α2 noradrenergic receptor suppressed CaMKII signaling in spinal dorsal horn of mice with inflammatory pain

European Journal of Pharmacology

Volumn 724, Issue 1, 2014, Pages 16-23

  Wang, Xin Tai ^a   Lian, Xia ^a   Xu, Ying Ming ^a   Suo, Zhan Wei ^a   Yang, Xian ^a   Hu, Xiao Dong ^a  

^a LANZHOU UNIVERSITY   (China)

Author keywords

Amino 3 hydroxy 5 methylisoxazole 4 propionic acid receptor; 2 noradrenergic receptor; Calcium calmodulin dependent protein kinase II; Inflammatory pain; N methyl d aspartate receptor

Indexed keywords

ALPHA 2 ADRENERGIC RECEPTOR; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; CLONIDINE; CYCLIC AMP DEPENDENT PROTEIN KINASE; GLUTAMATE RECEPTOR 1; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 1; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2B; PHOSPHOPROTEIN PHOSPHATASE; THREONINE;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPHOSPHORYLATION; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; INFLAMMATORY PAIN; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; SIGNAL TRANSDUCTION; SPINAL CORD DORSAL HORN;

CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE II; INFLAMMATORY PAIN; N-METHYL-D-ASPARTATE RECEPTOR; Α(2) NORADRENERGIC RECEPTOR; Α-AMINO-3-HYDROXY-5-METHYLISOXAZOLE-4-PROPIONIC ACID RECEPTOR;

ADRENERGIC ALPHA-2 RECEPTOR AGONISTS; ANIMALS; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE TYPE 2; CLONIDINE; FREUND'S ADJUVANT; INFLAMMATION; INJECTIONS, SPINAL; MALE; MICE; PAIN; POSTERIOR HORN CELLS; RECEPTORS, AMPA; RECEPTORS, N-METHYL-D-ASPARTATE; SIGNAL TRANSDUCTION;

EID: 84891807932     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2013.12.026     Document Type: Article

References (44)

1. C. Bantel, J.C. Eisenach, F. Duflo, J.R. Tobin, and S.R. Childers Spinal nerve ligation increases alpha2-adrenergic receptor G-protein coupling in the spinal cord Brain Res. 1038 2005 76 82 (Pubitemid 40340963)
2. A. Barria, and R. Malinow NMDA receptor subunit composition controls synaptic plasticity by regulating binding to CaMKII Neuron 48 2005 289 301 (Pubitemid 41476362)
3. K.U. Bayer, P. De Koninck, A.S. Leonard, J.W. Hell, and H. Schulman Interaction with the NMDA receptor locks CaMKII in an active conformation Nature 411 2001 801 805 (Pubitemid 32588103)
4. K.U. Bayer, E. LeBel, G.L. McDonald, H. O'Leary, H. Schulman, and P. De Koninck Transition from reversible to persistent binding of CaMKII to postsynaptic sites and NR2B J. Neurosci. 26 2006 1164 1174 (Pubitemid 43237049)
5. R.D. Blitzer, J.H. Connor, G.P. Brown, T. Wong, S. Shenolikar, R. Iyengar, and E.M. Landau Gating of CaMKII by cAMP-regulated protein phosphatase activity during LTP Science 280 1998 1940 1942
6. S.A. Brandt, and A. Livingston Receptor changes in the spinal cord of sheep associated with exposure to chronic pain Pain 42 1990 323 329
7. G.P. Brown, R.D. Blitzer, J.H. Connor, T. Wong, S. Shenolikar, R. Iyengar, and E.M. Landau Long-term potentiation induced by theta frequency stimulation is regulated by a protein phosphatase-1-operated gate J. Neurosci. 20 2000 7880 7887
8. 2+/calmodulin-dependent protein kinase II reverses experimental neuropathic pain in mice J. Pharmacol. Exp. Ther. 330 2009 650 659
9. R. Drdla-Schutting, J. Benrath, G. Wunderbaldinger, and J. Sandkuhler Erasure of a spinal memory trace of pain by a brief, high-dose opioid administration Science 335 2012 235 238
10. F. Duflo, X. Li, C. Bantel, C. Pancaro, M. Vincler, and J.C. Eisenach Peripheral nerve injury alters the alpha2 adrenoceptor subtype activated by clonidine for analgesia Anesthesiology 97 2002 636 641 (Pubitemid 34977324)
11. L. Fang, J. Wu, X. Zhang, Q. Lin, and W.D. Willis Increased phosphorylation of the GluR1 subunit of spinal cord alpha-amino-3-hydroxy-5- methyl-4-isoxazole propionate receptor in rats following intradermal injection of capsaicin Neuroscience 122 2003 237 245 (Pubitemid 37329962)
12. E.M. Garry, A. Moss, A. Delaney, F. O'Neill, J. Blakemore, J. Bowen, H. Husi, R. Mitchell, S.G. Grant, and S.M. Fleetwood-Walker Neuropathic sensitization of behavioral reflexes and spinal NMDA receptor/CaM kinase II interactions are disrupted in PSD-95 mutant mice Curr. Biol. 13 2003 321 328 (Pubitemid 36230023)
13. Y.X. Ge, W.J. Xin, N.W. Hu, T. Zhang, J.T. Xu, and X.G. Liu Clonidine depresses LTP of C-fiber evoked field potentials in spinal dorsal horn via NO-cGMP pathway Brain Res. 1118 2006 58 65 (Pubitemid 44633858)
14. S.J. Geng, F.F. Liao, W.H. Dang, X. Ding, X.D. Liu, J. Cai, J.S. Han, Y. Wan, and G.G. Xing Contribution of the spinal cord BDNF to the development of neuropathic pain by activation of the NR2B-containing NMDA receptors in rats with spinal nerve ligation Exp. Neurol. 222 2010 256 266
15. A.R. Halt, R.F. Dallapiazza, Y. Zhou, I.S. Stein, H. Qian, S. Juntti, S. Wojcik, N. Brose, A.J. Silva, and J.W. Hell CaMKII binding to GluN2B is critical during memory consolidation EMBO J. 31 2012 1203 1216
16. J.L. Hylden, and G.L. Wilcox Intrathecal morphine in mice: a new technique Eur. J. Pharmacol. 67 1980 313 316 (Pubitemid 10007057)
17. J.W. Kable, L.C. Murrin, and D.B. Bylund In vivo gene modification elucidates subtype-specific functions of alpha(2)-adrenergic receptors J. Pharmacol. Exp. Ther. 293 2000 1 7 (Pubitemid 30180916)
18. S.Y. Kang, C.Y. Kim, D.H. Roh, S.Y. Yoon, J.H. Park, H.J. Lee, A.J. Beitz, and J.H. Lee Chemical stimulation of the ST36 acupoint reduces both formalin-induced nociceptive behaviors and spinal astrocyte activation via spinal alpha-2 adrenoceptors Brain Res. Bull. 86 2011 412 421
19. T.I. Kanui, A. Tjolsen, A. Lund, N. Mjellem-Joly, and K. Hole Antinociceptive effects of intrathecal administration of alpha-adrenoceptor antagonists and clonidine in the formalin test in the mouse Neuropharmacology 32 1993 367 371 (Pubitemid 23122637)
20. T. Katano, T. Nakazawa, T. Nakatsuka, M. Watanabe, T. Yamamoto, and S. Ito Involvement of spinal phosphorylation cascade of Tyr1472-NR2B, Thr286-CaMKII, and Ser831-GluR1 in neuropathic pain Neuropharmacology 60 2011 609 616
21. Y. Kawasaki, E. Kumamoto, H. Furue, and M. Yoshimura Alpha 2 adrenoceptor-mediated presynaptic inhibition of primary afferent glutamatergic transmission in rat substantia gelatinosa neurons Anesthesiology 98 2003 682 689 (Pubitemid 36262595)
22. J.E. Lisman, and A.M. Zhabotinsky A model of synaptic memory: a CaMKII/PP1 switch that potentiates transmission by organizing an AMPA receptor anchoring assembly Neuron 31 2001 191 201 (Pubitemid 32762974)
23. Y. Lu, Y.N. Sun, X. Wu, Q. Sun, F.Y. Liu, G.G. Xing, and Y. Wan Role of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptor subunit GluR1 in spinal dorsal horn in inflammatory nociception and neuropathic nociception in rat Brain Res. 1200 2008 19 26
24. 2+/calmodulin-dependent protein kinase II J. Pharmacol. Exp. Ther. 325 2008 267 275 (Pubitemid 351439181)
25. P.T. Ly, and W. Song Loss of activated CaMKII at the synapse underlies Alzheimer's disease memory loss J. Neurochem. 119 2011 673 675
26. 2+/calmodulin-dependent kinase II autophosphorylation J. Neurosci. 19 1999 2500 2510 (Pubitemid 29162399)
27. A.B. Malmberg, L.R. Hedley, J.R. Jasper, J.C. Hunter, and A.I. Basbaum Contribution of alpha(2) receptor subtypes to nerve injury-induced pain and its regulation by dexmedetomidine Br. J. Pharmacol. 132 2001 1827 1836 (Pubitemid 32397975)
28. H. Mansikka, J. Lahdesmaki, M. Scheinin, and A. Pertovaara Alpha(2A) adrenoceptors contribute to feedback inhibition of capsaicin-induced hyperalgesia Anesthesiology 101 2004 185 190 (Pubitemid 38833281)
29. M.J. Millan, K. Bervoets, J.M. Rivet, P. Widdowson, A. Renouard, S. Le Marouille-Girardon, and A. Gobert Multiple alpha-2 adrenergic receptor subtypes. II. Evidence for a role of rat R alpha-2 A adrenergic receptors in the control of nociception, motor behavior and hippocampal synthesis of noradrenaline J. Pharmacol. Exp. Ther. 270 1994 958 972 (Pubitemid 24315208)
30. A. Moncada, C.M. Cendan, J.M. Baeyens, and E. Del Pozo Inhibitors of serine/threonine protein phosphatases antagonize the antinociception induced by agonists of alpha 2 adrenoceptors and GABAB but not kappa-opioid receptors in the tail flick test in mice Pain 114 2005 212 220 (Pubitemid 40279103)
31. M. Narita, K. Miyoshi, M. Narita, and T. Suzuki Changes in function of NMDA receptor NR2B subunit in spinal cord of rats with neuropathy following chronic ethanol consumption Life Sci. 80 2007 852 859 (Pubitemid 46149857)
32. A. Pertovaara Noradrenergic pain modulation Prog. Neurobiol. 80 2006 53 83 (Pubitemid 44692016)
33. S. Pezet, F. Marchand, R. D'Mello, J. Grist, A.K. Clark, M. Malcangio, A.H. Dickenson, R.J. Williams, and S.B. McMahon Phosphatidylinositol 3-kinase is a key mediator of central sensitization in painful inflammatory conditions J. Neurosci. 28 2008 4261 4270
34. 2+-calmodulin-dependent protein kinase II function mediates synaptic and motor deficits in experimental parkinsonism J. Neurosci. 24 2004 5283 5291 (Pubitemid 38747668)
35. K. Shen, M.N. Teruel, J.H. Connor, S. Shenolikar, and T. Meyer Molecular memory by reversible translocation of calcium/calmodulin-dependent protein kinase II Nat. Neurosci. 3 2000 881 886
36. A.J. Silva, C.F. Stevens, S. Tonegawa, and Y. Wang Deficient hippocampal long-term potentiation in alpha-calcium-calmodulin kinase II mutant mice Science 257 1992 201 206
37. M. Sonohata, H. Furue, T. Katafuchi, T. Yasaka, A. Doi, E. Kumamoto, and M. Yoshimura Actions of noradrenaline on substantia gelatinosa neurones in the rat spinal cord revealed by in vivo patch recording J. Physiol. 555 2004 515 526 (Pubitemid 38380008)
38. S. Strack, and R.J. Colbran Autophosphorylation-dependent targeting of calcium/calmodulin-dependent protein kinase II by the NR2B subunit of the N-methyl-d-aspartate receptor J. Biol. Chem. 273 1998 20689 20692 (Pubitemid 28385342)
39. X.M. Wang, Z.J. Zhang, R. Bains, and S.S. Mokha Effect of antisense knock-down of alpha(2a)- and alpha(2c)-adrenoceptors on the antinociceptive action of clonidine on trigeminal nociception in the rat Pain 98 2002 27 35 (Pubitemid 34722466)
40. J.Q. Wu, J.Y. Guo, W. Tang, C.S. Yang, C.D. Freel, C. Chen, A.C. Nairn, and S. Kornbluth PP1-mediated dephosphorylation of phosphoproteins at mitotic exit is controlled by inhibitor-1 and PP1 phosphorylation Nat. Cell Biol. 11 2009 644 651
41. L.J. Wu, and M. Zhuo Targeting the NMDA receptor subunit NR2B for the treatment of neuropathic pain Neurotherapeutics 6 2009 693 702
42. H.B. Yang, X. Yang, J. Cao, S. Li, Y.N. Liu, Z.W. Suo, H.B. Cui, Z. Guo, and X.D. Hu cAMP-dependent protein kinase activated Fyn in spinal dorsal horn to regulate NMDA receptor function during inflammatory pain J. Neurochem. 116 2011 93 104
43. H.W. Yang, X.D. Hu, H.M. Zhang, W.J. Xin, M.T. Li, T. Zhang, L.J. Zhou, and X.G. Liu Roles of CaMKII, PKA, and PKC in the induction and maintenance of LTP of C-fiber-evoked field potentials in rat spinal dorsal horn J. Neurophysiol. 91 2004 1122 1133 (Pubitemid 38250397)
44. Y. Zhou, E. Takahashi, W. Li, A. Halt, B. Wiltgen, D. Ehninger, G.D. Li, J.W. Hell, M.B. Kennedy, and A.J. Silva Interactions between the NR2B receptor and CaMKII modulate synaptic plasticity and spatial learning J. Neurosci. 27 2007 13843 13853 (Pubitemid 350278268)