Molecular memory by reversible translocation of calcium/calmodulin-dependent protein kinase II

Nature Neuroscience

Volumn 3, Issue 9, 2000, Pages 881-886

  Shen, K ^a   Teruel, M N ^a,b   Connor, J H ^a   Shenolikar, S ^a   Meyer, T ^a,b  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP DEPENDENT PROTEIN KINASE; PHOSPHOPROTEIN PHOSPHATASE 1; PROTEIN KINASE (CALCIUM,CALMODULIN) II;

ARTICLE; AUTOPHOSPHORYLATION; DISSOCIATION; ENZYME REGULATION; NERVE CELL PLASTICITY; NERVE CELL STIMULATION; PRIORITY JOURNAL; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; SYNAPSE;

ANILINE COMPOUNDS; ANIMALS; ANIMALS, NEWBORN; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CELLS, CULTURED; ELECTRIC STIMULATION; FLUORESCENT DYES; GLUTAMIC ACID; GREEN FLUORESCENT PROTEINS; HIPPOCAMPUS; INDICATORS AND REAGENTS; LUMINESCENT PROTEINS; MEMORY; NEURONAL PLASTICITY; NEURONS; PHOSPHORYLATION; SYNAPTIC MEMBRANES; XANTHENES;

EID: 0033860922     PISSN: 10976256     EISSN: None     Source Type: Journal    
DOI: 10.1038/78783     Document Type: Article

References (31)

1. Bennett, M. K. et al. Purification and characterization of a calmodulin-dependent protein kinase that is highly concentrated in brain. J. Biol. Chem. 258, 12735-12744 (1983).
2. 2+/calmodulin-dependent protein kinase in rat brain. J. Neurosci. 5, 3270-3277 (1985).
3. Braun, A. P. & Schulman, H. The multifunctional calcium/calmodulin-dependent protein kinase: from form to function. Annu. Rev. Physiol. 57, 417-445 (1995).
4. Meyer, T., Hanson, P. I., Stryer, L. & Schulman, H. Calmodulin trapping by calcium-calmodulin-dependent protein kinase. Science 256, 1199-1202 (1992).
5. Malinow, R., Madison D.V., & Tsien, R. W. Persistent protein kinase activity underlying long-term potentiation. Nature 335, 820-824 (1988).
6. Pettit, D. L., Perlman, S. & Malinow, R. Potentiated transmission and prevention of further LTP by increased CaMKII activity in postsynaptic hippocampal slice neurons. Science 266, 1881-1885 (1994).
7. Lledo, P. M. et al. Calcium/calmodulin-dependent kinase II and long-term potentiation enhance synaptic transmission by the same mechanism. Proc. Natl. Acad. Sci. USA 92, 11175-11179 (1995).
8. Silva, A. et al. Deficient hippocampal long-term potentiation in alpha-calcium-calmodulin kinase II mutant mice. Science 257, 201-206 (1992).
9. Silva, A. et al. Impaired spatial learning in alpha-calcium-calmodulin kinase II mutant mice. Science 257, 206-211 (1992).
10. Mayford, M. et al. Control of memory formation through regulated expression of a CaMKII transgene. Science 274, 1678-1683 (1996).
11. Mayford, M. et al. CaMKII regulates the frequency-response function of hippocampal synapses for the production of both LTD and LTP. Cell 81, 891-904 (1995).
12. Bach, M. E. et al. Impairment of spatial but not contextual memory in CaMKII mutant mice with a selective loss of hippocampal LTP in the range of the theta frequency. Cell 81, 905-915 (1995).
13. Giese, K. P. et al. Autophosphorylation at Thr286 of the alpha calcium-calmodulin kinase II in LTP and learning. Science 279, 870-873 (1998).
14. Cho, Y. H. et al. Abnormal hippocampal spatial representations in alphaCaMKIIT286A and CREBalphaDelta-mice. Science 279, 867-869 (1998).
15. Shen, K. & Meyer, T. Dynamic control of CaMKII translocation and localization in hippocampal neurons by NMDA receptor stimulation. Science 284, 162-167 (1999).
16. Gardoni, F. et al. AlphaCaMKII binding to the C-terminal tail of NMDA receptor subunit NR2A and its modulation by autophosphorylation. FEBS Lett. 456, 394-398 (1999).
17. Leonard, A. S. et al. Calcium/calmodulin-dependent protein kinase II is associated with the N-methyl-D-aspartate receptor. Proc. Natl. Acad. Sci. USA 96, 3239-3244 (1999).
18. Strack, S. & Colbran, R. J. Autophosphorylation-dependent targeting of calcium/calmodulin-dependent protein kinase II by the NR2B subunit of the N-methyl-D-aspartate receptor. J. Biol. Chem. 273, 20689-20692 (1998).
19. Ouyang, Y. et al. Visualization of the distribution of autophosphorylated calcium/calmodulin-dependent protein kinase II after tetanic stimulation in the CA1 area of the hippocampus. J. Neurosci. 17, 5416-5427 (1997).
20. Hanson, P. I., Meyer, T., Stryer, L. & Schulman, H. Dual role of calmodulin in autophosphorylation of multifunctional CaM kinase may underlie decoding of calcium signals. Neuron 12, 943-956 (1994).
21. 2+/calmodulin-dependent protein kinase II. Mutation of threonine 286 to alanine and aspartate. J. Biol. Chem. 264, 16759-16763 (1989).
22. 2+ independent for functional studies. Biochemistry 29, 1679-1684 (1990).
23. Shenolikar, S. Protein phosphatases - new avenues for cell regulation. Annu. Rev. Cell Biol. 10, 55-86 (1994).
24. 2+/calmodulin-dependent protein kinase II by protein phosphatases 1 and 2A. J. Neurochem. 68, 2119-2128 (1997).
25. Shields, S. M., Ingebritsen, T. S. & Kelly, P. T. Identification of protein phosphatase 1 in synaptic junctions: dephosphorylation of endogenous calmodulin-dependent kinase II and synapse-enriched phosphoproteins. J. Neurosci. 5, 3414-3422 (1985).
26. Blitzer, R. D. et al. Gating of CaMKII activity by cAMP-regulated phosphatase during LTP. Science 28, 1940-1943 (1998).
27. Colbran, R. J. & Soderling, T. R. Calcium/calmodulin-independent autophosphorylation sites of calcium/calmodulin-dependent protein kinase II. J. Biol. Chem. 265, 11213-11219 (1990).
28. 2+/calmodulin-dependent protein kinase analyzed by sitedirected mutagenesis. J. Biol. Chem. 267, 17216-17224 (1992).
29. 2+/calmodulin is inhibited by autophosphorylation of threonine within the calmodulinbinding domain. J. Biol. Chem. 265, 11204-11212 (1990).
30. Shen, K, Teruel, M. N., Subramanian, K. & Meyer, T. CaMKIIbeta functions as an F-actin targeting module that localizes CaMKIIalpha/beta heterooligomers to dendritic spines. Neuron 21, 593-606 (1998).
31. Teruel, M. N., Blanpied, T., Shen, K., Augustine, G. J. & Meyer, T. A versatile microporation technique for the transfection of CNS neurons. J. Neurosci. Methods 93, 37-48 (1999).