Relationship between use of antidepressants and risk of fractures: A meta-analysis

Osteoporosis International

Volumn 24, Issue 1, 2013, Pages 121-137

  Rabenda, V ^a   Nicolet, D ^a   Beaudart, C ^a   Bruyere O ^a   Reginster, J Y ^a  

^a UNIVERSITY OF LIÈGE   (Belgium)

Author keywords

Antidepressants; Fractures; Meta analysis; Selective serotonin reuptake inhibitor; Tricyclic antidepressants

Indexed keywords

ANTIDEPRESSANT AGENT; SEROTONIN UPTAKE INHIBITOR; TRICYCLIC ANTIDEPRESSANT AGENT;

ARTICLE; COLLES FRACTURE; DEPRESSION; DISEASE ASSOCIATION; FEMUR FRACTURE; FRACTURE; HIP FRACTURE; HUMAN; LIMB FRACTURE; META ANALYSIS; OUTCOME ASSESSMENT; PRIORITY JOURNAL; RISK ASSESSMENT; SPINE FRACTURE; SYSTEMATIC REVIEW;

ANTIDEPRESSIVE AGENTS; ANTIDEPRESSIVE AGENTS, TRICYCLIC; FRACTURES, BONE; HUMANS; RISK ASSESSMENT; SEROTONIN UPTAKE INHIBITORS;

EID: 84872306548     PISSN: 0937941X     EISSN: 14332965     Source Type: Journal    
DOI: 10.1007/s00198-012-2015-9     Document Type: Article

References (82)

1. Hayes D (2004) Recent developments in antidepressant therapy in special populations. Am J Manag Care 10(suppl l):S179-S185
2. Rabheru K (2004) Special issues in the management of depression in older patients. Can J Psychiatry 49(suppl1):41S-50S
3. Emslie G, Judge R (2000) Tricyclic antidepressants and selective serotonin reuptake inhibitors: use during pregnancy, in children/adolescents and in the elderly. Acta Psychiatr Scand Suppl 403:26-34
4. Ray WA (1992) Psychotropic drugs and injuries among the elderly: a review. J Clin Psychopharmacol 12:386-396
5. Thapa PB, Gideon P, Cost TW et al (1998) Antidepressants and the risk of falls among nursing home residents. N Engl J Med 339:875-882
6. Ruthazer R, Lipsitz LA (1993) Antidepressants and falls among elderly people in long-term care. Am J Public Health 83:746-749
7. Woolcott JC, Richardson KJ, Wiens MO, Patel B, Marin J, Khan KM, Marra CA (2009) Meta-analysis of the impact of 9 medication classes on falls in elderly persons. Arch Intern Med 169:1952-1960
8. Bloch F, Thibaud M, Dugué B, Brèque C, Rigaud AS, Kemoun G (2011) Psychotropic drugs and falls in the elderly people: updated literature review and meta-analysis. J Aging Health 2:329-346
9. Warden SJ, Robling AG, Haney EM, Turner CH, Bliziotes MM (2010) The emerging role of serotonin (5-hydroxytryptamine) in the skeleton and its mediation of the skeletal effects of low-density lipoprotein receptor-related protein 5 (LRP5). Bone 46:4-12
10. Haney EM, Warden SJ (2008) Skeletal effects of serotonin (5-hydroxytryptamine) transporter inhibition: evidence from clinical studies. J Musculoskelet Neuronal Interact 8:133-145
11. Tsapakis EM, Gamie Z, Tran GT, Adshead S, Lampard A, Mantalaris A, Tsiridis E (2011) The adverse skeletal effects of selective serotonin reuptake inhibitors. Eur Psychiatry. doi: 10.1016/j.eurpsy.2010.10.006
12. Diem SJ, Blackwell TL, Stone KL, Yaffe K, Haney EM, Bliziotes MM, Ensrud KE (2007) Use of antidepressants and rates of hip bone loss in older women: the study of osteoporotic fractures. Arch Intern Med 167:1240-1245
13. Williams LJ, Henry MJ, Berk M, Dodd S, Jacka FN, Kotowicz MA, Nicholson GC, Pasco JA (2008) Selective serotonin reuptake inhibitor use and bone mineral density in women with a history of depression. Int Clin Psychopharmacol 23:84-87
14. Haney EM, Chan BK, Diem SJ, Ensrud KE, Cauley JA, Barrett-Connor E, Orwoll E, Bliziotes MM, Osteoporotic Fractures in Men Study Group (2007) Association of low bone mineral density with selective serotonin reuptake inhibitor use by older men. Arch Intern Med 167:1246-1251
15. Ginzburg R, Rosero E (2009) Risk of fractures with selective serotonin-reuptake inhibitors or tricyclic antidepressants. Ann Pharmacother 43:98-103
16. Schwan S, Hallberg P (2009) SSRIs, bone mineral density, and risk of fractures - a review. Eur Neuropsychopharmacol 19:683-692
17. Haney EM, Warden SJ, Bliziotes MM (2010) Effects of selective serotonin reuptake inhibitors on bone health in adults: time for recommendations about screening, prevention and management? Bone 46:13-17
18. Takkouche B, Montes-Martínez A, Gill SS, Etminan M (2007) Psychotropic medications and the risk of fracture: a meta-analysis. Drug Saf 30:171-184
19. Liberati A, Altman D, Tetzlaff J, Mulrow C, Gotzsche PC, Ioannidis JPA et al (2009) The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. J Clin Epidemiol 62:e1-e34
20. Wells GA, Shea B, O'Connell D, Petersen J, Welch V, Losos M, Tugwell P The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomized studies in meta-analyses. Department of Epidemiology and Community Medicine, University of Ottawa, Canada; http://www.ohri.ca/programs/clinical-epidemiology/ oxford.htm
21. Begg CB, Mazumdar M (1994) Operating characteristics of a rank correlation test for publication bias. Biometrics 50:1088-1101
22. Egger M, Davey Smith G, Schneider M, Minder C (1997) Bias in meta-analysis detected by a simple graphical test. BMJ 315:629-634
23. Orwin R (1983) A fail-safe N for effect size in meta-analysis. J Educ Stat 8:157-159
24. Rosenthal R (1979) The 'file drawer problem' and tolerance for null results. Psychol Bull 86:638-641
25. Hatal R, Keitz S, Wyer P, Guyatt G, Evidence-Based Medicine Teaching Tips Working Group (2005) Tips for learners of evidence-based medicine: 4. Assessing heterogeneity of primary studies in systematic reviews and whether to combine their results. CMAJ 172:661-665
26. Ray WA, Griffin MR, Schaffner W, Baugh DK, Melton LJ 3rd (1987) Psychotropic drug use and the risk of hip fracture. N Engl J Med 316:363-369
27. Jensen J, Nielsen LH, Lyhne N, Hallas J, Brøsen K, Gram LF (1991) Drugs and femoral neck fracture: a case-control study. J Intern Med 229:29-33
28. Ray WA, Griffin MR, Malcolm E (1991) Cyclic antidepressants and the risk of hip fracture. Arch Intern Med 151:754-756
29. Cumming RG, Klineberg RJ (1993) Psychotropics, thiazide diuretics and hip fractures in the elderly. Med J Aust 158:414-417
30. Lichtenstein MJ, Griffin MR, Cornell JE, Malcolm E, Ray WA (1994) Risk factors for hip fractures occurring in the hospital. Am J Epidemiol 140:830-838
31. Herings RM, Stricker BH, de Boer A, Bakker A, Sturmans F, Stergachis A (1996) Current use of thiazide diuretics and prevention of femur fractures. J Clin Epidemiol 49:115-119
32. Gambassi G, Lapane KL, Sgadari A, Bernabei R (1998) Elderly patients, use of antidepressants, and hip fracture. Lancet 352(9125):400, author reply 401-2
33. Liu B, Anderson G, Mittmann N, To T, Axcell T, Shear N (1998) Use of selective serotonin-reuptake inhibitors or tricyclic antidepressants and risk of hip fractures in elderly people. Lancet 351(9112):1303-1307
34. Wang PS, Bohn RL, Glynn RJ, Mogun H, Avorn J (2001) Zolpidem use and hip fractures in older people. J Am Geriatr Soc 49:1685-1690
35. Partanen J, Heikkinen J, Jämsä T, Jalovaara P (2002) Characteristics of lifetime factors, bone metabolism, and bone mineral density in patients with hip fracture. J Bone Miner Metab 20:367-375
36. Hubbard R, Farrington P, Smith C, Smeeth L, Tattersfield A (2003) Exposure to tricyclic and selective serotonin reuptake inhibitor antidepressants and the risk of hip fracture. Am J Epidemiol 158:77-84
37. Kaye JA, Jick H (2004) Epidemiology of lower limb fractures in general practice in the United Kingdom. Inj Prev 10:368-374
38. French DD, Campbell R, Spehar A, Cunningham F, Foulis P (2005) Outpatient medications and hip fractures in the US: a national veterans study. Drugs Aging 22:877-885
39. Hugenholtz GW, Heerdink ER, van Staa TP, Nolen WA, Egberts AC (2005) Risk of hip/femur in patients using antipsychotics. Bone 37:864-870
40. Vestergaard P, Rejnmark L, Mosekilde L (2005) Reduced relative risk of fractures among users of lithium. Calcif Tissue Int 77:1-8
41. Vestergaard P, Rejnmark L, Mosekilde L (2006) Anxiolytics, sedatives, antidepressants, neuroleptics and the risk of fracture. Osteoporos Int 17:807-816
42. Bolton JM, Metge C, Lix L, Prior H, Sareen J, Leslie WD (2008) Fracture risk from psychotropic medications: a population-based analysis. J Clin Psychopharmacol 28:384-391
43. Perreault S, Dragomir A, Blais L, Moride Y, Rossignol M, Ste-Marie LG, Fernandès JC (2008) Population-based study of the effectiveness of bone-specific drugs in reducing the risk of osteoporotic fracture. Pharmacoepidemiol Drug Saf 17:248-259
44. Abrahamsen B, Brixen K (2009) Mapping the prescriptiome to fractures in men - a national analysis of prescription history and fracture risk. Osteoporos Int 20:585-597
45. van den Brand MW, Pouwels S, Samson MM, van Staa TP, Thio B, Cooper C, Leufkens HG, Egberts AC, Verhaar HJ, de Vries F (2009) Use of anti-depressants and the risk of fracture of the hip or femur. Osteoporos Int 20:1705-1713
46. Verdel BM, Souverein PC, Egberts TC, van Staa TP, Leufkens HG, de Vries F (2010) Use of antidepressant drugs and risk of osteoporotic and non-osteoporotic fractures. Bone 47:604-609
47. Guo Z, Wills P, Viitanen M, Fastbom J, Winblad B (1998) Cognitive impairment, drug use, and the risk of hip fracture in persons over 75 year old: a community-based prospective study. Am J Epidemiol 148:887-892
48. Jacqmin-Gadda H, Fourrier A, Commenges D, Dartigues JF (1998) Risk factors for fractures in the elderly. Epidemiology 9:417-423
49. Ensrud KE, Blackwell T, Mangione CM, Bowman PJ, Bauer DC, Schwartz A, Hanlon JT, Nevitt MC, Whooley MA, Study of Osteoporotic Fractures Research Group (2003) Central nervous system active medications and risk for fractures in older women. Arch Intern Med 163:949-957
50. Lewis CE, Ewing SK, Taylor BC, Shikany JM, Fink HA, Ensrud KE, Barrett-Connor E, Cummings SR, Orwoll E, Osteoporotic Fractures in Men (MrOS) Study Research Group (2007) Predictors of non-spine fracture in elderly men: the MrOS study. J Bone Miner Res 22:211-219
51. Richards JB, Papaioannou A, Adachi JD, Joseph L, Whitson HE, Prior JC, Goltzman D, Canadian Multicentre Osteoporosis Study Research Group (2007) Effect of selective serotonin reuptake inhibitors on the risk of fracture. Arch Intern Med 167:188-194
52. Spector W, Shaffer T, Potter DE, Correa-de-Araujo R, Rhona Limcangco M (2007) Risk factors associated with the occurrence of fractures in U.S. nursing homes: resident and facility characteristics and prescription medications. J Am Geriatr Soc 55:327-333
53. Cooper C, Jakob F, Chinn C, Martin-Mola E, Fardellone P, Adami S, Thalassinos NC, Melo-Gomes J, Torgerson D, Gibson A, Marin F (2008) Fracture incidence and changes in quality of life in women with an inadequate clinical outcome from osteoporosis therapy: the Observational Study of Severe Osteoporosis (OSSO). Osteoporos Int 19:493-501
54. Spangler L, Scholes D, Brunner RL, Robbins J, Reed SD, Newton KM, Melville JL, Lacroix AZ (2008) Depressive symptoms, bone loss, and fractures in postmenopausal women. J Gen Intern Med 23:567-574
55. Ziere G, Dieleman JP, van der Cammen TJ, Hofman A, Pols HA, Stricker BH (2008) Selective serotonin reuptake inhibiting antidepressants are associated with an increased risk of nonvertebral fractures. J Clin Psychopharmacol 28:411-417
56. Nurminen J, Puustinen J, Piirtola M, Vahlberg T, Kivelä SL (2010) Psychotropic drugs and the risk of fractures in old age: a prospective population-based study. BMC Publ Health 10:396
57. Huybrechts KF, Rothman KJ, Silliman RA, Brookhart MA, Schneeweiss S (2011) Risk of death and hospital admission for major medical events after initiation of psychotropic medications in older adults admitted to nursing homes. CMAJ 183:E411-E419
58. Diem SJ, Blackwell TL, Stone KL, Cauley JA, Hillier TA, Haney EM, Ensrud KE, Study of Osteoporotic Fractures Research Group (2011) Use of antidepressant medications and risk of fracture in older women. Calcif Tissue Int 88:476-484
59. Gagne JJ, Patrick AR, Mogun H, Solomon DH (2011) Antidepressants and fracture risk in older adults: a comparative safety analysis. Clin Pharmacol Ther 89:880-887
60. Ducy P, Karsenty G (2010) The two faces of serotonin in bone biology. J Cell Biol 191:7-13
61. Diem SJ, Blackwell TL, Stone KL, Yaffe K, Cauley JA, Whooley MA, Ensrud KE, Study of Osteoporotic Fractures (2007) Depressive symptoms and rates of bone loss at the hip in older women. J Am Geriatr Soc 55:824-831
62. Eskandari F, Martinez PE, Torvik S, Phillips TM, Sternberg EM, Mistry S, Ronsaville D, Wesley R, Toomey C, Sebring NG, Reynolds JC, Blackman MR, Calis KA, Gold PW, Cizza G, Premenopausal, Osteoporosis Women, Alendronate, Depression (POWER) Study Group (2007) Low bone mass in premenopausal women with depression. Arch Intern Med 167:2329-2336
63. Jacka FN, Pasco JA, Henry MJ, Kotowicz MA, Dodd S, Nicholson GC, Berk M (2005) Depression and bone mineral density in a community sample of perimenopausal women: Geelong Osteoporosis Study. Menopause 12:88-91
64. Mezuk B, Eaton WW, Golden SH, Wand G, Lee HB (2008) Depression, antidepressants, and bone mineral density in a population-based cohort. J Gerontol A Biol Sci Med Sci 63:1410-1415
65. Michelson D, Stratakis C, Hill L, Reynolds J, Galliven E, Chrousos G, Gold P (1996) Bone mineral density in women with depression. N Engl J Med 335:1176-1181
66. Robbins J, Hirsch C, Whitmer R, Cauley J, Harris T (2001) The association of bone mineral density and depression in an older population. J Am Geriatr Soc 49:732-736
67. Mussolino ME (2005) Depression and hip fracture risk: the NHANES I epidemiologic follow-up study. Public Health Rep 120:71-75
68. Coelho R, Silva C, Maia A, Prata J, Barros H (1999) Bone mineral density and depression: a community study in women. J Psychosom Res 46:29-35
69. Yazici KM, Akinci A, Sütçü A, Ozçakar L (2003) Bone mineral density in premenopausal women with major depressive disorder. Psychiatry Res 117:271-275
70. Whooley MA, Kip KE, Cauley JA, Ensrud KE, Nevitt MC, Browner WS (1999) Depression, falls, and risk of fracture in older women. Study of Osteoporotic Fractures Research Group. Arch Intern Med 159:484-490
71. Whooley MA, Cauley JA, Zmuda JM, Haney EM, Glynn NW (2004) Depressive symptoms and bone mineral density in older men. J Geriatr Psychiatry Neurol 17:88-92
72. Jorgensen NR, Schwarz P, Holme I, Henriksen BM, Petersen LJ, Backer V (2007) The prevalence of osteoporosis in patients with chronic obstructive pulmonary disease - A cross sectional study. Respir Med 101:177-185
73. Vrieze A, de Greef MH, Wijkstra PJ, Wempe JB (2007) Low bone mineral density in COPD patients related to worse lung function, low weight and decreased fat-free mass. Osteoporos Int 18:1197-1202
74. van Manen JG, Bindels PJE, Dekker FW, IJzermans CJ, van der Zee JS, Schadé E (2002) Risk of depression in patients with chronic obstructive pulmonary disease and its determinants. Thorax 57:412-416
75. Uretmen S, Gol M, Cimrin D, Irmak E (2005) Effects of chronic liver disease on bone mineral density and bone metabolism markers in postmenopausal women. Eur J Obstet Gynecol Reprod Biol 123:67-71
76. Bianchi G, Marchesini G, Nicolino F, Graziani R, Sgarbi D, Loguercio C, Abbiati R, Zoli M (2005) Psychological status and depression in patients with liver cirrhosis. Dig Liver Dis 37:593-600
77. George J, Ganesh HK, Acharya S, Bandgar TR, Shivane V, Karvat A, Bhatia SJ, Shah S, Menon PS, Shah N (2009) Bone mineral density and disorders of mineral metabolism in chronic liver disease. World J Gastroenterol 15:3516-3522
78. Strotmeyer ES, Cauley JA (2007) Diabetes mellitus, bone mineral density, and fracture risk. Curr Opin Endocrinol Diabetes Obes 14:429-435
79. Talbot F, Nouwen A (2000) A review of the relationship between depression and diabetes in adults: is there a link? Diabetes Care 23:1556-1562
80. Campayo A, de Jonge P, Roy JF, Saz P (2010) Depressive disorder and incident diabetes mellitus: the effect of characteristics of depression. Am J Psychiatry 167:580-588
81. Canalis E, Mazziotti G, Giustina A, Bilezikian JP (2007) Glucocorticoid-induced osteoporosis: pathophysiology and therapy. Osteoporos Int 18:1319-1328
82. Van Staa TP, Leufkens HG, Abenhaim L, Zhang B, Cooper C (2000) Use of oral corticosteroids and risk of fractures. J Bone Miner Res 15:993-1000