Inhibition of hepatobiliary transporters by a novel kinase inhibitor contributes to hepatotoxicity in beagle dogs

Drug Metabolism Letters

Volumn 7, Issue 1, 2013, Pages 15-22

  Daniels, John Scott ^a   Lai, Yurong ^a   South, Sarah ^a   Chiang, Po Chang ^a   Walker, Daniel ^a   Feng, Bo ^a   Mireles, Rouchelle ^a   Whiteley, Laurence O ^a   Mckenzie, Jeremy W ^a   Stevens, Jeffrey ^a   Mourey, Robert ^a   Anderson, David ^a   Davis Jr , John W ^a  

^a PFIZER INC   (United States)

Author keywords

Acute toxicity; Metabolism; Transporters; Xenobiotic

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; BENZOTHIOPHENE DERIVATIVE; BILE SALT; BILE SALT EXPORT PUMP; BILIRUBIN; IDITOL DEHYDROGENASE; MULTIDRUG RESISTANCE ASSOCIATED PROTEIN 2; MULTIDRUG RESISTANCE PROTEIN; PF 022; PHOSPHOTRANSFERASE INHIBITOR; PIPERAZINE; UNCLASSIFIED DRUG;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BEAGLE; BILE ACID BLOOD LEVEL; DEALKYLATION; DISEASE SEVERITY; DRUG BLOOD LEVEL; DRUG TOLERABILITY; HYPERBILIRUBINEMIA; IC 50; IN VITRO STUDY; IN VIVO STUDY; LIVER TOXICITY; MALE; MAXIMUM PLASMA CONCENTRATION; MEMBRANE VESICLE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANIMALS; AREA UNDER CURVE; BILE; CARRIER PROTEINS; CELL LINE; DOGS; DRUG RESISTANCE, MULTIPLE; DRUG-INDUCED LIVER INJURY; FLUORESCEINS; FLUORESCENT DYES; LIVER; MALE; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; P-GLYCOPROTEIN; PROTEIN KINASE INHIBITORS; TAUROCHOLIC ACID;

EID: 84891840238     PISSN: 18723128     EISSN: None     Source Type: Journal    
DOI: 10.2174/18723128112066660018     Document Type: Article

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