Insulin resistance, iron, and the liver

Lancet

Volumn 355, Issue 9222, 2000, Pages 2181-2182

  Ferrannini, E ^a  

^a UNIVERSITY OF PISA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; GLUCOSE TRANSPORTER; INSULIN; IRON; SOMATOMEDIN B; TRANSFERRIN; TRANSFERRIN RECEPTOR;

BODY MASS; FATTY LIVER; GENE LINKAGE DISEQUILIBRIUM; GLUCOSE CLAMP TECHNIQUE; GLUCOSE TOLERANCE; HUMAN; HYPERINSULINEMIA; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; IRON OVERLOAD; LIVER DISEASE; MAJOR CLINICAL STUDY; NOTE; OBESITY; PRIORITY JOURNAL; PROTEIN TRANSPORT;

EID: 0034709677     PISSN: 01406736     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0140-6736(00)02397-7     Document Type: Note

References (20)

1. R Moirand AM Mortaji O Loréal F Paillard P Brissot Y Deugnier A new syndrome of liver iron overload with normal transferrin saturation Lancet 349 1997 95 97
2. GM Reaven Pathophysiology of insulin resistance in human disease Physiol Rev 75 1995 473 486
3. MH Mendler B Turlin R Moirand Insulin resistance-associated hepatic iron overload Gastroenterology 117 1999 1155 1163
4. E Ferrannini SM Haffner BD Mitchell MP Stern Hyperinsulinemia: the key feature of a cardiovascular and metabolic syndrome Diabetologia 34 1991 416 422
5. E Ferrannini A Natali P Bell P Cavallo-Perin N Lalic G Mingrone Insulin resistance and hypersecretion in obesity J Clin Invest 100 1997 1166 1173
6. T Goto T Onuma K Takebe JG Kral The influence of fatty liver on insulin clearance and insulin resistance in non-diabetic Japanese subjects Int J Obes Relat Metab Disord 19 1995 841 845
7. MA Banerji MC Buckley RL Chaiken D Gordon HE Lebovitz JG Kral Liver fat, serum triglycerides and visceral adipose tissue in insulin-sensitive and insulin-resistant black men with NIDDM Int J Obes Relat Metab Disord 19 1995 846 850
8. P Marceau S Biron FS Hould Liver pathology and the metabolic syndrome X in severe obesity J Clin Endocrinol Metab 84 1999 1513 1517
9. H Knobler A Schattner T Zhornicki Fatty liver-an additional and treatable feature of the insulin resistance syndrome QJM 92 1999 73 79
10. E Ferrannini MP Stern Primary insulin resistance: a risk syndrome Leslie RDG Robbins DC Diabetes: clinical science in practice 1995 Cambridge University Press Cambridge 200 220
11. D Guyader Y Gandon JY Robert Magnetic resonance imaging and assessment of liver iron content in genetic hemochromatosis J Hepatol 15 1992 304 308
12. JW Rowe JR Wands E Mezey Familial hemochromatosis: characteristics of the precirrhotic stage in a large kindred Medicine (Baltimore) 56 1977 197 211
13. D Conte D Manachino A Colli Prevalence of genetic hemochromatosis in a cohort of Italian patients with diabetes mellitus Ann Intern Med 128 1998 370 373
14. C Niederau M Berger W Stremmel Hyperinsulinaemia in noncirrhotic haemachromatosis: impaired hepatic insulin degradation? Diabetologia 26 1984 441 444
15. S Del Prato F Leonetti DC Simonson P Sheehan M Matsuda RA DeFronzo Effect of sustained physiologic hyperinsulinaemia and hyperglycaemia on insulin secretion and insulin sensitivity in man Diabetologia 37 1994 1025 1035
16. P Dandona MA Hussain Z Varghese D Politis DM Flynn AV Hoffbrand Insulin resistance and iron overload Ann Clin Biochem 20 1983 77 79
17. RJ Davis S Corvera MP Czech Insulin stimulates cellular iron uptake and causes the redistribution of intracellular transferrin receptors to the plasma membrane J Biol Chem 261 1986 8708 8711
18. LI Tanner GE Lienhard Insulin elicits a redistribution oftransferrin receptors in 3T3–L1 adipocytes through an increase in the rate constant for receptor externalization J Biol Chem 262 1987 8975 8980
19. LI Tanner GE Lienhard Localization of transferrin receptors and insulin-like growth factor II receptors in vesicles from 3T3–L1 adipocytes that contain intracellular glucose transporters J Cell Biol 108 1989 1537 1545
20. JC Sibille H Kondo P Aisen Interactions between isolated hepatocytes and Kupffer cells in iron metabolism: a possible role for ferritin as an iron carrier protein Hepatology 8 1988 296 301