Differential expression of mouse orexin receptor type-2 (OX2R) variants in the mouse brain

Brain Research

Volumn 1103, Issue 1, 2006, Pages 20-24

  Chen, Jing ^a   Karteris, Emmanouil ^a   Collins, Dawn ^a   Randeva, Harpal S ^a  

^a UNIVERSITY OF WARWICK   (United Kingdom)

Author keywords

FISH; Localization; Orexin; Orexin receptor; Splice variant

Indexed keywords

OREXIN 2 RECEPTOR;

ARTICLE; BRAIN; BRAIN CORTEX; CEREBELLUM; CORPUS STRIATUM; GENE EXPRESSION; IN SITU HYBRIDIZATION; MESENCEPHALON; MOUSE; NONHUMAN; PONS; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; ANTIGENS, SURFACE; BRAIN CHEMISTRY; IN SITU HYBRIDIZATION, FLUORESCENCE; MICE; RECEPTORS, CELL SURFACE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; VARIATION (GENETICS);

EID: 33746062450     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2006.05.054     Document Type: Article

References (12)

1. Chemelli R.M., Willie J.T., Sinton C.M., Elmquist J.K., Scammell T., Lee C., Richardson J.A., Williams S.C., Xiong Y., Kisanuki Y., Fitch T.E., Nakazato M., Hammer R.E., Saper C.B., and Yanagisawa M. Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation. Cell 98 (1999) 437-451
2. Chen J., and Randeva H.S. Genomic organization of mouse orexin receptors: characterization of two novel tissue-specific splice variants. Mol. Endocrinol. 18 (2004) 2790-2804
3. de Lecea L., Kilduff T.S., Peyron C., Gao X., Foye P.E., Danielson P.E., Fukuhara C., Battenberg E.L., Gautvik V.T., Bartlett III F.S., Frankel W.N., van den Pol A.N., Bloom F.E., Gautvik K.M., and Sutcliffe J.G. The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity. Proc. Natl. Acad. Sci. U. S. A. 95 (1998) 322-327
4. Harris G.C., Wimmer M., and Aston-Jones G. A role for lateral hypothalamic orexin neurons in reward seeking. Nature 437 (2005) 556-559
5. Ida T., Nakahara K., Murakami T., Hanada R., Nakazato M., and Murakami N. Possible involvement of orexin in the stress reaction in rats. Biochem. Biophys. Res. Commun. 270 (2000) 318-323
6. Karteris E., Papadopoulou N., Grammatopoulos D.K., and Hillhouse E.W. Expression and signalling characteristics of the corticotrophin-releasing hormone receptors during the implantation phase in the human endometrium. J. Mol. Endocrinol. 32 (2004) 21-32
7. Lambe E.K., Olausson P., Horst N.K., Taylor J.R., and Aghajanian G.K. Hypocretin and nicotine excite the same thalamocortical synapses in prefrontal cortex: correlation with improved attention in rat. J. Neurosci. 25 (2005) 5225-5229
8. Lin L., Faraco J., Li R., Kadotani H., Rogers W., Lin X., Qiu X., de Jong P.J., Nishino S., and Mignot E. The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene. Cell 98 (1999) 365-376
9. Lopez M., Seoane L., Senaris R.M., and Dieguez C. Prepro-orexin mRNA levels in the rat hypothalamus, and orexin receptors mRNA levels in the rat hypothalamus and adrenal gland are not influenced by the thyroid status. Neurosci. Lett. 300 (2001) 171-175
10. Paxinos, and Franklin. G. The Mouse Brain in Stereotaxic Coordinates. 2nd ed. (2001), Academic Press, San Diego
11. Sakurai T., Amemiya A., Ishii M., Matsuzaki I., Chemelli R.M., Tanaka H., Williams S.C., Richardson J.A., Kozlowski G.P., Wilson S., Arch J.R., Buckingham R.E., Haynes A.C., Carr S.A., Annan R.S., McNulty D.E., Liu W.S., Terrett J.A., Elshourbagy N.A., Bergsma D.J., and Yanagisawa M. Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell 92 (1998) 573-585
12. Willie J.T., Chemelli R.M., Sinton C.M., Tokita S., Williams S.C., Kisanuki Y.Y., Marcus J.N., Lee C., Elmquist J.K., Kohlmeier K.A., Leonard C.S., Richardson J.A., Hammer R.E., and Yanagisawa M. Distinct narcolepsy syndromes in Orexin receptor-2 and Orexin null mice: molecular genetic dissection of Non-REM and REM sleep regulatory processes. Neuron 38 (2003) 715-730