Progressing the global antimalarial portfolio: Finding drugs which target multiple Plasmodium life stages

Parasitology

Volumn 141, Issue 1, 2014, Pages 66-76

  Smith, Paul W ^a   Diagana, Thierry T ^a   Yeung, Bryan K S ^a  

^a Novartis Institute for Tropical Diseases   (Singapore)

Author keywords

imidazolopiperazines; malaria; phenotypic screening; spiroindolones

Indexed keywords

ALANINE DERIVATIVE; ALPHA METHYL ALANINE DERIVATIVE; ANTIMALARIAL AGENT; ARTEMISININ; ARTESUNATE; CHLOROQUINE; GLYCINE DERIVATIVE; GNF 179; IMIDAZOLOPIPERAZINE; INDOLE DERIVATIVE; MEFLOQUINE; NF 54; NITD 609; PIPERAZINE DERIVATIVE; SPIROINDOLONE; UNCLASSIFIED DRUG; IMIDAZOLE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIMALARIAL ACTIVITY; AREA UNDER THE CURVE; ARTICLE; BLOOD LEVEL; CHIRAL CHROMATOGRAPHY; CROSS RESISTANCE; CRYSTAL STRUCTURE; CYTOTOXICITY; DRUG DEVELOPMENT; DRUG HALF LIFE; DRUG SCREENING; ENANTIOMER; GAMETOCYTE; GENET (CLONE); HUMAN; IC 50; IN VITRO STUDY; IN VIVO STUDY; LIVER MICROSOME; MAXIMUM PLASMA CONCENTRATION; MOUSE; NONHUMAN; OXIDATION; PARASITE CLEARANCE; PARASITEMIA; PHARMACOPHORE; PHYSICAL CHEMISTRY; PLASMODIUM; PLASMODIUM (LIFE CYCLE STAGE); PLASMODIUM BERGHEI; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; RACEMIC MIXTURE; RODENT MALARIA; SCHIZONT; SINGLE DRUG DOSE; STRUCTURE ACTIVITY RELATION; SURVIVAL; X RAY ANALYSIS; X RAY CRYSTALLOGRAPHY; ZOONOSIS; CHEMISTRY; DRUG EFFECTS; DRUG RESISTANCE; ERYTHROCYTE; GROWTH, DEVELOPMENT AND AGING; LIFE CYCLE STAGE; LIVER; MALARIA, FALCIPARUM; METABOLISM; PARASITOLOGY;

ANTIMALARIALS; DRUG DISCOVERY; DRUG EVALUATION, PRECLINICAL; DRUG RESISTANCE; ERYTHROCYTES; HUMANS; IMIDAZOLES; INDOLES; LIFE CYCLE STAGES; LIVER; MALARIA, FALCIPARUM; PIPERAZINES; PLASMODIUM FALCIPARUM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84891866446     PISSN: 00311820     EISSN: 14698161     Source Type: Journal    
DOI: 10.1017/S0031182013000747     Document Type: Article

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