypocretin/orexin. J. Neurosci. 1998, 18:7962-7971.
    • (1998) J. Neurosci. , vol.18 , pp. 7962-7971
    • Van Den Pol, A.N.1    Gao, X.B.2    Obrietan, K.3    Kilduff, T.S.4    Belousov, A.B.5
  • 46
    • 80054811622 scopus 로고    scopus 로고
    • Heteromultimerization of cannabinoid CB(1) receptor and orexin OX(1) receptor generates a unique complex in which both protomers are regulated by orexin A
    • Ward R.J., Pediani J.D., Milligan G. Heteromultimerization of cannabinoid CB(1) receptor and orexin OX(1) receptor generates a unique complex in which both protomers are regulated by orexin A. J. Biol. Chem. 2011, 286:37414-37428.
    • (2011) J. Biol. Chem. , vol.286 , pp. 37414-37428
    • Ward, R.J.1    Pediani, J.D.2    Milligan, G.3
  • 48
    • 0034065518 scopus 로고    scopus 로고
    • Effects of food restriction on the hypothalamic prepro-orexin gene expression in genetically obese mice
    • Yamamoto Y., Ueta Y., Serino R., Nomura M., Shibuya I., Yamashita H. Effects of food restriction on the hypothalamic prepro-orexin gene expression in genetically obese mice. Brain Res. Bull. 2000, 51:515-521.
    • (2000) Brain Res. Bull. , vol.51 , pp. 515-521
    • Yamamoto, Y.1    Ueta, Y.2    Serino, R.3    Nomura, M.4    Shibuya, I.5    Yamashita, H.6
  • 49
    • 0033516576 scopus 로고    scopus 로고
    • Identification and molecular characterization of m3 muscarinic receptor dimers
    • Zeng F.-Y., Wess J. Identification and molecular characterization of m3 muscarinic receptor dimers. J. Biol. Chem. 1999, 274:19487-19497.
    • (1999) J. Biol. Chem. , vol.274 , pp. 19487-19497
    • Zeng, F.-Y.1    Wess, J.2


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