Structure-based ligand design of novel bacterial RNA polymerase inhibitors

ACS Medicinal Chemistry Letters

Volumn 2, Issue 10, 2011, Pages 729-734

  McPhillie, Martin J ^a   Trowbridge, Rachel ^a,b   Mariner, Katherine R ^a   O'Neill, Alex J ^a   Johnson, A Peter ^a   Chopra, Ian ^a   Fishwick, Colin W G ^a  

^a UNIVERSITY OF LEEDS   (United Kingdom)

^b UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

Bacterial RNA polymerase; myxopyronin B; small molecule inhibitors; structure based ligand discovery

Indexed keywords

BACTERIAL RNA; MYXOPYRONIN B; RNA POLYMERASE; SCAFFOLD PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG BINDING; DRUG DESIGN; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ESCHERICHIA COLI; IC 50; INHIBITION KINETICS; PRIORITY JOURNAL; THERMUS THERMOPHILUS;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; THERMUS THERMOPHILUS;

EID: 80054720220     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/ml200087m     Document Type: Article

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