Pharmacokinetics of kakkalide and its main metabolites in rat plasma determined by HPLC-DAD and LC-MSn

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 879, Issue 5-6, 2011, Pages 395-402

  Bai, Xue ^a   Qu, Jialin ^a   Lu, Jing ^a   Kano, Yoshihiro ^a   Yuan, Dan ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Glucuronidation; HPLC and LC MSn; Kakkalide; Oral administration; Pharmacokinetics; Rat

Indexed keywords

DRIED FLOWERS; GLUCURONIDATION; GLUCURONIDES; HPLC AND LC-MSN; HPLC METHOD; HPLC-DAD; HPLC-UV; IN-VIVO; ISOFLAVONES; KAKKALIDE; LC/MS/MS; ORAL ADMINISTRATION; PARENT COMPOUNDS; PHARMACOKINETIC PROFILES; PUERARIA LOBATA; RAT PLASMA; RECIRCULATIONS; TIME POINTS; TRACE AMOUNTS;

BIOMOLECULES; IRIDIUM; METABOLITES; PHARMACOKINETICS; PLASMA (HUMAN); PLASMAS; TELLURIUM COMPOUNDS;

METABOLISM;

6 OH BIOCHANIN A GLUCURONIDE; ECTORIGENIN 7 O GLUCURONIDE; GLUCURONIDE; IRISOLIDONE 7 O GLUCURONIDE; ISOFLAVONE DERIVATIVE; KAKKALIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONJUGATE; DRUG BLOOD LEVEL; DRUG ELIMINATION; DRUG METABOLISM; DRUG STABILITY; GLUCURONIDATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIQUID CHROMATOGRAPHY; MALE; MASS SPECTROMETRY; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; AREA UNDER CURVE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHROMATOGRAPHY, LIQUID; DRUG STABILITY; GLUCURONIDES; GLYCOSIDES; ISOFLAVONES; MALE; PUERARIA; RATS; RATS, WISTAR; TANDEM MASS SPECTROMETRY;

PUERARIA MONTANA VAR. LOBATA; RATTUS;

EID: 79451475890     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2010.12.025     Document Type: Article

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