Molecular basis for regulatory subunit diversity in cAMP-dependent protein kinase: Crystal structure of the type IIβ regulatory subunit

Structure

Volumn 9, Issue 1, 2001, Pages 73-82

  Diller, Thomas C ^a   Madhusudan, M ^a   Xuong, Nguyen Huu ^a   Taylor, Susan S ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

cAPK; Regulatory subunit; RII structure

Indexed keywords

CYCLIC AMP DEPENDENT PROTEIN KINASE;

AMINO ACID SEQUENCE; ARTICLE; BINDING SITE; CATALYSIS; CRYSTAL STRUCTURE; ENZYME BINDING; ENZYME REGULATION; ENZYME SUBUNIT; GENE CASSETTE; GENETIC CONSERVATION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN MOTIF; SIGNAL TRANSDUCTION;

AMINO ACID SEQUENCE; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; ELECTRONS; HYDROGEN; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PHOSPHATES; PROTEIN BINDING; PROTEIN ISOFORMS; PROTEIN STRUCTURE, TERTIARY;

EID: 0035148589     PISSN: 09692126     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0969-2126(00)00556-6     Document Type: Article

References (50)

1. Evidence for the preferential binding of the catabolite gene activator protein (CAP) to DNA containing the lac promoter
2. Cyclic nucleotide-binding domains in proteins having diverse functions
3. A cyclic nucleotide-gated conductance in olfactory receptor cilia
4. Primary structure of cAMP-gated channel from bovine olfactory epithelium
5. A family of cAMP-binding proteins that directly activate Rap1
6. Predicted structures of cAMP binding domains of type I and type II regulatory subunits of cAMP-dependent protein kinase
7. Regulatory subunit of protein kinase A: Structure of deletion mutant with cAMP binding domains
8. Structure of a complex of catabolite gene activator protein and cyclic AMP refined at 2.5 Å resolution
9. The kinetics of the interaction between cyclic AMP and the regulatory moiety of protein kinase II
10. Localization of A-kinase through anchoring proteins
11. cAMP mediated proteolysis of the catalytic subunit of cAMP-dependent protein kinase
12. The distribution and dissociation of cyclic adenosine 3′:5′-monophosphate-dependent protein kinases in adipose, cardiac, and other tissues
13. Heterogenous distribution of the cAMP receptor protein RII in the nervous system: Evidence for its intracellular accumulation on microtubules, microtubule-organizing centers, and in the area of the Golgi complex
14. Characterization and comparison of membrane-associated and cytosolic cAMP-dependent protein kinases
15. Comparison of adenosine 3′:5′-monophosphate-dependent protein kinases from rabbit skeletal and bovine heart muscle
16. The molecular cloning of a type II regulatory subunit of the cAMP-dependent protein kinase from rat skeletal muscle and mouse brain
17. Genetically lean mice result from targeted disruption of the RIIβ subunit of protein kinase A
18. Compensatory regulation of RIα protein levels in protein kinase A mutant mice
19. PKA isoforms, neural pathways, and behaviour: Making the connection
20. Mutation of the RIIβ subunit of protein kinase A differentially affects lipolysis but not gene induction in white adipose tissue
21. Cyclic AMP, PKA, and the physiological regulation of adiposity
22. Loss of haloperidol induced gene expression and catalepsy in protein kinase A-deficient mice
23. High ethanol consumption and low sensitivity to ethanol-induced sedation in protein kinase A-mutant mice
24. AMoRe: An automated package for molecular replacement
25. Solvent content of protein crystals
26. Crystallography and NMR system: A new software suite for macromolecular structure determination
27. Main-chain bond lengths and bond angles in protein structures
28. PROCHECK - A program to check the stereochemical quality of protein structures
29. The kinetics of association of cyclic AMP to the two types of binding sites associated with protein kinase II from bovine myocardium
30. Studies on the function of the two intrachain cAMP binding sites of protein kinase
31. 3-cAMP
32. Active site mutations define the pathway for cooperative activation of cAMP-dependent protein kinase
33. Relationships between structural domains and function in the regulatory subunit of cAMP-dependent protein kinases I and II from porcine skeletal muscle
34. Interaction of the regulatory and catalytic subunits of cAMP-dependent protein kinase: Electrostatic sites on the type Iα regulatory subunit
35. Dissecting cAMP binding domain A in the RIα, subunit of cAMP-dependent protein kinase: Distinct subsites for recognition of cAMP and the catalytic subunit
36. Arg-242 [Arg-241] is necessary for allosteric coupling of cyclic AMP-binding sites A and B of RI subunit of cyclic AMP-dependent protein kinase
37. Processing of x-ray diffraction data collected in oscillation mode
38. Accurate bond and angle parameters for x-ray protein-structure refinement
39. TOM: A FRODO subpackage for protein-ligand fitting with interactive energy minimization
40. xdIMAPMAN and xdIDATAMAN - Programs for reformatting, analysis and manipulation of biomacromolecular electron-density maps and reflection data sets
41. The free R value: A novel statistical quantity for assessing the accuracy of crystal structures
42. Conformation of polypeptides and proteins
43. The native rat olfactory cyclic nucleotide-gated channel is composed of three distinct subunits
44. Improved methods for building protein models in electron density maps and the location of errors in these models
45. MOLSCRIPT: A program to produce both detailed and schematic plots of protein structures
46. Dictionary of protein secondary structure: Pattern recognition of hydrogen-bonded and geometrical features
47. The CCP4 suite; programs for protein crystallography
48. Protein folding and association: Insights from the interfacial and thermodynamic properties of hydrocarbons