Association between use of benzodiazepines and risk of fractures: A meta-analysis

Osteoporosis International

Volumn 25, Issue 1, 2014, Pages 105-120

  Xing, D ^a   Ma, X L ^a,b   Ma, J X ^b   Wang, J ^b   Yang, Y ^a   Chen, Y ^a  

^a TIANJIN HOSPITAL   (China)

^b TIANJIN MEDICAL UNIVERSITY   (China)

Author keywords

Benzodiazepine; Bone fractures; Meta analysis; Osteoporosis

Indexed keywords

BENZODIAZEPINE DERIVATIVE;

ARM FRACTURE; ARTICLE; DISEASE ASSOCIATION; FEMUR FRACTURE; FEMUR NECK FRACTURE; FOOT FRACTURE; FRACTURE; FRAGILITY FRACTURE; HAND FRACTURE; HIP FRACTURE; HUMAN; HUMERUS FRACTURE; META ANALYSIS; OSTEOPOROSIS; PRIORITY JOURNAL; RISK ASSESSMENT; SPINE FRACTURE; SYSTEMATIC REVIEW; WRIST FRACTURE;

AGED; BENZODIAZEPINES; CASE-CONTROL STUDIES; COHORT STUDIES; HUMANS; OSTEOPOROTIC FRACTURES; PSYCHOTROPIC DRUGS; RESEARCH DESIGN; RISK ASSESSMENT;

EID: 84891858320     PISSN: 0937941X     EISSN: 14332965     Source Type: Journal    
DOI: 10.1007/s00198-013-2446-y     Document Type: Article

References (69)

1. Lin PC, Lu CM (2005) Hip fracture: family caregivers' burden and related factors for older people in Taiwan. J Clin Nurs 14(6):719-726 (Pubitemid 40847319)
2. Shyu YI, Chen MC, Liang J, Lu JF, Wu CC, Su JY (2004) Changes in quality of life among elderly patients with hip fracture in Taiwan. Osteoporos Int 15(2):95-102 (Pubitemid 38258314)
3. Leibson CL, Tosteson AN, Gabriel SE, Ransom JE, Melton LJ (2002) Mortality, disability, and nursing home use for persons with and without hip fracture: a population-based study. J Am Geriatr Soc 50(10):1644-1650 (Pubitemid 35192535)
4. [No authors listed] (2003) Diet, nutrition and the prevention of chronic diseases. World Health Organ Tech Rep Ser 916 (1-149)
5. Gehlbach SH, Avrunin JS, Puleo E (2007) Trends in hospital care for hip fractures. Osteoporos Int 18(5):585-591 (Pubitemid 46525536)
6. Wu Q, Qu W, Crowell MD, Hentz JG, Frey KA (2012) Tricyclic antidepressant use and risk of fractures: a meta-analysis of cohort and case-control studies. J Bone Miner Res 28(4):753-763
7. Rabenda V, Nicolet D, Beaudart C, Bruyere O, Reginster JY (2013) Relationship between use of antidepressants and risk of fractures: a meta-analysis. Osteoporos Int 24(1):121-137
8. Jette N, Lix LM, Metge CJ, Prior HJ, McChesney J, Leslie WD (2011) Association of antiepileptic drugs with nontraumatic fractures: a population-based analysis. Arch Neurol 68(1):107-112
9. Zint K, Haefeli WE, Glynn RJ, Mogun H, Avorn J, Sturmer T (2010) Impact of drug interactions, dosage, and duration of therapy on the risk of hip fracture associated with benzodiazepine use in older adults. Pharmacoepidemiol Drug Saf 19(12):1248-1255
10. Nurminen J, Puustinen J, Piirtola M, Vahlberg T, Kivela SL (2010) Psychotropic drugs and the risk of fractures in old age: a prospective population-based study. BMC Public Health 10:396
11. Chang CM, Wu EC, Chang IS, Lin KM (2008) Benzodiazepine and risk of hip fractures in older people: a nested case-control study in Taiwan. Am J Geriatr Psychiatry 16(8):686-692
12. Bolton JM, Metge C, Lix L, Prior H, Sareen J, Leslie WD (2008) Fracture risk from psychotropic medications: a population-based analysis. J Clin Psychopharmacol 28(4):384-391
13. Kang DY, Park S, Rhee CW, Kim YJ, Choi NK, Lee J, Park BJ (2012) Zolpidem use and risk of fracture in elderly insomnia patients. J Prev Med Public Health 45(4):219-226
14. Ensrud KE, Blackwell T, Mangione CM, Bowman PJ, Bauer DC, Schwartz A, Hanlon JT, Nevitt MC, Whooley MA (2003) Central nervous system active medications and risk for fractures in older women. Arch Intern Med 163(8):949-957 (Pubitemid 36519740)
15. Pierfitte C, Macouillard G, Thicoipe M, Chaslerie A, Pehourcq F, Aissou M, Martinez B, Lagnaoui R, Fourrier A, Begaud B et al (2001) Benzodiazepines and hip fractures in elderly people: case-control study. BMJ 322(7288):704-708 (Pubitemid 32238775)
16. Ray WA, Griffin MR, Downey W (1989) Benzodiazepines of long and short elimination half-life and the risk of hip fracture. JAMA 262(23):3303-3307 (Pubitemid 20012552)
17. Wang PS, Bohn RL, Glynn RJ, Mogun H, Avorn J (2001) Zolpidem use and hip fractures in older people. J Am Geriatr Soc 49(12):1685-1690 (Pubitemid 34007997)
18. Wagner AK, Zhang F, Soumerai SB, Walker AM, Gurwitz JH, Glynn RJ, Ross-Degnan D (2004) Benzodiazepine use and hip fractures in the elderly: who is at greatest risk? Arch Intern Med 164(14):1567-1572 (Pubitemid 38970480)
19. Brown MJ, Mezuk B (2012) Brains, bones, and aging: psychotropic medications and bone health among older adults. Curr Osteoporos Rep 10(4):303-311
20. Smith AJ, Tett SE (2010) Improving the use of benzodiazepines - is it possible? A non-systematic review of interventions tried in the last 20 years. BMC Health Serv Res 10:321
21. Stroup DF, Berlin JA, Morton SC, Olkin I, Williamson GD, Rennie D, Moher D, Becker BJ, Sipe TA, Thacker SB (2000) Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta-analysis Of Observational Studies in Epidemiology (MOOSE) group. JAMA 283(15):2008-2012 (Pubitemid 30214957)
22. Moher D, Liberati A, Tetzlaff J, Altman DG (2009) Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. J Clin Epidemiol 62(10):1006-1012
23. Stang A (2010) Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Eur J Epidemiol 25(9):603-605
24. Furukawa TA, Guyatt GH, Griffith LE (2002) Can we individualize the 'number needed to treat'? An empirical study of summary effect measures in meta-analyses. Int J Epidemiol 31(1):72-76 (Pubitemid 34284903)
25. Higgins JP, Thompson SG (2002) Quantifying heterogeneity in a meta-analysis. Stat Med 21(11):1539-1558 (Pubitemid 34746062)
26. Higgins JP, Thompson SG, Deeks JJ, Altman DG (2003) Measuring inconsistency in meta-analyses. BMJ 327(7414):557-560 (Pubitemid 37088507)
27. DerSimonian R, Laird N (1986) Meta-analysis in clinical trials. Control Clin Trials 7(3):177-188 (Pubitemid 17189972)
28. Sterne JA, Gavaghan D, Egger M (2000) Publication and related bias in meta-analysis: power of statistical tests and prevalence in the literature. J Clin Epidemiol 53(11):1119-1129
29. Begg CB, Mazumdar M (1994) Operating characteristics of a rank correlation test for publication bias. Biometrics 50(4):1088-1101
30. Egger M, Davey SG, Schneider M, Minder C (1997) Bias in meta-analysis detected by a simple, graphical test. BMJ 315(7109):629-634 (Pubitemid 27387172)
31. Duval S, Tweedie R (2000) Trim and fill: a simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis. Biometrics 56(2):455-463 (Pubitemid 30422636)
32. Peters JL, Sutton AJ, Jones DR, Abrams KR, Rushton L (2007) Performance of the trim and fill method in the presence of publication bias and between-study heterogeneity. Stat Med 26(25):4544-4562 (Pubitemid 350020393)
33. Perreault S, Dragomir A, Blais L, Moride Y, Rossignol M, Ste-Marie LG, Fernandes JC (2008) Population-based study of the effectiveness of bone-specific drugs in reducing the risk of osteoporotic fracture. Pharmacoepidemiol Drug Saf 17(3):248-259 (Pubitemid 351404036)
34. Schlienger RG, Kraenzlin ME, Jick SS, Meier CR (2004) Use of beta-blockers and risk of fractures. JAMA 292(11):1326-1332 (Pubitemid 39223223)
35. Vestergaard P, Rejnmark L, Mosekilde L (2004) Fracture risk associated with use of antiepileptic drugs. Epilepsia 45(11):1330-1337 (Pubitemid 39470036)
36. Sgadari A, Lapane KL, Mor V, Landi F, Bernabei R, Gambassi G (2000) Oxidative and nonoxidative benzodiazepines and the risk of femur fracture. The Systematic Assessment of Geriatric Drug Use Via Epidemiology Study Group. J Clin Psychopharmacol 20(2):234-239 (Pubitemid 30202367)
37. Vestergaard P, Tigaran S, Rejnmark L, Tigaran C, Dam M, Mosekilde L (1999) Fracture risk is increased in epilepsy. Acta Neurol Scand 99(5):269-275 (Pubitemid 29202183)
38. Guo Z, Wills P, Viitanen M, Fastbom J, Winblad B (1998) Cognitive impairment, drug use, and the risk of hip fracture in persons over 75 years old: a community-based prospective study. Am J Epidemiol 148(9):887-892 (Pubitemid 28484108)
39. Jacqmin-Gadda H, Fourrier A, Commenges D, Dartigues JF (1998) Risk factors for fractures in the elderly. Epidemiology 9(4):417-423 (Pubitemid 28298364)
40. Herings RM, Stricker BH, de Boer A, Bakker A, Sturmans F (1995) Benzodiazepines and the risk of falling leading to femur fractures. Dosage more important than elimination half-life. Arch Intern Med 155(16):1801-1807
41. Cummings SR, Nevitt MC, Browner WS, Stone K, Fox KM, Ensrud KE, Cauley J, Black D, Vogt TM (1995) Risk factors for hip fracture in white women. Study of Osteoporotic Fractures Research Group. N Engl J Med 332(12):767-773
42. Lichtenstein MJ, Griffin MR, Cornell JE, Malcolm E, Ray WA (1994) Risk factors for hip fractures occurring in the hospital. Am J Epidemiol 140(9):830-838 (Pubitemid 24341994)
43. Cumming RG, Klineberg RJ (1993) Psychotropics, thiazide diuretics and hip fractures in the elderly. Med J Aust 158(6):414-417 (Pubitemid 23096353)
44. Jensen J, Nielsen LH, Lyhne N, Hallas J, Brosen K, Gram LF (1991) Drugs and femoral neck fracture: a case-control study. J Intern Med 229(1):29-33
45. Stevens A, Mulrow C (1989) Drugs affecting postural stability and other risk factors in the hip fracture epidemic - case-control study. Community Med 11(1):27-34 (Pubitemid 19122819)
46. Ray WA, Griffin MR, Schaffner W, Baugh DK, Melton LR (1987) Psychotropic drug use and the risk of hip fracture. N Engl J Med 316(7):363-369 (Pubitemid 17034260)
47. Ray WA (1992) Psychotropic drugs and injuries among the elderly: a review. J Clin Psychopharmacol 12(6):386-396
48. Olkkola KT, Ahonen J (2008) Midazolam and other benzodiazepines. Handb Exp Pharmacol 182:335-360
49. Leipzig RM, Cumming RG, Tinetti ME (1999) Drugs and falls in older people: a systematic review and meta-analysis: I. Psychotropic drugs J Am Geriatr Soc 47(1):30-39 (Pubitemid 29044264)
50. Campbell AJ, Robertson MC, Gardner MM, Norton RN, Buchner DM (1999) Psychotropic medication withdrawal and a home-based exercise program to prevent falls: a randomized, controlled trial. J Am Geriatr Soc 47(7):850-853 (Pubitemid 29326016)
51. Koopmans R, Dingemanse J, Danhof M, Horsten GP, van Boxtel CJ (1991) The influence of dosage time of midazolam on its pharmacokinetics and effects in humans. Clin Pharmacol Ther 50(1):16-24
52. Albrecht S, Ihmsen H, Hering W, Geisslinger G, Dingemanse J, Schwilden H, Schuttler J (1999) The effect of age on the pharmacokinetics and pharmacodynamics of midazolam. Clin Pharmacol Ther 65(6):630-639 (Pubitemid 29294026)
53. Cumming RG, Le Couteur DG (2003) Benzodiazepines and risk of hip fractures in older people: a review of the evidence. CNS Drugs 17(11):825-837 (Pubitemid 37082985)
54. Petitjean S, Ladewig D, Meier CR, Amrein R, Wiesbeck GA (2007) Benzodiazepine prescribing to the Swiss adult population: results from a national survey of community pharmacies. Int Clin Psychopharmacol 22(5):292-298 (Pubitemid 47237548)
55. Esposito E, Barbui C, Patten SB (2009) Patterns of benzodiazepine use in a Canadian population sample. Epidemiol Psichiatr Soc 18(3):248-254
56. Swift CG, Swift MR, Hamley J, Stevenson IH, Crooks J (1984) Side-effect 'tolerance' in elderly long-term recipients of benzodiazepine hypnotics. Age Ageing 13(6):335-343 (Pubitemid 15205673)
57. Eto F, Saotome I, Furuichi T, Ogasawara M (1998) Effects of long-term use of benzodiazepines on gait and standing balance in the elderly. Ann N Y Acad Sci 860:543-545 (Pubitemid 29046020)
58. Bribes E, Bourrie B, Esclangon M, Galiegue S, Vidal H, Casellas P (2002) Involvement of the peripheral benzodiazepine receptor in the development of rheumatoid arthritis in Mrl/lpr mice. Eur J Pharmacol 452(1):111-122 (Pubitemid 35248131)
59. Casellas P, Galiegue S, Basile AS (2002) Peripheral benzodiazepine receptors and mitochondrial function. Neurochem Int 40(6):475-486 (Pubitemid 34159148)
60. Takkouche B, Montes-Martinez A, Gill SS, Etminan M (2007) Psychotropic medications and the risk of fracture: a meta-analysis. Drug Saf 30(2):171-184 (Pubitemid 46193066)
61. Jorgensen NR, Schwarz P, Holme I, Henriksen BM, Petersen LJ, Backer V (2007) The prevalence of osteoporosis in patients with chronic obstructive pulmonary disease: a cross sectional study. Respir Med 101(1):177-185 (Pubitemid 44835231)
62. Vrieze A, de Greef MH, Wijkstra PJ, Wempe JB (2007) Low bone mineral density in COPD patients related to worse lung function, low weight and decreased fat-free mass. Osteoporos Int 18(9):1197-1202 (Pubitemid 47300271)
63. Uretmen S, Gol M, Cimrin D, Irmak E (2005) Effects of chronic liver disease on bone mineral density and bone metabolism markers in postmenopausal women. Eur J Obstet Gynecol Reprod Biol 123(1):67-71 (Pubitemid 41563096)
64. Strotmeyer ES, Cauley JA (2007) Diabetes mellitus, bone mineral density, and fracture risk. Curr Opin Endocrinol Diabetes Obes 14(6):429-435 (Pubitemid 350059352)
65. Nurminen J, Puustinen J, Piirtola M, Vahlberg T, Lyles A, Kivela SL (2012) Opioids, antiepileptic and anticholinergic drugs and the risk of fractures in patients 65 years of age and older: a prospective population-based study. Age Ageing 42(3):318-324
66. Romas E (2005) Bone loss in inflammatory arthritis: mechanisms and therapeutic approaches with bisphosphonates. Best Pract Res Clin Rheumatol 19(6):1065-1079 (Pubitemid 41748514)
67. van Staa TP, Leufkens HG, Cooper C (2000) Use of nonsteroidal anti-inflammatory drugs and risk of fractures. Bone 27(4):563-568
68. Van Staa TP, Leufkens HG, Abenhaim L, Zhang B, Cooper C (2000) Use of oral corticosteroids and risk of fractures. J Bone Miner Res 15(6):993-1000 (Pubitemid 30350061)
69. Kinjo M, Setoguchi S, Schneeweiss S, Solomon DH (2005) Bone mineral density in subjects using central nervous system-active medications. Am J Med 118(12):1414 (Pubitemid 41832340)