Opioids, antiepileptic and anticholinergic drugs and the risk of fractures in patients 65 years of age and older: A prospective population-based study

Age and Ageing

Volumn 42, Issue 3, 2013, Pages 318-324

  Nurminen, Janne ^a   Puustinen, Juha ^a,b,c   Piirtola, Maarit ^a,d   Vahlberg, Tero ^a   Lyles, Alan ^e,f   Kivelä, Sirkka Liisa ^a,b,f  

^a UNIVERSITY OF TURKU   (Finland)

^b Härkätie Health Center   (Finland)

^c HOSPITAL DISTRICT OF SOUTHWEST FINLAND   (Finland)

^d UKK INSTITUTE FOR HEALTH PROMOTION RESEARCH   (Finland)

^e UNIVERSITY OF BALTIMORE   (United States)

^f UNIVERSITY OF HELSINKI   (Finland)

Author keywords

Concomitant use; Fracture risk; Medication; Old age; Older people

Indexed keywords

ANTICONVULSIVE AGENT; BENZODIAZEPINE; CHOLINERGIC RECEPTOR BLOCKING AGENT; NARCOTIC ANALGESIC AGENT; NEUROLEPTIC AGENT;

AGED; ARTICLE; BONE FRAGILITY; CONTROLLED STUDY; DISEASE ASSOCIATION; DRUG SAFETY; DRUG USE; FEMALE; FINLAND; FOLLOW UP; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROSPECTIVE STUDY; RISK ASSESSMENT; SEX DIFFERENCE;

AGE FACTORS; AGED; ANALGESICS, OPIOID; ANTICONVULSANTS; CHI-SQUARE DISTRIBUTION; CHOLINERGIC ANTAGONISTS; FEMALE; FINLAND; FRACTURES, BONE; HUMANS; LONGITUDINAL STUDIES; MALE; POLYPHARMACY; PROSPECTIVE STUDIES; RISK FACTORS; SEX FACTORS; TIME FACTORS;

EID: 84877091414     PISSN: 00020729     EISSN: 14682834     Source Type: Journal    
DOI: 10.1093/ageing/afs178     Document Type: Article

References (30)

1. Cummings SR, Nevitt MC, Browner WS et al. Risk factors for hip fracture in white women. Study of Osteoporotic Fractures Research Group. N Engl J Med 1995; 332: 767-73.
2. Hasselman CT, Vogt MT, Stone KL, Cauley JA, Conti SF. Foot and ankle fractures in elderly white women. Incidence and risk factors. J Bone Joint Surg Am 2003; 85: 820-4.
3. Wagner AK, Zhang F, Soumerai SB et al. Benzodiazepine use and hip fractures in the elderly: who is at greatest risk? Arch Intern Med 2004; 164: 1567-72.
4. Ensrud KE, Blackwell T, Mangione CM et al. Study of Osteoporotic Fractures Research Group: central nervous system active medications and risk for fractures in older women. Arch Intern Med 2003; 163: 949-57.
5. Ray WA, Griffin MR, Malcolm E. Cyclic antidepressants and the risk of hip fracture. Arch Intern Med 1991; 151: 754-6.
6. Liu B, Anderson G, Mittmann N, To T, Axcell T, Shear N. Use of selective serotonin-reuptake inhibitors of tricyclic antidepressants and risk of hip fractures in elderly people. Lancet 1998; 351: 1303-7.
7. Jacqmin-Gadda H, Fourrier A, Commenges D, Dartiques JF. Risk factors for fractures in the elderly. Epidemiology 1998; 9: 417-23.
8. Spector W, Shaffer T, Potter DE, Correa-de-Araujo R, Rhona Limcangco M. Risk factors associated with the occurrence of fractures in U.S. nursing homes: resident and facility characteristics and prescription medications. J Am Geriatr Soc 2007; 55: 327-33.
9. Wang PS, Bohn RL, Glynn RJ, Mogun H, Avorn J. Hazardous benzodiazepine regimens in the elderly: effects of half-life, dosage, and duration on risk of hip fracture. Am J Psychiatry 2001; 158: 892-8.
10. Ray WA, Griffin MR, Schaffner W, Baugh DK, Melton LJ III. Psychotropic drug use and the risk of hip fracture. N Engl J Med 1987; 316: 363-9.
11. Liperoti R, Onder G, Lapane KL et al. Conventional or atypical antipsychotics and the risk of femur fracture among elderly patients: results of a case-control study. J Clin Psychiatry 2007; 68: 929-34.
12. Takkouche B, Montes-Martínez A, Gill SS, Etminan M. Psychotropic medications and the risk of fracture: a meta-analysis. Drug Saf 2007; 30: 171-84.
13. Souverein PC, Webb DJ, Weil JG, Van Staa TP, Egberts AC. Use of antiepileptic drugs and risk of fractures: case-control study among patients with epilepsy. Neurology 2006; 66: 1318-24.
14. Westergaard P. Epilepsy, osteoporosis and fracture risk: a meta-analysis. Acta Neurol Scand 2005; 112: 277-86.
15. Mattson RH, Gidal BE. Fractures, epilepsy, and antiepileptic drugs. Epilepsy Behav 2004; 5 (Suppl. 2): S36-40.
16. Berdot S, Bertrand M, Dartigues JF. Inappropriate medication use and risk of falls: a prospective study in a large community-dwelling elderly cohort. BMC Geriatr 2009; 9: 30.
17. Nurminen J, Puustinen J, Piirtola M, Vahlberg T, Kivelä SL. Psychotropic drugs and the risk of fractures in old age: a prospective population-based study. BMC Public Health 2010; 10: 396.
18. Isoaho R, Puolijoki H, Huhti E, Kivelä SL, Tala E. Prevalence of asthma in elderly Finns. J Clin Epidemiol 1994; 47: 1109-18.
19. Piirtola M, Vahlberg T, Isoaho R, Aarnio P, Kivelä SL. Predictors of fractures among the aged: a population-based study with 12-years follow-up in a Finnish municipality. Aging Clin Exp Res 2008; 20: 242-52.
20. Classification of Medicines (ATC) and Defined Daily Doses (DDD) 2000. Helsinki, Finland: National Agency of Medicines, 2000.
21. Guo Z, Wills P, Viitanen M, Fastbom J, Winblad B. Cognitive impairment, drug use, and the risk of hip fracture in persons over 75 years old: a community-based prospective study. Am J Epidemiol 1998; 148: 887-92.
22. Kamal-Bahl SJ, Stuart BC, Beers MH. Propoxyphene use and risk for hip fractures in older adults. Am J Geriatr Pharmacother 2006; 4: 219-26.
23. Vestergaard P, Rejnmark L, Mosekilde L. Fracture risk associated with the use of morphine and opiates. J Intern Med 2006; 260: 76-87.
24. Vestergaard P, Tigaran S, Rejnmark L, Tigaran C, Dam M, Mosekilde L. Fracture risk is increased in epilepsy. Acta Neurol Scand 1999; 99: 269-75.
25. Vestergaard P, Rejnmark L, Mosekilde L. Fracture risk associated with use of antiepileptic drugs. Epilepsia 2004; 45: 1330-7.
26. Sirven JI. Acute and chronic seizures in patients older than 60 years. Mayo Clin Proc 2001; 76: 175-83.
27. Kinjo M, Setoguchi S, Schneeweiss S, Solomon DH. Bone mineral density in subjects using central nervous systemactive medications. Am J Med 2005; 118: 1414.
28. Daniell HW. Hypogonadism in men consuming sustained-action oral opioids. J Pain 2002; 3: 377-384.
29. Ali II, Schuh L, Barkley GL, Fates JR. Antiepileptic drugs and reduced bone mineral density. Epilepsy Behav 2004; 5: 296-300.
30. Kiebzak GM, Beinard GA, Perser K, Ambrose CG, Siff SJ, Heggeness MH. Undertreatment of osteoporosis in men with hip fracture. Arch Intern Med 2002; 162: 2217-22.