α 2A adrenoceptors contribute to feedback inhibition of capsaicin-induced hyperalgesia

Anesthesiology

Volumn 101, Issue 1, 2004, Pages 185-190

  Mansikka, Heikki ^a   Lähdesmäki, Janne ^b   Scheinin, Mika ^b   Pertovaara, Antti ^b  

^a TURKU UNIVERSITY HOSPITAL   (Finland)

^b UNIVERSITY OF TURKU   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

12 ETHYLSULFONYL 5,8,8A,9,10,11,12,12A,13,13A DECAHYDRO 3 METHOXY 6H ISOQUINO[2,1 G][1,6]NAPHTHYRIDINE; ALPHA 2 ADRENERGIC RECEPTOR BLOCKING AGENT; ALPHA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; ALPHA 2A ADRENERGIC RECEPTOR; ATIPAMEZOLE; CAPSAICIN; DEXMEDETOMIDINE; FADOLMIDINE; RADIOLIGAND; TRITIUM; UNCLASSIFIED DRUG;

ABDOMEN; ADRENERGIC SYSTEM; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; HINDLIMB; HYPERALGESIA; KNOCKOUT MOUSE; MOUSE; NEGATIVE FEEDBACK; NONHUMAN; PAIN; PRIORITY JOURNAL; RECEPTOR BINDING;

ADMINISTRATION, RECTAL; ADRENERGIC ALPHA-AGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANIMALS; BEHAVIOR, ANIMAL; CAPSAICIN; COLON; FEEDBACK; FOOT; GLUTAMIC ACID; HYPERALGESIA; INJECTIONS; MICE; MICE, KNOCKOUT; PAIN MEASUREMENT; RECEPTORS, ADRENERGIC, ALPHA-2; SPINAL CORD; SYNAPTOSOMES;

EID: 3042551691     PISSN: 00033022     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000542-200407000-00029     Document Type: Article

References (34)

1. Pertovaara A: Antinociception induced by alpha-2-adrenoceptor agonists, with special emphasis on medetomidine studies. Prog Neurobiol 1993; 40:691-709
2. 2-adrenergic receptor subtype function. Rev Physiol Biochem Pharmacol 2001; 142:161-85
3. Kable JW, Murrin LC, Bylund DB: In vivo gene modification elucidates subtype specific functions of alpha-2-adrenergic receptors. J Pharmacol Exp Ther 2000; 293:1-7
4. 2A-adrenoceptor subtype. Neuropharmacology 2003; 44:882-92
5. MacDonald E, Kobilka BK, Scheinin M: Gene targeting: Homing in on alpha-2-adrenoceptor subtype function. Trends Pharmacol Sci 1997; 18:211-9
6. Hunter JC, Fontana DJ, Hedley LR, Jasper JR, Lewis R, Link RE, Secchi R, Sutton J, Eglen RM: Assessment of the role of alpha-2-adrenoceptor subtypes in the antinociceptive, sedative and hypothermic action of dexmedetomidine in transgenic mice. Br J Pharmacol 1997; 122:1339-44
7. Lakhlani PP, MacMillan LB, Guo TZ, McCool BA, Lovinger DM, Maze M, Limbird LE: Substitution of a mutant alpha-2A-adrenergic receptor via 'hit and run' gene targeting reveals the role of this subtype in sedative, analgesic and anesthetic-sparing responses in vivo. Proc Natl Acad Sci U S A 1997; 94:9950-5
8. Stone LS, MacMillan LB, Kitto KF, Limbird LE, Wilcox GL: The alpha-2A-adrenergic receptor subtype mediates spinal analgesia evoked by alpha-2-agonists and is necessary for spinal adrenergic-opioid synergy. J Neurosci 1997; 17:7157-65
9. 2A-adrenoceptor subtype is not involved in inflammatory hyperalgesia or morphine-induced antinociception. Eur J Pharmacol 2003; 468:183-9
10. 2 receptor subtypes to nerve injury-induced pain and its regulation by dexmedetomidine. Br J Pharmacol 2001; 132:1827-36
11. 2A adrenoceptor and the sympathetic postganglionic neuron contribute to the development of neuropathic heat hyperalgesia in mice. Pain 2000; 85:345-58
12. 2A-Adrenoceptor stimulation reduces capsaicin-induced glutamate release from spinal cord synaptosomes. J Pharmacol Exp Ther 2001; 299:939-44
13. Altman JD, Trendelenburg AU, MacMillan L, Bernstein D, Limbird L, Starke K, Kobilka BK, Hein L: Abnormal regulation of the sympathetic nervous system in the alpha-2A-adrenergic receptor knockout mice. Mol Pharmacol 1999; 56:154-61
14. Lähdesmäki J, Sallinen J, MacDonald E, Kobilka BK, Fagerholm V, Scheinin M: Behavioural and neurochemical characterization of alpha(2A)-adrenergic receptor knockout mice. Neuroscience 2002; 113:289-99
15. Laird JMA, Martinez-Caro L, Garcia-Nicas E, Cervero F: A new model of visceral pain and referred hyperalgesia in the mouse. Pain 2001; 92:335-42
16. Laird JMA, Soustova V, Wood JN, Cervero F: Deficits in visceral pain and referred hyperalgesia in Nav1.8 (5NS/PN3)-null mice. J Neurosci 2002; 22:8352-6
17. Mansikka H, Shiotani M, Winchurch R, Raja SN: Neurokinin-1 receptors are involved in behavioral responses to high-intensity heat stimuli and capsaicin-induced hyperalgesia in mice. ANESTHESIOLOGY 1999; 90:1643-9
18. Pertovaara A, Wei H: Attenuation of ascending nociceptive signals to the rostroventromedial medulla induced by alpha-2-adrenoceptor agonist, MPV-2426, following intrathecal application in neuropathic rats. ANESTHESIOLOGY 2000; 92:1082-92
19. Wei H, Jyvasjarvi E, Niissalo S, Hukkanen M, Waris E, Konttinen YT, Pertovaara A: The influence of chemical sympathectomy on pain responsivity and alpha-2-adrenergic antinociception in neuropathic animals. Neuroscience 2002; 114:655-68
20. Tsuruoka M, Willis WD: Bilateral lesions in the area of the nucleus locus coeruleus affect the development of hyperalgesia during carrageenan-induced inflammation. Brain Res 1996; 726:233-6
21. Tyce GM, Yaksh TL: Monoamine release from cat spinal cord by somatic stimuli: an intrinsic modulatory system. J Physiol (Lond) 1981; 314:513-29
22. Mansikka H, Idänpään-Heikkilä JJ, Pertovaara A: Different roles of alpha-2-adrenoceptors of the medulla versus the spinal cord in modulation of mustard oil-induced central hyperalgesia in rats. Eur J Pharmacol 1996; 297:19-26
23. Xu M, Wei H, Kontinen VK, Kalso E, Pertovaara A: The dissociation of sedative from spinal antinociceptive effects following administration of a novel alpha-2-adrenoceptor agonist, MPV-2426, in the locus coeruleus in the rat. Acta Anaesthesiol Scand 2000; 44:648-55
24. Guo TZ. Jiang JY, Buttermann AE, Maze M: Dexmedetomidine injection into the locus ceruleus produces antinociception. ANESTHESIOLOGY 1996; 84:873-81
25. 2-adrenergic receptors regulate sympathetic neurotransmission. Nature 1999; 402:181-4
26. Fairbanks CA, Stone LS, Kitto KF, Nguyen HO, Posthumus IJ, Wilcox GL: Alpha-2C-adrenergic receptors mediate spinal analgesia and adrenergic-opioid synergy. J Pharmacol Exp Ther 2002; 300:282-90
27. Danzebrink RM, Gebhart GF: Antinociceptive effects of intrathecal adrenoceptor agonists in a rat model of visceral antinociception. J Pharmacol Exp Ther 1990; 253:698-705
28. Harada Y, Nishioka K, Kitahata L, Kishikawa K, Collins JG: Visceral antinociceptive effects of spinal clonidine combined with morphine, [D-Pen2, D-Pen5]enkephalin, or U50,488H. ANESTHESIOLOGY 1995; 83:344-52
29. Pertovaara A, Kalmari J: Comparison of the visceral antinociceptive effects of spinally administered MPV-2426 (fadolmidine) and clonidine in the rat. ANESTHESIOLOGY 2003; 98:189-94
30. 2-adrenoceptor antagonists enhance responses of dorsal horn neurones to formalin induced inflammation. Eur J Pharmacol 1998; 347:201-4
31. Kanui TI, Tjolsen A, Lund A, Mjellem-Joly N, Hole K: Antinociceptive effects of intrathecal administration of alpha-adrenoceptor antagonists and clonidine in the formalin test in the mouse. Neuropharmacology 19 93; 32:367-71
32. Fasmer OB, Berge OG, Tveiten L, Hole K: Changes in nociception after 6-hydroxydopamine lesions of descending catecholaminergic pathways in mice. Pharmacol Biochem Behav 1986; 24:1441-4
33. Martin WJ, Gupta NK, Loo CM, Rohde DS, Basbaum AI: Differential effects of neurotoxic destruction of descending noradrenergic pathways on acute and persistent nociceptive processing. Pain 1999; 80:57-65
34. 2-adrenoceptor subtype binding, brain neurochemistry and behaviour in comparison with yohimbine. Naunyn Schmiedebergs Arch Pharmacol 1997; 356:570-82