An in silico structure-based approach to anti-infective drug discovery

Parasitology

Volumn 141, Issue 1, 2014, Pages 17-27

  Cunningham, Fraser ^a   Mcphillie, Martin J ^a   Johnson, A Peter ^a   Fishwick, Colin W G ^a  

^a UNIVERSITY OF LEEDS   (United Kingdom)

Author keywords

bacterial resistance; D ala D ala ligase; DHODH; in silico drug discovery; malaria; RNA polymerase

Indexed keywords

A 77 1726; ANTIINFECTIVE AGENT; ENZYME INHIBITOR; TERIFLUNOMIDE; UNCLASSIFIED DRUG; D-ALANYLALANINE SYNTHETASE; DIHYDROOROTATE DEHYDROGENASE; LIGAND; OXIDOREDUCTASE; PEPTIDE SYNTHASE; PROTOZOAL PROTEIN;

ANTIBIOTIC RESISTANCE; ARTICLE; COMPUTER MODEL; DRUG DESIGN; MALARIA; NONHUMAN; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; ANTAGONISTS AND INHIBITORS; BACTERIAL INFECTIONS; CHEMISTRY; COMPUTER INTERFACE; DRUG DEVELOPMENT; ECONOMICS; GENETICS; HIGH THROUGHPUT SCREENING; HUMAN; MALARIA, FALCIPARUM; METABOLISM; MICROBIOLOGY; MOLECULAR DOCKING; PARASITOLOGY; UTILIZATION;

ANTI-INFECTIVE AGENTS; BACTERIAL INFECTIONS; DRUG DESIGN; DRUG DISCOVERY; ENZYME INHIBITORS; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; LIGANDS; MALARIA, FALCIPARUM; MOLECULAR DOCKING SIMULATION; OXIDOREDUCTASES ACTING ON CH-CH GROUP DONORS; PEPTIDE SYNTHASES; PROTOZOAN PROTEINS; USER-COMPUTER INTERFACE;

EID: 84891857612     PISSN: 00311820     EISSN: 14698161     Source Type: Journal    
DOI: 10.1017/S0031182013000693     Document Type: Article

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